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Searching for alternatives to brain regeneration

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Neural Regeneration Research 2021年第11期16卷 2198-2200页

作者： chiara La Rosa Luca Bonfanti Neuroscience Institute Cavalieri Ottolenghi(NICO) OrbassanoItaly Department of Veterinary Sciences University of TurinGrugliascoItaly

Brain regeneration from an evolutionary perspective:Brain regeneration(the full restoration of tissue after loss from injury or disease)is the most sought after goal for researchers working in developmental *** also appears to be the most challenging to achieve when considering the mammalian *** remarkable regenerative capacities can be present in the central nervous systems of many non-mammalian vertebrates(e.g.,fish,amphibians),these kinds of processes appear to be dramatically reduced in mammals(Bonfanti,2011).

关键词： regeneration sought injury

Recent developments of lactic acid bacteria and their metabolites on foodborne pathogens and spoilage bacteria:Facts and gaps

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Food Bioscience 2022年第3期47卷 1312-1329页

作者： Hafize Fidan Tuba Esatbeyoglu Vida Simat Monica Trif Giulia Tabanelli Tina Kostka chiara Montanari Salam A.Ibrahim FatihÖzogul Department of Tourism and Culinary Management University of Food Technologies4002PlovdivBulgaria Institute of Food Science and Human Nutrition Gottfried Wilhelm Leibniz University HannoverAm Kleinen Felde 3030167HannoverGermany University Department of Marine Studies University of SplitRuđera Boškovića 3721000SplitCroatia Centre for Innovative Process Engineering (CENTIV) GmbH 28857SykeGermany Department of Agricultural and Food Sciences University of Bologna40127BolognaItaly Food Microbiology and Biotechnology Laboratory North Carolina Agricultural and Technical State UniversityGreensboroNC27411USA Department of Seafood Processing Technology Faculty of FisheriesCukurova University01330AdanaTurkey

Lactic acid bacteria(LAB)are common microorganisms found in various ecosystems including in plants,fermented foods,and the human *** the biodiversity of lactic acid microflora and characterization of LAB is a new approach to form a variety of starter communities to create innovative nutritional food *** has been growing interest in LAB isolated from non-dairy environments as these bacteria exhibit significant metabolic diversity and have unique taste-forming *** may be prevented,or treated by LAB but the treatment of disease conditions with LAB is highly dependent on the host's microbiome and diet and varies in both effectiveness and side effects from individual to *** perspectives on the study of LAB may be related to the expansion of our knowledge in the fields of genetics and genetic *** application of genetic science may help to improve existing strains and develop new strains with characteristics designed for specific ***,the preservative effects of LAB and their metabolites,as well as their interaction on the growth of food borne pathogens and food spoilage microorganisms were *** addition,the competitive models for microbial growth between LAB and other microorganisms as well as the role of LAB in the elimination of toxic compounds in food products were ***,the review provided an overview of the risks and benefits of using LAB in the food industry.

关键词： Lactic acid bacteria Starter culture Fermented products Food-borne pathogens Microbial interaction

Bone without borders-Monetite-based calcium phosphate guides bone formation beyond the skeletal envelope

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Bioactive Materials 2023年第1期19卷 103-114页

作者： Furqan A.Shah Martina Jolic chiara Micheletti Omar Omar Birgitta Norlindh Lena Emanuelsson Håkan Engqvist Thomas Engstrand Anders Palmquist Peter Thomsen Department of Biomaterials Sahlgrenska AcademyUniversity of GothenburgGothenburgSweden Department of Materials Science and Engineering McMaster UniversityHamiltonOntarioCanada Department of Engineering Sciences Applied Materials Science SectionUppsala UniversityUppsalaSweden Department of Reconstructive Plastic Surgery Karolinska University HospitalStockholmSweden

Calcium phosphates(CaP)represent an important class of osteoconductive and osteoinductive *** proof-of-concept,we show how a multi-component CaP formulation(monetite,beta-tricalcium phosphate,and calcium pyrophosphate)guides osteogenesis beyond the physiological *** a sheep model,hollow dome-shaped constructs were placed directly over the occipital *** 12 months,large amounts of bone(~75%)occupy the hollow space with strong evidence of ongoing *** of both compact bone(osteonal/osteon-like arrangements)and spongy bone(trabeculae separated by marrow cavities)reveal insights into function/need-driven microstructural *** within the CaP also contain both woven bone and vascularised lamellar *** actively contribute to CaP degradation/*** the constituent phases,only calcium pyrophosphate persists within osseous(cutting cones)and non-osseous(macrophages)*** a translational perspective,this multi-component CaP opens up exciting new avenues for osteotomy-free and minimally-invasive repair of large bone defects and augmentation of the dental alveolar ridge.

