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Stoichiometric Ti_(3)C_(2)T_(x)Coating for Inhibiting Dendrite Growth in Anode-Free Lithium Metal Batteries

Energy & Environmental Materials 2024年第4期7卷 153-162页

作者： Xiangrong Zeng Manmatha Mahato Woong Oh Hyunjoon Yoo Van Hiep Nguyen Saewoong Oh Geetha Valurouthu Soon-Ki Jeong chi won ahn Yury Gogotsi Il-Kwon Oh National Creative Research Initiative for Functionally Antagonistic Nano-Engineering Department of Mechanical EngineeringKorea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Korea Department of Materials Science&Engineering and A.J.Drexel Nanomaterials InstituteDrexel UniversityPhiladelphiaPennsylvania 19104USA Department of Energy Engineering Soonchunhyang University22Soonchunhyang-roSinchang-myeonAsan-siChungcheongnam-do 31538Korea National Nanofab Center(NNFC) Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Korea

Lithium metal batteries(LMBs)and anode-free LMBs(AFLMBs)present a solution to the need for batteries with a significantly superior theoretical energy ***,their adoption is hindered by low Coulombic efficiency(CE)and rapid capacity fading,primarily due to the formation of unstable solid electrolyte interphase(SEI)layer and Li dendrite growth as a result of uneven Li ***,we report on the use of a stoichiometric Ti_(3)C_(2)T_(x)(S-Ti_(3)C_(2)T_(x))MXene coating on the copper current collector to enhance the cyclic stability of an anode-free lithium metal *** S-Ti_(3)C_(2)T_(x)coating provides abundant nucleation sites,thereby lowering the overpotential for Li nucleation,and promoting uniform Li ***,the fluorine(-F)termination of S-Ti_(3)C_(2)T_(x)participates in the SEI formation,producing a LiF-rich SEI layer,vital for stabilizing the SEI and improving cycle *** equipped with S-Ti_(3)C_(2)T_(x)@Cu current collectors displayed reduced Li consumption during stable SEI formation,resulting in a significant decrease in capacity *** with S-Ti_(3)C_(2)T_(x)@Cu current collectors achieved a high initial capacity density of 4.2 mAh cm^(-2),70.9%capacity retention after 50 cycles,and an average CE of 98.19%in 100 *** innovative application of MXenes in the energy field offers a promising strategy to enhance the performance of AFLMBs and could potentially accelerate their commercial adoption.

关键词： anode-free lithium metal batteries stoichiometric MXene solid electrolyte interphase surface terminations

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The Characteristics of CLHS Driving for High Luminance Efficiency in AC PDP

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Plasma Science and Technology 2016年第11期18卷 1116-1122页

作者： Gun-Su KIM chi-Hyung ahn Seok-Hyun LEE Department of Electrical and Electronic Engineering Youngsan UniversityYangsanGyeongnam 50510Korea Korea Railroad Research Institute Uiwang Gyeonggi 16105Korea School of Electrical Engineering Inha UniversityIncheon 22212Korea

This paper proposes a CLHS （Capacitor Less Half Sustain） driving method that is applied to a long gap panel to reduce the power consumption. In order to reduce the power consumption in moving images, the luminous efficiency should be improved at the low discharge load （〈25%）. The weight of reactive power consumption tends to increase as the low discharge load decreases. Thus, it is very important to improve the luminous efficiency at low discharge load. It is well known that a long gap panel improves the luminance and the luminous efficiency but it is very difficult to drive the panel due to high driving voltage. It is confirmed that the main factors which cause a long gap panel to increase the minimum driving voltages are not only a long discharge gap but also self-erasing discharge. Self-erasing discharge is generated between the address and sustain electrodes in a sustain period. The CLHS driving method can reduce the reactive power consumption in a sustain period because energy recovery capacitors were removed in the sustain circuit. The CLHS driving method can reduce the minimum driving voltage of the long gap panel because the self-erasing discharge was prevented. When the CLHS driving method was applied to the panel with an ITO gap of 100 μm, Vs and VA minimum voltages are reduced by about 9 V and 12 V compared with those of the normal driving method. The luminance and the luminous efficiency also increased by about 24.3% and 33.3% at the discharge load of 4% compared with those at the normal condition.

