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The intragraft vascularized bone marrow component plays a critical role in tolerance induction after reconstructive transplantation

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Cellular & Molecular Immunology 2021年第2期18卷 363-373页

作者： Cheng-hung lin Madonna R.Anggelia Hui-Yun Cheng Aline Yen ling Wang Wen-Yu Chuang chih-hung lin W.P.Andrew Lee Fu-Chan Wei Gerald Brandacher Center for Vascularized Composite Allotransplantation Department of Plastic and Reconstructive SurgeryChang Gung Memorial HospitalChang Gung Medical College and Chang Gung UniversityTaoyuanTaiwanChina Graduate Institute of Biomedical Sciences College of MedicineChang Gung UniversityTaoyuanTaiwanChina Department of Pathology Chang Gung Memorial HospitalChang Gung Medical College and Chang Gung UniversityTaoyuanTaiwanChina Department of Plastic and Reconstructive Surgery Chiayi Chang Gung Memorial HospitalChiayi CountyTaiwanChina Department of Plastic and Reconstructive Surgery Vascularized Composite Allotransplantation(VCA)LaboratoryJohns Hopkins University School of MedicineBaltimoreMDUnited States

The role of the vascularized bone marrow component as a continuous source of donor-derived hematopoietic stem cells that facilitate tolerance induction of vascularized composite allografts is not completely *** this study,vascularized composite tissue allograft transplantation outcomes between recipients receiving either conventional bone marrow transplantation(CBMT)or vascularized bone marrow(VBM)transplantation from Balb/c(H2d)to C57BL/6(H2b)mice were *** high-or low-dose CBMT(1.5×10^(8)or 3×10^(7)bone marrow cells,respectively)was *** addition,recipients were treated with costimulation blockade(1 mg anti-CD154 and 0.5 mg CTLA4Ig on postoperative days 0 and 2,respectively)and short-term rapamycin(3 mg/kg/day for the first posttransplant week and then every other day for another 3 weeks).Similar to high-dose conventional bone marrow transplantation,5/6 animals in the vascularized bone marrow group demonstrated long-term allograft survival(>120 days).In contrast,significantly shorter median survival was noted in the low-dose CBMT group(~64 days).Consistently high chimerism levels were observed in the VBM transplantation ***,low levels of circulating CD4^(+)and CD8^(+)T cells and a higher ratio of Treg to Teff cells were maintained in VBM transplantation and high-dose CBMT recipients(>30 days)but not in low-dose VBM transplant ***-specific hyporesponsiveness was shown in tolerant recipients in *** of the vascularized bone marrow component after secondary donor-specific skin transplantation did not affect either primary allograft or secondary skin graft survival.

关键词： Vascularized composite allotransplantation Costimulation blockade Donor-specific tolerance Vascularized bone marrow transplantation Chimerism

Prediction-Based Lossless Data Hiding by ACB Algorithm

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通讯和计算机（中英文版） 2012年第2期9卷 142-147页

作者： Ching-Yu Yang chih-hung lin Wu-chih Hu Dept. of Computer Science and Information Engineering National Penghu University of Science and Technology Penghu Taiwan Graduate Institute of Mathematics and Science Education National Chiayi University Chiayi Taiwan

Early detection of diabetic kidney disease: Present limitations and future perspectives

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World Journal of Diabetes 2016年第14期7卷 290-301页

作者： chih-hung lin Yi-Cheng Chang Lee-Ming Chuang Depart-ment of Internal Medicine National Taiwan University Hospital Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Graduate Institute of Medical Genomics and Proteomics College of Medicine National Taiwan University Institute of Biomedical Science Academia Sinica

Diabetic kidney disease(DKD) is one of the most common diabetic complications, as well as the leading cause of chronic kidney disease and end-stage renal disease around the world. To prevent the dreadful consequence, development of new assays for diagnostic of DKD has always been the priority in the research field of diabetic complications. At present, urinary albumin-to-creatinine ratio and estimated glomerular filtration rate(eG FR) are the standard methods for assessing glomerular damage and renal function changes in clinical practice. However, due to diverse tissue involvement in different individuals, the so-called "non-albuminuric renal impairment" is not uncommon, especially in patients with type 2 diabetes. On the other hand, the precision of creatinine-based GFR estimates is limited in hyperfiltration status. These facts make albuminuria and eG FR less reliable indicators for early-stage DKD. In recent years, considerable progress has been made in the understanding of the pathogenesis of DKD, along with the elucidation of its genetic profiles and phenotypic expression of different molecules. With the help of ever-evolving technologies, it has gradually become plausible to apply the thriving information in clinical practice. The strength and weakness of several novel biomarkers, genomic, proteomic and metabolomic signatures in assisting the early diagnosis of DKD will be discussed in this article.

