Renal Cortical Necrosis: An Unusual Complication of <i>Plasmodium malariae</i>Malaria

作     者：Ahmed Tall Lemrabott Mouhamadou Moustapha Cissé Sidy Mohamed Seck Elhadji Fary Ka Maria Faye Aliou Ndongo Cherif Dial Younoussa Keita Khodia Fall Abdou Niang Boucar Diouf 

作者机构：Department of Nephrology Aristide Le Dantec University Hospital Dakar Senegal Faculty of Medicine Gaston Berger University Saint-Louis Senegal Anatomo-Pathology Laboratory Grand-Yoff General Hospital Dakar Senegal 

出 版 物：《Open Journal of Nephrology》 (肾脏病（英文）)

年 卷 期：2015年第5卷第4期

页      面：99-104页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Renal Cortical Necrosis Plasmodium malariae Acute Kidney Injury Malaria 

摘      要：Renal cortical necrosis (RCN) is anecdotal in malaria. To our knowledge, RCN secondary to Plasmodium malariae has not yet been published. We report a case of severe malaria complicated by RCN. A 29 year old Senegalese patient was transferred to our department for anuria in a context of severe malaria. The diagnosis was RCN secondary to a severe Plasmodium malariae malaria. Physical examination showed anuria, anaemic syndrome, haemorrhagic syndrome and a generally impaired condition. There was a normocytic normochromic anaemia aplastic, thrombocytopenia leukocytosis of 11.580/mm3, serum creatinine of 12.45 mg/dl and blood urea of 252 mg/dl. The Plasmodium malariae had been shown to thick blood film with high parasite density. The molecular study was able to confirm the infestation of this parasite. Treatment consisted of four haemodialysis sessions and antimalarial molecules. Initial evolution was favourable with a recovery through diuresis and a partial improvement in renal function. Given the persistence of impaired renal function, a renal biopsy was performed. This confirmed the RCN. At last consultation, he had no symptoms and his last glomerular filtration rate (GFR) was 30 mL/min/1.73 m2.