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Contribution of Anti-p63 Antibodies in the Interpretation of Benign Label Prostatic Biopsies

Open Journal of Pathology 2024年第2期14卷 31-44页

作者： Ibou Thiam Fabrice Senghor Frenette Codja Kor Ndiaye Mohamed Moustapha cherif dial Pathological Anatomy Department Aristide Le Dantec University Hospital Dakar Senegal Pathological Anatomy Department H&#244pital de la Paix Ziguinchor Senegal Pathological Anatomy Department Idrissa Pouye University Hospital Dakar Senegal

Introduction: Prostate cancer is the second most common cancer in men. The diagnosis is most often based on the prostate biopsies’ analysis and on histological criteria recognizable on standard coloring. In some cases, the use of immunohistochemistry is important. Objectives: This paper aims to specify the p63 phenotypic profile of lesions diagnosed benign, with minimal suspect foci, difficult to interpret, HGPIN (high grade intraepithelial neoplasia) and LGPIN (low-grade prostatic intraepithelial neoplasia) and evaluate the manual technique of p63 immunohistochemistry. Patients and Method: This was a retrospective, descriptive study of prostate biopsies recorded in the PAC service of the HALD from January 1st, 2018 to December 31st, 2018. It was completed by a manual immunohistochemical study of the blocks enrolled from November 19th to December 4th, 2020 in the PAC department of the HPD. The studied parameters were: registry number, age, clinical stage, prostate volume, PSA level, microscopic appearance and p63 immunohistochemical profile. Results: Our study included 60 prostate biopsies. The ages of our patients varied from 45 to 77 years, with an average of 64.2 years and a standard deviation of 6.2. The majority of patients were at clinical stage cT2b (33%) with a prostate volume varying between 33.15 and 169.4 cc. The minimum value of PSA in our series is 5 ng/ml, the maximum being 100 ng/ml with an average level of 24.1 ng/ml and a standard deviation of 21.2. Our series included 50 adenomyomatous hyperplasias, 7 adenomyomatous hyperplasias associated with chronic prostatitis, 2 HGPIN and 1 LGPIN. After re-reading we found 5 discordant cases, which corresponded to minimal suspect foci (kappa = 0.5098). The p63 marking was informative in 53 cases, i.e. 88%, and non-informative in 7 cases, i.e. 12%. Among the uninformative markings, 2 were due to lack of tissue adhesion to the slides. Among the informative markings, 11 were negative. p63 immunohistochemistry was

关键词： Prostate Cancer Diagnosis Anti-p6 Antibody

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Overview of Adrenals Tumors in Dakar Hospitals

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Open Journal of Internal Medicine 2024年第2期14卷 141-150页

作者： Nafy Ndiaye Yakham Mohamed Leye Mouhamadou Moustapha Ndong Ngoné Diaba Diack Amadou Fall Cisse Abdoulaye Leye Baidy Sy Kane Alpha Omar Touré cherif Mohamed dial Pape Saloum Diop Internalmedeccine and Endocrinology Department Teaching Hospital of Pikine Dakar Senegal General Surgery Department Aristide Le Dantec Teaching Hospital of Dakar Dakar Senegal Anatomo-Pathology Department General Hospital of Grand Yoff Dakar Dakar Senegal General Surgery Department General Hospital of Grand Yoff Dakar Dakar Senegal

