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Identification and semisynthesis of(-)-anisomelic acid as oral agent against SARS-CoV-2 in mice

National Science Review 2022年第11期9卷 29-36页

作者： Hai-Xin Yu Nan Zheng chi-tai yeh chien-Ming Lee Qi Zhang Wen-Lv Zheng Qing Chang Yuan-He Li Yu-Jun Li Gui-Zhen Wu Jun-Min Quan Lin-Qi Zhang Yew-Min Tzeng Zhen Yang Laboratory of Chemical Genomics School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Department of Medicinal Research and Education Taipei Medical University-Shuang Ho Hospital Department of Applied Science Taitung University Center for Global Health and Infectious Diseases Comprehensive AIDS Research Center and Beijing Advanced Innovation Center for Structural Biology School of Medicine Tsinghua University Lanzhou Institute of Separation Science State Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education and Beijing National Laboratory for Molecular Science(BNLMS) College of Chemistry and Molecular EngineeringPeking University Shenzhen Bay Laboratory NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Department of Applied Chemistry Chaoyang University of Technology

(-)-Anisomelic acid, isolated from Anisomeles indica(L.) Kuntze(Labiatae) leaves, is a macrocyclic cembranolide with a trans-fused α-methylene-γ-lactone motif. Anisomelic acid effectively inhibits SARS-Co V-2 replication and viral-induced cytopathic effects with an EC50 of 1.1 and 4.3 μM, *** studies of SARS-CoV-2-infected K18-hACE2 mice showed that oral administration of anisomelic acid and subcutaneous dosing of remdesivir can both reduce the viral titers in the lung tissue at the same level. To facilitate drug discovery, we used a semisynthetic approach to shorten the project timelines. The enantioselective semisynthesis of anisomelic acid from the naturally enriched and commercially available starting material(+)-costunolide was achieved in five steps with a 27% overall *** developed chemistry provides opportunities for developing anisomelic-acid-based novel ligands for selectively targeting proteins involved in viral infections.

关键词： identification enantioselective semisynthesis (−)-anisomelic acid oral agent anti-SARS-CoV-2

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Stress Analysis of Printed Circuit Board with Different Thickness and Composite Materials Under Shock Loading

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Computer Modeling in Engineering & Sciences 2020年第2期122卷 661-674页

作者： Kuan-Ting Liu Chun-Lin Lu Nyan-Hwa tai Meng-Kao yeh Department of Power Mechanical Engineering National Tsing Hua UniversityHsinchu30013Taiwan. Department of Materials Science and Engineering National Tsing Hua UniversityHsinchu30013Taiwan.

In this study,the deformation and stress distribution of printed circuit board(PCB)with different thickness and composite materials under a shock loading were analyzed by the finite element *** standard 8-layer PCB subjected to a shock loading 1500 g was evaluated ***,the finite element models of the PCB with different thickness by stacking various number of layers were *** addition to changing thickness,the core material of PCB was replaced from woven E-glass/epoxy to woven carbon fiber/epoxy for structural *** non-linear material property of copper foil was considered in the *** results indicated that a thicker PCB has lower stress in the copper foil in PCBs under the shock *** stress difference between the thicker PCB(2.6 mm)and thinner PCB(0.6 mm)is around 5%.Using woven carbon fiber/epoxy as core material could lower the stress of copper foil around 6.6%under the shock loading 1500 g for the PCB with 0.6 mm *** the other hand,the stress level is under the failure strength of PCBs with carbon fiber/epoxy core layers and thickness 2.6 mm when the peak acceleration changes from 1500 g to 5000 *** study could provide a reference for the design and proper applications of the PCB with different thickness and composite materials.

关键词： Stress analysis printed circuit board composite material finite element analysis shock loading.

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Radial nerve recovery following closed nailing of humeral shaft fractures without radial nerve exploration: A retrospective study

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World Journal of Clinical Cases 2021年第27期9卷 8044-8050页

作者： Kuei-Lin yeh Chen-Kun Liaw tai-Yin Wu Chung-Pei Chen Department of Orthopedics Shin Kong Wu-Ho Su Memorial HospitalTaipei City 111Taiwan Department of Orthopedics School of MedicineCollege of MedicineTaipei Medical UniversityTaipei City 11031Taiwan Department of Orthopedics Shuang Ho HospitalTaipei Medical UniversityNew Taipei City 23561Taiwan Graduate Institute of Biomedical Optomechatronics College of Biomedical EngineeringResearch Center of Biomedical DeviceTaipei Medical UniversityTaipei City 11301Taiwan Department of Family Medicine Zhongxing BranchTaipei City HospitalTaipei City 10341Taiwan Institute of Epidemiology and Preventive Medicine National Taiwan UniversityTaipei City 10055Taiwan National taipei University of Nursing and Health Science Taipei City 11219Taiwan Department of Orthopedics Cathay General HospitalNew Taipei City 221Taiwan