关键词： Bone Calcium phosphate Monetite Calcium pyrophosphate Electron microscopy Raman spectroscopy

Circulating tumor cells isolation:the "post-EpCAM era"

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Chinese Journal of Cancer Research 2015年第5期27卷 461-470页

作者： Cristina Raimondi chiara Nicolazzo Angela Gradilone Dipartimento Medicina Molecolare Sapienza Universita di RomaRoma Italy

Circulating tumor cells （CTCs） represent a submicroscopic fraction detached from a primary tumor and in transit to a secondary site. The prognostic significance of CTCs in metastatic cancer patients was demonstrated for the first time more than ten years ago. To date, it seems clear enough that CTCs are highly heterogeneous and dynamically change their shape. Thus, the inadequacy of epithelial cell adhesion molecule （EpCAM） as universal marker for CTCs detection seems unquestionable and alternative methods able to recognize a broader spectrum of phenotypes are definitely needed. In this review the pleiotropic functions of EpCAM are discussed in detail and the role of the molecule in the biology of CTCs is critically dissected.

关键词： Epithelial cell adhesion molecule(EpCAM) circulating tumor cells(CTCs) epithelial-mesenchymal transition EpICD

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World Journal of Gastroenterology 2022年第12期28卷 1226-1238页

作者： Nadia Marascio Salvatore Rotundo Angela Quirino Giovanni Matera Maria Carla Liberto chiara Costa Alessandro Russo Enrico Maria Trecarichi Carlo Torti Department of Health Sciences Unit of MicrobiologyUniversity“Magna Graecia”of CatanzaroCatanzaro 88100Italy Department of Medical and Surgical Sciences Unit of Infectious and Tropical Diseases"Magna Graecia"University of CatanzaroCatanzaro 88100Italy

Hepatitis E virus(HEV)and hepatitis C virus(HCV)are both RNA viruses with a tropism for liver parenchyma but are also capable of extrahepatic *** E is usually a viral acute fecal-oral transmitted and self-limiting disease presenting with malaise,jaundice,nausea and ***,HEV causes a chronic infection in immunocompromised persons and severe fulminant hepatitis in pregnant *** HCV infection is typically asymptomatic for decades until chronic complications,such as cirrhosis and cancer,*** being two very different viruses in terms of phylogenetic and clinical presentations,HEV and HCV show many similarities regarding possible transmission through organ transplantation and blood transfusion,pathogenesis(production of antinuclear antibodies and cryoglobulins)and response to treatment with some direct-acting antiviral *** both HEV and HCV are well studied individually,there is a lack of knowledge about coinfection and its *** aim of this review is to analyze current literature by evaluating original articles and case reports and to hypothesize some interactions that can be useful for research and clinical practice.

关键词： Hepatitis C virus Hepatitis E virus Co-infection Genomic variability Extrahepatic diseases Vaccine

Hearing(Technological)Anomalies:An Analysis of Han Song's"The Rebirth Bricks"

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2020年第2期14卷 228-253页

作者： chiara Cigarini Modern and Contemporary Chinese Literature Beijing Normal UniversityBeijing 100875China

Contemporary Chinese science fiction author and journalist Han Song's works often cross the lines dividing reality from imagination,science fiction from literary mainstream,technology from the *** article,focusing in particular on Han's novella"The Rebirth Bricks"(Zaisheng zhuan),aims to investigate the role played by the senses in a shift from the science fictional novum to the fictional"uncanny."Featuring technological bricks,haunted by sounds of the dead which are perceived through sight and hearing,this novella is analyzed from the standpoint of this perceptual complementarity which expresses Han Song's"science fictional re-enchantment,"a re-use of supernatural themes of the past that allow him to express the(technological)anomalies of China's current reality.