Introduction: Adrenal tumours (AT) are commonly encountered in clinical practice. For any patient presenting an adrenal mass, there are two crucial points to consider: is the adrenal mass malignant and is it hormonally active? The objective of our study was to evaluate the epidemiological, diagnostic, therapeutic, and evolutionary aspects of AT in a developing country. Methodology: We conducted a retrospective study spanning 17 years (from January 2005 to October 2022) in four Dakar hospital services. We included all patient medical records with explored AT. Results: AT was diagnosed in 35 patients who had a mean age of 36.62 years (range: 12-79), and a female predominance (26 women to 9 men). Among these patients, 17.2 % had incidental AT. Hypertension was the commonest presenting symptom in 27 patients (77%), which was associated with Mnards triad in 14 patients (40%). Abdominal pain was reported by 20 patients (57%), and 14 presented with an abdominal mass. Among the patients, 29 had functional AT: 22 with pheochromocytoma, 5 with primary hyperaldosteronism, and 2 with hypercortisolism. Imaging evaluations revealed that 33 patients had unilateral AT and one had bilateral AT. Tumour sizes varied, 5 patients had tumours 10 cm. Two patients presented with metastases. The therapeutic approach involved adrenalectomy in 32 patients. Perioperative complications were observed in five patients, including haemorrhage (two patients), hypotension (two cases), and hypertensive crisis (one case). One patient with bilateral pheochromocytoma developed acute adrenal insufficiency postoperatively, followed by abdominal herniation. Histopathological examination confirmed pheochromocytoma in 21 patients, Conns adenoma in 5, adrenocortical carcinoma in 3, cortisol adenoma in 2, and adrenal cyst in 1 patient. Non-functional AT included adrenocortical carcinoma (three patients), adrenal cyst (one patient), and pheochromocytoma (two patients). After a one-year follow-up, 29 patients wit

关键词： Tumour Adrenal Pheochromocytoma Conn Adrenocortical Carcinoma Dakar

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Lesions Superimposed by Traditional Medicine on Renal Biopsies in Senegal

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Open Journal of Pathology 2023年第4期13卷 224-228页

作者： cherif Mouhamed Moustapha dial Toni Djibrilla Gani El Hadji Fary Ka Abdou Niang Boucar Diouf Pathology Laboratory of the Idrissa Pouye General Hospital Dakar Senegal Reference General Hospital Niamey Niger Nephrology Department of Aristide le Dantec Hospital Dakar Senegal

Traditional African medicine products are responsible for kidney damage that baffles both nephrologists and pathologists. Renal biopsies reveal acute or chronic inflammatory changes that cannot be explained by the progressive stage of the basic lesion of the nephropathy. The aim of this study is to analyze the lesions superimposed on 73 kidney biopsies from patients who took traditional herbal medications to treat the symptoms of kidney disease.

关键词： Nephropathy Traditional Medicine Pharmacopoeia Senegal

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Hyperalgesic Lumbosciatica Symptomatic of a Spinal Schwannoma: A Case Report

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Open Journal of Modern Neurosurgery 2022年第2期12卷 61-66页

作者： Magatte Gaye Omar Thiam cherif Mouhamed dial Lounceny Fatoumata Barry Mohameth Faye Nantene Doumbia Youssoupha Sakho Department of Neurosurgery Hopital General Grand Yoff Dakar Senegal Department of Pathology Hopital General Grand Yoff Dakar Senegal

Introduction: Spinal schwannomas also known as neurinomas are often benign slow growing lesion that may develop from Schwann cells of the spinal roots, it is a nerve sheath tumor. The authors reported a case of a patient presenting a hyperalgesic lumbosciatica symptomatic of a spinal schwannoma. Observation: A 36-year-old female patient, with a history of asthma under treatment was admitted to our department because of one year lasting of an intermittent fashion bilateral L5 hyperalgesic lumbosciatica. The initial examination has shown back muscles contractures and a segmental deficit of the right lower limb in L5 and S1, but no genital or sphincter disorders were noted. The lumbosacral CT scan was without particularity but the magnetic resonance imaging (MRI) revealed an intradural, extra medullary lesion at the level of L1-L2. A monobloc resection of the lesion was done. The follow-up is good. Pathology concluded in schwannoma WHO grade I classification. Conclusion: Lumbar neurinoma that grows slowly is most often manifested by a radiculalgia often hyperalgesic and disabling. MRI is the examination of choice to make the diagnosis and complete removal is possible.