关键词： PDP plasma long gap CLHS

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Development of a 3D subcutaneous construct containing insulin-producing beta cells using bioprinting

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Bio-Design and Manufacturing 2022年第2期5卷 265-276页

作者： chi B.ahn Ji-Hyun Lee Joo H.Kim Tae H.Kim Hee-Sook Jun Kuk H.Son Jin W.Lee Department of Molecular Medicine College of MedicineGachon University155Gaetbeol-roYeonsu-kuIncheonRepublic of Korea Department of Health Sciences and Technology GAIHSTGachon University155Gaetbeol-roYeonsu-kuIncheonRepublic of Korea College of Pharmacy Gachon University191Hambangmoe-roYeonsu-kuIncheonRepublic of Korea Department Thoracic and Cardiovascular Surgery Gachon University Gil Medical CenterCollege of MedicineGachon University21Namdong-daero 774 beon-gilNamdong-guIncheonRepublic of Korea

Type 1 diabetes is caused by insulin deficiency due to the loss of beta cells in the islets of *** severe cases,islet transplantation into the portal vein is ***,due to the loss of transplanted islets and the failure of islet function,the 5-year insulin independence rate of these patients is<50%.In this study,we developed a long-term,insulin-secreting,3 Dbioprinted construct implanted subcutaneously with the aim of preventing islet *** bioprinted construct was fabricated by the multi-layer bioprinting of beta-cell(mouse insulinoma-6:MIN-6)-encapsulated alginate bioink and poly(caprolactone)biodegradable polymer.A glucose response assay revealed that the bioprinted constructs proliferated and released insulin normally during the 4-week in vitro *** MIN-6 generated clusters with a diameter of 100-200μm,similar to the original pancreatic islets in the *** an in vivo study using type 1 diabetes mice,animals implanted with bioprinted constructs showed three times higher insulin secretion and controlled glucose levels at 8 weeks after *** the implanted,bioprinted constructs had a positive effect on insulin secretion in the experimental animals,the survival rate of the implanted group(75%)was three times higher than that of the non-implanted group(25%).The results suggest that the proposed,3 D-bioprinted,subcutaneous construct can be a better alternative to portal vein islet transplantation.

关键词： 3D bioprinting Subcutaneous construct Type 1 diabetes Insulin Beta cells

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Live Fibular Graft for the Treatment of Long Bone Tumors in children

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Journal of Cancer Therapy 2017年第3期8卷 225-233页

作者： Seung-Koo Rhee Mohammed Einayet Abdelhameed chi-Hoon ahn Cheol-U Kim Department of Orthopaedic Surgery Bone & Joint Tumor Division Daejeon Sun Medical Center Daejeon Korea Department of Orthopaedic Surgery Sharg Alneel Hospital Khartom Sudan

Purposes: We would like to inform the characteristics of recurred osteo-fibrous dysplasia (OFD), and also the possible use of vascularized composite autograft and allografts (VCA) combined with live fibular graft (LFG) for the treatment of aggressive benign bone tumor and osteogenic sarcomas in children. Materials and Methods: We reviewed one boy with recurred OFD after LFG, and other four children with osteogenic sarcoma in long bone which was treated with LFG and VCA, and followed them for average 9 years (3 - 14 years). Survival of the LFG and VCA was estimated by the ISOLS Functional Radiologic Scoring System, but not with Kaplans-Meier’s scoring system because of a small series of case reports. Results: All succeed after surgeries initially, but the cause of recurrence of OFD was still unclear, and one girl with osteogenic sarcoma on distal femur died with skip and lung metastasis, 4 years after surgeries. Conclusions: The causes of recurred OFD are not found thru pathologic studies of our patient, but we believe the multifocal origin of tumor cells even on the adjacent soft tissues in OFD is one of the causes. The excised long bone tumor is recycled by pasteurization or autoclaving, or allograft, then LFG, and neo-adjuvant chemotherapy would be one of elective surgery for the treatment of malignant long bone tumors in children. The LFG into recycled autograft or allograft bone is difficult to perform simultaneously, but very effective to increase more earlier regenerative vascularities and also the stabilities of the dead bones in children.

关键词： Live Fibular Graft Vascularized Composite Allograft or Autograft Osteofibrous Dysplasia Osteogenic Sarcoma children

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Anti-inflammatory activity of ginsenosides in LPS-stimulated RAW 264.7 cells

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Science Bulletin 2015年第8期60卷 773-784,M0003页

作者： Sungeun ahn Muhammad Hanif Siddiqi Hae-Yong Noh Yu-Jin Kim Yeon-Ju Kim chi-Gyu Jin Deok-Chun Yang Ginseng Genetic Bank Graduate School of BiotechnologyCollege of Life Science Kyung Hee University

