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Association of renal function with cardiac reverse remodeling and long-term outcome in heart failure patients following cardiac resynchronization therapy

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chinese Medical Journal 2014年第23期127卷 4036-4042页

作者： Cai chi Hua Wei ding Ligang Wang Jing Chen Keping Yang Xinwei Liu Zhimin Zhang Shu Centre of Arrhythmia Diagnosis and Treatment Fuwai Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100037 China

Background Renal insufficiency （RI） is significantly associated with clinical prognosis in patients with heart failure （HF）,but direct evidences on the relation between renal function and clinical outcome in patients receiving cardiac resynchronization therapy （CRT） are *** aim of the current study was to systematically evaluate the association of baseline and 6-month renal function with cardiac reverse remodeling and long-term outcome after *** We retrospectively evaluated 190 consecutive patients who underwent CRT at Fuwai Hospital from January 2008 to April *** function tests,echocardiographic measurement,and clinical parameters at baseline and after 6 months of CRT were *** endpoint events included all-cause mortality,cardiac transplantation,and unplanned hospitalizations for *** At baseline,compared with normal renal function or mild RI （estimated glomerular filtration rate （eGFR）〉-60 ml·min-1·1.73 m-2）,moderate-to-severe RI （eGFR 〈60 ml·min-1·1.73 m-2） exerted a negative influence on cardiac reverse remodeling *** 6-month follow-up,114 （60.0%） patients were classified as responders and showed significant renal function improvement,whereas renal function deteriorated in non-responders and subsequently 41 （25.6%） patients developed worsening renal function （WRF）.During the mean follow-up of （24.3±17.1） months,both patients with baseline eGFR 〈60 ml·min^-1·1.73 m^-2 and those with WRF experienced worse event-free survival （P 〈0.01,respectively）.Conclusions：This analysis identified that baseline eGFR as well as WRF after CRT were found to be independent determinants of the combined endpoints of all-cause mortality and HF-related hospitalizations in CRT recipients.

关键词： heart failure renal insufficiency cardiac resynchronization therapy clinical outcome

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New and little-known species of chloropidae from Guizhou(Ⅳ)(Diptera: Acalyptratae)

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贵州科学 1992年第2期 54-55页

作者： Yang ding Yang chi-kun (Beijing AgriculturaI University, Beijing 100094)

Sineurina n. name is given here to replace Pseudeurina Yang et Yang, 1990(Guizhou Sci. 1990 (3): 2-3.), which is preoccupied by de Meijere (1904) (Bijdr. Dierk. 17-18: 112.). Sineurina guizhouensis (Yang et Yang) is new combination for Pseudineurina guizhouensis Yang et Yang, 1990. Genus Elachiptereicus Becker is recorded from china for the first time, and contains 1 new species from Guizhou. The types are kept in the Insect Collections of Beijing Agricultural University.

关键词： New and little-known species of chloropidae from Guizhou Acalyptratae Diptera

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Infant feces-derived Bifidobacterium breve CCFM1078 inhibits the occurrence of rheumatoid cachexia by IRS1/PI3K/Akt signaling pathway

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Food Science and Human Wellness 2024年

作者： Bowen Li Mengfan ding Chen chi Guoxun Shi Xiaoming Liu Jianxin Zhao Paul Ross Catherine Stanton Wei Chen Bo Yang State Key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University Department of Rheumatology， Jiangnan University Medical Center International Joint Research Center for Probiotics & Gut Health， Jiangnan University APC Microbiome Ireland， University College Cork Teagasc Food Research Centre National Engineering Research Center for Functional Food， Jiangnan University

This study aimed to investigate the effects of infant feces-derived Bifidobacterium breve CCFM1078 on rheumatoid cachexia （RC）. Twenty-four female Wistar rats were assigned to three groups: CON group （normal saline by gavage）， CIA group （collagen-induced arthritis， normal saline by gavage）， and CCFM1078 group (collagen-induced arthritis， 3×109CFU/rat/day B breve CCFM1078 gavage). The results demonstrated that B. breve CCFM1078 not only improved skeletal muscle function in CIA rats， but also modulated the gut microbiota， skeletal muscle metabolism and hormone levels， reduced inflammation in the knee joint and skeletal muscles， decreased activity of the NF-κB inflammatory signaling pathway， enhanced the IRS1/PI3K/Akt signaling pathway， promoted skeletal muscle differentiation， and maintained skeletal muscle fiber diameter， consequently slowing down the progression of RC. These findings suggested that B. breve CCFM1078 may have a beneficial role as part of a dietary intervention for RC， enhancing overall therapeutic effects.

