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light at night and lung cancer risk:A worldwide interdisciplinary and time-series study

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chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 56-62页

作者： Runchen Wang Qixia Wang Jianfu li Jianrong Zhang Shixuan Lyu Wenhao chi Zhiming Ye Xuanzhuang Lu ying Shi Yubin Wang Xinjian Wu Ruiyu Hu Mónica Pérez-Ríos Jianxing He Wenhua liang Department of Thoracic Surgery and Oncology The First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthGuangzhouGuangdong 510120China Department of Respiratory Disease China State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510120China Centre for Cancer Research&Department of General Practice Faculty of MedicineDentistry and Health SciencesUniversity of MelbourneVictorian Comprehensive Cancer CentreMelbourneVictoria 3010Australia Department of Civil Engineering University of BristolBristolBS81TRUK Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China University of chinese Academy of Sciences Beijing 100049China Nanshan School Guangzhou Medical UniversityGuangzhouGuangdong 511436China State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing Wuhan UniversityWuhanHubei 430079China GNSS Research Center Wuhan UniversityWuhanHubei 430079China First Clinical School Guangzhou Medical UniversityGuangzhouGuangdong 511436China Preventive Medicine and Public Health Department University of Santiago de CompostelaCIBER de Epidemiología y Salud Pública(CIBERESP)Health Research Institute of Santiago de Compostela(IDIS)Santiago de CompostelaGalicia 15782Spain Southern Medical University GuangzhouGuangdong 510515China

Background:light at night(LAN)has become a concern in interdisciplinary research in recent *** global interdisciplinary study aimed to explore the exposure-lag-response association between LAN exposure and lung cancer ***:LAN data were obtained from the Defense Meteorological Satellite Program’s Operational linescan *** of lung cancer incidence,socio-demographic index,and smoking prevalence of populations in 201 countries/territories from 1992 to 2018 were collected from the Global Burden of Disease *** correlation tests and population-weighted linear regression analysis were used to evaluate the correlation between LAN exposure and lung cancer incidence.A distributed lag nonlinear model(DLNM)was used to assess the exposure-lag effects of LAN exposure on lung cancer ***:The Spearman correlation coefficients were 0.286-0.355 and the population-weighted linear regression correlation coefficients were *** adjustment for socio-demographic index and smoking preva-lence,the Spearman correlation coefficients were 0.264-0.357 and the population-weighted linear regression correlation coefficients were *** the DLNM,the maximum relative risk was 1.04(1.02-1.06)at LAN exposure of 8.6 with a 2.6-year lag *** adjustment for socio-demographic index and smoking prevalence,the maximum relative risk was 1.05(1.02-1.07)at LAN exposure of 8.6 with a 2.4-year lag ***:High LAN exposure was associated with increased lung cancer incidence,and this effect had a specific lag *** with traditional individual-level studies,this group-level study provides a novel paradigm of effective,efficient,and scalable screening for risk factors.

关键词： light at night Satellite imagery Lung cancer Distributed lag nonlinear model(DLNM) Melatonin

Heparin is an effective treatment for preventing liver failure after hepatectomy

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World Journal of Gastroenterology 2024年第22期30卷 2881-2892页

作者： Zhi-ying Xu Min Peng Ming-Ming Fan Qi-Fei Zou Yi-Ran li Dong Jiang Hepatic Surgery IV Shanghai Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China Ultrasound Diagnosis PLA Naval Medical CenterShanghai 200437China Department of Ultrasound Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China