Ginsenosides, the main active constituents of Panax ginseng Meyer （P. ginseng）, have potential therapeutic effects. All tested ginsenosides except gin- senoside F1 have previously been reported in inflammation studies using the RAW 264.7 macrophage cell line. We ex- amined the anti-inflammatory effects of single sugar moiety ginsenosides such as compound K （CK）, Rh2, Rhl, and F1 that were isolated from P. ginseng through in silico docking studies. We investigated their biological activity predictions, including absorption, distribution, metabolism, excretion, and toxicity and PASS properties, on the suppression of NF- κB, followed by in vitro validation in lipopolysaccharide （LPS）-stimulated RAW 264.7 macrophage cells. The molecular docking results of our study showed that all treated ginsenosides are non-toxic and may be drug-like molecules. The molecular binding interactions of these ginsenosides with the active residues of NF-κB noticeably support their anti-inflammatory activity. CK and Rhl sig- nificantly reduced the production of nitric oxide, cyclooxy- genase-2 （COX-2）, and pro-inflammatory cytokines such as prostaglandin E2 and tumor necrosis factor alpha （TNF-α） in a dose-dependent manner. Real-time PCR and Western blot analyses further confirmed that protopanaxadiols （PPDs） and protopanaxatriols （PPTs） inhibitory effects may have been due to the down-regulation of TNF-α, inducible nitric oxide synthase, COX2, nuclear factor kappa B （NF-κB）, and I kappa B kinase. The expression of co-stimulatory molecules such as ROS was also inhibited by CK and Rhl in a dose- dependent manner. Furthermore, activation of NF-κB in LPS-stimulated RAW 264.7 macrophages was significantly suppressed by CK and Rhl. Taken together, these results provide evidence that PPD- and PPT-type ginsenosides in- cluding CK and Rhl may exhibit strong anti-inflammatory effects by inhibiting pro-inflammatory mediators through down-regulation of NF-κB.

关键词： Ginsenosides Protopanaxadiol Protopanaxatriol Inflammation NF-κB/IKK RAW 264.7

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Efficacy of Pegylated Interferon Monotherapy versus Sequential Therapy of Entecavir and Pegylated Interferon in Hepatitis B e Antigen-Positive Hepatitis B Patients： A Randomized, Multicenter, Phase IIIb Open-Label Study （POTENT Study）

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chinese Medical Journal 2018年第14期131卷 1645-1651页

作者： Dae won Jun Sang Bong ahn Tae Yeob Kim Joo Hyun Sohn Sang Gyune Kim Se Whan Lee Byung Ho Kim Dong Joon Kim Ja Kyung Kim Hyoung Su Kim Seong Gyu Hwang won Choong Choi won Young Tak Heon Ju Lee Ki Tae Yoon Byung Cheol Yun Sung Wook Lee Soon Koo Baik Seung Ha Park Ji won Park Sol Ji Park Ji Sung Lee Department of Internal Medicine Hanyang University Seoul Hospital Hanyang University Seou104763 Korea Department of Internal Medicine Nowon Eulji Hospital Eulji University Seou101830 Korea Department of Internal Medicine Hanyang University Guri Hospital Hanyang University Guri 11923 Korea Department of Internal Medicine SoonChunHyang University Bucheon Hospital SoonChunHyang University Bucheon 14584 Korea Department of Internal Medicine SoonChunHyang University Cheonan Hospital SoonChunHyang University Cheonan 31151 Korea Department of Internal Medicine Kyung Hee University Hospital Kyung Hee University Seoul 02453 Korea Department of Internal Medicine Chuncheon Sacred Heart Hospital Hallym University Chuncheon 24252 Korea Department of Internal Medicine Kangdong Sacred Heart Hospital Hallym University Seou105355 Korea Department of Internal Medicine Gangnam Severance Hospital Yonsei University Seou106273 Korea Department of Internal Medicine CHA Bundang Medical Center CHA University Seongnam 13496 Korea Department of Internal Medicine Sanggye Paik Hospital Inje University Seoul 01757 Korea Department of Internal Medicine Kyungpook National University Hospital Kyungpook National University Daegu 41944 Korea Department of Internal Medicine Yeungnam University Medical Center Yeungnam University Daegu 42415 Korea Department of Internal Medicine Pusan National University Yangsan Hospital Pusan National University Yangsan 50612 Korea Department of Internal Medicine Kosin University Gospel Hospital Kosin University Pusan 49267 Korea Department of Internal Medicine Dong A University Medical Center Dong A University Pusan 49201 Korea Department of Internal Medicine Wonju Severance Christian Hospital Yonsei University Wonju 26426 Korea Department of Internal Medicine Haeundae Paik Hospital Inje University Pusan 48108 Korea Department of Internal Medicine Hallym University Sacred Heart Hospital Hallym University Anyang 14068 Korea Department of Cli