关键词： Diabetic kidney disease Early diagnosis Genomics Biomarkers

An Improved Modeling of TDR Signal Propagation for Measuring Complex Dielectric Permittivity

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Journal of Earth Science 2015年第6期26卷 827-834页

作者： chih-Ping lin Shr-Hong Tang Chun-hung lin chih-Chung Chung Civil Engineering National Chiao Tung University Information Management St.Mary's Medicine Nursing and Management College Disaster Prevention and Water Environment Research Center National Chiao Tung University Civil Engineering National Central University

Time domain reflectometry（TDR） is a measurement technique based upon transmission line theory. The solutions of transmission line equations are reformulated in terms of independent physical properties, instead of coupled per-unit-length circuit parameters. The complete TDR response is effectively modeled by a non-uniform transmission line using the non-recursive ABCD matrix approach. Approaches to calibrate line parameters and perform TDR measurements based upon such model are introduced with an example on dielectric spectroscopy. TDR modeling in terms of decoupled physical parameters and non-recursive algorithm allows more convenient calibration of line parameters and facilitates interpretation of TDR measurements.

关键词： time domain reflectometry transmission line theory transmission line measurements dielectric measurements spectroscopy soll measurements.

Gender Classification Based on Multi-Scale and Run-Length Features

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Journal of Electronic Science and Technology 2017年第3期15卷 251-257页

作者： Sheng-hung Wang chih-Yang lin Jing-Tong Fu Department of Computer Science and Information Engineering Asia University Taichung 41354 Department of Bioinformatics and Medical Engineering Asia University Taichung 41354

Human faces can convey substantial information about a person,such as his or her age,race,identity,gender,and *** facial information can be obtained through techniques like human facial tracking and detection,facial recognition,gender classification,emotion recognition,as well as age *** these,gender classification is particularly important due to its diverse applications in the fields such as video surveillance and commercial *** this thesis,we propose a method of gender classification based on run-length *** proposed method uses a run-length histogram to record the position information of pixels,thereby efficiently improves the recognition rate and makes the technique suitable for a big-data multimedia *** experimental results show that the proposed method can achieve better accuracy than a multi-scale based method can.

关键词： Index Terms--Gender classification run-length,texture feature.

Single-incision vs three-incision laparoscopic cholecystectomy for complicated and uncomplicated acute cholecystitis

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World Journal of Gastroenterology 2013年第43期19卷 7743-7750页

作者： Shu-hung Chuang Pai-Hsi Chen chih-Ming Chang chih-Sheng lin Department of Biological Science and Technology National Chiao Tung University Department of Surgery Mackay Memorial HospitalHsin-Chu Branch College of Management Fu Jen Catholic University Department of Nursing Mackay Memorial HospitalHsin-Chu Branch

AIM:To compare the clinical outcome of single-incision laparoscopic cholecystectomy(SILC)and three-incision laparoscopic cholecystectomy(3ILC)for acute ***:From July 2009 to September 2012,136patients underwent SILC or 3ILC for acute cholecystitis at a tertiary referral *** experienced surgeon performed every procedure using 5 or 10 mm 30-degree laparoscopes,straight instruments,and conventional *** patients with perforated gallbladder and diffuse peritonitis and 23 patients with mild acute cholecystitis were *** remaining 108 patients were divided into complicated and uncomplicated groups according to pathologic *** demography,clinical data,operative results and complications were recorded and ***:Fifty patients with gangrenous cholecystitis,gallbladder empyema,or hydrops were classified as the complicated group,and 58 patients with acute cholecystitis were classified as the uncomplicated ***-three(46.0%)of the patients in the complicated group(n=50)and 39(67.2%)of the patients in the uncomplicated group(n=58)underwent SILC;all others underwent *** postoperative length of hospital stay(PLOS)was significantly shorter in the SILC subgroups than the 3ILC subgroups(3.5±1.1 d vs 4.6±1.3 d,P<0.01 in the complicated group;2.9±1.1 d vs 3.7±1.4 d,P<0.05 in the uncomplicated group).The maximum body temperature recorded at day 1 and at day 2 following the procedure was lower in the SILC subgroups,but the difference reached statistical significance only in the uncomplicated group(37.41±0.56℃vs 37.80±0.72℃,P<0.05 on postoperative day 1;37.10±0.43℃vs 37.57±0.54℃,P<0.01 on postoperative day 2).The operative time,estimated blood loss,postoperative narcotic use,total length of hospital stay,conversion rates,and complication rates were similar in both SILC and 3ILC *** complicated group had longer operative time(122.2±35.0 min vs 106.6±43.6 min,P<0.05),longer PLOS(4.1±1.3 d vs 3.2±1.2 d,P<0.