BACKGROUND Posthepatectomy liver failure(PHLF)is one of the most important causes of death following liver ***,an established anticoagulant,can protect liver function through a number of mechanisms,and thus,prevent liver *** To look at the safety and efficacy of heparin in preventing hepatic dysfunction after *** The data was extracted from Multiparameter Intelligent Monitoring in Intensive Care III(MIMIC-III)v1.4 pinpointed patients who had undergone hepatectomy for liver cancer,subdividing them into two cohorts:Those who were injected with heparin and those who were *** statistical evaluations used were unpaired ttests,Mann-Whitney U tests,chi-square tests,and Fisher’s exact tests to assess the effect of heparin administration on PHLF,duration of intensive care unit(ICU)stay,need for mechanical ventilation,use of continuous renal replacement therapy(CRRT),incidence of hypoxemia,development of acute kidney injury,and ICU *** regression was utilized to analyze the factors related to PHLF,with propensity score matching(PSM)aiming to balance the preoperative disparities between the two *** In this study,1388 patients who underwent liver cancer hepatectomy were *** yielded 213 matched pairs from the heparin-treated and control *** univariate analyses indicated that heparin potentially reduces the risk of PHLF in both matched and unmatched *** analysis in the matched cohorts confirmed a significant association,with heparin reducing the risk of PHLF(odds ratio:0.518;95%confidence interval:0.295-0.910;P=0.022).Additionally,heparin treatment correlated with improved short-term postoperative outcomes such as reduced ICU stay durations,diminished requirements for respiratory support and CRRT,and lower incidences of hypoxemia and ICU *** liver failure is an important hazard following hepatic *** ICU care heparin administration has been proved to decr

关键词： liver resection Posthepatectomy liver failure Prophylactic treatment Heparin Prognosis of hepatectomy

Development and Validation of Diagnostic Criteria for Elderly Atopic Dermatitis

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International Journal of Dermatology and Venereology 2024年第1期7卷 1-5页

作者： Shang-Shang Wang Zheng li Chao-ying Gu Hui-Bin Yin Yue-Meng Wu Xu Yao Wei li Department of Dermatology Shanghai Institute of DermatologyHuashan HospitalFudan UniversityShanghai 200040China Department of Allergy and Rheumatology Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIsHospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Objective:Elderly atopic dermatitis(AD)is a newly identified subtype of *** specific diagnostic criteria are needed for elderly AD has been *** study aimed to propose diagnostic criteria for elderly AD and evaluate the ***:A hospital-based study was *** screened the clinical features of 1,312 patients with AD of different ages in 1 cohort and proposed a set of diagnostic criteria for elderly *** criteria were then validated in another cohort of 223 patients clinically diagnosed with elderly AD by dermatologists specialized in AD to examine the diagnostic sensitivity compared with other criteria by chi-square ***:Based on the patients’clinical features,a set of diagnostic criteria for elderly AD were *** new diagnostic criteria showed significantly higher sensitivity than the classical diagnostic criteria(P<0.001),especially for mild and moderate AD(P<0.001).Of all 223 patients with elderly AD,93.3%fulfilled our criteria,while only 43.5%,65.5%,and 52.0%fulfilled the Hanifin and Rajka criteria,the Japanese Dermatology Academy criteria,and the United Kingdom Working Party criteria,***:The newly proposed criteria for elderly AD yielded high diagnostic sensitivity,particularly for mild and moderate AD.

关键词： atopic dermatitis elderly diagnostic criteria sensitivity clinical features atypical

Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia:a prospective,single arm,phase I trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2250-2259页

作者： Yunfei Chen Yanmei Xu ying chi Ting Sun Yuchen Gao Xueqing Dou Zhibo Han Feng Xue Huiyuan li Wei liu Xiaofan liu Huan Dong Rongfeng Fu Mankai Ju Xinyue Dai Wentian Wang Yueshen Ma Zhen Song Jundong Gu Wei Gong Renchi Yang Lei Zhang State Key Laboratory of Experimental Hematology National Clinical Research Centre for Blood DiseasesHaihe Laboratory of Cell EcosystemTianjin Key Laboratory of Gene Therapy for Blood DiseasesCAMS Key Laboratory of Gene Therapy for Blood DiseasesInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Tianjin Institutes of Health Science Tianjin 301600China National Clinical Research Center for Hematologic Diseases Jiangsu Institute of HematologyThe First Affiliated Hospital of Soochow UniversitySuzhou 215006China National Engineering Research Centre of Cell Products Tianjin Key Laboratory of Engineering Technologies for Cell PharmaceuticalAmCellGene Engineering Co.LtdTianjin 300457China School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College100730 BeijingChina

