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Optical cross-talk reduction in a quantumdot-based full-color micro-light-emitting-diode display by a lithographic-fabricated photoresist mold

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Photonics Research 2017年第5期5卷 411-416页

作者： HUANG-YU LIN CHIN-WEI SHER DAN-HUA HSIEH XIN-YIN CHEN HUANG-MING PHILIP CHEN TENG-MING CHEN KEI-MAY LAU CHYONG-HUA CHEN chien-CHUNG LIN hao-CHUNG KUO Department of Photonics and Institute of Electro-Optical Engineering National Chiao Tung University Department of Applied Chemistry National Chiao Tung University Department of Electric and Computer Engineering Hong Kong University of Science and Technology Institute of Photonic System National Chiao Tung University

In this study, a full-color emission red–green–blue(RGB) quantum-dot(QD)-based micro-light-emitting-diode(micro-LED) array with the reduced optical cross-talk effect by a photoresist mold has been demonstrated. The UV micro-LED array is used as an efficient excitation source for the QDs. The aerosol jet technique provides a narrow linewidth on the micrometer scale for a precise jet of QDs on the micro-LEDs. To reduce the optical cross-talk effect,a simple lithography method and photoresist are used to fabricate the mold, which consists of a window for QD jetting and a blocking wall for cross-talk reduction. The cross-talk effect of the well-confined QDs in the window is confirmed by a fluorescence microscope, which shows clear separation between QD pixels. A distributed Bragg reflector is covered on the micro-LED array and the QDs' jetted mold to further increase the reuse of UV *** enhanced light emission of the QDs is 5%, 32%, and 23% for blue, green, and red QDs, respectively.

关键词： QDs Optical cross-talk reduction in a quantumdot-based full-color micro-light-emitting-diode display by a lithographic-fabricated photoresist mold

Intermittent Fault Diagnosability of Interconnection Networks

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Journal of Computer Science & Technology 2017年第6期32卷 1279-1287页

作者： Jia-Rong Liang hao Feng Xiaojiang Du School of Computer and Electronic Information Guangxi University Nanning 530004 China Department of Computer and Information Sciences Temple University Philadelphia PA 19122 U.S.A.

An interconnection network＇s diagnosability is an important metric for measuring its self-diagnostic capability. Permanent fault and intermittent fault are two different fault models that exist in an interconnection network. In this paper, we focus on the problem pertaining to the diagnosability of interconnection networks in an intermittent fault situation. First, we study a class of interconnection networks called crisp three-cycle networks, in which the Chin-number （the number of common vertices each pair of vertices share） is no more than one. Necessary and sufficient conditions are derived for the diagnosability of crisp three-cycle networks under the PMC （Preparata, Metze, and chien） model. A simple check can show that many well-known intereonnection networks are crisp three-cycle networks. Second, we prove that an intereonnection network S is a ti-fault diagnosable system without repair if and only if its minimum in-degree is greater than ti under the BGM （Barsi, Grandoni, and Masetrini） model. Finally, we extend the necessary and sufficient conditions to determine whether an interconnection network S is ti-fault diagnosable without repair under the MM （Maeng and Malek） model from the permanent fault situation to the intermittent fault situation.

关键词： diagnosability intermittent fault PMC(Preparata,Metze,and chien)model BGM(Barsi,Grandoni,and Masetrini)model MM(Maeng and Malek)model

Family Competition Pheromone Genetic Algorithm for Comparative Genome Assembly

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Journal of Electronic Science and Technology 2014年第4期12卷 405-409页

作者： chien-hao Su chien-Shun Chiou Jung-Che Kuo Pei-Jen Wang Cheng-Yan Kao Hsueh-Ting Chu the Biodiversity Research Center Academia Sinica the Center for Research Diagnostics and Vaccine Development Centers for Disease Control the Department of Computer Science and Information Engineering National Taiwan University the Department of Computer Science and Information Engineering Asia University

Genome assembly is a prerequisite step for analyzing next generation sequencing data and also far from being solved. Many assembly tools have been proposed and used extensively. Majority of them aim to assemble sequencing reads into contigs; however, we focus on the assembly of contigs into scaffolds in this paper. This is called scaffolding, which estimates the relative order of the contigs as well as the size of the gaps between these contigs. Pheromone trail-based genetic algorithm （PGA） was previously proposed and had decent performance according to their paper. From our previous study, we found that family competition mechanism in genetic algorithm is able to further improve the results. Therefore, we propose family competition pheromone genetic algorithm （FCPGA） and demonstrate the improvement over PGA.

关键词： Genetic algorithm genome typing,next generation sequencing.