关键词： Single-incision laparoscopic cholecystectomy Single-incision laparoscopic surgery Laparoen doscopic single site surgery Cholecystectomy Acute cholecystitis Complicated cholecystitis Gangrenous cholecystitis

Fine-tuning the spatial allocation of phytohormones for smart canopy, smart breeding, and smart agriculture

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Science China Life Sciences 2025年第1期 309-310页

作者： Tao Zhou lin Li National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University HuBei HongShan Laboratory

The dual challenges of global climate change and population growth have increased demand for higher crop yields per unit area. The innovative technology of smart agriculture aims to synergize breeding, cultivation, and production through the application of biological and informatics technologies. Historically, the “Green Revolution” introduced semidwarf varieties of certain key crops by utilizing mutations affecting gibberellin pathways, which significantly increased planting densities and yields.

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A New Step for a Sustainable and Balanced Urban Policy in Asian Living Historic City Conservation: The Case of Qufu, China

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China City Planning Review 2015年第3期24卷 56-65页

作者： Roland lin chih-hung Faculty of Architecture and Planning.Tianjin University Faculty of Architecture and Planning Tongji University CREOPS(Centre de Recherche en Extreme-Orient de I'Universite ParisSorbonne) UNESCO.World Heritage Centre

Taking the case of Qufu(birthplace of Confucius), China, a world cultural heritage site and a Chinese living historic city, the author analyses the current situation/issues of culture heritage assessment and the planning of urban conservation, renewal and development. The objective of this article is to explore related issues to generate guidance for selecting appropriate methodologies(strategies) and principles(tools/planning/tasks/action) to assess cultural heritage values and cultural signifi cance in the Asian living historic city context as part of an integrated culture-oriented development planning. The author calls for the necessity of an interdisciplinary approach to realize such development planning, with the participation of researchers and specialists from interdisciplinary areas: city planning, transportation, housing, territory studies, tourism, cultural heritage preservation, history, sociology, economy, archaeology, architecture, anthropology, museum studies, art/aesthetic studies, etc., for a new step in a sustainable and balanced urban policy.

关键词： cultural heritage urban conservation urban policy

Interannual variability of boreal summer intraseasonal oscillation over the northwestern Pacific influenced by the Pacific Meridional Mode

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 6-11页

作者： Haoyu Zhou Pang-Chi Hsu lin Chen Yitian Qian Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environmental Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and TechnologyNanjingChina

During the boreal summer,intraseasonal oscillations exhibit significant interannual variations in intensity over two key regions:the central-western equatorial Pacific(5°S-5°N,150°E-150°W)and the subtropical Northwestern Pacific(10°-20°N,130°E-175°W).The former is well-documented and considered to be influenced by the ENSO,while the latter has received comparatively less attention and is likely influenced by the Pacific Meridional Mode(PMM),as suggested by partial correlation analysis *** elucidate the physical processes responsible for the enhanced(weakened)intraseasonal convection over the subtropical northwestern Pacific during warm(cold)PMM years,the authors employed a moisture budget *** findings reveal that during warm PMM years,there is an increase in summer-mean moisture over the subtropical northwestern *** increase interacts with intensified vertical motion perturbations in the region,leading to greater vertical moisture advection in the lower troposphere and consequently resulting in convective *** a process is pivotal in amplifying intraseasonal convection *** observational findings were further verified by model experiments forced by PMM-like sea surface temperature patterns.

关键词： Boreal summer intraseasonal oscillation Interannual variability Pacific Meridional Mode Moisture budget analysis