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Behaviors of recycled aggregate concrete-filled steel tubular columns under eccentric loadings

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Frontiers of Structural and Civil Engineering 2019年第3期13卷 628-639页

作者： Vivian W.Y.tam Jianzhuang XIAO Sheng LIU Zixuan chen Department of Structural Engineering Tongji UniversityShanghai 200092China University of Western Sydney School of ComputingEngineering and Mathematics and Institute for Infrastructure EngineeringLocked Bag 1797PenrithNSW 2751Australia

The paper investigates the behaviors of recycled aggregate concrete-filled steel tubular(RACFST)columns under eccentric loadings with the incorporation of expansive agents.A total of 16 RACFST columns were tested in this *** main parameters varied in this study are recycled coarse aggregate replacement percentages(0%,30%,50%,70%,and 100%),expansive agent dosages(0%,8%,and 15%)and an eccentric distance of compressive load from the center of the column(0 and 40 mm).Experimental results showed that the ultimate stresses of RACFST columns decreased with increasing recycled coarse aggregate replacement percentages but appropriate expansive agent dosages can reduce the decrement;the incorporation of expansive agent decreased the ultimate stresses of RACFST columns but an appropriate dosage can increase the deformation *** recycled coarse aggregate replacement percentages have limited influence on the ultimate stresses of the RACFST columns and has more effect than that of the normal aggregate concretesteel tubular columns.

关键词： concrete filled steel tubes recycled aggregate concrete columns expansive agent eccentric load

*** acknowledges the financial support from the Engineering and Physical Sciences Research Council(***/L022559/1,EP/L022559/2,EP/V050311/1,and EP/W004399/1);Royal Society(***130230 and IE161214);H2020 Marie Skłodowska-Curie Actions(No.790666);*** supported by a PhD Studentship provided by Queen Mary University of London and china Scholarship Council(CSC).

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Nano Research 2022年第8期15卷 7432-7452页

作者： Lumin chen Somia Yassin Hussain Abdalkarim Houyong Yu Xiang chen Dongping Tang yingzhan Li Kam chiu tam The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education Zhejiang Sci-Tech UniversityHangzhou 310018China Department of Chemical Engineering University of WaterlooWaterlooOntario N2L 3G1Canada

Advanced energy and sensor devices with novel applications(e.g.,mobile equipment,electric vehicles,and medical-healthcare systems)are one of the important foundations of modern intelligent ***,there are still some scientific issues that seriously hinder the further development of devices,including unsustainability,high material cost,complex fabrication process,safety issues,and unsatisfactory *** has aroused tremendous attention in recent decades,because of its abundant resources,renewability,degradability,low-cost,and unique physical/chemical *** merits make nanocellulose as matrix materials to fabricate advanced functional composites for use in energy-related fields extremely ***,we comprehensively discuss the recent progress of nanocellulose for emerging energy storage/harvesting and sensor *** preparation methodologies of nanocellulose combined with conductive materials are firstly highlighted,including carbon materials,conductive polymers,metal/metal oxide nanoparticles,metal-organic frameworks(MOFs),and covalent organic frameworks(COFs).We then focus on the nanocellulose-based advanced materials for the application in the areas of supercapacitors,lithium-ion batteries,solar cells,triboelectric nanogenerators,moisture-enabled electric generators,and ***,the future research directions of nanocellulose-based functional materials in energy-related devices are presented.

关键词： nanocellulose conductive composites supercapacitors lithium-ion batteries solar cells nanogenerators sensors

Genome-wide analysis identified 17 new loci influencing intraocular pressure in chinese population

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Science china(Life Sciences) 2019年第2期62卷 153-164页

作者： Lulin Huang Yuhong chen ying Lin Pancy O.S.tam yilian cheng yi Shi Bo Gong Fang Lu Jialiang Yang Haixin Wang yi yin Yong Cao Dan Jiang Ling Zhong Bai Xue Jing Wang Fang Hao Dean-Yao Lee chi-Pui Pang Xinghuai Sun Zhenglin Yang The Key Laboratory for Human Disease Gene Study of Sichuan Province Sichuan Provincial People's Hospital School of MedicineUniversity of Electronic Science and Technology of China Institute of chengdu Biology Sichuan Translational Medicine Hospital Chinese Academy of Sciences Department of Ophthalmology Visual Science Eye and ENT Hospital Shanghai Medical School Fudan University Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong Department of Ophthalmology Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital

