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Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway

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Food Science and Human Wellness 2024年第3期13卷 1711-1728页

作者： Crystal Ngofi Zumbi Chun-Hsu Pan Hui-Yu Huang chieh-hsi wu Program in Clinical Drug Development from Herbal Medicine College of PharmacyTaipei Medical UniversityTaipei 11031China Program in Drug Discovery and Development Industry College of PharmacyTaipei Medical UniversityTaipei 11031China School of Pharmacy Taipei Medical UniversityTaipei 11031China Graduate Institute of Metabolism and Obesity Sciences Taipei Medical UniversityTaipei 11031China

Restenosis is a common complication following coronary *** traditional use of seaweeds for health benefits has increasingly been explored,however few studies exist reporting its protective effects on the development of restenosis and gut *** aim of this study was to investigate the potential of seaweed extracts(SE) of Ascophyllum nodosum and Fucus vesiculosus in inhibiting intimal hyperplasia in a rat model of restenosis and its underlying mechanisms in macrophages and vascular smooth muscle cells(vSMCs).16S rRNA sequencing was done to investigate the regulatory effect of SE on the gut microbiome of injured *** indicated by the results,SE significantly inhibited the progression of intimal hyperplasia in vivo,attenuated inflammation in macrophages and could inhibit the proliferation,dedifferentiation and migration of *** was observed through immunoblotting assays that treatment with SE significantly upregulated PTEN expression in macrophages and inhibited the upregulation of PI3K and AKT expression in ***,according to the 16S rRNA gene sequencing analysis,supplementation with SE modulated gut microbiota composition in injured *** conclusion,SE could ameliorate intimal hyperplasia by inhibiting inflammation and vSMCs proliferation through the regulation of the PTEN/PI3K/AKT pathway and modulating the gut microbiome.

关键词： Ascophyllum nodosum Fucus vesiculosus PTEN/PI3K/AKT Restenosis Macrophage Vascular smooth muscle cells Gut microbiota

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Cell Surface Transmembrane Protein Database for Detecting Potential Targets of Antibody Drug in Application of Cancer Therapies

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Journal of Life Sciences 2010年第7期4卷 46-52页

作者： Po-Yuan Chen Cheng-Shang Kao Mien-De Jhuo Tzu-Hurng Cheng Wei-Tse Hsu Che-Yen Ou Tzu-Ching Shih chieh-hsi wu Department of Biological Science and Technology China Medical University Taichung 404 Taiwan Parexel-Apex International Taipei Taiwan Department of Medical Radiology Technology China Medical University and Department of Radiology China Medical UniversityHospital Taichung 404 Taiwan Department of Pharmacy China Medical University Taichung 404 Taiwan

Background： Antibody drug conjugated （ADC） is one kind of very important method of therapy to cancer diseases. In this research, the authors introduce BLAST and some other important algorithms to create transmembrane protein databases. These databases are acquired from well-known databases such as NCBI or Swiss-Prot as template, and then collect all possible transmembrane protein by using BLAST or physical character. After collect these databases, the authors will aim at each nucleotide sequences to design the probes of oligonucleotide microarray, which can detect the high express transmembrane proteins very efficiently. Finally, the authors can accelerate the anti-cancer drug discovery by using these databases. Result： This study constructed a web service, the Transmembrane Protein Database, to researchers that are interested in or need to oligonucleotide microarray probe design for detecting potential targets of antibody drug. With user friendly web based windows containing each necessary selections, users can easily choose the parameters and get the suitable probe design suggestions. Conclusion： Transmembrane protein database is very important and powerful in detecting cancers or other human disease. By using this database, the authors offer a good strategy in transmembrane protein research as well.

关键词： Antibody drug transmembrane protein databases.

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Computational Screening of Novel Mitogen-activated Protein Kinase Kinase-1 （MEK1） Inhibitors by Docking and Scoring

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Journal of Life Sciences 2011年第6期5卷 434-442页

作者： Po-Yuan Chen Hong-Jye Hong Mien-De Jhuo Tzu-Hurng Cheng Wei-Tse Hsu chieh-hsi wu Che-YenOu Yeng-Ting Yui Jing-Pin Lin Jing-Gung Chung Department of Biological Science and Technology China Medical University Taichung 40402 Taiwan College of Chinese Medicine China Medical University Taichung 40402 Taiwan Schools of Pharmacy and Chinese Medicine China Medical University Taichung 40402 Taiwan Departments of Biotechnology Asia University Taichung 40402 Taiwan

The mitogen-activated protein kinase （MAPK） cell signal transduction pathways play a key role in determining the survival of cells. If these pathways can be controlled, they will prohibit the proliferation of cancer cells. To attain this goal, the authors utilize many drugs to interact with mitogen-activated protein kinase kinase-1 （MEK1） in MAPK, and use computer aided drug design （CADD） to analyze the ligand activities of proteins in MEKL The results show that in these drugs, the aromatic group in the terminal of the protein and the PHE209 will induce the stacking force, which is highly related to the actual activities of these drugs.