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沙质草原植物群落退化与沙化演替

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生态学杂志 2006年第9期25卷 1044-1051页

作者：丁勇牛建明杨持内蒙古大学生态与环境科学系呼和浩特010021

应用TWINSPAN(two-way indicator species analysis)、DCA(detrended correspondence analysis)和CCA(canonical correspondence analysis)技术,对多伦县1984和2001年的28个样地草原植物群落调查数据及相对应的2001年的24个样地土壤调查数据进行分析。结果表明,研究区域的植物群落按照其退化、沙化或恢复演替序列可以分为5个阶段,不同时间的草原植物群落演替序列在空间格局上具有相似性,对比17年的动态变化,也呈现同一演替序列特征;与1984年相比,2001年研究区草原植物群落总体上有明显的退化迹象;草原植物群落退化、沙化或恢复演替与土壤变化具有一定相关性,土壤质地、养分和有机质变化在时间上较植物群落变化明显滞后。

关键词：沙质草原退化沙化植物群落演替多伦县

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Acute liver injury in a COVID-19 infected woman with mild symptoms:A case report

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World Journal of Clinical Cases 2023年第2期11卷 472-478页

作者： Pei-Hsuan Lai Dah-ching ding Department of Obstetrics and Gynecology Hualien Tzu Chi HospitalHualien 970Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)has spread rapidly,resulting in a pandemic in January *** studies have focused on the natural history and consequences of acute liver injury(ALI)in mild or asymptomatic COVID-19 patients,manifested by elevated aminotransferase *** is usually expected for severe COVID-19 ***,we present a COVID-19 case with mild respiratory symptoms and significantly elevated alanine aminotransferase(ALT)and aspartate aminotransferase(AST)*** SUMMARY A 60-year-old woman without medical history or chronic illness received three COVID-19 vaccinations since the start of the *** patient was infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and presented with mild symptoms on July 12th,***-recovery,she underwent an examination at our hospital on August 30th,*** and ALT levels in the liver function test were 207 U/L(normal value<39,5.3-fold increase)and 570 U/L(normal value<52,10.9-fold increase),*** patient was diagnosed with ALI,and no treatment was *** following week,blood tests showed a reduction in both levels(ALT 124 U/L,AST 318 U/L).Two weeks later,AST and ALT levels had decreased to near the expected upper limits(ALT 40 U/L,AST 76 U/L).CONCLUSION Clinicians should pay attention to liver function testing during COVID-19 recovery regardless of the disease’s severity.

关键词： COVID-19 Hepatitis Pneumonia Aspartate aminotransferase Alanine aminotransferase Case report

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Untreated Prior Pulmonary Tuberculosis Adversely Affects Pregnancy Outcomes in Infertile Women Undergoing in vitro Fertilization and Embryo Transfer: A Large Retrospective Cohort Study

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Biomedical and Environmental Sciences 2021年第2期34卷 130-138页

作者： GAI Xiao Yan chi Hong Bin ZENG Lin CAO Wen Li CHEN Li Xue ZHANG Chen LU Ming NING Lan ding CHANG Chun ZHANG Wei Xia LIU Ping LI Rong SUN Yong Chang QIAO Jie Department of Respiratory and Critical Care Medicine Peking University Third HospitalBeijing 100191China Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Beijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China Tuberculosis Department Beijing Geriatric HospitalBeijing 102699China Information Center Peking University Third HospitalBeijing 100191China

Objective Prior pulmonary tuberculosis(PTB) on chest X-ray(CXR) was commonly found in infertile patients receiving examinations before in vitro fertilization and embryo transfer(IVF-ET). It was unclear whether untreated PTB would affect pregnancy outcomes after *** We conducted a retrospective cohort study of 14,254 infertile patients who had received IVFET at Peking University Third Hospital in 2017. Prior PTB was defined as the presence of signs suggestive of old or inactive PTB on CXR, with or without a clinical TB history. Patients who had prior PTB on CXR but had not received a clinical diagnosis and anti-TB therapy were included for analysis. Live birth,clinical pregnancy, and miscarriage rates were compared between the untreated PTB and non-PTB *** The untreated PTB group had significantly lower clinical pregnancy(31.7% vs. 38.1%) and live birth(23.8% vs. 30.6%) rates than the non-PTB group(both P < 0.001). Multivariate analysis revealed that untreated PTB was a risk factor for decreased live birth rate [odds ratio(OR), 0.80;95% confidence interval(CI), 0.66–0.98;P = 0.028] in all patients and for increased miscarriage(OR, 4.19;95% CI,1.69–10.39;P = 0.002) and decreased live birth(OR, 0.45;95% CI, 0.24–0.83;P = 0.011) rates in patients with unexplained *** Untreated PTB was associated with adverse pregnancy outcomes after IVF-ET, especially in patients with unexplained infertility, highlighting the clinical significance of PTB in this specific patient population.

