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Imipramine Inhibits Adipogenic Differentiation in Both 3T3-L1 Preadioocvtes and Mouse Marrow Stromal Cells

Journal of Genetics and Genomics 2012年第4期39卷 173-180页

作者： Haifang Li chi-chun fong Yao Chen Guoping Cai Mengsu Yang Department of Biology and Chemistry City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong SARChina Department of Biological Sciences and Biotechnology Tsinghua UniversityBeijing 100084China Shenzhen Key Laboratory of Biochip Research City University of Hong KongShenzhen 518057China

Imipramine （IM） has been widely used clinically for the treatment of mental disorders. Its actions on tissues or organs other than the nervous system also need to be understood for its proper clinical use. In this study, the effects of IM on adipogenic differentiation in both 3T3-L1 preadipocytes and mouse marrow stromal cells （MSCs） were investigated. The results showed that fewer adipocytic cells were developed from 3T3-L1 preadipocytes in the presence of 0.001 to 1 μmol/L of IM as compared to control. Similar inhibitory effect was also observed in mouse MSCs. The decrease in the formation of adipocytes was accompanied with significant down-regulation at mRNA expression of the early adipogenic transcription factor, peroxisome proliferator-activated receptor γ2 （PPARγ2）. Western blot analysis further revealed that the protein expression of PPARγ2 was reduced markedly in ceils treated with IM at concentrations of 0.01, 0.1 and 1 μmol/L, suggesting that the suppression on PPAR72 was involved in IM＇s inhibition on MSCs adipogenesis. Moreover, IM at the above concentrations could stimulate the mRNA expression of β2-adrenergic receptor （AR） and β3-AR, which implicated that the effect of IM on adipogenic differentiation was partially mediated by β-ARs. Our results demonstrated for the first time that the conventional antidepressive imipramine exerts accompanied inhibitory effect on adipocyte formation, which may have possible clinical implications.

关键词： Imipramine Adipogenic differentiation 3T3-L1 preadipocytes Marrow stromal cells (MSCs)

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Concerted Steric and Electronic Strategy in Thermostable Salicylaldiminato Nickel Catalysts for Ethylene(Co)polymerization

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chinese Journal of Polymer Science 2024年第8期42卷 1085-1092页

作者： Hong-Yu Ji Hong-Liang Mu chun-Feng Tang Yu-Xing Zhang Yue chi Zhong-Bao Jian Key Laboratory of Advanced Structural Materials Ministry of EducationSchool of Materials Science and EngineeringChangchun University of TechnologyChangchun 130012China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Olefin polymerization is one of the most im portant chemical reactions in *** work presents a strategy that emphasizes the synergistic meta/poro-steric hindrance of N-aryl groups and electronic effects in newly synthesized neutral salicylaldiminato nickel *** nickel(Ⅱ)catalysts exhibit exceptional thermostability,ranging from 30℃to 130℃,demonstrating enhanced catalytic activities and broadly regulated polyethylene molecular weights(3-341 kg·mol^(-1))and controlled polymer branch density(2-102 brs/1000C).The preferred catalyst Ni3 with concerted steric and electronic effects enables the production of solid-state semi-crystalline polyethylene materials at temperatures below 90℃.Notably,Ni3 exhibits an impressive tolerance of 110℃and can withstand even the challenging polymerization temperature of 130℃,leading to the production of polyethylene wax and ***,functionalized polyethylene is produced.

关键词： Polyolefin Salicylaldiminato ligand Nickel catalyst Oil Wax

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Fluoro-functionalized plant biomass adsorbent:Preparation and application in extraction of trace perfluorinated compounds from environmental water samples

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Journal of Environmental Sciences 2024年第3期137卷 703-715页

作者： Xi Tan Yan Shi chun-Feng Ma Quan chi Yu-Hang Yang Wen-Xiang Zhang Hua-Ming Xiao Xian Wang Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission School of Chemistry and Materials ScienceSouth-Central Minzu UniversityWuhan 430074China School of Pharmaceutical Sciences South-Central Minzu UniversityWuhan 430074China Key Laboratory of Oilseeds Processing of Ministry of Agriculture Hubei Key Laboratory of Lipid Chemistry and NutritionOil Crops Research Institute of the Chinese Academy of Agricultural SciencesWuhan 430062China

Perfuorinated compounds(PFCs)are toxic and widely present in the environment,and therefore effective adsorbents are required to remove PFCs from environmental *** the present study,a new type of fuorinated biomass materials was synthesized via an ingenious fuorosilanization *** adsorbents were applied for the adsorption of 13typical PFCs,including perfuorocarboxylic acids(PFCAs)and perfuorosulfonic acids(PFSAs).By comparing their adsorption performance,Fluorinated cedar slag(FCS)was discovered to have the best absorption efficiency and enabled highly efficient enrichment of *** adsorption recovery of FCS with the investigated PFCs is greater than 90%under the optimal adsorption *** to the high affinity of F-F sorbent-sorbate interaction,FCS had good adsorption capacities of PFCs from aqueous solution,with the maximum adsorption capacity of 15.80 mg/g for PFOS and 10.71 mg/g for PFOA,***,the adsorption time could be achieved in a short time(8 min).Using the FCS absorbent,an innovative FCS-solid phase extraction assisted with high performance liquid chromatography-electrospray-tandem mass spectrometry(FCS-SPE-HPLC-ESI-MS/MS)method was first developed to sensitively detect PFCs in the environmental water *** intra-day and inter-day recovery rates of the 13 compounds ranged from 90.7%-104.3%,with the RSD of 2.1%-4.7%(intra-day)and 2.5%-8.5%(inter-day),*** research demonstrates the potential of the newly fuoro-functionalized plant biomass to adsorb PFCs from environmental water,with the advantages of high adsorption efficiencies,high antiinterference,easy operation and low economic cost.