Background： Until now, various types of combined therapy with nucleotide analogs and pegylated interferon （Peg-INF） in patients with hepatitis B patients have been tried. Howe6ver, studies regarding the benefits of de novo combination, late-add on, and sequential treatmentare very limited. The objective of the current study was to identify the efficacy of sequential treatment of Peg-INF after short-term antiviral treatment. Methods： Between June 2010 and June 2015, hepatitis 13 e antigen （HBeAg）-positive patients （n = 162） received Peg-IFN for 48 weeks （mono-treatment group, n = 81） and entecavir （ETV） for 12 weeks with a 48-week course of Peg-IFN starting at week 5 of ETV therapy （sequential treatment group, n = 81）. The primary endpoint was HBeAg seroconversion at the end of follow-up period after the 24-week treatment. The primary endpoint was analyzed using chi-square test, Fisher＇s exact test, and regression ***： HBeAg seroconversion rate （18.2% vs. 18.2%, t = 0.03, P = 1.000） and seroclearance rate （19.7% vs. 19.7%, t = 0.03, P = 1.000） were same in both mono-treatment and sequential treatment groups. The rate of alanine aminotransferase （ALT） normalization （45.5% vs. 54.5%, t = 1.12, P = 0.296） and serum hepatitis B virus （HBV）-DNA 〈2000 U/L （28.8% vs. 28.8%, t = 0.10, P = 1.000） was not different in sequential and mono-treatment groups at 24 weeks of Peg-INF. Viral response rate （HBeAg seroconversion and serum HBV-DNA 〈2000 U/L） was not different in the two groups （12.1% vs. 16.7%, t = 1.83, P = 0.457）. Baseline HBV-DNA level （7 log10 U/ml vs. 7.5 log10 U/ml, t = 1.70, P = 0.019） and hepatitis B surface antigen titer （3.6 log10 U/ml vs. 4.0 log10 U/ml, t = 2.19, P = 0.020） were lower and predictors of responder in mono-treatment and sequential treatment groups, respectively. Conclusions： The current study shows no differences in HBeAg seroconversion rate, ALT normalization, and HBV-DNA levels between mono-therapy and sequential therapy regimens.

关键词： Entecavir Hepatitis B Peginterferon Alfa-2a

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Incidence and Clinical Characteristics of Deep Vein Thrombosis (DVT) after Total Knee Arthroplasty (TKA) with DVT Chemoprophylaxis

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World Journal of Cardiovascular Diseases 2014年第11期4卷 531-538页

作者： Yong Sung won Mihyeong Kim Kang Woong Jun Woo Seok Nam Sanghyun ahn Jeong-Kye Hwang Sang-Dong Kim Sun-Cheol Park Sang Seob Yun won-Chul Lee Jang-Sang Park Jang Yong Kim Division of Vascular Surgery Department of Surgery The Catholic University of Korea School of Medicine Seoul Korea Department of Preventive Medicine The Catholic University of Korea School of Medicine Seoul Korea

Objective: Deep vein thrombosis (DVT) after total knee arthroplasty (TKA) is very common and leading cause of death due to this procedure. The objective of this study was to investigate the incidence and clinical characteristics of DVT after TKA with DVT chemoprophylaxis. Methods: This is a prospective cohort study in single institution. The patients received postoperative DVT chemoprophylaxis (low molecular weight heparin (LMWH) or Fondaparinux), followed by duplex ultrasonography to check for DVT 1 - 2 weeks after TKA. The clinical characteristics were summarized and analysed by chi-square test and regression analysis. Results: Five hundred and thirty four patients were enrolled from January 2007 to December 2010. DVT chemoprophylaxis was administered in 524 (98.1%) of the 534 patients. DVT occurred in 9 subjects (1.69%);8 subjects had DVT in the leg, and 1 subject had a pulmonary embolism. Among them, asymptomatic DVT was observed in 5 patients (0.94%). Univariate analysis showed that surgical methods (revision, P = 0.0007), body mass index (BMI) (>25, P = 0.0028), low platelet count (less than 150 × 103, P = 0.0219), time in the intensive care unit (ICU) (P < 0.0001), no administration of prophylactic LMWH (P = 0.0392), and a history of DVT (P < 0.0001) were significant risk factors of DVT. Conclusions: The incidence of DVT was 1.69% after TKA with prophylactic antithrombotic therapy. Revision surgery, BMI, low platelet count, time in ICU, absence of prophylactic LMWH and history of DVT were significant risk factors of DVT.

