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Apolipoprotein E elicits targetdirected miRNA degradation to maintain neuronal integrity

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Neural Regeneration Research 2025年第9期20卷 2577-2578页

作者： Jiazi Tan chin-Tong ong Temasek Life Sciences Laboratory National University of SingaporeSingapore Department of Biological Sciences National University of SingaporeSingapore

Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous *** are three predominant human ApoE protein isoforms with cysteine and arginine substitutions at amino acid positions 112 and 158 that impact their lipidation and related functions(Flowers and Rebeck,2020).ApoE2 is characterized by Cys112 and Cys158,ApoE3 by Cys112 and Arg158,whereas ApoE4 contains Arg112 and Arg158.

关键词： metabolism glycoprotein maintain

Enrichment of novel Tau isoform with altered biochemical properties in Alzheimer's disease

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Neural Regeneration Research 2023年第11期18卷 2397-2398页

作者： chin-Tong ong Temasek Life Sciences Laboratory and Department of Biological SciencesNational University of SingaporeSingapore

Aberrant splicing in sporadic Alzheimer’s disease:Alzheimer’s disease (AD) is a progressive neurodegenerative disorder cha racterized by the presence of extracellular amyloid-β plaques and Tau-containing intracellular neurofib rilla ry tangles (Knopman et al.,2021).Cognitive decline in AD due to neuronal and synaptic loss is caused by the complex interplay between pathological amyloid-β and Tau species with the impaired innate clearance *** are two types of AD based on disease aetiology (Knopman et al.,2021).

关键词： Alzheimer impaired

Increased intron retention is linked to Alzheimer’s disease

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Neural Regeneration Research 2020年第2期15卷 259-260页

作者： chin-Tong ong Swarnaseetha Adusumalli Temasek Life Sciences Laboratory Department of Biological Sciences National University of Singapore

Intron retention in aging and Alzheimer's disease (AD): AD is an age-related neurodegenerative disorder with pathological accumulation of amyloid plaque (Masters et al., 2015), which can be classified into familial and sporadic form. In familial AD, mutations in genes encoding either amyloid precursor protein or presenilin (PS1 and PS2) cause overproduction of amyloid-42 molecules and early onset of dementia.

关键词： retention Alzheimer's disease dementia

Regulation of aging by NELF-A and RNA polymerase Ⅱ elongation

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Neural Regeneration Research 2024年第7期19卷 1415-1416页

作者： chin-Tong ong Zhen-Kai Ngian Temasek Life Sciences Laboratory and Department of Biological Sciences National University of SingaporeSingaporeSingapore Department of Genetics Harvard Medical SchoolBostonMAUSA Institute of Molecular and Cell Biology Agency for ScienceTechnology and ResearchSingaporeSingapore

Epigenetic regulation of aging:Aging is defined as the gradual decline of physiological function and cellular integrity,causing o rganismal vulnerability to age-onset diseases and *** in different animal models have l... 详细信息

关键词： aging twelve integrity

Noise robustness of an operational modal-based structural damage-detection scheme using impact-synchronous modal analysis

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2023年第9期24卷 782-800页

作者： Pei Yi SIOW Zhi Chao ong Shin yee KHOO Kok-Sing LIM Department of Mechanical Engineering Faculty of EngineeringUniversiti MalayaKuala Lumpur 50603Malaysia Photonics Research Centre Deputy Vice Chancellor(Research and Innovation)OfficeUniversiti MalayaKuala Lumpur 50603Malaysia

Data-driven damage-detection schemes are usually unsupervised machine-learning models in practice,as these do not require any ***-based features are commonly used in these schemes but often require several other parameters to accurately correlate with damage,as they may not globally represent the model,making them less sensitive to *** data,such as frequency response functions(FRFs)and principal component analysis(PCA)reduced FRFs(PCA-FRFs),inherits the dynamic characteristics of the structure,and it changes when damage occurs,thus showing sensitivity to ***,noise from the environment or external sources such as wind,operating machines,or the in-service system itself,can reduce the modal data's sensitivity to damage if not handled properly,which affects damage-detection *** study proposes a noise-robust operational modal-based structural damage-detection scheme that uses impact-synchronous modal analysis(ISMA)to generate clean,static-like FRFs for damage *** allows modal data collection without requiring shutdown conditions,and its denoising feature aids in generating clean,static-like FRFs for damage *** results showed that the FRFs obtained through ISMA under noise conditions have frequency response assurance criterion(FRAC)and cross signature assurance criterion(CSAC)scores greater than 0.9 when compared with FRFs obtained through experimental modal analysis(EMA)under static conditions;this validates the denoising feature of *** the denoised FRFs are reduced to PCA-FRFs and used in an unsupervised learning-based damage-detection scheme,zero false alarms occur.