关键词： Fluoro-functionalized biomass Perfuorinated compounds(PFCs) Adsorption efficiency Mass spectrometry(MS) Fluorinated cedar slag(FCS)

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Adenocarcinoma of sigmoid colon with metastasis to an ovarian mature teratoma: A case report

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World Journal of Clinical Cases 2024年第4期12卷 853-858页

作者： Wei Wang chun-chi Lin Wen-Yi Liang Shih-ching Chang Jeng-Kai Jiang Division of Colorectal Surgery Department of SurgeryTaipei Veterans General HospitalTaipei 11217Taiwan Faculty of Medicine School of MedicineNational Yang Ming Chiao Tung UniversityTaipei 112304Taiwan Department of Pathology Taipei Veteran General HospitalTaipei 11217Taiwan

BACKGROUND Colorectal cancer ranks third in global cancer-related mortality,often due to metastases to liver and *** metastases are less common,accounting for 3.6%to 7.4%of *** contrast,mature ovarian teratomas are frequently ***-to-tumor metastasis is a rare phenomenon,with a limited number of documented *** cases of mature ovarian teratomas metastasizing from different cancers have been *** report focuses on a case of tumor-totumor metastasis from sigmoid colon adenocarcinoma to a mature ovarian *** SUMMARY A 41-year-old Taiwan residents woman with no known systemic diseases presented with lower back pain,which led to imaging revealing malignant lesions in the spine,pelvis,liver,and multiple lung *** was diagnosed with sigmoid colon adenocarcinoma with metastases to the liver,lung,bone,and a left ovarian *** involved radiotherapy and chemotherapy,resulting in regression of the primary tumor and stable lung and liver *** to abdominal symptoms,she underwent exploratory surgery,unveiling a mature teratoma in the left ovary with signs of metastatic *** Consider resecting mature ovarian teratomas with concurrent colorectal adenocarcinoma to prevent tumor-to-tumor metastasis.

关键词： Tumor-to-tumor metastasis Colorectal cancer Ovarian teratoma Adeno carcinoma Case report

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A prospective cohort of men with localized prostate cancer on active surveillance protocol in Hong Kong,china:what did we learn?

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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan ching-Ho Ko Cindy Yeuk-Lam Hong Samuel chi-Hang Yee Jeremy Yuen-chun Teoh Samson Yun-Sang Chan Ho-Man Tam chi-Kwok Chan chi-Fai Ng Peter Ka-Fung chiu SH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH Ho Urology Centre,Prince of Wales Hospital,Hong Kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

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Cytokine landscapes of pregnancy:mapping gestational immune phases

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Gynecology and Obstetrics Clinical Medicine 2024年第1期4卷 56-64页

作者： Sulagna Dutta Pallav Sengupta fong fong Liew Basic Medical Sciences Department College of MedicineAjman UniversityAjmanUAE Department of Biomedical Sciences Gulf Medical UniversityAjmanUAE Department of Preclinical Sciences Faculty of DentistryMAHSA UniversityKuala LumpurMalaysia

Background Synchronised physiological adaptations occur during pregnancy to achieve systemic,immune and neuroendocrine equilibrium in the mother's body,allowing semiallogenic fetal *** text Depending on the cytokine profile alterations occurring through pregnancy,the latter can be divided into three distinct *** the first immunological phase of pregnancy,proinflammatory cytokines promote inflammatory reactions needed for *** the second phase,a possible change from proinflammatory to anti-inflammatory cytokines creates a symbiosis between maternal and fetal components,ensuring fetal *** the third phase,inflammatory and cytolytic cytokines operate again to reinforce an inflammatory environment for *** article offers a detailed account of immune adaptations during pregnancy and highlights the distinctive cytokine profiles that mark each *** By providing a simplified depiction of pregnancy phases based on cytokine profiles,the article aims to inspire more research in reproductive immunology and improve the management of pregnancy-related inflammation and infection.

