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Outcomes assessment of hepatitis C virus-positive psoriatic patients treated using pegylated interferon in combination with ribavirin compared to new Direct-Acting Antiviral agents

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World Journal of Hepatology 2018年第2期10卷 329-336页

作者： Giovanni Damiani chiara franchi Paolo Pigatto Andrea Altomare Alessia Pacifico Stephen Petrou Sebastiano Leone Maria Caterina Pace Marco Fiore Study Center of Young Dermatologists Italian Network (YDIN) Gised Bergamo Italy and Clinical Dermatology IRCCS Galeazzi Orthopaedic Institute Department of Biomedical Surgical and Dental Sciences University of Milan Clinical Dermatology IRCCS Galeazzi Orthopaedic Institute San Gallicano Dermatological Institute IRCCS Department of Emergency Medicine St. George’s University Medical School Division of Infectious Diseases "San Giuseppe Moscati" Hospital Department of Anesthe-siological Surgical and Emergency Sciences University of Campania "Luigi Vanvitelli"

AIM To evaluate the outcomes in biological treatment and quality of life of psoriatic patients with chronic hepatitis C(CHC) treated with new Direct-Acting Antiviral agents(DAAs) compared to pegylated interferon-2α plus ribavirin(P/R) *** This is a retrospective study involving psoriatic patients in biological therapy who underwent anti-hepatitis C virus(HCV) treatment at the Department of Dermatology Galeazzi Orthopaedic Institute Milan, Italy from January 2010 to November 2017. The patients were divided into two groups: patients that underwent therapy with DAAs and patients that underwent HCV treatment with P/R. Patients were assessed by a dermatologist for psoriasis symptoms, collecting Psoriasis Area Severity Index(PASI) scores and the Dermatology Quality of Life Index(DLQI). PASI and DLQI scores were evaluated 24 wk after the end of HCV treatment and were assumed as an outcome of the progression of psoriasis. Switching to a different b DMARD was considered as an inadequate response to biological therapy. The dropout of HCV therapy and sustained virological response(SVR) were considered as outcomes of HCV *** Fifty-nine psoriatic patients in biological therapy underwent antiviral therapy for CHC. Of this, 27 patients were treated with DAAs and 32 with P/R. After 24 wk post treatment, the DLQI and the PASI scores were significantly lower(P < 0.001 and P < 0.005, respectively) in the DAAs group compared with P/R group. None of the patients in the DAAs group(0/27) compared to 8 patients of the P/R group(8/32) needed a shift in biological *** DAAs seem to be more effective and safe than P/R in HCV-positive psoriatic patients on biological treatment. Fewer dermatological adverse events may be due to interferon-free therapy.

关键词： Hepatitis C virus New Direct-Acting Antiviral agents Psoriasis Biological disease modifying drugs

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Lower limb suspension induces threshold-specific alterations of motor units properties that are reversed by active recovery

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Journal of Sport and Health Science 2024年第2期13卷 264-276页

作者： Giacomo Valli Fabio Sarto Andrea Casolo Alessandro Del Vecchio Martino V.franchi Marco V.Narici Giuseppe De Vito Department of Biomedical Sciences University of PadovaPadova 35131Italy Department Artificial Intelligence in Biomedical Engineering Friedrich-Alexander UniversityErlangen-Nurnberg 91052Germany

Purpose:This study aimed to non-invasively test the hypothesis that(a) short-term lower limb unloading would induce changes in the neural control of force production(based on motor units(MUs) properties) in the vastus lateralis muscle and(b) possible changes are reversed by active recovery(AR).Methods:Ten young males underwent 10 days of unilateral lower limb suspension(ULLS) followed by 21 days of *** ULLS,participants walked exclusively on crutches with the dominant leg suspended in a slightly flexed position(15°-20°) and with the contralateral foot raised by an elevated *** AR was based on resistance exercise(leg press and leg extension) and executed at 70% of each participant’s 1repetition maximum,3 times/*** voluntary isometric contraction(MVC) of knee extensors and MUs properties of the vastus lateralis muscle were measured at baseline,after ULLS,and after *** were identified using high-density electromyography during trapezoidal isometric contractions at 10%,25%,and 50% of the current MVC,and individual MUs were tracked across the 3 data collection ***:We identified 1428 unique MUs,and 270 of them(18.9%) were accurately *** ULLS,MVC decreased by 29.77%,MUs absolute recruitment/derecruitment thresholds were reduced at all contraction intensities(with changes between the 2 variables strongly correlated),while discharge rate was reduced at 10% and 25% but not at 50% *** MVC and MUs properties fully recovered to baseline levels after *** changes were observed in the pool of total as well as tracked ***:Our novel results demonstrate,non-invasively,that 10 days of ULLS affected neural control predominantly by altering the discharge rate of lower-threshold but not of higher-threshold MUs,suggesting a preferential impact of disuse on motoneurons with a lower depolarization ***,after 21 days of AR,the impaired MUs properties were fully restored to baseline levels,highlighting the plas

