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Synthesis of binaphthyl bridged chiral bis-corrole

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chinese Chemical Letters 2009年第1期20卷 21-24页

作者： Ping Lian Hai Yang Liu Lan Ying Liu Lei Shi Huan Feng Jiang chi kwong chang Department of Chemistry and Life Sicence Gannan Normal University Ganzhou 341000 China Department of Chemistry South China University of Technology Guangzhou 510641 China Department of Chemistry The Hong Kong University of Science and Technology Hong Kong China

chiral bis-corrole 1 and 2 were prepared by reaction of （s）-2,2′-bis（bromomethyl）-1, 1′-binaphthyl and 10-（4-hydroxylphenyl）- 5,15-bis（pentafluorophenyl）corrole or 10-（3-hydroxylphenyl）-5,15-bis（pentafluorophenyl）corrole in DMF at 60 ℃ in the presence of anhydrous K2CO3 with an isolated yield -8%. Both 1 and 2 exhibit unsymmetrical induced circular dichroism （ICD） in the soret band with positive exciton chirality.

关键词： chiral bis-corrole Synthesis ICD

Silver(Ⅱ) 5,10,15,20-tetra(ethoxycarbonyl) porphyrin:An unexpected six-coordinate linear assembled structure

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chinese Chemical Letters 2018年第9期29卷 1404-1408页

作者： Hua-Hua Wang Hai-Yang Liu Fan Cheng Atif Ali Lei Shi Xin-Yan Xiao chi-kwong chang School of Chemistry and Chemical Engineering Key Laboratory of Functional Molecular Engineering of Guangdong Province South China University of Technology Department of Chemistry Southern University of Science and Technology Department of Chemistry Guangdong University of Education Department of Chemistry Michigan State University

The crystal structure of silver（Ⅱ） 5,10,15,20-tetra（ethoxycarbonyl）porphyrin （Ag[Ⅱ]TECP） revealed it formed a one-dimensional coordination polymer through weak Ag-O interactions with an unusual six-coordinated... 详细信息

关键词： Porphyrin Silver Six-coordinated assembly Crystal structure Hydrogen bond

Case synthesis of a β-chloro bulky bis-pocket corrole:Crystallographic characterization and photophysical properties

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chinese Chemical Letters 2018年第12期29卷 1888-1892页

作者： Atif Ali Fan Cheng Wei-Hong Wen Xiao Ying Jaipal KANDhadi Hui Wang Hai-Yang Liu chi-kwong chang Department of Chemistry Key Laboratory of Functional Molecular Engineering of Guangdong Province South China University of Technology Department of Applied Physics South China University of Technology State Key Laboratory of Optoelectronics Materials and Technologies Sun Yat-sen University Department of Chemistry Michigan State University

A new 2-chloro-5,10,15-tris（2,4,6-triphenylphenyl）-corrole was accidentally synthesized in an acceptable yield of 5.7% during the synthesis of its parent corrole, in which DDQ served as oxidant and chlorinating agent. The compound was well characterized by X-ray diffraction analysis,;H NMR, mass spectroscopy and absorption spectroscopy. Photophysical properties tests revealed that the chlorination caused a sharp decrease in fluorescence intensity, fluorescence life time, and fluorescence quantum *** investigation demonstrated the positive shift of redox potentials for chlorinated corrole as compared to non-chlorinated corrole.

关键词： Corrole β-Chlorination Synthesis Photophysical properties Singlet oxygen

Solvent effects on oxygen atom transfer reaction between manganese(V)-oxo corrole and alkene

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chinese Chemical Letters 2013年第6期24卷 447-449页

作者： Lan Yu Qi Wang Lu Dai Wei-Ying Li Rong Chen Mian HR Mahmood Hai-Yang Liu chi-kwong chang Department of Chemistry South China University of Technology Department of Chemistry Michigan State University

Pseudo-first order reaction rate constants of 5,10,15-tris（pentafluorophenyl）corrole Mn（V）-oxo （F_（15）CMn（V）-oxo）,5,15-bis（pentafluorophenyl）-10-（phenyl）corrole Mn（V）-oxo（F_（10）CMn（V）-oxo）,5,15- bis（phenyl）-10-（pentafluorophenyl）corrole Mn（V）-oxo（F_5CMn（V）-oxo） and 5,10,15-tris（phenyl）corrole Mn（V）-oxo（F_0CMn（V）-oxo） with a series of alkene substrates in different solvents were determined by UV-vis *** results indicated that the oxygen atom transfer pathway between Mn（V）-oxo corrole and alkene is solvent-dependent.

关键词： Corrole Mn(V)-oxo corrole Oxygen atom transfer reaction Solvent effect

Reductive demetalation of manganese corroles:The substituent effect

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chinese Chemical Letters 2008年第8期19卷 1000-1003页

作者： Hai Yang Liu Ling Chen Fei Yam Hai Ying Zhan Xiao Ying Xiang Li Wang Huan Feng Jiang chi kwong chang Department of Chemistry South China University of Technology Guangzhou 510641 China Department of Chemistry The Hong Kong University of Science and Technology Hong Kong China Department of Applied Physics South China University of Technology Guangzhou 510641 China

The reductive demetalation of manganese corroles was investigated in CH2Cl2/HCl （aqueous） solvent by using SnCl2 as reducing agent. It was found that the demetalation yields depend on the substituents of corrole macrocycle significantly. Electron- rich manganese corrole undergoes reductive demetalation more easily than electron-deficient ones. The isolated reductive demetalation yield of manganese 5,10,15-tris（phenyl）corrole in present system is moderate （46%）. As for electron-deficient Mn（Ⅲ） 5,10,15-tris（pentafluorophenyl）corrole, the acid-induced demetalation in HOAc-HESO4 （V/V = 3：1） is preferable with an isolated yield of 67%.