关键词： Chinese science fiction Han Song science fictional re-enchantment zhiguai sensory

New Role for an Old Rule: N-end Rule-Mediated Degradation of Ethylene Responsive Factor Proteins Governs Low Oxygen Response in Plants

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Journal of Integrative Plant Biology 2013年第1期55卷 31-39页

作者： Francesco Licausi chiara Pucciariello Pierdomenico Perata Plant Lab Institute of Life Sciences Scuola Superiore Sant' Anna

The N-end rule pathway regulates protein degradation, which depends on exposed N-terminal sequences in prokaryotes and eukaryotes. In plants, conserved and specific enzymes stimulate selective proteolysis. Although a number of developmental and growth phenotypes have been reported for mutants in the N-end rule, its function has remained unrelated to specific physiological pathways. The first report of the direct involvement of the N-end rule in stress responses focused on hypoxic signaling and how the oxygen-dependent oxidation of cystein promotes the N-end rule-mediated degradation of ethylene responsive factor （ERF）-VII proteins, the master regulators of anaerobic responses. It has been suggested that plants have evolved specific mechanisms to tune ERF-VII availability in the nucleus. In this review, we speculate that ERF-VII proteins are reversibly protected from degradation via membrane sequestration. The oxidative response in plants subjected to anoxic conditions suggests that reactive oxygen and nitrogen species （reactive oxygen species and reactive nitrogen species） may interact or interfere with the N-end rule pathway-mediated response to hypoxia.

关键词： Ethylene response factor flooding hypoxia N-end rule pathway ubiquitin.

“Starry liver”-Von Meyenburg complex clinical case presentation and differential diagnosis discussion:A case report

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World Journal of Hepatology 2022年第7期14卷 1520-1527页

作者： Kateryna Priadko Marco Niosi Luigi Maria Vitale chiara De Sio Marco Romano Ilario De Sio Department of Precision Medicine and Hepato-Gastroenterology Unit University Hospital and Universitàdegli Studi della Campania Luigi VanvitelliNaples 80138Italy Internal Medicine Unit Camilliani HospitalCasoria 80026Italy

BACKGROUND Von Meyenburg complex(VMC)(i.e.,biliary hamartoma)is a rare congenital disorder characterized by multiple dilated cystic bile ducts,without clear trends in sex or age *** to the low number of published cases and the lack of recognized guidelines,the management of such patients remains a clinical *** SUMMARY We present a case of symptomatic VMC that was diagnosed after imaging and histopathological *** the patient’s condition,a conservative treatment strategy was ***,laboratory,and clinical follow-up demonstrated the stable condition of the patient receiving conservative *** VMC is a potentially non-life threatening condition,but its recognition is crucial for the management of patients.

关键词： Biliary hamartoma Von Meyenburg complex Liver polycystic disease Ultrasonography imaging Magnetic resonance imaging Case report

Fungal spores and pollen in particulate matter collected during agricultural activities in the Po Valley(Italy)

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Journal of Environmental Sciences 2016年第8期28卷 229-240页

作者： chiara Telloli Milvia Chicca Marilena Leis Carmela Vaccaro Italian National Agency for New Technologies Energy and Sustainable Economic Development (ENEA) Technical Unit for Environmental Assessment Models Methods and Technologies (UTVALAMB) Air Quality Laboratory (AIR) Department of Life Science and Biotechnologies Ferrara University Department of Physics and Earth Sciences Ferrara University

Airborne particulate matter（PM） containing fungal spores and pollen grains was sampled within a monitoring campaign of wheat threshing, plowing and sowing agricultural operations. Fungal spores and pollen grains were detected and identified on morphological basis. No studies were previously available about fungal spore and pollen content in agricultural PM in the Po Valley. Sampling was conducted in a Po Valley farmland in Mezzano（Ferrara, Italy）. The organic particles collected were examined by scanning electron microscopy with energy dispersive X-ray spectrometer. Fungal spores and pollen grains were identified when possible at the level of species. The most frequent components of the organic particles sampled were spores of Aspergillus sp., which could represent a risk of developing allergies and aspergillosis for crop farmers.

关键词： Wheat Aspergillosis Emilia-Romagna Morphology SEM–EDS