关键词： Disuse High-density EMG Muscle disuse Neural impairment Neuromuscular degeneration

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Interferometric method to estimate the eigenvalues of a non-Hermitian two-level optical system

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Photonics Research 2022年第4期10卷 1134-1145页

作者： STEFANO BIASI RICCARDO franchi FILIPPO MIONE LORENZO PAVESI Nanoscience Laboratory Dipartimento di FisicaUniversita di Trento38123 TrentoItaly

Non-Hermitian physics has found a fertile ground in optics. Recently, the study of mode coalescence, i.e., exceptional points, has led to the discovery of intriguing and counterintuitive phenomena. Degeneracies are typically modeled through the coupled mode theory to determine the behavior of eigenstates and eigenvalues. However,the complex nature of the eigenvalues makes their characterization from the response spectrum difficult. Here,we demonstrate that a coherent interferometric excitation allows estimation of both the real and imaginary parts of the eigenvalues. We study the clockwise and counter-clockwise modes in optical microresonators both in the case of Hermitian and non-Hermitian intermodal coupling. We show the conditions by which a resonant doublet,due to the dissipative coupling of counter-propagating modes caused by surface roughness backscattering, merges to a single Lorentzian. This permits us to estimate the optimal quality factor of the microresonator in the absence of modal coupling caused by backscattering. Furthermore, we demonstrate that a taiji microresonator working at an exceptional point shows a degeneracy splitting only in one propagation direction and not in the other. This follows from the strongly non-Hermitian intermodal coupling caused by the inner S-shaped waveguide.

关键词： eigenvalues exceptional intuitive

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eHealth,telehealth,and telemedicine in the management of the COVID-19 pandemic and beyond:Lessons learned and future perspectives

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World Journal of Clinical Cases 2022年第8期10卷 2363-2368页

作者： Andrea Giacalone Luca Marin Massimiliano Febbi Thomas franchi Marcos Roberto Tovani-Palone Department of Industrial Engineering Technologies for Sports Medicine and RehabilitationUniversity of Rome Tor VergataRome 00133Italy Department of Research Asomi College of SciencesMarsa MRS 19112Malta The Medical School The University of SheffieldSheffield S102RXUnited Kingdom Department of Pathology and Legal Medicine Ribeirão Preto Medical SchoolUniversity of São PauloRibeirão Preto 14049-900Brazil

In this article,we discuss evidence supporting the effective implementation of e Health,telehealth,and telemedicine during the coronavirus disease 2019 pandemic,with a view towards its permanent future integration in *** performed a literature search for articles describing the use of telehealth/telemedicine in the pandemic context using five *** articles selected describe the use of telemedicine as its advantages in terms of practicality and *** synthesis of articles is applicable to high-,middle-and lowincome *** of the notable benefits include breaking down geographical and time barriers,reducing waiting lists and crowding in healthcare facilities,and saving on national healthcare ***,there are a number of difficulties with the widespread implementation of telemedicine services that mainly relate to bureaucratic and regulatory ***,it is also important to make healthcare professionals and providers aware of the limits of this tool to avoid potential cases of *** in turn will have to be made aware of and be educated on the use of this new healthcare modality before it is accepted by *** the current socio-economic climate,it is therefore essential to implement a telehealth model aimed at efficiency and continuity of healthcare,as well as leading to an improvement in the quality of life of patients,whilst optimising existing resources and reducing *** that regard,the adoption of e Health,telehealth,and telemedicine services should be considered highly timely,despite current existing limitations.