关键词： Docking and scoring computational screening mitogen-activated protein kinase kinase-1 (MEK1).

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Historical development of the Gauss-Bonnet theorem

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Science China Mathematics 2008年第4期51卷 777-784页

作者： wu Hung-hsi(H.wu) Department of Mathematics University of California

A historical survey of the Gauss-Bonnet theorem from Gauss to Chern.

关键词： Gauss-Bonnet theorem Chern classes characteristic classes 01-02 53-03 53C20

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A Low Complexity Algorithm for Subcarrier-and-Bit Allocation in OFDMA-Based LTE Systems

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Journal of Electronic Science and Technology 2016年第4期14卷 355-361页

作者： Wei-Chiang wu chieh-Yen Hsu the Department of Electrical Engineering Da-Yeh University

In this paper, we propose optimum and sub-optimum resource allocation and opportunistic scheduling solutions for orthogonal frequency division multiple access （OFDMA）-based multicellular systems. The applicability, complexity, and performance of the proposed algorithms are analyzed and numerically evaluated. In the initial setup, the fractional frequency reuse （FFR） technique for inter-cell interference cancellation is applied to classify the users into two groups, namely interior and exterior users. Adaptive modulation is then employed according to the channel state information （CSI） of each user to meet the symbol error rate （SER） requirement. There then, we develop subcarrier-and-bit allocation method, which maximizes the total system throughput subject to the constraints that each user has a minimum data rate requirement. The algorithm to achieve the optimum solution requires high computational complexity which hinders it from practicability. Toward this suboptimum method with the reduced to the order of O（NIO, the total number of subcarriers end, we complexity propose a extensively where N and K denote and users, respectively. Numerical results show that the proposed algorithm approaches the optimum solution, yet it enjoys the features of simplicity, dynamic cell configuration, adaptive subearrier-and-bit allocation, and spectral efficiency.

关键词： Adaptive modulation fractional frequency reuse multiuser subcarrier-and-bit allocation,opportunistic scheduling orthogonal frequency division multiple access.

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Superior mesenteric artery syndrome in a diabetic patient with acute weight loss

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World Journal of Gastroenterology 2009年第47期15卷 6004-6006页

作者： Meng-chieh wu I-Chen wu Jeng-Yih wu Deng-Chyang wu Wen-Ming Wang Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan China Department of Medicine Faculty of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan China Division of Internal Medicine Kaohsiung Municipal Hsiao-Kang Hospital Kaohsiung 813 Taiwan China

Superior mesenteric artery(SMA)syndrome is an un- common disease resulting compression of the third portion of the duodenum from the superior mesenteric *** disease shares many common manifestations with diabetic gastroparesis,including postprandial fullness,nausea,vomiting,and ***,it is often overlooked in diabetic ***,we report a 41-year-old man with poorly controlled diabetic mellitus who developed SMA syndrome due to rapid weight loss. The diagnosis was confirmed by computed tomography and an upper gastrointestinal *** condition improved after parenteral nutrient,strict sugar control, and gradual weight gain.

关键词： Diabetes mellitus Superior mesenteric artery syndrome Gastroparesis

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Two case reports of gastroendoscopy-associated Acinetobacter baumannii bacteremia

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World Journal of Gastroenterology 2013年第18期19卷 2835-2840页

作者： Chang-Hua Chen Shun-Sheng wu chieh-Chen Huang Section of Infectious Diseases Department of Internal Medicine Changhua Christian Hospital Changhua 500 Taiwan Section of Gastroenterology Department of Internal Medicine Changhua Christian Hospital Changhua 500 Taiwan Department of Life Science College of Life Science National Chung Hsing University Taichung 402 Taiwan

Two cases of gastroendoscopy-associated Acinetobacter baumannii (A. baumannii ) bacteremia were discovered at the study hospital. The first case was a 66-year-old woman who underwent endoscopic retrograde cholangiopancreatography and endoscopic retrograde papillotomy, and then A. baumannii bacteremia occurred. The second case was a 70-year-old female who underwent endoscopic retrograde biliary drainage due to obstruction of intra-hepatic ducts, and bacteremia occurred due to polymicrobes (Escherichia coli , viridans streptococcus , and A. baumannii ). After a literature review, we suggest that correct gastroendoscopy technique and skill in drainage procedures, as well as antibiotic prophylaxis, are of paramount importance in minimizing the risk of gastroendoscopy-associated bacteremia.

