检索结果-南通市图书馆

No increased risk of dementia in patients receiving androgen deprivation therapy for prostate cancer： a 5-year follow-up study

引用

Asian Journal of Andrology 2017年第4期19卷 414-417页

作者： Li-Ting Kao Herng-ching lin Shiu-Dong chung Chao-Yuan Huang Graduate Institute of Life Science National Defense Medical Center Taipei 110 Taiwan China Sleep Research Center Taipei Medical University Hospital Taipei 110 Taiwan China Division of Urology Department of Surgery Far Eastern Memorial Hospital Taipei 110 Taiwan China Graduate Program in Biomedical Informatics College of Informatics Yuan Ze University Chung Li 320 Taiwan China Department of Urology National Taiwan University Hospital College of Medicine National Taiwan University Taipei 110 Taiwan China School of Public Health Taipei Medical University Taipei 110 Taiwan China

Prior studies suggested that the use of androgen deprivation therapy （ADT） in patients with prostate cancer （PC） might cause the impairment of cognitive function which is one of the common symptoms of dementia; however, the association between ADT and cognitive impairment still remains controversial. This retrospective cohort study aimed to investigate the relationship between ADT and subsequent risk of dementia using a population-based dataset, Data for this study were taken from the Taiwan （China） Longitudinal Health Insurance Database 2005. We included 755 PC patients who received ADT in the study cohort and 559 PC patients who did not receive ADT in the comparison cohort. Each patient was individually tracked for a 5-year period to define those who subsequently received a diagnosis of dementia. Results show that the incidence rates of dementia per 100 person-years were 2.35 （95% confidence interval [95% CI]： 1.82-2.98） and 1.85 （95% Ch 1.35-2.48） for PC patients who received ADT and those who did not receive ADT, respectively. The adjusted hazard ratio （HR） for dementia for PC patients who received ADT was 1.21 （95% Ch 0.82-1.78, P = 0,333） compared to those who did not receive ADT. In addition, the adjusted HRs for dementia for PC patients receiving ADT with gonadotropin-releasing hormone （GnRH） agonists and without GnRH agonists were 1.39 （95% Ch 0.80-2.40, P = 0.240） and 1.13 （95% CI： 0.75-1.71, P = 0.564）, respectively, compared to PC patients not receiving ADT. We concluded that there was no difference in the risk of subsequent dementia between PC patients who did and those who did not receive ADT.

关键词： androgen deprivation therapy dementia epidemiology prostate cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Healthcare utilization and costs in patients with benign prostatic hyperplasia： a population-based study

引用

Asian Journal of Andrology 2016年第6期18卷 942-945页

作者： Shiu-Dong chung Ya-Mei Tzeng Herng-ching lin Chao-Yuan Huang Division of Urology Department of Surgery Far Eastern Memorial Hospital New Taipei City Taiwan China School of Medicine Fu-Jen Catholic University New Taipei City Taiwan China Sleep Research Center Taipei Medical University Hospital Taipei Taiwan China Graduate Institute of Life Science National Defense Medical Center Taipei Taiwan China Department of Urology National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan China School of Public Health Taipei Medical University Taipei Taiwan China

This study aimed to investigate differences in healthcare service utilization between patients with and those without benign prostatic hyperplasia （BPH） using Taiwan＇s National Health Insurance population-based database. A total of 7413 patients with BPH and 7413 age-matched patients without BPH were included. The outcome variable was 1-year utilization of healthcare services Jncluding the number of outpatient visits, inpatient days, and the costs of outpatient and inpatient treatments. In addition, we separated healthcare services into urology services and nonurology services for analysis. We found that as to the utilization of outpatient urological services, patients with BPH had more outpatient services （7.84 vs 0.52, P 〈 0.001）, higher outpatient costs （US$372 vs US$34, P 〈 0.001）, a longer length of inpatient stay （0.55 vs 0.11, P 〈 0.001）, higher in-patients costs （US$149 vs US$32, P 〈 0.001）, and higher total costs （US$521 vs US$67, P 〈 0.001） than the comparison group. As for nonurological services, patients with BPH also had more outpatient services （49.11 vs 24.79, P〈 0.001）, higher outpatient costs （US$1794 vs US$1014, P〈 0.001）, a longer length of in-patient stay （3.72 vs 2.04, P〈 0.001）, higher inpatient costs （US$874 vs US$486, P〈 0.001）, and higher total costs （US$2668 vs US$1500, P 〈 0.001） compared to comparison patients. We also found that the average total cost was about 2-fold greater for patients with BPH than comparison patients. We concluded that patients with BPH had higher healthcare utilization than comparison patients without BPH.