Intraocular pressure(IOP) is a major risk factor for glaucoma. Genetic determinants of intraocular pressure can provide critical insights into the genetic architecture of glaucoma and, as a result, open new avenues for therapeutic intervention. We performed a genome-wide association study and replication analysis of 8,552 chinese participants. In the genome-wide association study, we identified 51 loci that surpassed the significance of P<9×10^(-7), and we formally replicated these loci. A combined discovery and replication meta-analysis identified 21 genome-wide loci that surpassed the genome-wide significance of P<5×10^(-8), including 4 previously reported loci: rs145063132(7 p21.2, ETV1/DGKB), rs548030386(7 q31.2, ST7 near CAV1/CAV2), rs7047871(9 p24.2, GLIS3), and rs2472494(9 q31.1, ABCA1/SLC44 A1). Of the 17 newly identified loci, five were reported to have ocular related phenotypes: PTCH2(rs7525308 in 1 p34.1), LRIF1/DRAM2(rs1282146 in 1 p13.3), COLEC11(rs201143466 in 2 p25.3),SPTBN1(rs4514918 in 2 p16.2), and CRK(rs11078446 in 17 p13.3). The genetic loci identified in this study not only increase our understanding of the genes involved in intraocular pressure but also provide important genetic markers to improve future genetic screening and drug discovery for intraocular pressure disorders.

关键词： intraocular pressure glaucoma genome-wide association study

Abnormally activated wingless/integrated signaling modulates tumor-associated macrophage polarization and potentially promotes hepatocarcinoma cell growth

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World Journal of Gastroenterology 2024年第41期30卷 4490-4495页

作者： Wei-Lu Wang Paul Kwong Hang tam Yan chen School of Pharmacy Faculty of MedicineMacao University of Science and TechnologyMacao 999078China

In this article,we comment on the article by Huang et *** urgent development of new therapeutic strategies targeting macrophage polarization is critical in the fight against liver ***-associated macrophages(tams),primarily of the M2 subtype,are instrumental in cellular communication within the tumor microenvironment and are influenced by various signaling pathways,including the wingless/integrated(Wnt)*** of the Wnt signaling pathway is pivotal in promoting M2 tams polarization,which in turn can exacerbate hepatocarcinoma cell proliferation and *** manuscript emphasizes the burgeoning significance of the Wnt signaling pathway and M2 tams polarization in the pathogenesis and progression of liver cancer,highlighting the potential therapeutic benefits of inhibiting the Wnt ***,we point out areas in Huang et al’s study that require further research,providing guidance and new directions for similar studies.

关键词： Liver cancer Hepatocarcinoma cell Wingless/integrated signaling pathway M2 tumor-associated macrophages Polarization

Evaluation of the association of C5 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy

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Eye and Vision 2019年第1期6卷 291-297页

作者： Ke Liu Li Ma Timothy Y.Y.Lai Marten E.Brelen Pancy O.S.tam Clement C.Tham chi Pui Pang Li Jia chen Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong KongChina Department of Ophthalmology and Visual Sciences Prince of Wales HospitalHong KongChina

Background:Neovascular age-related macular degeneration(AMD)and polypoidal choroidal vasculopathy(PCV)are sight-threatening maculopathies with both environmental and genetic risk *** have previously shown relative risks posed by genes of the complement pathways to neovascular AMD and ***:In this study,we investigated the haplotype-tagging single nucleotide polymorphisms(SNPs)in the complement component 5(C5)gene in 708 unrelated chinese individuals:200 neovascular AMD patients,233 PCV patients and 275 *** tagging SNPs in C5 were *** single SNP association analysis,haplotype-based association analysis and gene-gene interaction analysis between C5 and other AMD-associated genes were ***:The results revealed none of the six tagging SNPs of the C5 gene had a significant association with neovascular AMD or PCV(P>0.05).We also found insignificant haplotype-based association,and no significant SNPSNP interaction between C5 and other genes(including C2-CFB-RDBP-SKIV2L,SERPING1,CETP,ABCG1,PGF,ANGPT2,CFH and HTRA1)for neovascular AMD and ***:This study showed no statistical significance in the genetic association of C5 with neovascular AMD or PCV in a Hong Kong chinese *** studies in large samples from different populations are warranted to elucidate the role of C5 in the genetic susceptibility of AMD and PCV.