BACKGROUND Radial nerve palsy due to humeral shaft fracture is the most common peripheral nerve injury associated with long bone *** antegrade nailing surgical technique is becoming popular for the fixation of these fractures with minimal *** analyzed nerve recovery in patients with humeral shaft fracture and radial nerve palsy treated with humeral nail fixation without nerve *** To assess the radial nerve recovery rate and time from humeral shaft fracture with surgical treatment using close *** We retrospectively collected data of patients who underwent undergone surgical nail fixation for humeral shaft fractures between October 1,2016,and March 31,***,we analyzed the primary or secondary radial nerve palsy recovery rate and radial nerve motor function recovery *** The study included 70 patients who underwent surgical treatment for closed-or Gustilo type I open humeral shaft fractures using a nail fixation technique without radial nerve *** patients suffered from primary(n=5)and secondary(n=5)radial nerve palsy.A 100%radial nerve recovery rate was *** mean recovery time was 4.3 *** The study results indicate full recovery of radial nerve palsies from humeral shaft fracture using close nailing *** need not be concerned about the occurrence of permanent nerve palsies.

关键词： Humeral shaft fracture Radial nerve palsy Close nailing fixation Nerve exploration

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Numerical simulations of the wavefront distortion of inter-spacecraft laser beams caused by solar wind and magnetospheric plasmas

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Plasma Science and Technology 2020年第11期22卷 23-35页

作者： Lingfeng LU Ying LIU Huizong DUAN Yuanze JIANG Hsien-chi yeh TianQin Research Center for Gravitational Physics and School of Physics and Astronomy Sun Yat-sen University(Zhuhai Campus)Zhuhai 519082People's Republic of China MOE Key Laboratory of Fundamental Physical Quantities Measurement&Hubei Key Laboratory of Gravitation and Quantum Physics PGMF and School of PhysicsHuazhong University of Science and TechnologyWuhan 430074People's Republic of China

Plasma turbulence may lead to additional wavefront distortion of inter-spacecraft laser beams during the operation of spaceborne gravitational wave(GW)observatories,*** *** making use of the Space Weather Modelling Framework(SWMF)model and realistic orbit data for the Tian Qin constellation,the characteristic parameters of the plasma turbulence present at the Tian Qin orbit are *** a first step,this work is based on the assumptions that the cold plasma approximation is valid and that the effects of the electromagnetic field induced by charge separation within the Debye length on the laser's wavefront can be *** atmospheric turbulence-laser interaction model is then applied to analyze the effects of the plasma turbulence on the inter-spacecraft laser's *** preliminary results show that the wavefront distortion caused by the plasma turbulence is 10^-9 rad,which is significantly less than the designated error budget,i.e.10^-6 rad,and thus will not affect the laser interferometry.

关键词： plasma turbulence gravitational wave detection laser interferometry

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Successful management of delirium with dexmedetomidine in a patient with haloperidol-induced neuroleptic malignant syndrome:A case report

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World Journal of Clinical Cases 2022年第2期10卷 625-630页

作者： chi-Ju Yang ching-Tang chiu Yu-Chang yeh Anne Chao Department of Pharmacy National Taiwan University HospitalTaipei 100220Taiwan Department of Anesthesiology National Taiwan University HospitalTaipei 100220Taiwan

BACKGROUND We report a case of lorazepam-induced agitated delirium treated with haloperidol,which in turn triggered the onset of neuroleptic malignant syndrome(NMS).The latter condition,a medical emergency,was effectively treated with medical treatment and dexmedetomidine,a versatile and highly selective shortacting alpha-2 adrenergic agonist with sedative-hypnotic and anxiolytic *** SUMMARY A 65-year-old man with a history of bipolar disorder presented to the emergency department with severe abdominal discomfort after binge *** his hospital stay,he received intravenous lorazepam for *** the next day,he became delirious and was thus treated with seven doses(5 mg each)of haloperidol over a 48 h *** of NMS(hyperthermia,rigidity,myoclonus of upper limbs,impaired consciousness,tachypnea,and dark urine)became apparent and haloperidol was immediately suspended and brisk diuresis was *** intensive care unit admission,he was confused,disoriented,and markedly *** infusion was started with the goal of achieving a Richmond Agitation-Sedation Scale score of-1 or *** was resolved gradually and the patient stabilized,permitting discontinuation of dexmedetomidine after 3 *** Dexmedetomidine may be clinically helpful for the management of NMS,most likely because of its sympatholytic activity.