关键词： benign prostatic hyperplasia epidemiology health care utilization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Locally Enhanced Flow and Electric Fields Through a Tip Effect for Efficient Flow‑Electrode Capacitive Deionization

引用

Nano-Micro Letters 2025年第2期17卷 1-17页

作者： Ziquan Wang Xiangfeng Chen Yuan Zhang Jie Ma Zhiqun lin Amor Abdelkader Maria‑Magdalena Titirici Libo Deng College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Research Center for Environmental Functional Materials College of Environmental Science and EngineeringTongji University1239 Siping RoadShanghai 200092People’s Republic of China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore Department of Engineering Faculty of Science and TechnologyBournemouth UniversityTalbot CampusFern BarrowPooleEngland BH125BBUK Institut de Chimie de Nice UniversitéCôte d’AzurUMR CNRS 727228 Av.Valrose06108 NiceFrance Department of Chemical Engineering Imperial College LondonSouth Kensington CampusExhibition RdLondon SW72AZUK

Low-electrode capacitive deionization(FCDI)is an emerging desalination technology with great potential for removal and/or recycling ions from a range of ***,it still suffers from inefficient charge transfer and ion transport kinetics due to weak turbulence and low electric intensity in flow electrodes,both restricted by the current ***,a new tip-array current collector(designated as T-CC)was developed to replace the conventional planar current collectors,which intensifies both the charge transfer and ion transport *** effects of tip arrays on flow and electric fields were studied by both computational simulations and electrochemical impedance spectroscopy,which revealed the reduction of ion transport barrier,charge transport barrier and internal *** the voltage increased from 1.0 to 1.5 and 2.0 V,the T-CC-based FCDI system(T-FCDI)exhibited average salt removal rates(ASRR)of 0.18,0.50,and 0.89μmol cm^(-2) min^(-1),respectively,which are 1.82,2.65,and 2.48 folds higher than that of the conventional serpentine current collectors,and 1.48,1.67,and 1.49 folds higher than that of the planar current ***,with the solid content in flow electrodes increased from 1 to 5 wt%,the ASRR for T-FCDI increased from 0.29 to 0.50μmol cm^(-2) min^(-1),which are 1.70 and 1.67 folds higher than that of the planar current ***,a salt removal efficiency of 99.89%was achieved with T-FCDI and the charge efficiency remained above 95%after 24 h of operation,thus showing its superior long-term stability.

关键词： Flow-electrode Capacitive deionization Current collector Tip effect Desalination

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Design of multifunctional interfaces on ceramic solid electrolytes for high-performance lithium-air batteries

引用

Green Energy & Environment 2025年第1期10卷 183-192页

作者： Yunxin Shi Ziyang Guo Changhong Wang Mingze Gao Xiaoting lin Hui Duan Yonggang Wang Xueliang Sun College of Energy Material and Chemistry College of Chemistry and Chemical EngineeringInner Mongolia UniversityHohhot010021China Department of Mechanical and Materials Engineering Western UniversityLondonONN6A 5B9Canada Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New EnergyiChEM(Collaborative Innovation Center of Chemistry for Energy Materials)Fudan UniversityShanghai200433China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingboZhejiang315100China