Patients with refractory immune thrombocytopenia(ITP)frequently encounter substantial bleeding risks and demonstrate limited responsiveness to existing *** cord-derived mesenchymal stem cells(UC-MSCs)present a promising alternative,capitalizing on their low immunogenicity and potent immunomodulatory effects for treating diverse autoimmune *** prospective phase I trial enrolled eighteen eligible patients to explore the safety and efficacy of UC-MSCs in treating refractory *** research design included administering UC-MSCs at escalating doses of 0.5×10^(6)cells/kg,1.0×10^(6)cells/kg,and 2.0×10^(6)cells/kg weekly for four consecutive weeks across three cohorts during the dose-escalation phase,followed by a dose of 2.0×10^(6)cells/kg weekly for the dose-expansion *** events,platelet counts,and changes in peripheral blood immunity were monitored and recorded throughout the administration and follow-up ***,12(with an addition of three patients in the 2.0×10^(6)cells/kg group due to dose-limiting toxicity)and six patients were enrolled in the dose-escalation and dose-expansion phase,*** patients(13/18,72.2%)experienced one or more treatment emergent adverse *** adverse events occurred in four patients(4/18,22.2%),including gastrointestinal hemorrhage(2/4),profuse menstruation(1/4),and acute myocardial infarction(1/4).The response rates were 41.7%in the dose-escalation phase(5/12,two received 1.0×10^(6)cells/kg per week,and three received 2.0×10^(6)cells/kg per week)and 50.0%(3/6)in the dose-expansion *** overall response rate was 44.4%(8/18)among all enrolled *** sum up,UC-MSCs are effective and well tolerated in treating refractory ITP(*** ID:NCT04014166).

关键词： doses immunity treatment

Predictive performance of the variation rate of the driving pressure on the outcome of invasive mechanical ventilation in patients with acute respiratory distress syndrome

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chinese Journal of Traumatology 2024年第2期27卷 107-113页

作者： Hui-Dan Jing Jun-ying Tian Wei li Bing-ling He Hong-Chao li Fu-Xia Jian Cui Shang Feng Shen Department of Intensive Care Unit The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China Department of Intensive Care Unit Army Medical Center of PLAChongqing400042China College of Foreign Languges Chongqing Medical UniversityChongqing400016China

Purpose:To assess the value of the driving pressure variation rate(ΔP%)in predicting the outcome of weaning from invasive mechanical ventilation in patients with acute respiratory distress ***:In this case-control study,a total of 35 patients with moderate-severe acute respiratory distress syndrome were admitted to the intensive care unit between January 2022 and December 2022 and received invasive mechanical ventilation for at least 48 h were *** were divided into successful weaning group and failed weaning group depending on whether they could be removed from ventilator support within 14 *** measures including driving pressure,PaO2:FiO2,and positive end-expiratory pressure,*** assessed every 24 h from day 0 to day 14 until successful weaning was *** measurement data of non-normal distribution were presented as median(Q1,Q3),and the differences between groups were compared by Wilcoxon rank sum *** categorical data use the chi-square test or Fisher's exact test to *** predictive value ofΔP%in predicting the outcome of weaning from the ventilator was analyzed using receiver operating characteristic ***:Of the total 35 patients included in the study,17 were successful vs.18 failed in weaning from a ventilator after 14 days of mechanical *** cut-off values of the medianΔP%measured by Operator 1 *** 2 in the first 4 days were≥4.17%and 4.55%,respectively(p<0.001),with the area under curve of 0.804(sensitivity of 88.2%,specificity of 64.7%)and 0.770(sensitivity of 88.2%,specificity of 64.7%),*** was a significant difference in mechanical ventilation duration between the successful weaning group and the failure weaning group(8(6,13)vs.12(7.5,17.3),p=0.043).The incidence of ventilator-associated pneumonia in the successful weaning group was significantly lower than in the failed weaning group(0.2‰vs.2.3‰,p=0.001).There was a significant difference noted between these

