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Gastrointestinal stromal tumor of the stomach with axillary lymph node metastasis: A case report

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World Journal of Gastroenterology 2017年第9期23卷 1720-1724页

作者： Naoki kubo Nobumichi Takeuchi Department of Surgery Ina central HospitalInashiNagano 396-8555Japan

Gastrointestinal stromal tumors (GISTs) are the most common type of gastrointestinal mesenchymal tumors, although metastasis to the perigastric lymph nodes is relatively rare, compared with liver or peritoneal metastasis. In this report, we describe a case of stomach GIST with a solitary simultaneous metastasis in the left axillary lymph node. A 68-year-old man was diagnosed with a large upper-stomach GIST, and computed tomography and positron emission tomography revealed masses in the left axilla and right mediastinum. We did not detect evidence of metastases to the liver, or other sites including the perigastric lymph nodes, although findings from the surgically resected axillary lymph nodes were compatible with GIST metastasis. Treatment using imatinib markedly reduced the gastric and mediastinal lesions, and this response persisted for 3 years. The patient subsequently experienced rapid growth of the gastric lesion without mediastinal or axilla recurrence, which required palliative surgery. Despite continuing medical treatment(sunitinib and regorafenib), the patient died of liver metastases 23 mo after the surgery. Based on our findings, it appears that the axillary lymph nodes can be a potential metastatic site for GIST metastasis.

关键词： Gastrointestinal stromal tumor Axillary Lymph node Metastasis Imatinib

Characteristics of Transient Vortices in the Boundary Layer on a Rotating Disk under Orbital Motion

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Journal of Thermal Science 2013年第6期22卷 600-605页

作者： Mizue Munekata Naoya Jobi Keiichiro kubo Hiroyuki Yoshikawa Department of Mechanical System Engineering Kumamoto University

The objective of this study is to experimentally examine the characteristics of transient vortices in the boundary layer on a disk undergoing both rotation and orbital motion. The velocity fluctuations on a rotating, orbiting disk （disk radius equal to orbital radius） are measured by the hot-wire method, and the effects of orbital motion on the transient vortices in the boundary layer are examined. When the ratio of the orbital speed to the speed of rotation is i-0.025, the interval of transient vortices depends on only the orbital radius, regardless of the directions of rota- tion and orbital motion. The rate of low-frequency disturbances increases as the orbital speed increases, and the vortices induced by these low-frequency disturbances travel over the disk and then develop in the region of in- creased velocity. Consequently, no vortices generated on a rotating disk under orbital motion are stationary rela- tive to the disk.

关键词： Boundary layer transition Transient vortex Rotating disk Velocity measurement Hot-wire ane-mometer

Is germinal center selection required for influenza vaccination?

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Cellular & Molecular Immunology 2017年第8期14卷 655-657页

作者： Kosuke Miyauchi Masato kubo Laboratory for Cytokine Regulation Research Center for Integrative Medical Science(IMS)RIKEN Yokohama InstituteYokohamaKanagawa 230-0045Japan Division of Molecular Pathology Research Institute for Biomedical ScienceTokyo University of ScienceNodaChiba 278-0022Japan

It has long been believed that the generation of high-affinity neutralizing antibodies is critical for antiviral humoral *** production of high-affinity antibodies depends on the formation of germinal centers(GC)in ly... 详细信息

关键词： centers center neutral

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极端动物保护主义与实验动物福利伦理

中国比较医学杂志 2024年第5期34卷 106-112页

作者：田雪梅久保幸子吴英杰苏涛山东第一医科大学附属省立医院教育处济南250021 山东第一医科大学附属省立医院模式动物研究所济南250021

实验动物作为“活的试剂”,推动了生命科学和医学的飞速发展,其福利伦理问题日益受到社会各界的关注。实验动物福利伦理不仅是动物保护主义的重要组成部分,也对于保障实验动物的权益、促进科学研究的合理性与道德性具有重要意义。然而,... 详细信息

实验动物作为“活的试剂”,推动了生命科学和医学的飞速发展,其福利伦理问题日益受到社会各界的关注。实验动物福利伦理不仅是动物保护主义的重要组成部分,也对于保障实验动物的权益、促进科学研究的合理性与道德性具有重要意义。然而,在动物保护主义的演变过程中,极端动物保护主义作为一种偏激的观点和理论逐渐浮现。本文旨在从实验动物福利伦理的视角出发,总结动物保护主义的主要理论和实验动物福利伦理的发展历程;分析极端动物保护主义的主要问题;并针对我国实验动物福利伦理的现状提出建议,以期为我国的实验动物福利伦理实践和制度建设提供参考。

关键词：实验动物福利伦理审查动物保护主义制度建设

Practical BRDF reconstruction using reliable geometric regions from multi-view stereo

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Computational Visual Media 2019年第4期5卷 325-336页

作者： Taishi Ono Hiroyuki kubo Kenichiro Tanaka Takuya Funatomi Yasuhiro Mukaigawa Nara Institute of Science and Technology IkomaNara 630-0192Japan

In this paper,we present a practical method for reconstructing the bidirectional reflectance distribution function(BRDF)from multiple images of a real object composed of a homogeneous *** key idea is that the BRDF can be sampled after geometry estimation using multi-view stereo(MVS)*** contribution is selection of reliable samples of lighting,surface normal,and viewing directions for robustness against estimation errors of *** method is quantitatively evaluated using synthesized images and its effectiveness is shown via real-world experiments.