High-energy-density lithium(Li)–air cells have been considered a promising energy-storage system,but the liquid electrolyte-related safety and side-reaction problems seriously hinder their *** address these above issues,solid-state Li–air batteries have been widely ***,many commonly-used solid electrolytes generally face huge interface impedance inLi–air cells and also showpoor stability towards ambient air/Li ***,we fabricate a differentiating surface-regulated ceramic-based composite electrolyte(DSCCE)by constructing disparately LiI-containing polymethyl methacrylate(PMMA)coating and Poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP)layer on both sides of Li_(1.5)Al_(0.5)Ge_(1.5)(PO_(4))_(3)(LAGP).The cathode-friendly LiI/PMMA layer displays excellent stability towards superoxide intermediates and also greatly reduces the decomposition voltage of discharge products in Li–air ***,the anode-friendly PVDF-HFP coating shows low-resistance properties towards ***,Li dendrite/passivation derived from liquid electrolyte-induced side reactions and air/I-attacking can be obviously suppressed by the uniformand compact composite *** a result,the DSCCE-based Li–air batteries possess high capacity/low voltage polarization(11,836mAh g^(-1)/1.45Vunder 500mAg^(-1)),good rate performance(capacity ratio under 1000mAg^(-1)/250mAg^(-1) is 68.2%)and longterm stable cell operation(~300 cycles at 750 mA g^(-1) with 750 mAh g^(-1))in ambient air.

关键词： Li-air batteries Li_(1.5)Al_(0.5)Ge_(1.5)(PO_(4))_(3) Polymers Composite electrolyte Ambient air

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical and Sr-Nd compositions and ^(40)Ar/^(39)Ar ages of NW-trending dolerite dikes of Burkina Faso: Evidence for a Mesoproterozoic magmatism in the West African Craton

引用

Geoscience Frontiers 2018年第6期9卷 1957-1980页

作者： Boukare Tapsoba ching-Hua Lo Urbain Wenmenga Yoshiyuki Iizuka Sun-lin chung Gregory Shellnutt Department of Geosciences National Taiwan University UFR-SVT Département de Géologie Université Pr.Joseph Ki-Zerbo de Ouagadougou Institute of Earth Sciences Academia Sinica Department of Earth Sciences National Taiwan Normal University

The Paleoproterozoic basement of the northeastern part of the Leo-Man craton is intruded by generally NW-trending dikes. These regional scale dikes extend over 1000 km in Burkina Faso, Mali and Niger. We present chemical and Sr-Nd isotope compositions, as well as 40 Ar/39 Ar ages of these dikes with the following strikes N98°-N112°, and N114°-N124° in NE Burkina Faso. Field relationships show that the dikes are posterior to all other rock types dated between 2.26 Ga and 2.0 Ga. Chemical data indicate that the dikes are continental flood basalts and composed of low-Ti(TiO2 ≤ 2 wt.%) sub-alkaline basalts and andesites. They exhibit a minor negative Europium anomaly(0.86-0.99) and slightly fractionated REE patterns((La/Yb)_N= 2.5-9.1; Yb_N = 9.5-19.9). The ratios of Th/Ta(1.3-11.4) and Ce/Pb(5.2-58.5)suggest a varying crustal assimilation of the dike magmas during ascent in the continental crust for all studied samples. Calculated P-T conditions indicate that the magma reached temperatures of 1285 ℃(calculated from olivine compositions) and pressures of 6.9 kbar(calculated for pyroxene minerals).Calculated initial 87 Sr/86 Sr(0.70040-0.70260) and ε_(Nd)(t)=+2.1 to-3.5 at 1575 Ma,also point to a crustal contamination with the most primitive samples showing T_(DM) values of 1946 Ma and 2154 Ma. The low values of La/Ba(<0.2) and Nb/La(<1.0), contrast with the low Th/Nb(<0.9), and suggest a lithospheric mantle or subduction-modified mantle as possible source for the dikes. Sr-Nd data, Mg# and NbTa-Zr-Y-Th-Tb-Yb compositions further suggest that the most primitive samples were emplaced in a none orogenic setting and their magmas were subjected to variable crustal contaminations. Literature and the present whole rock 40 Ar/39 Ar age determinations show that the dikes were emplaced during a widespread Mesoproterozoic magmatism between 1.6 Ga and 1.2 Ga, and were affected by a thermal event causing the argon systematics resetting, best constrained by the date of sample KK1(123