关键词： Corrole Manganese Demetalation

Photodynamic therapy-mediated modulation of inflammatory cytokine production by Epstein–Barr virus-infected nasopharyngeal carcinoma cells

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Cellular & Molecular Immunology 2010年第4期7卷 323-326页

作者： Ho-Kee Koon Kwok-Wai Lo Kwok-Nam Leung Maria Li Lung Chris chi-kwong chang Ricky Ngok-Shun Wong Wing-Nang Leung Nai-Ki Mak Department of Biology Hong Kong Baptist UniversityKowloonHong Kong Department of Anatomical and Cellular Biology and State Key Laboratory in Oncology in South china Prince of Wales HospitalShatinHong Kong Department of Biochemistry and Food and nutritional Sciences Programme The Chinese University of Hong KongShatinHong Kong Department of Biology Hong Kong University of Science and TechnologyHong Kong Department of Chemistry Hong Kong University of Science and TechnologyKowloonHong Kong School of chinese Medicine The Chinese University of Hong KongShatinHong Kong

Nasopharyngeal carcinoma(NPC)is a malignant disease associated with Epstein–Barr virus(EBV)*** study aims to examine the effects of EBV infection on the production of proinflammatory cytokines in NPC cells after the Zn-BC-AM photodynamic therapy(PDT)*** were treated with the photosensitiser Zn-BC-AM for 24 h before light *** ELISA was used to evaluate the production of *** the same experimental condition,HK-1-EBV cells produced a higher basal level of IL-1a(1561 pg/ml),IL-1b(16.6 pg/ml)and IL-8(422.9 pg/ml)than the HK-1 *** the light dose of 0.25–0.5 J/cm2,Zn-BC-AM PDT-treated HK-1-EBV cells were found to produce a higher level of IL-1a and IL-1b than the HK-1 *** production of IL-1b appeared to be mediated via the IL-1b-converting enzyme(ICE)-independent *** contrast,the production of angiogenic IL-8 was downregulated in both HK-1 and HK-1-EBV cells after Zn-BC-AM *** results suggest that Zn-BC-AM PDT might indirectly reduce tumour growth through the modulation of cytokine production.

关键词： Photodynamic therapy nasopharyngeal carcinoma cytokines Epstein-Barr virus

The Identification of Corrole-based Terminal High-valent CoⅤ≡O Complexes and Their Reactivity Towards Alkene

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The Identification of Corrole-based Terminal High-valent Co...

Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

中国化学会第五届卟啉与酞菁学术研讨会

作者： Hai-Yang Liu Atif Ali Fan Cheng Bei Wan Manzoor Hussain Xiao-Ying chi-kwong chang Department of Chemistry South China University of Technology Department of Chemistry Karakoram International University Department of Applied Physics South China University of Technology Department of Chemistry Michigan State University

High valent cobalt-oxo species have been suggested the critical reactive intermediate in cobalt catalyzed oxidation ***,definitive assignment of terminal high-valent(Co-O) species remains *** we report the first demonstration of corrole-based high-valent terminal(Co≡O) *** corrole Co≡O complexes were obtained by oxidation of cobalt corroles using KHSO in *** Raman spectrum provides the conclusive evidence for the triply bonded terminal(Co≡O) specie which exhibits a diatomic Co-O vibration band around 847 *** smooth reaction between prepared(Co≡O) complexes and styrene provides the compelling evidence that terminal Co≡O complex is one of the reactive intermediate in cobalt-catalyzed oxidation of organic substrate.

关键词： Corrole Cobalt Metal-oxo Oxidation Activity

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning chang Liu Yu-chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

三羟基咔咯及其镓配合物与DNA的相互作用、光断裂和光动力抗肿瘤活性（英文）

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无机化学学报 2019年第9期35卷 1687-1697页

作者：陈璇汪华华 Waseem Akram 孙艳梅廖玉辉司利平刘海洋张启光华南理工大学化学系广东省功能分子工程重点实验室广州510641 南方医科大学皮肤病医院分子诊疗中心广州510091 佛山科学技术学院材料科学与能源工程学院佛山528000 Department of Chemistry Michigan State University E. Lansing MI 48824 USA

合成了一个三羟基咔咯10-(4-羟基苯基)-5,15-双(4-(2-羟乙基)氨基-2,3,5,6-四氟苯基)咔咯(1)及其镓配合物(1-Ga)。光谱滴定实验、粘度测试和分子对接模拟结果表明,1和1-Ga通过外部结合模式与小牛胸腺DNA发生相互作用。琼脂糖凝胶电泳实... 详细信息

合成了一个三羟基咔咯10-(4-羟基苯基)-5,15-双(4-(2-羟乙基)氨基-2,3,5,6-四氟苯基)咔咯(1)及其镓配合物(1-Ga)。光谱滴定实验、粘度测试和分子对接模拟结果表明,1和1-Ga通过外部结合模式与小牛胸腺DNA发生相互作用。琼脂糖凝胶电泳实验结果表明1和1-Ga显示出良好的光核酸酶活性。2种化合物对A549,HepG2,MCF-7肿瘤细胞有显著的光毒性。光辐照后,它们能通过活性氧物种(ROS)介导的线粒体途径诱导HepG2细胞凋亡。此外,1-Ga能使肿瘤细胞周期阻滞在G2/M期。

关键词：咔咯镓 DNA断裂光动力治疗抗肿瘤活性