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Differentiation between dysplastic nodule and early-stage hepatocellular carcinoma: The utility of conventional MR imaging

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World Journal of Gastroenterology 2013年第42期19卷 7433-7439页

作者： chen-Te Chou Jung-Mao Chou Ting-An Chang Shiu-Feng Huang chia-bang chen Yao-Li chen Ran-Chou chen Department of Biomedical Imaging and Radiological Science National Yang-Ming Medical University Department of Radiology Chang-Hua Christian Hospital Department of Pathology Taipei City Hospital Transplant Medicine and Surgery Research Centre Chang-Hua Christian Hospital Department of Radiology Taipei City Hospital

AIM:To elucidate the variety of ways early-stage hepatocellular carcinoma(HCC)can appear on magnetic resonance(MR)imaging by analyzing T1-weighted,T2-weighted,and gadolinium-enhanced dynamic ***:Seventy-three patients with well-differentiated HCC(wHCC)or dysplastic nodules were retrospectively identified from medical records,and new histological sections were prepared and *** tumor nodules were categorized into three groups:dysplastic nodule(DN),wHCC compatible with Edmondson-Steiner grade I HCC(w1-HCC),and wHCC compatible with Edmondson-Steiner gradeⅡHCC(w2-HCC).The signal intensity on pre-contrast MR imaging and the enhancing pattern for each tumor were recorded and compared between the three tumor ***:Among the 73 patients,14 were diagnosed as having DN,40 were diagnosed as having w1-HCC,and 19 were diagnosed as having *** measurements on T2-weighted axial images(T2WI)were statistically significant between DNs and wHCC(P=0.006)and between DN and w1-HCC(P=0.02).The other imaging features revealed no significant differences between DN and wHCC or between DN and *** on both T1W out-phase imaging(P=0.007)and arterial enhancement on dynamic study(P=0.005)showed statistically significant differences between w1-HCC and *** other imaging features revealed no significant differences between w1-HCC and ***:In the follow-up for a cirrhotic nodule,increased signal intensity on T2WI may be a sign of malignant ***,a noted loss of hyperintensity on T1WI and the detection of arterial enhancement might indicate further progression of the histological grade.

关键词： Dysplastic nodule Hepatocellular carcinoma Histological grading Magnetic resonance imaging Well-differentiated hepatocellular carcinoma

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CFD Simulation of a container ship in random waves using a coupled level-set and volume of fluid method

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Journal of Hydrodynamics 2023年第2期35卷 222-231页

作者： Hamn-Ching chen chia-Rong chen Zachry Department of Civil and Environmental Engineering Texas A&M UniversityCollege StationTexasUSA

The coupled level-set and volume of fluid(CLSVOF)method is an advanced interface-capturing method that has been extended to handle overset grid ***,artificial uneven interface may be observed across block boundaries of different sizes and *** present an improved inter-grid VOF interpolation and mass correction scheme to address the *** demonstrate the capability of the improved CLSVOF method,it is applied to the simulation of a container ship in pitch and heave motions under both head sea and following sea irregular wave *** simulation proves that the improved CLSVOF method is capable of revealing detailed physics difficult to see with other *** phenomena simulated in our work include the extensive greenwater propagation on the ship deck,the breakup of overtopping waves into small droplets,and the formation and collapse of air pockets in sudden bow and stern slamming which cause strong and highly localized impacts on the ship bow,stern,and rudder.

关键词： Computational fluid dynamics(CFD) couple level-set and volume of fluid(CLSVOF)method random waves overset grid system violent free surface flow bow and stern slamming

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Porous Cube-like In_2O_3 Nanoparticles and Their Sensing Characteristics toward Ethanol

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Journal of Materials Science & Technology 2008年第4期24卷 667-674页

作者： Chih-chia HUANG chen-Sheng YEH Natl cheng Kung Univ Dept Chem Tainan 70101 Taiwan