关键词： Haloperidol Dexmedetomidine Delirium Neuroleptic malignant syndrome Alpha-2 adrenergic agonists Case report

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The protoplast two-way fusions and fusant characteristics of Antrodia cinnamomea and Cordyceps militaris

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Food Science and Human Wellness 2022年第5期11卷 1240-1251页

作者： Wei-Kuang Lai Yang-Chang Wu tai-Sheng yeh Chun-Ren Hsieh Yi-Hong Tsai chien-Kei Wei chi-Ying Li Ying-Chen Lu Fang-Rong Chang Graduate Institute of Natural Products Kaohsiung Medical UniversityKaohsiung 807TaiwanChina Graduate Institute of Integrated Medicine China Medical UniversityTaichung 404TaiwanChina chinese Medicine Research and Development Center China Medical University HospitalTaichung 404TaiwanChina Department of Food Science and Nutrition Meiho UniversityPingtung 912TaiwanChina Department of Food Science National Chiayi UniversityChiayi City 600TaiwanChina Drug Development and Value Creation Research Center Kaohsiung Medical UniversityKaohsiung 807TaiwanChina Department of Medical Research Kaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung 807TaiwanChina Department of Marine Biotechnology and Resources National Sun Yat-sen UniversityKaohsiung 804TaiwanChina

This study generated two fused protoplasts of Antrodia cinnamomea and Cordyceps militaris in two *** protoplasts of *** were inactivated by heat to inactivate biochemical processes and enzymatic activities in the cytoplasm,and the protoplasts of *** were inactivated by UV radiation to invalidate their genome function,then they were fused under optimal conditions to get a fusion rate as(7.42±0.8)×10^(-6) fusants/mL;the new fusants were abbreviated as *** the other hand,when *** and *** were treated with heat and UV oppositely using similar experiments,the fusion rate was(9.70±0.68)×10^(-5) fusants/mL,and the new fusants were abbreviated as *** selected each of two best-growing fused colonies Ac-Cm-1,Ac-Cm-2,Cm-Ac-1,and Cm-Ac-2,together with parental *** and ***,and studied their morphology,growth antagonism tests,and genetic relationships by 18 S rRNA *** comparison with the initial cultures of 4 fusants,the yields of adenosine,biomass,cordycepic acid,cordycepin,total polysaccharide,and total triterpenoids were increased up 1.305-50.1563 times in the optimal medium *** gene stability tests,those of the four fusants and their outputs were stabilized within 10 generations.

关键词： Medicinal fungi Protoplast fusion Antrodia cinnamomea Cordyceps militaris Secondary metabolite

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Manufacture of a hollow corner cube retroreflector for next generation of lunar laser ranging

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Research in Astronomy and Astrophysics 2018年第11期18卷 55-62页

作者： Yun He Qi Liu Hui-Zong Duan Jing-Jing He Yuan-Ze Jiang Hsien-chi yeh TIANQIN Research Center for Gravitational Physics School of Physics and Astronomy Sun Yat-sen University MOE Key Laboratory of Fundamental Quantities Measurement School of Physics Huazhong University of Science and Technology Key Laboratory of Gravitation and Quantum Physics of Hubei Province School of Physics Huazhong University of Science and Technology

Lunar laser ranging has made significant contributions to the study of gravitational physics and the Earth-Moon system. The best results for fundamental gravitational experiments have been achieved using lunar laser ranging data accumulated so far. However, corner cube retroreflector arrays placed on the Moon currently set a limit on the laser-ranging precision, which is approximately several centimeters for a single photon received. To achieve millimeter precision, next generation of lunar laser ranging using a single hollow retroreflector with a large aperture has been proposed. We developed a prototype hollow retroreflector with a 100-mm aperture using silicate bonding together with a new fabrication method. Dihedral angle offsets of 0.5′′, 0.8′′and 1.9′′were realized, which partly come close to meeting the requirements(offset of 0.6′′for each dihedral angle) for lunar laser ranging. Fluctuation of the wavefront is approximately 1.038λ at 633 nm. A thermal cycle test ranging from -40℃ to +75℃ was carried out for 18.5 periods(approximately 5 d). After this test, the dihedral angle offsets were measured to be 0.39′′, 1.00′′and 2.06′′. The results indicate the potential application of our method for manufacturing a hollow retroreflector with a large aperture to realize lunar laser ranging.