关键词： Venous Thromboembolism Thromboprophylaxis Low Molecular Weight Heparin Anticoagulation Total Knee Arthroplasty

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Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun ahn Vladimir Kushnarev Tsz Kiu Cheung Ho ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law chi Seng Leung Chun Yin Tong Kai Kap wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

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Analysis on sports and recreation activity-related eye injuries presenting to the Emergency Department

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1499-1505页

作者： Sungbae Moon Hyun Wook Ryoo Jae Yun ahn Jung Bae Park Kang Suk Seo Sang Do Shin Kyoung Jun Song Kang Hyun Lee In Sool Yoo Jin Seong Cho Hyun Ho Ryu Tae Oh Jeong Seok Ran Yeom Young Taek Kim Sung Ok Hong Department of Emergency Medicine School of MedicineKyungpook National University Daegu 700-721 Korea Department of Emergency Medicine College of MedicineSeoul National University Seoul 110-799 Korea Department of Emergency Medicine Wonju College of Medicine Yonsei University Wonju Gangwon-do 220-701Korea Department of Emergency Medicine School of MedicineChungnam National University Daejeon 301-747 Korea Department of Emergency Medicine Gachon University Gil Medical Center Incheon 406-799 Korea Department of Emergency Medicine School of MedicineChonnam National University Gwangju 501-746 Korea Department of Emergency Medicine School of MedicineChonbuk National University Jeonju Jeollabuk-do 561-180Korea Department of Emergency Medicine School of MedicinePusan National University Busan 602-739 Korea Korean Centers for Disease Control & Prevention Cheongiu Chungcheongbuk-do 361-951 Korea

AIM：To investigate the incidence and general characteristics of sports-related eye injuries in patients visiting the Emergency Department. METHODS： A cross-sectional,multi-center,observational *** with an injured eye who visited the Emergency Department at one of nine hospitals in Korea were *** data were prospectively collected between March and September 2010 using a *** injuries that occurred during risky sports were examined by gender and ***,the rate of open globe injuries that occurred with and without protective eyewear was examined for each *** variables were compared using Student＇s t-test and categorical variables were compared using chi-square ***： A total of 446 patients had sports-related eye ***（10-19 years old） and young adults（20-29 years old） had the most eye *** injuries accounted for 0.2% of Emergency Department *** was the most common cause of sports-related eye injuries,followed by soccer and *** gear was worn by 9.4% of all *** that were 30-39 years of age had the highest rate of protective gear use,followed by patients that were 40-49 years of *** proportion of sports-related eye injuries that were open-globe injuries was highest for soccer and ***： Although injuries were most common in patients below the age of 10 years,these patients had the lowest rate of protective eyewear *** in adults over 40 years of age most commonly occurred during hiking,but the rate of protective eyewear use was *** athletes should be educated on and provided with protective eyewear and policies protective gear use should be *** older adults,eye protection should be encouraged,especially during hiking.

关键词： athletic injuries eye injuries protective devices sports.

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一项对比从富马酸替诺福韦二吡呋酯(TDF)转换为丙酚替诺福韦(TAF)和继续TDF治疗用于病毒学抑制的慢性乙型肝炎(CHB)患者的3期研究:第48周时的疗效和安全性结果

一项对比从富马酸替诺福韦二吡呋酯(TDF)转换为丙酚替诺福韦(TAF)...

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第十届全国疑难及重症肝病大会

作者： Pietro Lampertico Maria Buti Scott Fung Sang Hoon ahn Wan-Long Chuang won Young Tak Alnoor Ramji chi-Yi Chen Edward Tam Ho Bae Xiaoli Ma John F.Flaherty Anuj Gaggar Audrey Lau Becket Feierbach George Wu Vithika Suri Mani Subramanian Cong Cheng Huy N.Trinh Seung Kew Yoon Kosh Agarwal Young-Suk Lim Henry Chan Università degli Studi di Milano Division of Gastroenterology and Hepatology University Hospital Vall d'Hebron University Health Network Yonsei University Kaohsiung Medical University

背景和目的TAF是替诺福韦(TFV)的一种新型前体药物,近期获批用于治疗慢性乙型肝炎。与TDF相比,TAF的血浆稳定性更高,能够更有针对性地将TFV递送至肝脏且降低了TFV的循环水平。第48周和第96周时,TAF表现出不劣于TDF的疗效且改善肾脏和骨...

背景和目的TAF是替诺福韦(TFV)的一种新型前体药物,近期获批用于治疗慢性乙型肝炎。与TDF相比,TAF的血浆稳定性更高,能够更有针对性地将TFV递送至肝脏且降低了TFV的循环水平。第48周和第96周时,TAF表现出不劣于TDF的疗效且改善肾脏和骨骼安全性。本研究评估了从TDF转换为TAF vs.继续接受1年TDF治疗用于病情稳定的病毒学抑制患者时的疗效和安全性。

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