Porous cube-like crystalline In2O3 nanoparticles with an average diagonal length of 34.8 nm were fabricated by a laser ablation-reflux process to form In（OH）3, followed by a calcination treatment to yield porous In2O3. HRTEM （high-resolution transmission electronic microscopy）, XRD （X-ray diffraction）, BET （Brunauer-Emmett-Teller）, and XPS （X-ray photoelectron spectroscopy） analysis were used to characterize their crystalline structures, grain sizes, surface areas, and surface compositions. The as-prepared porous in-dium oxides were tested for their sensing properties toward ethanol. Non-porous In2O3 nanopowder （about 40 nm） was also examined in order to compare the results with the as-prepared porous In2O3 nanomaterials. The porous In2O3 exhibited much better performance than that of non-porosus In2O3, and showed enhanced sensitivity with a lower detection limit than other reported In2O3-based materials when exposed to ethanol. Good gas sensitivity and linear behavior as a function of ethanol concentration were observed in the porous In2O3 nanoparticles.

关键词： In2O3 Porosity Nanoparticles Gas sensor

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The fabrication and application of Ni-DNA nanowire-based nanoelectronic devices

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Nano Research 2019年第6期12卷 1293-1300页

作者： Pang-chia Chang chia-Yu Chang Wen-Bin Jian Chiun-Jye Yuan Yu-Chang chen chia-Ching Chang Department of Electrophysics "National Chiao Tung University"Hsinchu 30010TaiwanChina Department of Biological Science and Technology "National Chiao Tung University"Hsinchu 30068TaiwanChina Center for Intelligent Drug Systems and Smart Bio-devices(IDS^2B) "National Chiao Tung University"Hsinchu 30068TaiwanChina Institute of Physics "Academia Sinica"Taipei 11529TaiwanChina

DNA is a self-assembled,double stranded natural molecule that can chelate and align nickel ions between its base *** fabrication of a DNA-guided nickel ion chain (Ni-DNA) device was successful,as indicated by the conducting currents exhibiting a Ni ion redox reaction-driven negative differential resistance effect,a property unique to mem-elements (1).The redox state of nickel ions in the Ni-DNA device is programmable by applying an external bias with different polarities and writing times (2).The multiple states of Ni-DNA-based memristive and memcapacitive systems were characterized (3).As such,the development of Ni-DNA nanowire device-based circuits in the near future is proposed.

关键词： DNA-guided nickel ion chain (Ni-DNA) negative differential resistance (NDR) memristive systemmem capacitive system nanowire

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Platelet-rich plasma enhances adipose-derived stem cell-mediated angiogenesis in a mouse ischemic hindlimb model

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World Journal of Stem Cells 2018年第12期10卷 212-227页

作者： chia-Fang chen Han-Tsung Liao Department of Plastic and Reconstructive Surgery Chang Gung Memorial Hospital Craniofacial Research Center Chang Gung Memorial Hospital College of Medicine Chang Gung University

AIM To evaluate the angiogenic effect of platelet-rich plasma(PRP)-preconditioned adipose-derived stem cells(ADSCs) both in vitro and in a mouse ischemic hindlimb *** ADSCs were divided based on culture medium: 2.5% PRP, 5% PRP, 7.5% PRP, and 10% PRP. Cell proliferation rate was analyzed using the MTS assay. The gene expression of CD31, vascular endothelial growth factor, hypoxia-inducible factors, and endothelial cell nitric oxide synthase was analyzed using reverse transcription polymerase chain reaction. Cell markers and structural changes were assessed through immunofluorescence staining and the tube formation assay. Subsequently, we studied the in vivo angiogenic capabilities of ADSCs by a mouse ischemic hindlimb *** The proliferation rate of ADSCs was higher in the 2.5%, 5%, and 7.5% PRP groups. The expression of hypoxia-inducible factor, CD31, vascular endothelial growth factor, and endothelial cell nitric oxide synthase in the 5% and 7.5% PRP groups increased. The 5%, 7.5%, and 10% PRP groups showed higher abilities to promote both CD31 and vascular endothelial growth factor production and tubular structure formation in ADSCs. According to laser Doppler perfusion scan, the perfusion ratios of ischemic limb to normal limb were significantly higher in 5% PRP, 7.5% PRP, and human umbilical vein endothelial cells groups compared with the negative control and fetal bovine serum(FBS) groups(0.88 ± 0.08, 0.85 ± 0.07 and 0.81 ± 0.06 for 5%, 7.5% PRP and human umbilical vein endothelial cells compared with 0.42 ± 0.17 and 0.54 ± 0.14 for the negative control and FBS, P < 0.01).CONCLUSION PRP-preconditioned ADSCs presented endothelial cell characteristics in vitro and significantly improved neovascularization in ischemic hindlimbs. The optimal angiogenic effect occurred in 5% PRP-and 7.5% PRPpreconditioned ADSCs.