Immunopurification and Mass Spectrometry Identifies Protein Phosphatase 2A （PP2A） and BIN2/GSK3 as Regulators of AKS Transcription Factors in Arabidopsis

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Molecular Plant 2017年第2期10卷 345-348页

作者： Bu, Shuo-Lei Liu, Chao Liu, Ning Zhao, Ji-Long Ai, Lian-Feng Chi, hao Li, Kathy L. chien, Chih-Wei Burlingame, Alma L. Zhang, Sheng-Wei Wang, Zhi-Yong Hebei Normal Univ Hebei Collaborat Innovat Ctr Cell Signaling Hebei Key Lab Mol & Cellular Biol Coll Life Sci Shijiazhuang 050024 Hebei Peoples R China Carnegie Inst Sci Dept Plant Biol 290 Panama St Stanford CA 94305 USA Chinese Acad Sci Key Lab Intelligent Informat Proc Inst Comp Technol Beijing 100190 Peoples R China Univ Calif San Francisco Dept Pharmaceut Chem San Francisco CA 94158 USA

Dear Editor ABA induces the phosphorylation of three basic helix-loop-helix （bHLH） transcription factors, called AKSs （ABA-responsive ki- nase substrates; AKS1, AKS2, and AKS3）. The unphosphorylated AKSs facilitate stomatal opening through promoting the tran- scription of genes encoding inwardly rectifying K＋ channels （Takahashi et al., 2013）. AKS1 and AKS3 are also regulators of flowering （Ito et al., 2012）. However, the kinases and phosphatases that directly control the phosphorylation status of AKSs in vivo have not been fully characterized. Here,

关键词： quantitative proteomics mass spectrometry brassinosteroids protein phosphatase 2A affinity enrichment phosphorylation/dephosphorylation

Trousseau's syndrome in a patient with advanced stage gastric cancer

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World Journal of Gastroenterology 2015年第34期21卷 10049-10053页

作者： Tai-Long chien Kung-Ming Rau Wen-Jung Chung Wei-Chen Tai Shih-Ho Wang Yi-Chun Chiu Keng-Liang Wu Yeh-Pin Chou Chia-Che Wu Yen-hao Chen Seng-Kee Chuah Division of Gastroenterology Department of Internal MedicinePin-Tung An-Tai Hospital Division of Oncology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Division of Cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Division of Hepatogastroenterology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Division of General Surgery Department of SurgeryKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine

Patients with cancer are at high risk for thrombotic events,which are known collectively as Trousseau's syndrome. Herein,we report a 66-year-old male patient who was diagnosed with terminal stage gastric cancer and liver metastasis and who had an initial clinical presentation of upper gastrointestinal bleeding. Acute ischemia of the left lower leg that resulted in gangrenous changes occurred during admission. Subsequent angiography of the left lower limb was then performed. This procedure revealed arterial thrombosis of the left common iliac artery with extension to the external iliac artery,the left common iliac artery,the posterior tibial artery,and the peroneal artery,which were occluded by thrombi. Aspiration of the thrombi demonstrated that these were not tumor thrombi. The interesting aspect of our case was that the disease it presented as arterial thrombotic events,which may correlate with gastric adenocarcinoma. In summary,we suggested that the unexplained thrombotic events might be one of the initial presentations of occult malignancy and that thromboprophylaxis should always be considered.

关键词： Gastric cancer Arterial thrombotic events Troussea

Full-color micro-LED display with high color stability using semipolar(20-21) InGaN LEDs and quantum-dot photoresist

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Photonics Research 2020年第5期8卷 630-636页

作者： SUNG-WEN HUANG CHEN YU-MING HUANG KONTHOUJAM JAMES SINGH YU-chien HSU FANG-JYUN LIOU JIE SONG JOOWON CHOI PO-TSUNG LEE chien-CHUNG LIN ZHONG CHEN JUNG HAN TINGZHU WU hao-CHUNG KUO Department of Photonics&Graduate Institute of Electro-Optical Engineering College of Electrical and Computer EngineeringTaiwan Chiao Tung UniversityHsinchu 30010China Institute of Photonic System Taiwan Chiao Tung UniversityTainan 71150China Saphlux Inc. BranfordConnecticut 06405USA Departm ent of Electronic Science Fujian Engineering Research Center for Solid-State LightingXiamen UniversityXiamen 361005China Departm ent of Electrical Engineering Yale UniversityNew HavenConnecticut 06520USA

Red-green-blue(RGB)full-color micro light-emitting diodes(μ-LEDs)fabricated from semipolar(20-21)wafers,with a quantum-dot photoresist color-conversion layer,were *** semipolar(20-21)In Ga N/Ga Nμ-LEDs were fabricated on large(4 in.)patterned sapphire substrates by orientation-controlled *** semipolarμ-LEDs showed a 3.2 nm peak wavelength shift and a 14.7%efficiency droop under 200 A∕cm2injected current density,indicating significant amelioration of the quantum-confined Stark *** of the semipolarμ-LEDs’emission-wavelength stability,the RGB pixel showed little color shift with current density and achieved a wide color gamut(114.4%NTSC space and 85.4%Rec.2020).