关键词： eHealth Telehealth Telemedicine Coronavirus disease 2019 Pandemics Delivery of healthcare

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Novel mutation in the ligand-binding domain of the androgen receptor gene （1790p） associated with complete androgen insensitivity syndrome

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Asian Journal of Andrology 2008年第4期10卷 687-691页

作者： Florina Raicu Rossella Giuliani Valentina Gatta chiara Palka Paolo Guanciali franchi Pierluigi Lelli-Chiesa Stefano Tumini Liborio Stuppia Department of Clinical Sciences and Imaging G. d^t Annunzio University Foundation Chieti-Pescara 66013 Italy Department of Biomedical Sciences G. d^t Annunzio University Foundation Chieti-Pescara 66013 Italy Aging Research Center G. d^t Annunzio University Foundation Chieti-Pescara 66013 Italy Division of Pediatric Surgery G. d^t Annunzio University Foundation Chieti-Pescara 66013 Italy Department of Pediatrics and Gynecology G. d^t Annunzio University Foundation Chieti-Pescara 66013 Italy Institute of Molecular Genetics National Research Council IGM-CNR Bologna 40100 Italy Carol Davila University of Medicine and Pharmacy Bucharest 020027 Romania

Mutations in the X-linked androgen receptor （AR） gene cause androgen insensitivity syndrome （AIS）, resulting in an impaired embryonic sex differentiation in 46,XY genetic men. Complete androgen insensitivity （CAIS） produces a female external phenotype, whereas cases with partial androgen insensitivity （PALS） have various ambiguities of the genitalia. Mild androgen insensitivity （MAIS） is characterized by undermasculinization and gynecomastia. Here we describe a 2-month-old 46,XY female patient, with all of the characteristics of CAIS. Defects in testosterone （T） and dihydrotestosterone （DHT） synthesis were excluded. Sequencing of the AR gene showed the presence in exon 6 of a T to C transition in the second base of codon 790, nucleotide position 2369, causing a novel missense Leu790Pro mutation in the ligand-binding domain of the AR protein. The identification of a novel AR mutation in a girl with CAIS provides significant information due to the importance of missense mutations in the ligand-binding domain of the AR, which are able to induce functional abnormalities in the androgen binding capability, stabilization of active conformation, or interaction with coactivators.

关键词： androgen receptor novel androgen receptor gene mutation complete androgen insensitivity syndrome

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Biceps femoris long head sarcomere and fascicle length adaptations after 3 weeks of eccentric exercise training

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Journal of Sport and Health Science 2022年第1期11卷 43-49页

作者： Patricio A.Pincheira Melissa A.Boswell Martino V.franchi Scott L.Delp Glen A.Lichtwark School of Human Movement and Nutrition Sciences The University of QueenslandBrisbaneQLD 4072Australia Department of Bioengineering and Mechanical Engineering Stanford UniversityStanfordCA 94305USA Department of Biomedical Sciences University of PadovaPadova 35122Italy

Background:Eccentric exercise increases muscle fascicle lengths;however,the mechanisms behind this adaptation are still *** study aimed to determine whether biceps femoris long head(BFlh)fascicle length increases in response to 3 weeks of eccentric exercise training are the result of an in-series addition of sarcomeres within the muscle ***:Ten recreationally active participants(age=27±3 years;mass=70±14 kg;height=174±9 cm;mean±SD)completed 3 weeks of Nordic hamstring exercise(NHE)training on a custom exercise device that was instrumented with load *** collected in vivo sarcomere and muscle fascicle images of the BFlh in 2 regions(central and distal)by using microendoscopy and 3 dimension *** then estimated sarcomere length,sarcomere number,and fascicle length before and after the training ***:Eccentric knee flexion strength increased after the training(15%;p<0.001;η_(p)^(2)=0.75).Further,we found a significant increase in fascicle length(21%;p<0.001;η_(p)^(2)=0.81)and sarcomere length(17%;p<0.001;ηp2=0.90)in the distal but not in the central portion of the *** estimated number of sarcomeres in series did not change in either ***:Fascicle length adaptations appear to be heterogeneous in the BFlh in response to 3 weeks of NHE *** increase in sarcomere length,rather than the addition of sarcomeres in series,appears to underlie increases in fascicle length in the distal region of the *** mechanism driving regional increases in fascicle and sarcomere length remains unknown,but we speculate that it may be driven by regional changes in the pas sive tension of muscle or connective tis sue adaptations.