关键词： Platelet-rich plasma Adipose-derived stem cells Mesenchymal stem cell Angiogenesis Endothelial differentiation Mouse ischemic hindlimb model

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Evaluating the Risk of Disclosure and Utility in a Synthetic Dataset

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Computers, Materials & Continua 2021年第7期68卷 761-787页

作者： Kang-cheng chen chia-Mu Yu Tooska Dargahi Industrial Technology Research Institute Hsinchu310Taiwan National chiao Tung University Hsinchu320Taiwan University of Salford ManchesterM54WTUnited Kingdom

The advancement of information technology has improved the delivery of nancial services by the introduction of Financial Technology(FinTech).To enhance their customer satisfaction,Fintech companies leverage articial intelligence(AI)to collect ne-grained data about individuals,which enables them to provide more intelligent and customized ***,although visions thereof promise to make customers’lives easier,they also raise major security and privacy concerns for their *** privacy(DP)is a common privacy-preserving data publishing technique that is proved to ensure a high level of privacy ***,an important concern arises from the trade-off between the data utility the risk of data disclosure(RoD),which has not been well *** this paper,to address this challenge,we propose data-dependent approaches for evaluating whether the sufcient privacy is guaranteed in differentially private data *** the same time,by taking into account the utility of the differentially private synthetic dataset,we present a data-dependent algorithm that,through a curve tting technique,measures the error of the statistical result imposed to the original dataset due to the injection of random ***,we also propose a method that ensures a proper privacy budget,i.e.,will be chosen so as to maintain the trade-off between the privacy and *** comprehensive experimental analysis proves both the efciency and estimation accuracy of the proposed algorithms.

关键词： Differential privacy risk of disclosure privacy utility

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(Phospho)creatine:the reserve and merry-go-round of brain energetics

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Neural Regeneration Research 2023年第2期18卷 327-328页

作者： Hong-Ru chen Ton DeGrauw chia-Yi Kuan Department of Neurosciences University of Virginia School of MedicineCharlottesvilleVAUSA Department of Pediatrics Division of NeurologyEmory UniversityAtlantaGAUSA

Creatine transporter(CrT)-deficiency,the most common form of the cerebral creatine deficiency syndromes,causes cognition impairments and severe reduction of the brain creatine(Cr)and phosphocreatine(PCr)levels,and responds poorly to oral Cr supplement as a treatment *** ca uses of cognitive impairments in CrT-deficient children remain *** recently use gene-targeting to create a mouse model of CrT-deficiency to assess the impacts of Cr/PCr deficiency on brain energetics and stress-adaptation responses(chen et al.,2021).

关键词： impairment cerebral creatine

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Rapid synthesis of Ti-MCM-41 by microwave-assisted hydrothermal method towards photocatalytic degradation of oxytetracycline

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Journal of Environmental Sciences 2016年第6期28卷 76-87页

作者： Hanlin chen Yen-Ping Peng Ku-Fan chen chia-Hsiang Lai Yung-Chang Lin College of Environment and Energy South China University of Technology Department of Environmental Science and Engineering Tunghai University Department of Civil Engineering "National"Chi Nan University Department of Safety Health and Environmental EngineeringCentral Taiwan University of Science and Technology Department of Electrical Engineering Cheng Shiu University

