检索结果-南通市图书馆

Neural Regeneration Research 2025年第4期20卷 1069-1076页

作者： Evridiki Asimakidou Eka Norfaishanty Saipuljumri chih hung lo Jialiu Zeng Department of Clinical Neurosciences University of CambridgeCambridgeUK School of Applied Science Republic PolytechnicSingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s ***-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this *** lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory *** and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting *** insulin resistance further exacerbates brain insulin resistance and *** interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal ***,translating these findings to clinical practice requires further investigation into human *** conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and *** these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases.

关键词： Alzheimer’s disease inflammatory cytokines insulin resistance lipid

Defective lysosomal acidification:a new prognostic marker and therapeutic target for neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2023年第1期12卷 500-510页

作者： chih hung lo Jialiu Zeng Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore

Lysosomal acidification dysfunction has been implicated as a key driving factor in the pathogenesis of neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s *** genetic factors have been linked to lysosomal de-acidification through impairing the vacuolar-type ATPase and ion channels on the organelle *** lysosomal abnormalities are also present in sporadic forms of neurodegeneration,although the underlying pathogenic mechanisms are unclear and remain to be ***,recent studies have revealed early occurrence of lysosomal acidification impairment before the onset of neurodegeneration and late-stage ***,there is a lack of methods for organelle pH monitoring in vivo and a dearth of lysosome-acidifying therapeutic ***,we summarize and present evidence for the notion of defective lysosomal acidification as an early indicator of neurodegeneration and urge the critical need for technological advancement in developing tools for lysosomal pH monitoring and detection both in vivo and for clinical *** further discuss current preclinical pharmacological agents that modulate lysosomal acidification,including small molecules and nanomedicine,and their potential clinical translation into lysosome-targeting *** timely detection of lysosomal dysfunction and development of therapeutics that restore lysosomal function represent paradigm shifts in targeting neurodegenerative diseases.

关键词： Neurodegenerative diseases Alzheimer’s disease Parkinson’s disease Lysosomal de-acidification Autophagy dysfunction Early detection Prognostic marker Small molecules Nanomedicine Nanoparticles

Autolysosomal acidification impairment as a mediator for TNFR1 induced neuronal necroptosis in Alzheimer’s disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第9期19卷 1869-1870页

作者： Evridiki Asimakidou Richard Reynolds Anna M.Barron chih hung lo Department of Clinical Neurosciences University of CambridgeCambridgeUK Department of Brain Sciences Faculty of MedicineImperial College LondonLondonUK Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

Neuronal necroptosis-an emerging form of regulated cell death associated with neuroinflammatory signaling:Alzheimer’s disease(AD)is characterized by the presence of extracellular amyloid-β(Aβ)plaques and intracellular tau neurofibrillary tangles as well as progressive neuronal *** evidence has suggested that prolonged neuroinflammation with increased levels of cytokines,arising from neuronal injury,innate immune responses from glial cells,and peripheral inflammation,leads to neuronal death and AD progression.

关键词： Alzheimer death tau Aβ

Integrative multi-omics and systems bioinformatics in translational neuroscience:A data mining perspective

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2023年第8期13卷 836-850页

作者： Lance M.O'Connor Blake A.O'Connor Su Bin Lim Jialiu Zeng chih hung lo College of Biological Sciences University of MinnesotaMinneapolisMN55455USA School of Pharmacy University of WisconsinMadisonWI53705USA Department of Biochemistry and Molecular Biology Ajou University School of MedicineSuwon16499South Korea Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore308232Singapore

Bioinformatic analysis of large and complex omics datasets has become increasingly useful in modern day biology by providing a great depth of information,with its application to neuroscience termed *** mining of omics datasets has enabled the generation of new hypotheses based on differentially regulated biological molecules associated with disease mechanisms,which can be tested experimentally for improved diagnostic and therapeutic targeting of neurodegenerative ***,integrating multi-omics data using a systems bioinformatics approach will advance the understanding of the layered and interactive network of biological regulation that exchanges systemic knowledge to facilitate the development of a comprehensive human brain *** this review,we first summarize data mining studies utilizing datasets from the individual type of omics analysis,including epigenetics/epigenomics,transcriptomics,proteomics,metabolomics,lipidomics,and spatial omics,pertaining to Alzheimer's disease,Parkinson's disease,and multiple *** then discuss multi-omics integration approaches,including independent biological integration and unsupervised integration methods,for more intuitive and informative interpretation of the biological data obtained across different omics *** further assess studies that integrate multi-omics in data mining which provide convoluted biological insights and offer proof-of-concept proposition towards systems bioinformatics in the reconstruction of brain ***,we recommend a combination of high dimensional bioinformatics analysis with experimental validation to achieve translational neuroscience applications including biomarker discovery,therapeutic development,and elucidation of disease *** conclude by providing future perspectives and opportunities in applying integrative multi-omics and systems bioinformatics to achieve precision phenotyping of neurodegenerative diseases and towards personaliz