关键词： Age-related macular degeneration Polypoidal choroidal vasculopathy Complete component 5 C5 Genetic association Single-nucleotide polymorphism

Peptide asparaginyl ligases——renegade peptide bond makers

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Science china Chemistry 2020年第3期63卷 296-307页

作者： James P.tam Ning-Yu Chan Heng Tai Liew Shaun J.Tan Yu chen School of Biological Sciences Nanyang Technological UniversitySingapore 637551Singapore Synzymes and Natural Products Center Nanyang Technological UniversitySingapore 637551Singapore NTU Institute of Structural Biology Nanyang Technological UniversitySingapore 636921Singapore

Making peptide bonds is tightly controlled by genetic code and machinery which includes cofactors,ATP,and *** this regard,the stand-alone and genetic-code-independent peptide ligases constitute a new family of renegade peptide-bond makers.A prime example is butelase-1,an Asn/Asp(Asx)-specific ligase that structurally belongs to the asparaginyl endopeptidase ***-1 specifically recognizes a C-terminal Asx-containing tripeptide motif,Asn/Asp-Xaa-Yaa(Xaa and Yaa are any amino acids),to form a site-specific Asn-Xaa peptide bond either intramolecularly as cyclic proteins or intermolecularly as modified *** work in the past five years has validated that butelase-1 is a potent and versatile *** we review the advances in ligases,with a focus on butelase-1,and their applications in engineering bioactive peptides and precision protein modifications,antibody-drug conjugates,and live-cell labeling.

关键词： asparaginyl endopeptidase Asn-specific ligation bioorthogonal ligation butelase chemoenzymatic ligation live-cell labeling protein engineering protein modification site-specific labeling tandem ligation

Searching for GeV gamma-ray emission from the bulge of M31

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Research in Astronomy and Astrophysics 2019年第3期19卷 131-144页

作者： Li Feng Zhi-Yuan Li Meng Su Pak-Hin T.tam Yang chen School of Astronomy and Space Science Nanjing University Key Laboratory of Modern Astronomy and Astrophysics Nanjing University Department of Physics The University of Hong Kong Laboratory for Space Research The University of Hong Kong School of Physics and Astronomy Sun Yat-sen University

The three major large-scale, diffuse γ-ray structures of the Milky Way are the Galactic disk,a bulge-like GeV excess towards the Galactic center, and the Fermi bubble. Whether such structures can also be present in other normal galaxies remains an open question. M31, as the nearest massive normal galaxy, holds promise for spatially-resolving the γ-ray emission. Based on more than 8 years of Fermi-LAT observations, we use(1) disk,(2) bulge, and(3) disk-plus-bulge templates to model the spatial distribution of the γ-ray emission from M31. Among these, the disk-plus-bulge template delivers the best-fit, in which the bulge component has a TS value 25.7 and a photon-index of 2.57 ± 0.17, providing strong evidence for a centrally-concentrated γ-ray emission from M31, that is analogous to the Galactic center excess. The total0.2–300 GeV γ-ray luminosity from this bulge component is(1.16 ± 0.14) × 1038 erg s-1, which would require ～ 1.5 × 105 millisecond pulsars, if they were the dominant source. We also search for a Fermi bubble-like structure in M31 using the full dataset(pass8), but no significant evidence has been *** addition, a likelihood analysis using only photons with the most accurate reconstructed direction(i.e.,PSF3-only data) reveals a 4.8 σ point-like source located at ～10 kpc to the northwest of the M31 disk, with a luminosity of(0.97 ± 0.27) × 1038 erg s-1 and a pho@ton-$i·nd3 ex of 2.31 ± 0.18. Lacking a counterpart on the southeast side of the disk, the relation between this point-like source and a bubble-like structure remains elusive.