This study employed microwave-assisted hydrothermal method to synthesize Ti-MCM-41,which are mesoporous materials with a high surface area and excellent photocatalytic ability. Fourier transform infrared spectroscopy（FTIR）, X-ray diffraction（XRD）, X-ray photoelectron spectroscopy（XPS）, transmission electron microscopy（TEM）, and ultraviolet–visible spectroscopy（UV–Vis） were employed. The XRD findings showed that Ti-MCM-41 exhibited a peak at 2θ of 2.2°, which was attributed to the hexagonal MCM-41 structure. The BET（Brunauer–Emmett–Teller） results agreed with the TEM findings that Ti-MCM-41 has a pore size of about 3–5 nm and a high surface area of 883 m-2/g. FTIR results illustrated the existence of Si–O–Si and Si–O–Ti bonds in Ti-MCM-41. The appearance of Ti2 p peaks in the XPS results confirmed the FTIR findings that the Ti was successfully doped into the MCM-41 structure. Zeta（ζ）-potential results indicated that the iso-electric point（IEP） of Ti-MCM-41 was at about pH 3.02. In this study, the photocatalytic degradation of oxytetracycline（OTC） at different pH was investigated under Hg lamp irradiation（wavelength 365 nm）. The rate constant（K′obs） for OTC degradation was 0.012 min-1at pH 3. Furthermore, TOC（total organic carbon） and high resolution LC–MS（liquid chromatography–mass spectrometry） analyses were conducted to elucidate the possible intermediate products and degradation pathway for OTC. The TOC removal efficiency of OTC degradation was 87.0%, 74.4% and 50.9% at pH 3, 7 and 10, respectively. LC–MS analysis results showed that the degradation products from OTC resulted from the removal of functional groups from the OTC ring.

关键词： Oxytetracycline Ti-MCM-41 Microwave hydrothermal synthesis Photocatalytic degradation

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Influence of rice straw burning on the levels of polycyclic aromatic hydrocarbons in agricultural county of Taiwan

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Journal of Environmental Sciences 2009年第9期21卷 1200-1207页

作者： chia-Hsiang Lai Kang-Shin chen Hsin-Kai Wang Department of Health Safety and Environmental Engineering Central Taiwan University of Science and Technology Institute of Environmental Engineering Sun Yat-Sen University

Atmospheric particulate and polycyclic aromatic hydrocarbons （PAHs） size distribution were measured at Jhu-Shan （a rural site） and Sin-Gang （a town site） in central Taiwan during the rice straw burning and non-burning periods. The concentrations of total PAHs accounting for a roughly 58% （34%） increment in the concentrations of total PAHs due to rice-straw burning. Combustion-related PAHs during burning periods were 1.54-2.57 times higher than those during non-burning periods. The mass median diameter （MMD） of 0.88-1.21 μm in the particulate phase suggested that rice-straw burning generated the increase in coarse particle number. Chemical mass balance （CMB） receptor model analyses showed that the primary pollution sources at the two sites were similar. However, ricestraw burning emission was specifically identified as a significant source of PAH during burning periods at the two sites. Open burning of rice straws was estimated to contribute approximately 6.3%-24.6% to total atmospheric PAHs at the two sites.

关键词： rice straw open burning polycyclic aromatic hydrocarbons (PAHs) receptor mod

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The fate of regulatory T cells： survival or apoptosis

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Cellular & Molecular Immunology 2014年第1期11卷 11-13页

作者： chia-Rui Shen Wei-cheng Yang Hsin-Wei chen Department of Medical Biotechnology and Laboratory Science and Graduate Institute of Biomedical Science College of Medicine Chang Gung University Taoyuan Taiwan National Institute of Infectious Diseases and Vaccinology National Health Research Institutes Miaoli Taiwan Graduate Institute of Immunology China Medical University Taichung Taiwan Correspondence: Dr HW Chen No. 35 Keyan Road Zhunan Town Miaoli County 350 Taiwan.

Foxp3＋ regulatory T cells （Tregs） are unique in their immunosuppressive abilities and contribution to immune regulation. However, the homeostatic processes and survival programs that maintain the Treg population remain unclear. Here, we highlight the recent study by Pierson et al.,1 which dissected the regulatory mechanisms of Treg home- ostasis and survival.

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