关键词： Multi-omics integration Systems bioinformatics Data mining Human brain profile reconstruction Translational neuroscience

真空潜弧以超音波辅助制备奈米二氧化钛悬浮液之制程最佳化

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

过程工程学报 2004年第z1期4卷 413-418页

作者：罗志宏白升鑫张合钟清枝林鸿明台北科技大学机械工程系台北106 大同大学材料工程系台北104

本文以新式的奈米微粒制备方法-超音波辅助真空潜弧制程制备奈米二氧化钛悬浮液,针对该制程之制程参数,如电流、放电幅、崩溃电压与超音波振幅,搭配稳健性设计法进行研究,以期利用最少的实验来获得最佳之二氧化钛奈米悬浮微粒制备条件.... 详细信息

本文以新式的奈米微粒制备方法-超音波辅助真空潜弧制程制备奈米二氧化钛悬浮液,针对该制程之制程参数,如电流、放电幅、崩溃电压与超音波振幅,搭配稳健性设计法进行研究,以期利用最少的实验来获得最佳之二氧化钛奈米悬浮微粒制备条件.经由实验结果得知,以超音波辅助真空潜弧制程可获得分布小且均匀的二氧化钛奈米悬浮微粒在表面电位方面,所制备之悬浮液之零点电位值约为pH5,藉由悬浮液pH值的改变,越远离零点电位值之悬浮液呈现较好之分散性,越接近则产生凝聚现象.在光催化方面,所制备之奈米二氧化钛悬浮液在光波长360～380 nm时产生吸收紫外光现象,藉由穿透率与吸收波长的计算可获得制备之二氧化钛微粒能带间隙为3.4 eV.

关键词：奈米二氧化钛悬浮液稳健性设计法光催化

Ileocolonic mucormycosis in adult immunocompromised patients:A surgeon's perspective

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第9期16卷 1165-1170页

作者： Oswens Siu-hung lo Wai-Lun Law Division of Colorectal Surgery Department of SurgeryUniversity of Hong Kong Medical CentreQueen Mary Hospital

We report three cases of ileocolic mucormycosis in adult immunocompromised patients presenting as acute *** patients underwent laparotomy but two of them died from multiorgan failure before the diagnoses were *** diagnosis of gastrointestinal mucormycosis is rarely suspected,and antemortem diagnosis is made in only 25%-50% of *** cases illustrate the difficulty encountered by surgeons in managing acute abdomen in neutropenic patients with hematological *** management of colonic mucormycosis in the published literature is also reviewed.

关键词： Gastrointestinal mucormycosis Colon Immunocompromised Surgery

TEMPERATURE RESPONSIVE METHACRYLAMIDE POLYMERS WITH ANTIBACTERIAL ACTIVITY

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2010年第4期28卷 607-613页

作者：陈伯宽 Shuen-hung lo Shu-Feng Lee Department of Polymer Materials Kun Shan University

A new methacrylamide monomer, hexylamine methacrylamide （MAHA）, was synthesized and used in polymerizations. The homopolymer of MAHA and its copolymers were synthesized by free radical polymerization techniques with N-isopropyl acrylamide （NIPAAm） in two different compositions. The quatemization of the homopolymer and copolymers were carried out using 1-bromopropane. The copolymers with NIPAAm and a low MAHA content showed temperature-responsive behavior in an aqueous environment. The lower critical solution temperatures （LCSTs） of these polymers varied between 32℃ and 44℃. The LCSTs of quatemized copolymers were higher than those of neutral copolymers because they were more hydrophilic. The obtained homopolymers and copolymers were tested for antibacterial activities against S. aureus and E. coli. The quatemized water-soluble copolymers showed antibacterial activities against S. aureus. The quaternization resulted in the synthesis of both antibacterial and temperature-responsive copolymers.