关键词： Endoscopy Acinetobacter baumannii Bacteremia Antibiotic prophylaxis

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Oviraptorosaurian Eggs (Dinosauria) with Embryonic Skeletons Discovered for the First Time in China

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Acta Geologica Sinica(English Edition) 2008年第6期82卷 1089-1094页

作者： Yen-nien CHENG JI Qiang Xiao-chun wu hsi-yin SHAN Museum of Natural Science 1 Kuan Chien RD. Taichung Taiwan 40453 China Institute of Geology Chinese Academy of Geological Sciences 26 Baiwanzhuang Road Beijing 100037 China Canadian Museum of Nature P.O. Box 3443 STN ＇D＇ Ottawa ON KIP 6P4 Canada

Two elongatoolithid dinosaur eggs from the Upper Cretaceous of Ganzhou, Jiangxi Province and the embryonic skeletons they bear are described. They represent the first oviraptorosaurian eggs with embryonic skeletons in China and provide the first example that an oospecies can be correlated to certain dinosaur taxon/taxa. The two eggs are the same as the pair of the eggs inside a female oviraptorosaurian pelvis from the same horizon of the same area in both macro- and micro-structures of the egg shells, and can he referred to the oospecies, Macroolithus yaotunensis Zhao, 1975. The morphology of the preserved part of the embryonic skeletons indicates that they may have been laid by an oviraptorid, Heyuannia huangi from Guangdong Province or a closely related oviraptorosaurian, which may have been lived in the Ganzhou area too in the Late Cretaceous. The embryonic skeletons of the two eggs are not in the same developing stage. In one of the eggs, the postzygapophysis of the preserved vertebrae are well ossified, indicating that it was just hatched.

关键词： oviraptorosaurian Elongatoolithidae Macroolithus embryonic skeleton Upper Cretaceous Jiangxi

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In-Situ Rs and Improvement in Thermal Stability of Nickel Silicides Using Different Interlayer Films

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材料科学与工程（中英文A版） 2015年第3期5卷 164-170页

作者： Chi-Ting wu Wen-hsi Lee Ying-Lang Wang Shih-chieh Chang Department of Electrical Engineering National Cheng Kung University Tainan 701 Taiwan. Institute of Lighting and Energy Photonics National Chiao Tung University Hsinchu 30050 Taiwan

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Two-stage resection for malignant colonic obstructions:The timing of early resection and possible predictive factors

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World Journal of Gastroenterology 2012年第25期18卷 3267-3271页

作者： hsiang-Yu Yang Chang-chieh wu KuoFeng Hsu Kevin Cheng-Wen hsiao Division of Colon and Rectal Surgery Department of SurgeryTriService General HospitalNational Defense Medical CenterTaipei 114TaiwanChina

AIM:To study potential predictive factors for early radical resection in two-stage resection for left malignant colonic ***:Thirty-eight cases of left-sided obstructive colon cancer undergoing two-stage operations were reviewed between January 1998 and August *** were classified into two groups(n = 19 each):early radical resection(interval ≤ 10 d) and late radical resection(interval > 10 d).Baseline demographics,post-diversion outcome,perioperative data,tumor characteristics,outcome and complications were ***:The baseline demographics revealed no differences except for less pre-diversion sepsis in the early group(P < 0.001) and more obstruction days in the late group(P = 0.009).The mean intervals of early and late radical resections were 7.9 ± 1.3 d and 17.8 ± 5.5 d,respectively(P < 0.001).After diversion,the presence of bowel sounds,flatus,removal of the nasogastric tube and the resumption of oral feeding occurred earlier in the early *** operation time and duration of hospital stay were both significant reduced in the early *** rates did not differ between ***:The earlier recovery of bowel function seems to be predictive of early radical *** contrast,pre-diversion sepsis and more obstruction days were predictive of delayed radical resection.

关键词： Colorectal cancer Colostomy Diversion Obstruction Two-stage resection

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