关键词： gravitation: instrumentation miscellaneous: Moon

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Uncommon cause of voiding dysfunction in a female patient-vaginal abscess: A case report

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World Journal of Clinical Cases 2018年第16期6卷 1199-1201页

作者： chia-chi yeh Stephen Shei-Dei Yang Su-Cheng Huang Yi-Chun Wang Department of Family Medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical Foundation Department of Urology Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical Foundation Department of Obstetrics and Gynecology Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Department of Nephrology Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical Foundation School of Medicine Tzu Chi University

BACKGROUND Vaginal abscess is a treatable disease and should be considered in female patients with voiding difficulties and perineal tenderness. There are no reported cases of vaginal abscess causing voiding dysfunction in the absence of a previous surgery. Early diagnosis and drainage of vaginal abscesses may lead to excellent *** SUMMARY We presented a case of vaginal abscess that caused voiding dysfunction without surgery history. A 64-yearold woman had a past history of type 2 diabetes mellitus. She came to our clinic following urinary difficulty with perineal tenderness. Bladder ultrasonography revealed a pelvic cystic lesion with a mass effect on the bladder. The presence of a vaginal abscess was suspected following pelvic examination and transvaginal *** transvaginal drainage of the vaginal abscess and a full course of antibiotic treatment, she recovered well without any urination symptoms. CONCLUSION Voiding dysfunction caused by vaginal abscess is rare but should be considered in female patients with perineal tenderness.

关键词： Vaginal abscess Voiding dysfunction Female Case report

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Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression

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World Journal of Gastroenterology 2014年第14期20卷 3950-3959页

作者： Hsin-Chen Lee Kuo-Hung Huang Tien-Shun yeh chin-Wen chi Institute of Pharmacology School of MedicineNational Yang-Ming University Division of General Surgery Department of SurgeryTaipei Veterans General Hospital Institute of Clinical Medicine School of MedicineNational Yang-Ming University Department of Anatomy and Cell Biology School of MedicineNational Yang-Ming University Department of Medical Research and Education Taipei Veterans General Hospital

Energy metabolism reprogramming was recently identified as one of the cancer *** of the underlying mechanisms of energy metabolism reprogramming is mitochondrial dysfunction caused by mutations in nuclear genes or mitochondrial DNA(mtDNA).In the past decades,several types of somatic mtDNA alterations have been identified in gastric ***,the role of these mtDNA alterations in gastric cancer progression remains *** this review,we summarize recently identified somatic mtDNA alterations in gastric cancers as well as the relationship between these alterations and the clinicopathological features of gastric *** causative factors and potential roles of the somatic mtDNA alterations in cancer progression are also *** suggest that point mutations and mtDNA copy number decreases are the two most common mtDNA alterations that result in mitochondrial dysfunction in gastric *** two primary mutation types(transition mutations and mononucleotide or dinucleotide repeat instability)imply potential causative *** dysfunction-generated reactive oxygen species may be involved in the malignant changes of gastric *** search for strategies to prevent mtDNA alterations and inhibit the mitochondrial retrograde signaling will benefit the development of novel treatments for gastric cancer and other malignancies.

关键词： Gastric cancer Somatic mitochondrial DNA mutations Mitochondrial dysfunction

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Lymphoepithelioma-like cholangiocarcinoma:A mimic of hepatocellular carcinoma on imaging features

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World Journal of Gastroenterology 2015年第13期21卷 4089-4095页

作者： Tsan-chieh Liao chien-An Liu Nai-chi chiu Yi-Chen yeh Yi-You chiou Department of Radiology Taipei Veterans General Hospital National Yang-Ming University School of Medicine Department of Pathology Taipei Veterans General Hospital

Primary lymphoepithelioma-like carcinoma in the liver is extremely rare. A few cases of lymphoepithelioma-like cholangiocarcinoma have been reported, but few radiologic features were described. We reviewed 23 cases of lymphoepithelioma-like cholangiocarcinoma reported between 1996 and 2014 and describe a rare case of a 35-year-old woman in our hospital who was diagnosed with lymphoepithelioma-like cholangiocarcinoma of the liver and was a hepatitis B carrier. The tumor(1.6 cm) in our patient appeared to be hypoechoic in sonographic images and hypodense in computed tomography(CT) images. In addition, it was homogeneous hypointense in T1-weighted magnetic resonance(MR) images(MRI) and hyperintense in T2-weighted MRI. Dynamic gadolinium-enhanced MRI showed typical image pattern of hepatocellular carcinoma(HCC). The patient underwent a laparoscopic left hepatic lobectomy, and the resected tumor consisted of well-differentiated glandular cells with extensive lymphocytic infiltration that were immunoreactive to CK(AE1/AE3), CD3, and CD20. In addition, the tumor was positive for Epstein-Barr virus-encoded RNA in situ hybridization. Finally, lymphoepithelioma-like cholangiocarcinoma was diagnosed. In previous studies, the incidence is highest among middle-aged people. Most tumors appeared to be hypodense with either hypovascular or hypervascular patterns in CT images. This case report is the first study to address sonography, CT, and MRI observations and delineate pathologic correlations. We suggest that the imaging pattern of lymphoepithelioma-like cholangiocarcinoma, either the typical cholangiocarcinoma pattern or a mimic of HCC, should be considered in the differential lists for HCC.

关键词： Epstein-Barr virus Hepatocellular carcinoma Lympho

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