关键词： Driving pressure Driving pressure variation rate Acute respiratory distress syndrome Mechanical ventilation

A356铝合金微弧氧化膜微动磨损行为的研究

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稀有金属材料与工程 2024年第3期53卷 796-806页

作者：孙璐李元东马颖曹驰罗晓梅邱谨兰州理工大学材料科学与工程学院甘肃兰州730050 兰州理工大学省部共建有色金属先进加工与再利用国家重点实验室甘肃兰州730050 兰州理工大学温州泵阀工程研究院浙江温州325000

采用微弧氧化(MAO)在A356铝合金表面制备MAO膜,利用球-平面接触在SRV-V微动摩擦磨损机上探究变载荷和位移下微弧氧化对A356铝合金微动磨损机制的影响。结果表明:MAO膜由疏松层和致密层构成,其均匀性、致密性和结合力良好。MAO膜的摩擦... 详细信息

采用微弧氧化(MAO)在A356铝合金表面制备MAO膜,利用球-平面接触在SRV-V微动摩擦磨损机上探究变载荷和位移下微弧氧化对A356铝合金微动磨损机制的影响。结果表明:MAO膜由疏松层和致密层构成,其均匀性、致密性和结合力良好。MAO膜的摩擦系数、磨损率均低于A356铝合金,MAO膜减摩耐磨性较好。随位移增加MAO膜的摩擦耗散能系数低于A356铝合金,MAO膜能提升A356铝合金微动磨损过程的稳定性。载荷增加时A356铝合金磨损机制为磨粒磨损-粘着磨损,伴随犁削和疲劳剥层;MAO膜磨损机制为磨粒磨损-粘着磨损和疲劳剥落。位移增加时A356铝合金磨损机制为粘着磨损和疲劳剥落,伴随微犁削;MAO膜磨损机制为粘着磨损和疲劳剥层-粘着磨损和磨粒磨损。A356铝合金的磨痕内聚集Fe、O元素,存在材料转移和氧化磨损;MAO膜磨痕内聚集Fe元素,存在材料转移。

关键词： A356铝合金微弧氧化微动磨损磨损机制耐磨性

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基于深度学习的钢卷端面缺陷检测系统设计

计算机集成制造系统 2024年第5期30卷 1847-1855页

作者：张雪荣向峰李红军张弛周思聪左颖宝山钢铁股份有限公司中央研究院湖北武汉430080 武汉科技大学机械自动化学院湖北武汉430081 武汉纺织大学机械工程与自动化学院湖北武汉430073 北京航空航天大学自动化科学与电气工程学院北京100191

针对热轧钢卷端面图像背景复杂、缺陷特征各异、缺乏标准缺陷数据集,用传统视觉方法难以自动识别问题,提出了基于深度学习的热轧钢卷端面缺陷检测的技术架构,给出了该框架下的图像采集、预处理与分割、深度神经网络算法设计和缺陷特征... 详细信息

针对热轧钢卷端面图像背景复杂、缺陷特征各异、缺乏标准缺陷数据集,用传统视觉方法难以自动识别问题,提出了基于深度学习的热轧钢卷端面缺陷检测的技术架构,给出了该框架下的图像采集、预处理与分割、深度神经网络算法设计和缺陷特征数据库搭建等关键技术,最后开发了基于深度学习的钢卷端面缺陷检测系统,试验表明该系统的典型缺陷检出率在90%以上,解决了热轧钢卷端面缺陷长期依赖人工肉眼识别的行业性难题,实现了端面缺陷的在线、自动、精准检测,所形成的成套端面缺陷检测技术和装备,在钢铁行业多条热轧产线稳定、可靠地投用运行。