关键词： pregnancy mother alterations

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Finite-time Prescribed Performance Time-Varying Formation Control for Second-Order Multi-Agent Systems With Non-Strict Feedback Based on a Neural Network Observer

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1039-1050页

作者： chi Ma Dianbiao Dong the School of Mechanical Engineering Northwestern Polytechnical UniversityXi’an 710072China

This paper studies the problem of time-varying formation control with finite-time prescribed performance for nonstrict feedback second-order multi-agent systems with unmeasured states and unknown *** eliminate nonlinearities,neural networks are applied to approximate the inherent dynamics of the *** addition,due to the limitations of the actual working conditions,each follower agent can only obtain the locally measurable partial state information of the leader *** address this problem,a neural network state observer based on the leader state information is ***,a finite-time prescribed performance adaptive output feedback control strategy is proposed by restricting the sliding mode surface to a prescribed region,which ensures that the closed-loop system has practical finite-time stability and that formation errors of the multi-agent systems converge to the prescribed performance bound in finite ***,a numerical simulation is provided to demonstrate the practicality and effectiveness of the developed algorithm.

关键词： Finite-time control multi-agent systems neural network prescribed performance control time-varying formation control

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Use of subword tokenization for domain generation algorithm classification

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Cybersecurity 2024年第2期7卷 1-12页

作者： Sea Ran Cleon Liew Ngai fong Law University of Waterloo WaterlooCanada Department of Electrical and Electronic Engineering The Hong Kong Polytechnic UniversityKowloonHong Kong

Domain name generation algorithm(DGA)classification is an essential but challenging *** feature-extract-ing machine learning(ML)methods and deep learning(DL)models such as convolutional neural networks and long short-term memory have been ***,the performance of these approaches varies with different types of *** features in the ML methods can characterize random-looking DGAs better than Word-looking *** improve the classification performance on word-looking DGAs,subword tokenization is employed for the DL *** experimental results proved that the subword tokenization can provide excellent classification performance on the word-looking *** then propose an integrated scheme that chooses an appropriate method for DGA classification depending on the nature of the *** show that the integrated scheme outperformed existing ML and DL methods,and also the subword DL methods.

关键词： Botnet detection Domain names Network security Machine learning-based botnet detection

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Prostate health index can stratify patients with Prostate Imaging Reporting and Data System score 3 lesions on magnetic resonance imaging to reduce prostate biopsies

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Asian Journal of Andrology 2024年第1期26卷 20-24页

作者： John Shung-Lai Leung Wai-Kit Ma Brian Sze-Ho Ho Stacia Tsun-Tsun chun Rong Na Yongle Zhan chi-Yuen Ng chi-Ho Ip Ada Tsui-Lin Ng Yiu-chung Lam Division of Urology Department of SurgeryQueen Mary HospitalUniversity of Hong KongHong KongChina Division of Urology Department of SurgeryPrincess Margaret HospitalHongKongChina

We aim to evaluate prostate health index as an additional risk-stratification tool in patients with Prostate Imaging Reporting and Data System score 3 lesions on multiparametric magnetic resonance *** with biochemical or clinical suspicion of having prostate cancer who underwent multiparametric magnetic resonance imaging in two tertiary centers(Queen Mary Hospital and Princess Margaret Hospital,Hong Kong,china)between January 2017 and June 2022 were ***-magnetic resonance imaging fusion biopsies were performed after prostate health index *** who only had Prostate Imaging Reporting and Data System score 3 lesions were further stratified into four prostate health index risk groups and the cancer detection rates were *** of the 747 patients,47.3%had Prostate Imaging Reporting and Data System score 3 lesions *** detection rate of clinically significant prostate cancer in this group was 15.0%.The cancer detection rates of clinically significant prostate cancer had statistically significant differences:5.3%in prostate health index<25.0,7.4%in prostate health index 25.0-34.9,17.9%in prostate health index 35.0-54.9,and 52.6%in prostate health index≥55.0(P<0.01).Among the patients,26.9%could have avoided a biopsy with a prostate health index<25.0,at the expense of a 5.3%risk of missing clinically significant prostate *** health index could be used as an additional risk stratification tool for patients with Prostate Imaging Reporting and Data System score 3 *** could be avoided in patients with low prostate health index,with a small risk of missing clinically significant prostate cancer.

关键词： biopsy fusion biopsy magnetic resonance imaging prostate cancer prostate health index

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Design and pricing of maintenance service contract based on Nash non-cooperative game approach

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Journal of Systems Engineering and Electronics 2024年第1期35卷 118-129页

作者： SU chun HUANG Kui School of Mechanical Engineering Southeast UniversityNanjing 211189China

Nowadays manufacturers are facing fierce *** from the products,providing customers with multiple maintenance options in the service contract becomes more popular,since it can help to improve customer satisfaction,and ultimately promote sales and maximize profit for the *** considering the combinations of corrective maintenance and preventive maintenance,totally three types of maintenance service contracts are ***,attractive incentive and penalty mechanisms are adopted in the *** this basis,Nash non-cooperative game is applied to analyze the revenue for both the manufacturer and customers,and so as to optimize the pricing mechanism of maintenance service contract and achieve a win-win *** experiments are *** results show that by taking into account the incentive and penalty mechanisms,the revenue can be improved for both the customers and ***,with the increase of repair rate and improvement factor in the preventive maintenance,the revenue will increase gradually for both the parties.

关键词： maintenance service contract Nash game incentive and penalty mechanism corrective maintenance preventive maintenance

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