关键词： Lumbosciatica MRI Spinal Tumor Neurinoma Surgery

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Rhabdomyosarcoma in Dakar: An Update on Pronostics Factors

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Open Journal of Pathology 2022年第1期12卷 37-45页

作者： Abdou Magib Gaye Marie Joseph Dieme-Haouidi Ibou Thiam Fabrice Senghor Gabriel Nougnignon Comlan Deguenonvo cherif Mouhamed Moustapha dial Anatomy and Pathological Cytology Laboratory of the Aristide Le Dantec Hospital Dakar Senegal Anatomy and Pathological Cytology Laboratory of the Fann Hospital Dakar Senegal Anatomy and Pathological Cytology Laboratory of the Idrissa Pouye General Hospital Dakar Senegal

Rhabdomyosarcoma (RMS) belongs to the soft tissue sarcomas that have striated muscle differentiation. It is most common in young children under 5 years of age and adolescents. The definite diagnosis of rhabdomyosarcoma is based on histology and the positivity of striated muscle markers in immunohistochemistry. Our objective was to describe the prognostic characteristics of RMS diagnosed in Dakar. MATERIAL AND METHODS: This was a retrospective and descriptive study spread over nine (09) years from 1 January 2011 to 31 December 2019. It was conducted from the histological report archives of the anatomy and pathology laboratories of Dakar. Paraffin blocks were reread and immunohistochemically studied by manual method. Antidesmin and antimyogenin antibodies were used. RESULTS: We collected 44 patients with rhabdomyosarcoma out of 228 cases of soft tissue cancers, i.e. 19.29% of all malignant soft tissue tumours. The mean age of the patients was 25.41 ± 23.95 (standard deviation) years with a median age of 16 years and extremes of 6 months and 81 years. Patients were less than or equal to 17 years of age in 61.4% of cases. A clear male predominance was observed with 29 men (65.9%) against 15 women (34.1%). Rhabdomyosarcomas were located in the limbs in 34.1% of cases, in the head and neck in 29.5% of cases and in the genitourinary tract in 25% of cases. The average tumour size was 7.45 cm ± 4.64 (standard deviation) with a minimum of 2 cm and a maximum of 17 cm. It was greater than or equal to 5 cm in 15 patients (68.2%). Embryonal rhabdomyosarcoma (ERMS) was the most frequent histological type with 34 cases (77.3%), followed by pleomorphic rhabdomyosarcoma 7 cases (15.9%) and alveolar rhabdomyosarcoma 3 cases (6.8%). The histological subtypes of ERMS consisted of conventional ERMS (91.18%);botryoid RMS (5.88%) and spindle cell RMS (2.94%). The correlation between histological type and age was statistically significant (p = 0.039). A relationship was also observ

关键词： Rhabdomyosarcoma Prognosis Histology Dakar

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Laryngeal Cancers at the Pathological Anatomical Laboratory (ACP) in Dakar about 215 Cases

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Open Journal of Pathology 2023年第2期13卷 79-86页

作者： Marie Joseph Dieme Ahouidi Adama Diedhiou Abdou Magib Gaye Dibor Niang Falilatou Seidou Ibou Thiam cherif Mouhamed Moustapha dial Anatomy and Pathological Cytology Laboratory Fann Hospital Dakar Sénégal Anatomy and Pathological Cytology Laboratory Aristide Le Dantec Hospital Dakar Sénégal Anatomy and Pathological Cytology Laboratory Gaston Berger University St Louis Sénégal Anatomy and Pathological Cytology Laboratory Idrissa Pouye Hospital Dakar Sénégal

Introduction: Laryngeal cancer is the first cancer of upper aerodigestive tract. Dysphonia, dyspnea and dysphagia are evocative signs. Diagnosis is histological and squamous cell carcinoma is the most common type. The objective of our study was to discuss epidemiological and anatomo-pathological characteristics of laryngeal cancers diagnosed in different pathological anatomy and cytology (ACP) laboratories of Dakar hospitals. Material and method: This was a retrospective study spanning from January 2013 to December 2018 at the pathological anatomy laboratories of Fann, Aristide Le Dantec and Idrissa Pouye hospitals. All patients with laryngeal cancer confirmed at histology were included. Data collection was based on clinical records of the patients and archives of histological reports of the pathological laboratories. Data analysis was performed under the Excel software. Results: We collected 215 cases of laryngeal cancer. The average age was 58.01 years with extremes of 07 and 94 years. The male sex was predominant with 183 patients (85.12%) against 32 women (14.88%). The most noted risk factor was tobacco which affected 14 patients, or 60.87%. Three patients (13.04%) did not present any alcohol-smoking impregnation. Clinically, dysphonia was noted in 22 patients (26.51%). It was associated with dyspnea in 0.48% of cases and dysphagia in 3.61%. Laryngoscopy was performed in 62 patients or 28.83% of cases, nasofibroscopy in 6.45% of cases. Cord arythenoid fixity was noted in two patients (3.23%) and hypo-mobility in 1 patient (1.61%). The most frequent local extension was involvement of the piriform sinus with 11.29% of cases. Palpable lymphadenopathy reported in 17 patients (20.48%). Pathological examination was performed in all patients after post endoscopic biopsy in 92 patients (42.79%), and after obtaining the operative specimen in 123 cases (57.21%). The three floors affected 76 patients (35.35%). The ulcerative budding aspect most noted concerned 108 patients

