Incidence and Clinical Characteristics of Deep Vein Thrombosis (DVT) after Total Knee Arthroplasty (TKA) with DVT Chemoprophylaxis

作     者：Yong Sung Won Mihyeong Kim Kang Woong Jun Woo Seok Nam Sanghyun Ahn Jeong-Kye Hwang Sang-Dong Kim Sun-Cheol Park Sang Seob Yun Won-Chul Lee Jang-Sang Park Jang Yong Kim 

作者机构：Division of Vascular Surgery Department of Surgery The Catholic University of Korea School of Medicine Seoul Korea Department of Preventive Medicine The Catholic University of Korea School of Medicine Seoul Korea 

出 版 物：《World Journal of Cardiovascular Diseases》 (心血管病（英文）)

年 卷 期：2014年第4卷第11期

页      面：531-538页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Venous Thromboembolism Thromboprophylaxis Low Molecular Weight Heparin Anticoagulation Total Knee Arthroplasty 

摘      要：Objective: Deep vein thrombosis (DVT) after total knee arthroplasty (TKA) is very common and leading cause of death due to this procedure. The objective of this study was to investigate the incidence and clinical characteristics of DVT after TKA with DVT chemoprophylaxis. Methods: This is a prospective cohort study in single institution. The patients received postoperative DVT chemoprophylaxis (low molecular weight heparin (LMWH) or Fondaparinux), followed by duplex ultrasonography to check for DVT 1 - 2 weeks after TKA. The clinical characteristics were summarized and analysed by chi-square test and regression analysis. Results: Five hundred and thirty four patients were enrolled from January 2007 to December 2010. DVT chemoprophylaxis was administered in 524 (98.1%) of the 534 patients. DVT occurred in 9 subjects (1.69%);8 subjects had DVT in the leg, and 1 subject had a pulmonary embolism. Among them, asymptomatic DVT was observed in 5 patients (0.94%). Univariate analysis showed that surgical methods (revision, P = 0.0007), body mass index (BMI) (25, P = 0.0028), low platelet count (less than 150 × 103, P = 0.0219), time in the intensive care unit (ICU) (P 0.0001), no administration of prophylactic LMWH (P = 0.0392), and a history of DVT (P 0.0001) were significant risk factors of DVT. Conclusions: The incidence of DVT was 1.69% after TKA with prophylactic antithrombotic therapy. Revision surgery, BMI, low platelet count, time in ICU, absence of prophylactic LMWH and history of DVT were significant risk factors of DVT.