关键词： Mafic dike swarm Depleted mantle Mesoproterozoic Continental tholeiites Nuna West African Craton

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

引用

Science China Chemistry 2025年第1期68卷 297-307页

作者： Bin Fang Limin Wang Haoqin Li Jiaxin Zhang Yang Ding Pan Pan Li Bo Peng Hua Bai lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

关键词： hepatic ischemia-reperfusion injury low-background mtH2O2-activatable super-resolution imaging fluorogenic probe

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Righting Wrongs

引用

China Today 2025年第1期74卷 45-47页

作者： ZHOU lin 不详

Representatives from nearly 50 countries and regions share their thoughts on how to correct development imbalances and protect people’s rights in all ***,a small village in Zhejiang Province,is known for its beautiful scenery,with white egrets flying in a blue sky and mandarin fish jumping out of the clear water of its lakes and *** houses are equally picturesque,dainty three-storied villas with white walls and black tiles.

关键词： walls beautiful white

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Circle of Friends

引用

China Today 2025年第1期74卷 32-35页

作者： ZHOU lin 不详

CISCE brings together partners on the global industrial chain to collaborate and enhance global *** in South Yorkshire in north-central England,British Steel,originally founded in 1967,is the U.K.’s only manufacturer of *** now produces three million tons of crude steel annually and has the distinction of maintaining stable production even during the COVID-19 pandemic,with its ironmaking,steelmaking and all rolling mills in full operation.

关键词： annually partner CISC

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The correlation between plasma cytokine levels in jaundice-free children with biliary atresia

引用

World Journal of Pediatrics 2015年第4期11卷 352-357页

作者： Zhi-Hong Jian Li-ching Wang Chieh-chung lin Jiaan-Der Wang Division of Pediatric Gastroenterology Department of PediatricsTaichung Veterans General HospitalTaichung City 40705TaiwanChina Department of Public Health and Institute of Public Health Chung Shan Medical UniversityTaichung City 40201TaiwanChina School of Medicine China Medical UniversityTaichungTaiwanChina

Background:T helper(Th)cell cytokines modulate inflammation and play a role in biliary atresia(BA).The aim of the study is a cross-sectional assessment of the levels of Th cytokines in the jaundice-free post Kasai procedure ***:There were 40 jaundice-free patients with BA and 28 normal controls *** were divided into 3 groups,including normal liver function,impaired liver function,and portal *** concentration of Th1[interferon-γ(INF-γ),interleukin(IL)-2],Th2(IL-4,IL-10),Th3[transforming growth factor-β1(TGF-β1)],Th17(IL-17)cytokines,and stromal cell-derived factor-1α(SDF-1α)were ***:The IFN-γ level was significantly higher in the BA patients with impaired liver function and portal hypertension than controls(P<0.0001 andP<0.0001,respectively).There was a signifi cantly increase of TGF-β1 in all BA groups compared with controls(P=0.003).The reduction of SDF-1αexpression was found in BA groups(P<0.0001).IL-10 levels significantly correlated with aspartate aminotransferase to platelet ratio index(r=0.496,P=0.001).For the cytokine correlations,there were no correlations of Th1,Th2 and Th17 cytokine with the other measured cytokines,but TGF-β1 was negatively correlated with SDF-1αlevels(r=-0.327,P=0.039).Conclusions:IFN-γand IL-10 are likely to be involved in the disease progression in ***,TGF-β1 is found to be a suppression marker associated with SDF-1αlevels and reduced production of TGF-β1 may be associated with the disease progression.

关键词： biliary atresia gastroenterology immunology pediatric disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

引用

Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei Fang Xiaoqi lin Ruian Xu Lu Liu Yu Zhang Feng Tian Jiao Jiao Li Jiajia Xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：