关键词： LEDs photoresist sapphire

Sung Shu chien:the founder of modern Chinese botany

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Protein & Cell 2023年第2期14卷 79-83页

作者： Huan Liu Kaijing Huang Xuefan Yuan hao Cheng University of Science and Technology of China Hefei 230026China State Key Laboratory of Virology Wuhan 430072China Nanjing University of the Arts Nanjing 210013China Institute of Microbiology Chinese Academy of SciencesBeijing 100101China

Sung Shu chien(钱崇澍,1883–1965)(Fig.1)was a famous bota-nist and educator in China,one of the founders of Chinese plant taxonomy,plant physiology,geobotany,and *** devoted his whole life to scientific research and education,and was a founder of modern Chinese *** Shu chien pioneered several research fields in modern Chinese *** 1916,he published the first literature in Latin on the naming and classi-fication of *** the following year.

关键词： any education devoted

Intra-articular sustained-release of pirfenidone as a disease-modifying treatment for early osteoarthritis

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Bioactive Materials 2024年第9期39卷 255-272页

作者： Xiaobo Zhu Mingde Cao Kejia Li Yau-Tsz Chan Hon-Fai Chan Yi-Wah Mak hao Yao Jing Sun Michael Tim-Yun Ong Kevin Ki-Wai Ho chien-Wei Lee Oscar Kuang-Sheng Lee Patrick Shu-Hang Yung Yangzi Jiang Institute for Tissue Engineering and Regenerative Medicine School of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of ChinaChina School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of Chin1China Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong Special Administrative Region of Chin1China Center for Neuromusculoskeletal Restorative Medicine Hong Kong Special Administrative Region of Chin1China Key Laboratory for Regenerative Medicine Ministry of EducationSchool of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong Special Administrative Region of Chin1China Department of Orthopaedic Surgery The First Affiliated HospitalSchool of MedicineZhejiang UniversityChina

Osteoarthritis(OA)is a major clinical challenge,and effective disease-modifying drugs for OA are still lacking due to the complicated pathology and scattered treatment *** early treatments are urgently needed to prevent OA *** excessive amount of transforming growth factorβ(TGFβ)is one of the major causes of synovial fibrosis and subchondral bone sclerosis,and such pathogenic changes in early OA precede cartilage *** we report a novel strategy of intra-articular sustained-release of pirfenidone(PFD),a clinically-approved TGFβinhibitor,to achieve disease-modifying effects on early OA *** found that PFD effectively restored the mineralization in the presence of excessive amount of TGFβ1(as those levels found in patients’synovial fluid).A monthly injection strategy was then designed of using poly lactic-co-glycolic acid(PLGA)microparticles and hyaluronic acid(HA)solution to enable a sustained release of PFD(the“PLGA-PFD+HA”strategy).This strategy effectively regulated OA progression in destabilization of the medial meniscus(DMM)-induced OA mice model,including preventing subchondral bone loss in early OA and subchondral bone sclerosis in late OA,and reduced synovitis and pain with cartilage preservation *** finding suggests the promising clinical application of PFD as a novel disease-modifying OA drug.

关键词： TGFβ1 signaling Osteoarthritis Subchondral bone Pirfenidone DMOAD

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串行晶体学样品输运方法概述

生物化学与生物物理进展 2024年第7期51卷 1632-1644页

作者：李凌昊李冰翁祖谦上海科技大学大科学中心上海201210

样品输运方法是实现X射线自由电子激光串行飞秒晶体学研究的关键步骤之一。串行飞秒晶体学能够有效地捕捉到生物分子的超快动态过程,如蛋白质构象变化和化学反应中间态等。它对于科学家更好地理解生物分子的结构和功能,揭示生命活动的机... 详细信息

样品输运方法是实现X射线自由电子激光串行飞秒晶体学研究的关键步骤之一。串行飞秒晶体学能够有效地捕捉到生物分子的超快动态过程,如蛋白质构象变化和化学反应中间态等。它对于科学家更好地理解生物分子的结构和功能,揭示生命活动的机制,以及为药物研发和生物工程等领域提供重要的技术手段具有重要意义。在自由电子激光装置进行实验时,将样品输送至与自由电子激光脉冲相互作用区域是非常关键的。而选择合适的上样方法对于样品的消耗量和实验效率起着决定性作用,也是实验成功与否的一个重要因素。本文综述了目前串行晶体学样品输运方法的最新研究进展和未来发展方向。同时介绍了常用的样品输运方法及其适用范围,旨在为从事串行晶体学领域研究的科学家提供借鉴和参考。通过选择合适的样品输运方法,能够提高实验效率,减少样品消耗,并为研究者们在生物大分子结构生物学研究方面开辟新的可能性。

关键词： X射线自由电子激光串行晶体学结构生物学液流样品输运方法固定靶