关键词： Tuberculosis Embryo transfer In vitro fertilization Infertility Pregnancy outcome

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综合表观和运动模式的视频轮椅检测方法

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高技术通讯 2012年第2期22卷 153-158页

作者：李同治丁晓青方驰智能技术与系统国家重点实验室北京100084 清华信息科学与技术国家实验室北京100084 清华大学电子工程系北京100084

提出了一种通过综合利用表观和运动模式从视频中检测轮椅（包括坐轮椅的人）的方法。该方法首先使用两种特征描述轮椅的表观特性，并结合利用基于统计学习得到的分类器快速地排除非目标区域。针对由于直立行人和坐在轮椅人之间的表观相... 详细信息

提出了一种通过综合利用表观和运动模式从视频中检测轮椅（包括坐轮椅的人）的方法。该方法首先使用两种特征描述轮椅的表观特性，并结合利用基于统计学习得到的分类器快速地排除非目标区域。针对由于直立行人和坐在轮椅人之间的表观相似性，轮椅检测易受直立行人干扰的情况，进一步使用运动信息来区分轮椅和正常行人，降低了虚警。在收集的数据上测试了所提方法的性能，实验结果表明提出的方法能够以接近实时的速度进行检测，并且能够有效地降低正常行人的干扰。

关键词：轮椅检测运动模式级联检测类Haar特征梯度方向直方图(HOG)特征光流

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Price linkage between chinese and international nonferrous metals commodity markets based on VAR-DCC-GARCH models

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Transactions of Nonferrous Metals Society of china 2015年第3期25卷 1020-1026页

作者：岳意定刘笃池徐珊中南大学商学院长沙410083 华南理工大学工商管理学院广州510641

Using VAR-DCC-GARCH model,the literature on commodity price was extended by exploring the co-movement between chinese nonferrous metal prices and global nonferrous metal prices represented by the nonferrous metal prices from London Metal Exchange(LME).The results show that LME nonferrous metals prices still have a greater impact on chinese nonferrous metals ***,the impact of chinese nonferrous metals prices on LME nonferrous metals prices is still weak except for lead *** co-movement of nonferrous metal prices between LME and china presents hysteretic nature,and it lasts for 7-8trading ***,the co-movement between LME nonferrous metals prices and chinese nonferrous metals prices has the characteristics of time-varying,and the correlation of lead prices between LME and china is the more stable than all other nonferrous metals prices.

关键词： price linkage nonferrous metals commodity prices chinese metals commodity market LME co-movement VAR model DCC-GARCH model

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汽车驱动桥系统模态综合动力学建模与分析

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振动与冲击 2017年第9期36卷 7-12,27页

作者：周驰丁炜琦桂良进范子杰清华大学汽车工程系汽车安全与节能国家重点实验室北京100084 陕西汉德车桥有限公司西安710201

提出一种汽车驱动桥系统的模态综合动力学建模与分析方法,采用非线性轴承单元实现传动系模型与桥壳模型的耦合建模,采用模态综合法对驱动桥各部件的有限元模型进行缩维变换,能够在准确模拟驱动桥系统动力学特性的同时大大缩减系统模型规... 详细信息

提出一种汽车驱动桥系统的模态综合动力学建模与分析方法,采用非线性轴承单元实现传动系模型与桥壳模型的耦合建模,采用模态综合法对驱动桥各部件的有限元模型进行缩维变换,能够在准确模拟驱动桥系统动力学特性的同时大大缩减系统模型规模,从而快速准确地实现驱动桥系统的静力学非线性求解和动力学分析。以准双曲面齿轮有限元接触分析求得的动态啮合力作为系统激励,计算驱动桥系统的动力学响应,并进行试验验证,数值计算结果能够准确体现准双曲面齿轮动态啮合力激励下的驱动桥系统动力学特性,有效指导驱动桥的减振降噪设计。

关键词：驱动桥模态综合法准双曲面齿轮动力学分析

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Blood glucose-lowering activity of protocatechuic acid is mediated by inhibiting a-glucosidase

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Food Science and Human Wellness 2024年第3期13卷 1212-1219页

作者： Huafang ding Shouhe Huang Chui Yiu Chook Erika Kwek chi Yan Kaying Ma Jianhui Liu Hanyue Zhu Zhenyu Chen Food&Nutritional Sciences Programme School of Life SciencesThe Chinese University of Hong KongHong Kong 999077China

α-Glucosidase inhibitors are effective in controlling postprandial hyperglycemia,which play crucial roles in the management of type 2 *** acid(PCA)is one of phenolic acids existing not only in various plant foods but also as a major microbial metabolite of dietary anthocyanins in the large *** present study investigated the inhibitory mechanism of PCA on a-glucosidase in vitro and examined its effect on postprandial blood glucose levels in *** from in vitro experiments demonstrated that PCA was a mix-type inhibitor of *** by hydrogen bonds and van der Waals interactions,PCA reversibly bound withα-glucosidase to form a stable a-glucosidase-PCA complex in a spontaneous *** computational simulation found that PCA could insert into the active cavity of a-glucosidase and establish hydrogen bonds with catalytic amino acid *** binding aroused the steric hindrance for substrates to enter active sites and caused the structural changes of interacted catalytic amino acid *** also exhibited postprandial hypoglycemic capacity in diabetic *** study may provide the theoretical basis for the application of PCA as an active ingredient of functional foods in dietary management of diabetes.

关键词： Protocatechuic acid α-Glucosidase Postprandial hyperglycemia Inhibition mechanism

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