关键词： Methacrvlamide: NIPAAm: Antibacterial: Temperature-rest)onsive

Rare complication of inflammatory bowel disease-like colitis from glycogen storage disease type 1b and its surgical management:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第16期9卷 4081-4089页

作者： Frederick Chi-Wai Lui Oswens Siu-hung lo Department of Surgery LKS Faculty of MedicineThe University of Hong KongHong KongChina

BACKGROUND Glycogen storage disease(GSD)is an autosomal recessive inborn metabolic *** with GSD are prone to hypoglycaemia,hyperlactacidemia and *** type 1b(GSD-1b)patients specifically can develop neutropenia,recurrent bacterial infection and inflammatory bowel disease(IBD).Documentation of the long-term outcomes of surgical management of GSD-1b has been scarce,especially for Asian *** herein describe a case of GSD-1b complicated by IBD-like colitis and coloduodenal *** patient was managed successfully with surgical *** SUMMARY A 20-year-old Chinese lady confirmed by genetic testing to have GSD-1b was initially managed with uncooked cornstarch and granulocyte-colony stimulating *** recurrent abdominal symptoms,her condition was treated as clinical“Crohn’s disease”with mesalazine,prednisolone and azathioprine *** showed a tight stricture at the hepatic *** computerized tomographic colonography revealed a phlegmon at the ileocaecal region with a suspected coloduodenal *** an exploratory laparotomy was performed and severe colitis at the ascending colon with coloduodenal fistula was *** hemicolectomy with primary anastomosis and repair of the duodenum were *** management of complications from GSD-1b associated IBD-like colitis has rarely been ***-line treatment would usually be *** intervention like hemicolectomy is mainly reserved for refractory *** Surgical management of coloduodenal fistula in GSD-1b patients is a feasible and safe option when failed conservative management.

关键词： Glycogen storage disease Coloduodenal fistula Inflammatory bowel diseaselike colitis Case report Perioperative management

Terminal ileum gangrene secondary to a type Ⅳ paraesophageal hernia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第8期22卷 2642-2646页

作者： Ching Tsai Hsu Po Jen Hsiao chih Chien Chiu Jenq Shyong Chan Yee Fung Lin Yuan hung lo Chia Jen Hsiao Department of Internal Medicine Taoyuan Armed Forces General Hospital Tri-Service General Hospital National Defense Medical Center Division of Nephrology Department of Internal Medicine Taoyuan Armed Forces General Hospital Division of General Surgery Department of Surgery Taoyuan Armed Forces General Hospital Division of Gastroenterology Department of Internal Medicine Taoyuan Armed Forces General Hospital

Type Ⅳ paraesophageal hernia(PEH) is very rare, and is characterized by the intrathoracic herniation of the abdominal viscera other than the stomach into the chest. We describe a 78-year-old woman who presented at our emergency department because of epigastric pain that she had experienced over the past 24 h. On the day after admission, her pain became severe and was accompanied by right chest pain and dyspnea. Chest radiography revealed an intrathoracic intestinal gas bubble occupying the right lower lung field. Emergency explorative laparotomy identified a type Ⅳ PEH with herniation of only the terminal ileum through a hiatal defect into the right thoracic cavity. In this report, we also present a review of similar cases in the literature published between 1980 and 2015 in Pub Med. There were four published cases of small bowel herniation into the thoracic cavity during this period. Our patient represents a rare case of an individual diagnosed with type Ⅳ PEH with incarceration of only the terminal ileum.

关键词： Gangrene Hiatal Ileum Paraesophageal hernia Thoracic cavity

Ti-containing hydrogenated carbon films fabricated by high-power plasma magnetron sputtering

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2012年第6期22卷 1381-1386页

作者： YANG Peng SUNG Chia-chi FUH Yiin-Kuen CHU Chun-lin lo chih-hung Department of Engineering Science and Ocean Engineering National Taiwan UniversityTaipeiChina Department of Mechanical Engineering National Central UniversityChung liChina National Nano Device Laboratories HsinchuChina

To improve the characteristics of a diamond-like carbon （DLC） film, Ti-containing amorphous hydrogenated carbon thin films were deposited on sus304 stainless steel substrates by high-power plasma-sputtering with titanium metal as the solid plasma source in a mixed ArC2H2 atmosphere. The films were fabricated to obtain a multilayered structure of Ti/TiC/DLC gradient for improving adhesion and reducing residual stress. The effects of substrate bias and target-substrate distance on the films＇ properties were studied by glow discharge spectroscope, X-ray diffractometer, Raman spectroscope, nanoindenter, and a pin-on-disk tribometer. The results indicate that the films possess superior adhesive strength and toughness.

关键词： high-power plasma-sputtering Me-DLC diamond-like carbon