关键词： gamma-rays galaxies-galaxies individual(M31)

The Immense Impact of Reverse Edges on Large Hierarchical Networks

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Engineering 2024年第5期36卷 240-249页

作者： Haosen Cao Bin-Bin Hu Xiaoyu Mo Duxin chen Jianxi Gao Ye Yuan Guanrong chen tamás Vicsek Xiaohong Guan Hai-Tao Zhang MOE Engineering Research Center of Autonomous Intelligent Unmanned Systems State Key Laboratory of Intelligent Manufacturing Equipment and TechnologySchool of Artificial Intelligence and AutomationHuazhong University of Science and TechnologyWuhan 430074China School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Jiangsu Key Laboratory of Networked Collective Intelligence School of MathematicsSoutheast UniversityNanjing 210096China Department of Computer Science Rensselaer Polytechnic InstituteTroyNY 12180USA Department of Electronic Engineering City University of Hong KongHong Kong 999077China Department of Biological Physics Eötvös UniversityBudapest 1117Hungary MOE Key Laboratory for Intelligent Networks and Network Security School of Automation Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China

Hierarchical networks are frequently encountered in animal groups,gene networks,and artificial engineering systems such as multiple robots,unmanned vehicle systems,smart grids,wind farm networks,and so *** structure of a large directed hierarchical network is often strongly influenced by reverse edges from lower-to higher-level nodes,such as lagging birds’howl in a flock or the opinions of lowerlevel individuals feeding back to higher-level ones in a social *** study reveals that,for most large-scale real hierarchical networks,the majority of the reverse edges do not affect the synchronization process of the entire network;the synchronization process is influenced only by a small part of these reverse edges along specific *** surprisingly,a single effective reverse edge can slow down the synchronization of a huge hierarchical network by over 60%.The effect of such edges depends not on the network size but only on the average in-degree of the involved *** overwhelming majority of active reverse edges turn out to have some kind of“bunching”effect on the information flows of hierarchical networks,which slows down synchronization *** finding refines the current understanding of the role of reverse edges in many natural,social,and engineering hierarchical networks,which might be beneficial for precisely tuning the synchronization rhythms of these *** study also proposes an effective way to attack a hierarchical network by adding a malicious reverse edge to it and provides some guidance for protecting a network by screening out the specific small proportion of vulnerable nodes.

关键词： Synchronizability Large hierarchical networks Reverse edges Information flows Complex networks

Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis

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Cellular & Molecular Immunology 2011年第6期8卷 469-478页

作者： Da P chen Chun K Wong Lai S tam Edmund K Li Christopher WK Lam Department of Chemical Pathology The Chinese University of Hong KongPrince of Wales HospitalShatinNTHong KongChina Department of Clinical Laboratory Children’s Hospital of Chongqing Medical UniversityChongqingChina Department of Medicine and Therapeutics The Chinese University of Hong KongPrince of Wales HospitalNgan Shing StreetShatinNTHong KongChina Macao Institute for Applied Research in Medicine and Health Macao University of Science and TechnologyAvenida Wai LongTaipaMacaoChina

Hyperuricemia-mediated uric acid crystal formation may cause joint inflammation and provoke the destruction of joints through the activation of inflammasome-mediated innate immune ***,the immunopathological effects and underlying intracellular regulatory mechanisms of uric acid crystal-mediated activation of fibroblast-like synoviocytes(FLS)in rheumatoid arthritis(RA)have not been ***,we investigated the in vitro effects of monosodium urate crystals,alone or in combination with the inflammatory cytokines tumor-necrosis factor(TNF)-a or interleukin(IL)-1b,on the activation of human FLS from RA patients and normal control subjects and the underlying intracellular signaling mechanisms of treatment with these *** urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6,the chemokine CXCL8 and the matrix metalloproteinase(MMP)-1 from both normal and RA-FLS(all P,0.05).Moreover,the additive or synergistic effect on the release of IL-6,CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-a or *** experiments showed that the release of the measured inflammatory cytokine,chemokine and MMP-1 stimulated by monosodium urate crystals were differentially regulated by the intracellular activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways but not the p38 mitogen-activated protein kinase *** results therefore provide a new insight into the uric acid crystal-activated immunopathological mechanisms mediated by distinct intracellular signal transduction pathways leading to joint inflammation in RA.

关键词： cytokines fibroblast-like synoviocytes rheumatoid arthritis signal transduction uric acid