关键词： Impact-synchronous modal analysis(ISMA) Frequency response function(FRF) Principal component analysis(PCA) Unsupervised learning Damage detection

CDK5-mediated phosphorylation of CP190 may regulate locomotor activity in adult female Drosophila

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Journal of Genetics and Genomics 2018年第3期45卷 177-181页

作者： chin-Tong ong Wei-Qi Lin Temasek Life Sciences Laboratory National University of Singapore Department of Biological Sciences National University of Singapore

The three-dimensional organization of the genome plays a crucial role in regulating gene expression patterns in metazoans（ong and Corces,2014）.The nuclear architectural proteins are known to facilitate the formation of topological domains within the genome through mediating inter-and intra-chromosomal *** vertebrate,CCCTC-binding factor（CTCF）is the main architectural protein that mediates long-range chromosomal interactions among its DNA binding sites through a process that is stabilized by cohesin （Parelho et al., 2008; Wendt et al., 2008）.

关键词： CP CDK5-mediated phosphorylation of CP190 may regulate locomotor activity in adult female Drosophila

Effects of root morphology and anatomy on cadmium uptake and translocation in rice(Oryza sativa L.)

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Journal of Environmental Sciences 2019年第1期31卷 296-306页

作者： Lu Huang Wai chin Li Nora Fung yee Tam Zhihong Ye School of Life Sciences Sun Yat-sen University Department of Science and Environmental Studies The Education University of Hong Kong State Key Laboratory in Marine Pollution and Department of Chemistry City University of Hong Kong

A clear description of the certain mechanisms of cadmium(Cd) uptake and translocation in rice(Oryza sativa L.) may help to reduce Cd accumulation in rice grain. Hydroponic experiments were carried out to determine the effects of cultivation conditions(aerated and stagnant) on the uptake, translocation and subcellular distribution of Cd in relation to the morphology and anatomy of roots in two rice genotypes with different Cd accumulations in grains. Marked differences in morphology and anatomy were observed between these two genotypes under different cultivation conditions. Genotypes with low Cd accumulation in grains tended to develop fewer root tips per root surface area, larger root porosity and more mature apoplastic barriers. The stagnant cultivation condition decreased the number of root tips per root surface area but increased root porosity and accelerated apoplastic barrier formation in root *** Cd uptake studies revealed that rice plants with fewer number of root tips per root surface area reduced root Cd uptake ability, while mature apoplastic barriers increased root Cd retention in cell walls and the symplast. Thus, the fewer number of root tips per root surface area and the earlier formation of mature apoplastic barriers led to lower Cd uptake and translocation. The results indicated that the morphology and anatomy of roots could play important roles in Cd uptake and translocation in rice, and could be influenced by both genotype and cultivation conditions. The present results would be useful in screening and planting rice plants with low Cd accumulation.

关键词： Apoplastic barriers Cadmium Rice Root morphology

Biomarkers in Barrett's esophagus and esophageal adenocarcinoma:Predictors of progression and prognosis

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World Journal of Gastroenterology 2010年第45期16卷 5669-5681页

作者： chin-Ann J ong Pierre Lao-Sirieix Rebecca C Fitzgerald MRC Cancer Cell Unit Hutchison-MRC Research CentreCambridgeCB20XZUnited Kingdom

Barrett’s esophagus is a well-known premalignant lesion of the lower esophagus that is characterized by intestinal metaplasia of the squamous epithelium. It is clinically important due to the increased risk (0.5% per annum) of progression to esophageal adenocarcinoma (EA), which has a poor outcome unless diagnosed early. The current clinical management of Barrett’s esophagus is hampered by the lack of accurate predictors of progression. In addition, when patients develop EA, the current staging modalities are limited in stratifying patients into different prognostic groups in order to guide the optimal therapy for an individual patient. Biomarkers have the potential to improve radically the clinical management of patients with Barrett’s esophagus and EA but have not yet entered mainstream clinical practice. This is in contrast to other cancers like breast and prostate for which biomarkers are utilized routinely to inform clinical decisions. This review aims to highlight the most promising predictive and prognostic biomarkers in Barrett’s esophagus and EA and to discuss what is required to move the field forward towards clinical application.

关键词： Barrett’s esophagus Esophageal adenocar cinoma Esophageal dysplasia Prognosis

Graphical password： prevent shoulder-surfing attack using digraph substitution rules

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Frontiers of Computer Science 2017年第6期11卷 1098-1108页

作者： Lip yee POR chin Soon KU Amanul ISLAM Tan Fong ANG Department of Computer Science and Information Technology University of Malaya Kuala Lumpur 50603 Malaysia Department of Computer Science Universiti Tunku Abdul Rahman (Jalan Universiti) Kampar 31900 Malaysia

In this paper, a new scheme that uses digraph substitution rules to conceal the mechanism or activity re- quired to derive password-images is proposed. In the pro- posed method, a user is only required to click on one of the pass-image instead of both pass-images shown in each chal- lenge set for three consecutive sets. While this activity is sim- ple enough to reduce login time, the images clicked appear to be random and can only be obtained with complete knowl- edge of the registered password along with the activity rules. Thus, it becomes impossible for shoulder-surfing attackers to obtain the information about which password images and pass-images are used by the user. Although the attackers may know about the digraph substitution rules used in the pro- posed method, the scenario information used in each chal- lenge set remains. User study results reveal an average login process of less than half a minute. In addition, the proposed method is resistant to shoulder-surfing attacks.

关键词： graphical password authentication shoulder-surfing data and computer security digraph substitution rules