关键词： BRDF reconstruction multi-view stereo(MVS) photogrammetry rendering

Statistical modeling of nitrogen-dependent modulation of root system architecture in Arabidopsis thaliana

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Journal of Integrative Plant Biology 2016年第3期58卷 254-265页

作者： Takao Araya Takuya kubo Nicolaus von Wiren Hideki Takahashi Department of Biochemistry and Molecular Biology Michigan State UniversityEast LansingM148824USA Molecular Plant Nutrition Leibniz Institute of Plant Genetics and Crop Plant ResearchD-06466 GaterslebenGermany Graduate School of Environmental Science Hokkaido UniversitySapporo 060-0810Japan

Plant root development is strongly affected by nutrient availability. Despite the importance of structure and function of roots in nutrient acquisition,statistical modeling approaches to evaluate dynamic and temporal modulations of root system architecture in response to nutrient availability have remained as widely open and exploratory areas in root biology. In this study,we developed a statistical modeling approach to investigate modulations of root system architecture in response to nitrogen availability. Mathematical models were designed for quantitative assessment of root growth and root branching phenotypes and their dynamic relationships based on hierarchical con figuration of primary and lateral roots formulating the fishbone-shaped root system architecture in Arabidopsis thaliana. Time-series datasets reporting dynamic changes in root developmental traits on different nitrate or ammonium concentrations were generated for statistical analyses. Regression analyses unraveled key parameters associated with：（i） inhibition of primary root growth under nitrogen limitation or on ammonium;（ii） rapid progression of lateral root emergence in response to ammonium; and（iii） inhibition of lateral root elongation in the presence of excess nitrate or ammonium. This study provides a statistical framework for interpreting dynamic modulation of root system architecture,supported by metaanalysis of datasets displaying morphological responses of roots to diverse nitrogen supplies.

关键词： Ammonium mathematical modeling nitrate nitrogen root system architecture

History of the Chinese Medicinal Gelatin

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Chinese Medicine and Culture 2022年第1期5卷 39-45页

作者： Teruyuki kubo Zhong-Zhen Zhao School of Oriental Languages and Philosophy Zhejiang Gongshang UniversityHangzhou 310018China School of Chinese Medicine Hong Kong Baptist University7 Baptist University RoadKowloon TongHong Kong 999077China

This article discusses the history of animal glue(gelatin)used in medical practice in *** ancient times,gelatin was widely made from cowhide and has been found in excavations and wall paintings older than 2000 years in Egypt,Greece,and ***,it has been used medicinally almost exclusively in China and other East Asian countries influenced by Chinese *** 11th century,donkey-hide has gradually been replaced with cowhide in medicinal ***,donkey-hide gelatin is widely used medicinally in *** the Edo period,medicinal gelatin was imported to Japan from *** to the distaste for eating animal flesh in traditional Japanese culture,the production of gelatin and its medicinal use is not widespread in Japan.

关键词： Cowhide Donkey-hide E Jiao Gelatin Japan Medical history

Cancer-associated fibroblasts in hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第30期22卷 6841-6850页

作者： Norio kubo Kenichiro Araki Hiroyuki Kuwano Ken Shirabe Department of Hepatobiliary and Pancreatic Surgery Gunma University Graduate School of Medicine Department of General Surgical Science Gunma University Graduate School of Medicine

The hepatic stellate cells in the liver are stimulated sustainably by chronic injury of the hepatocytes, activating myofibroblasts, which produce abundant collagen. Myofibroblasts are the major source of extracellular proteins during fibrogenesis, and may directly, or secreted products, contribute to carcinogenesis and tumor progression. Cancer-associated fibroblasts(CAFs) are one of the components of the tumor microenvironment that promote the proliferation and invasion of cancer cells by secreting various growth factors and cytokines. CAFs crosstalk with cancer cells stimulates tumor progression by creating a favorable microenvironment for progression, invasion, and metastasis through the epithelial-mesenchymal transition. Basic studies on CAFs have advanced, and the role of CAFs in tumors has been elucidated. In particular, for hepatocellular carcinoma, carcinogenesis from cirrhosis is a known fact, and participation of CAFs in carcinogenesis is supported. In this review, we discuss the current literature on the role of CAFs and CAF-related signaling in carcinogenesis, crosstalk with cancer cells, immunosuppressive effects, angiogenesis, therapeutic targets, and resistance to chemotherapy. The role of CAFs is important in cancer initiation and progression. CAF-targeted therapy may be effective for suppression not only of fibrosis but also cancer progression.

关键词： Cancer associated fibroblast Hepatic stellate cell Hepatocellular carcinoma Immunosuppression Therapeutic target

Acquiring non-parametric scattering phase function from a single image

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Computational Visual Media 2018年第4期4卷 323-331页

作者： Yuki Minetomo Hiroyuki kubo Takuya Funatomi Mikio Shinya Yasuhiro Mukaigawa Nara Institute of Science and Technology 8916-5 Takayama-choIkomaNara630-0192Japan. Toho University 2-2-1 MiyamaFunabashiChiba274- 8510Japan. Dwango CG Research KADOKAWA Hongo Bldg.5-24-5 HongoBunkyo-kuTokyo113-0033Japan.

Acquiring accurate scattering properties is important for rendering translucent materials. In particular, the phase function, which determines the distribution of scattering directions, plays a significant role in the appearance of a material. We propose a distinctive scattering theory that approximates the effect of single scattering to acquire the non-parametric phase function from a single image. Furthermore, in various experiments, we measured the phase functions from several real diluted media and rendered images of these materials to evaluate the effectiveness of our theory.

关键词： scattering phase function measurement rendering