关键词： Hamstrings Nordic hamstring exercise Sarcomerogenesis

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L^1-Poincaré and Sobolev inequalities for differential forms in Euclidean spaces Dedicated to Professor Jean-Yves Chemin on the Occasion of His 60th Birthday

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Science China Mathematics 2019年第6期62卷 1029-1040页

作者： Annalisa Baldi Bruno franchi Pierre Pansu Dipartimento di Matematica Università di Bologna Laboratoire de Mathématiques d'Orsay Université Paris-Sud CNRSUniversité Paris-Saclay

In this paper, we prove Poincaré and Sobolev inequalities for differential forms in L^1(R^n). The singular integral estimates that it is possible to use for L^p, p > 1, are replaced here with inequalities which go ba... 详细信息

关键词： differential forms Sobolev-Poincaré inequalities homotopy formula

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A Recursive Basis for Primitive Forms in Symplectic Spaces and Applications to Heisenberg Groups

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Acta Mathematica Sinica,English Series 2016年第3期32卷 265-285页

作者： Annalisa BALDI Marilena BARNABEI Bruno franchi Dipartimento di Matematica Piazza di Porta S.Donato 540126 BolognaItaly

This paper is divided in two parts： in Section 2, we define recursively a privileged basis of the primitive forms in a symplectic space（V^（2n）, ω）. Successively, in Section 3, we apply our construction in the setting of Heisenberg groups H^n, n ≥ 1, to write in coordinates the exterior differential of the so-called Rumin＇s complex of differential forms in H^n.

关键词： Symplectic manifolds differential forms Heisenberg groups combinatorial functions

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There is life after coking for Ir nanocatalyst superlattices

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Nano Research 2022年第8期15卷 6969-6976页

作者： Antonio J.Martínez-Galera Haojie Guo Mariano D.Jiménez-Sánchez Stefano franchi Kevin C.Prince José M.Gómez-Rodríguez Departamento de Física de la Materia Condensada Universidad Autónoma de MadridMadrid E-28049Spain Instituto Nicolás Cabrera Universidad Autónoma de MadridMadrid E-28049Spain Elettra-Sincrotrone Trieste S.C.p.A. in Area Science ParkBasovizza(Trieste)34149Italy Condensed Matter Physics Center(IFIMAC) Universidad Autónoma de MadridMadrid E-28049Spain

Achieving superior performance of nanoparticle systems is one of the biggest challenges in *** major phenomena,occurring during the reactions,hinder the development of the full potential of nanoparticle catalysts:sintering and contamination with carbon containing species,sometimes called ***,we demonstrate that Ir nanocrystals,arranged into periodic networks on hexagonal boron nitride(h-BN)supports,can be restored without sintering after contamination by persistent *** restoration yields the complete removal of carbon from the nanocrystals,which keep their crystalline structure,allowing operation without *** findings,together with the possibility of fine tuning the nanocrystals size,confer this nanoparticle system a great potential as a testbed to extract key information about catalysis-mediated oxidation *** the case of the CO oxidation by O2,reaction of interest in environmental science and green energy production,the existence of chemical processes not observed before in other nanoparticle systems is demonstrated.

关键词： catalysis coke nanoparticles scanning tunneling microscopy(STM) X-ray photoemission spectroscopy(XPS)

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Majorana Representations of Finite Groups

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Algebra Colloquium 2020年第1期27卷 31-50页

作者： Clara franchi Alexander A.Ivanov Mario Mainardis Dipartimento di Matematica e Fisica Universita Cattolica del Sacro Cuore Via Musei 41I-25121 BresciaItaly Department of Mathematics Imperial College 180 Queen's Gt.LondonSW72AZUK Institute for System Analysis FRC CSCRASRussia Dipartimento di Matematica e Informatica Universita di Udine Via delle Scienze 206I-33100 UdineItaly

In this paper we give a brief overview of the theory of Majorana representations of finite groups.

关键词： axial algebras Majorana representations Monster group Monster algebra,association schemes

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