关键词： Laryngeal Cancer Carcinoma Dakar

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Isolated esophageal tuberculosis:A case report

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World Journal of Gastrointestinal Endoscopy 2022年第9期14卷 575-580页

作者： Ibrahima diallo Omar Touré Elhadji Souleymane Sarr Abdoul Sow Bineta Ndiaye Papa Silman Diawara cherif Mouhamed dial Ababacar Mbengue Fatou Fall Hepato-Gastroenterology Hopital Principal de DakarDakar 3006Senegal Hepatogastroenterology Hopital Principal de DakarDakar 3006Senegal Department of Pathology Hopital Principal de DakarDakar 3006Senegal Department of Biology Hopital Principal de DakarDakar 3006Senegal Department of Pathology Hopital Général Idrissa PouyeDakar 3006Senegal Department of Imaging Hopital Principal de DakarDakar 3006Senegal

BACKGROUND Tuberculosis is endemic in *** its extra-pulmonary localization is rare,esophageal tuberculosis,particularly the isolated form,is *** report here a case of isolated esophageal tuberculosis in an immunocompetent *** SUMMARY A 58-year-old man underwent consultation for mechanical dysphagia that had developed over 3 mo with non-quantified weight loss,anorexia,and *** digestive endoscopy showed extensive ulcerated lesions,suggesting *** diagnosis was confirmed by histopathology,which showed gigantocellular epithelioid granuloma surrounding a caseous *** computed tomography scan did not show another localization of the *** outcome was favorable with *** Esophageal tuberculosis should be considered when dysphagia is associated with atypical ulcerated lesions of the esophageal mucosa,in an endemic area.

关键词： Tuberculosis Esophagus Endoscopy Case report

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Thyroid Cancers in the Thies Regional Hospital Center: Morpho-Epidemiological Study on 14 Cases

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Open Journal of Pathology 2023年第3期13卷 153-163页

作者： Tonleu Linda Bentefouet Abou Sy Adama Ka Yannick Soubeiga Assane Sow Jacques Ammasiga Faye Marie Joseph Dieme Ahouidi cherif Mamadou Moustapha dial Malick Ndiaye Thies Training and Research Unit in Health Sciences Dixième-Thiès Thiès Senegal Cheikh Anta Diop University Dakar Senegal

Introduction: Thyroid cancers are malignant cell proliferations developed at the expense of the thyroid gland, and which can spread from a distance. Most cancers appear in the form of anterior cervical swelling. Ultrasound and pathological examination allow the diagnosis of certainty. In Thiès, the studies carried out on thyroid cancers essentially focus on clinico-radiological and therapeutic aspects. We propose, through this study, to describe the epidemiological aspects and the morphological characteristics of thyroid cancers at Thiès Regional Hospital Center. Methodology: This is a retrospective, descriptive and analytical study conducted over a period of 3 years and 6 months, from January 2019 to June 2022. All patients with thyroid cancer confirmed by histological examination were included. Results: The patients who met the inclusion criteria were fourteen in number (14). The average age of patients was 40, 7 +/- 19 years old with extremes of 08 years and 75 years. Our series reports an 86% majority of women against 14% of men, with a sex ratio of 0.17. The isolated thyroid nodule was the most frequent mode of revelation of papillary thyroid cancers in our series, representing 54.6% of patients. The samplings received at the laboratory were essentially total thyroidectomy specimens. The tumor size varied between 1.5 cm and 14 cm. Papillary thyroid carcinoma was the most frequent histological type, with a frequency of 78.6%, followed by gallbladder carcinoma and squamous cell carcinoma. Conclusion: Thyroid cancers affect young subjects and are discovered at a late stage in our context.