关键词：钢卷端部缺陷深度学习识别

基于EMD分量与小波包能量熵的轧辊磨削颤振在线预测

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金刚石与磨料磨具工程 2024年第1期44卷 73-84页

作者：朱欢欢迟玉伦张梦梦熊力应晓昂上海市高级技工学校制造工程系上海200437 上海理工大学机械工程学院上海200093 上海工程技术大学高职学院上海200437

针对轧辊磨削颤振时的时频域单一处理方法存在部分特征丢失的问题,提出了时频域相结合的方法对信号进行特征处理,并利用智能算法实现轧辊磨削颤振的在线预测。首先,利用经验模态分解(empirical mode decomposition,EMD)方法对振动传感... 详细信息

针对轧辊磨削颤振时的时频域单一处理方法存在部分特征丢失的问题,提出了时频域相结合的方法对信号进行特征处理,并利用智能算法实现轧辊磨削颤振的在线预测。首先,利用经验模态分解(empirical mode decomposition,EMD)方法对振动传感器信号进行分解获得各固有模态函数(intrinsic mode function,IMF),剔除“虚假分量”后计算表征轧辊磨削颤振的时域特征。然后,利用小波包能量熵对声发射传感器信号求解频率段节点能量熵值,获得表征轧辊磨削颤振的频域特征。最后,将上述时频域特征降维后代入智能算法模型实现对轧辊磨削加工的在线预测。结果表明:LV-SVM模型的磨削颤振分类平均准确率达92.75%,模型平均响应时间为0.7765 s;验证了时频域特性的EMD和小波包能量熵方法的LV-SVM在线预测轧辊磨削颤振的有效性。

关键词：轧辊磨削颤振 EMD分解固有模态函数小波包能量熵最小二乘支持向量机

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基于二次谐波产生光谱与显微成像的CdS纳米线空间取向研究

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物理学报 2024年第16期73卷 102-109页

作者：任立庆杨强姬超燃池娇胡云魏迎春许金友榆林学院能源工程学院榆林市高分辨太赫兹振动成像重点实验室榆林719000 华南师范大学华南先进光电子研究院广州510006

作为一种非线性光学效应,二次谐波产生(second harmonic generation,SHG)因其良好的偏振敏感性在获得物质成分、结构、特性等信息方面具有广泛应用.尽管前人利用SHG光谱或SHG显微成像方法探索研究了纳米线的精密定位或追踪问题,但是结... 详细信息

作为一种非线性光学效应,二次谐波产生(second harmonic generation,SHG)因其良好的偏振敏感性在获得物质成分、结构、特性等信息方面具有广泛应用.尽管前人利用SHG光谱或SHG显微成像方法探索研究了纳米线的精密定位或追踪问题,但是结合使用SHG光谱与SHG显微成像方法实现纳米材料结构与晶轴空间取向方面的研究鲜见报道.本研究分别使用SHG光谱与SHG显微成像方法研究了CdS纳米线空间取向问题.首先,基于全光学分析方法从实验上和理论上研究了硫化镉(CdS)纳米线SHG光谱强度随入射光偏振方向变化的规律,并详细分析了晶轴方位角γ,ω,φ对CdS纳米线SHG花型图的影响.其次,通过理论计算与实验测量结果相互验证,成功确定了单根CdS纳米线的3个晶轴取向.最后,利用偏振相关的SHG显微成像方法研究了单根CdS纳米线的空间取向,发现单根CdS纳米线不同部位具有不同的SHG响应.研究结果为SHG光谱与显微成像在纳米材料空间高精度定位研究提供了新的思路与重要参考,并为纳米材料在生物医学方面的潜在应用提供了重要启示.

关键词：二次谐波产生硫化镉纳米线偏振晶体取向