关键词： Thyroid Carcinoma Senegal Thiès Histopathology

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Epidermal Inclusion Cyst: A Rare Benign Breast Lesion

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Open Journal of Pathology 2022年第2期12卷 64-69页

作者： Abdou Magib Gaye Modukpè Colette Nadine Odah Moussa Guira Fabrice Senghor Gabriel Nougnignon Comlan Deguenonvo Amadou Ndiade Ibou Thiam Marie Joseph Dieme-Ahouidi cherif Mouhamed Moustapha dial Anatomy and Pathological Cytology Laboratory Aristide Le Dantec Hospital Dakar Senegal Public Care Center of Richard Toll Saint-Louis Senegal Anatomy and Pathological Cytology Laboratory Idrissa Pouye General Hospital Dakar Senegal Anatomy and Pathological Cytology Laboratory Fann Hospital Dakar Senegal

Epidermal inclusion cyst in the breast is an uncommon condition. It may be congenital, originating from hair follicles or occurring after trauma (breast reduction or breast cytology puncture) or consists of squamous metaplasia of the regular columnar epithelium within an ectatic ductus galactophorus. We report the case of a 22-year-old woman, with two pregnancies and with no particular pathological history, who presented with a 3 cm nodule of the right breast at the union of the upper quadrants, firm, mobile and painless. The skin, areola and nipple were unaffected. The axillary areas and the contralateral breast were unremarkable. The breast ultrasound showed a heterogeneous and well circumscribed hypoechoic mass classified as ACR3. Macroscopic examination revealed a unilocular cyst with a discretely thickened wall, abundant yellowish contents and measuring 2 cm on a long axis. Histologically, it was a cystic cavity whose wall was lined with a pseudo stratified keratinized squamous epithelium with a granular layer and whose lumen contained keratin lamellae. This cyst is surrounded by a more or less fibrous pallial tissue containing regular, sometimes dilated or even cystic milk ducts. The diagnosis of epidermal inclusion cyst of the breast on a background of fibrocystic mastopathy was thus concluded. The importance of this benign lesion lies in the differentiation between other non-neoplastic and neoplastic breast lesions.

关键词： Epidermal Inclusion Cyst Breast Fibrocystic Mastopathy Dakar Senegal

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Renal Cortical Necrosis: An Unusual Complication of <i>Plasmodium malariae</i>Malaria

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Open Journal of Nephrology 2015年第4期5卷 99-104页

作者： Ahmed Tall Lemrabott Mouhamadou Moustapha Cissé Sidy Mohamed Seck Elhadji Fary Ka Maria Faye Aliou Ndongo cherif dial Younoussa Keita Khodia Fall Abdou Niang Boucar Diouf Department of Nephrology Aristide Le Dantec University Hospital Dakar Senegal Faculty of Medicine Gaston Berger University Saint-Louis Senegal Anatomo-Pathology Laboratory Grand-Yoff General Hospital Dakar Senegal

Renal cortical necrosis (RCN) is anecdotal in malaria. To our knowledge, RCN secondary to Plasmodium malariae has not yet been published. We report a case of severe malaria complicated by RCN. A 29 year old Senegalese patient was transferred to our department for anuria in a context of severe malaria. The diagnosis was RCN secondary to a severe Plasmodium malariae malaria. Physical examination showed anuria, anaemic syndrome, haemorrhagic syndrome and a generally impaired condition. There was a normocytic normochromic anaemia aplastic, thrombocytopenia leukocytosis of 11.580/mm3, serum creatinine of 12.45 mg/dl and blood urea of 252 mg/dl. The Plasmodium malariae had been shown to thick blood film with high parasite density. The molecular study was able to confirm the infestation of this parasite. Treatment consisted of four haemodialysis sessions and antimalarial molecules. Initial evolution was favourable with a recovery through diuresis and a partial improvement in renal function. Given the persistence of impaired renal function, a renal biopsy was performed. This confirmed the RCN. At last consultation, he had no symptoms and his last glomerular filtration rate (GFR) was 30 mL/min/1.73 m2.

关键词： Renal Cortical Necrosis Plasmodium malariae Acute Kidney Injury Malaria

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