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Genetic diversity of the S-type small subunit ribosomal RNA gene of Plasmodium knowlesi isolates from Sabah,Malaysian Borneo and Peninsular Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 84-90页

作者： Eric Tzyy Jiann Chong Joveen Wan Fen Neoh Tiek Ying Lau Kek Heng Chua Yvonne Ai-Lian lim ping-Chin Lee Biotechnology Research Institute Universiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia Department of Biomedical Science Faculty of Medicine BuildingUniversity of Malaya50603 Kuala LumpurMalaysia Centre of Excellence for Research in AIDS(CERiA) University of Malaya50603 Kuala LumpurMalaysia Faculty of Science and Natural Resources Universiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia

Objective:To determine the genetic diversity of Plasmodium(P.)knowlesi isolates from Sabah,Malaysian Borneo and Peninsular Malaysia,targeting the S-type SSU rRNA gene and including aspects of natural selection and ***:Thirty-nine blood samples infected with *** were collected in Sabah,Malaysian Borneo and Peninsular *** S-type SSU rRNA gene was amplified using polymerase chain reaction,cloned into a vector,and *** natural selection and haplotype of the S-type SSU rRNA gene sequences were determined using DnaSP v6 and illustrated using NETWORK *** study's 39 S-type SSU rRNA sequences and eight sequences from the Genbank database were subjected to phylogenetic analysis using MEGA ***:Overall,the phylogenetic analysis showed no evidence of a geographical cluster of *** isolates from different areas in Malaysia based on the S-type SSU rRNA gene *** S-type SSU rRNA gene sequences were relatively conserved and with a purifying *** sharing of the S-type SSU rRNA gene was observed between the *** isolates in Sabah,Malaysian Borneo,but not between Sabah,Malaysian Borneo and Peninsular ***:This study suggests that the S-type SSU rRNA gene of *** isolates in Sabah,Malaysian Borneo,and Peninsular Malaysia has fewer polymorphic sites,representing the conservation of the *** features make the S-type SSU rRNA gene suitable for comparative studies,such as determining the evolutionary relationships and common ancestry among *** species.

关键词： Plasmodium knowlesi S-type small subunit ribosomal RNA Genetic diversity Natural selection Haplotype

Application of a microscopic optical potential of chiral effective field theory in (p, d) transfer reactions

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Nuclear Science and Techniques 2024年第1期35卷 134-144页

作者： Yi-ping Xu Si-Lu Chen Dan-Yang Pang School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China School of Physics Beihang UniversityBeijing 100191China

The microscopic global nucleon–nucleus optical model potential(OMP)proposed by Whitehead,lim,and Holt,the WLH potential(Whitehead et al.,Phys Rev Lett 127:182502,2021),which was constructed in the framework of many-body per-turbation theory with state-of-the-art nuclear interactions from chiral effective field theory(EFT),was tested with(p,d)transfer reactions calculated using adiabatic wave *** target nuclei included both stable and unstable nuclei,and the incident energies reached 200 *** results were compared with experimental data and predictions using the phenomenological global optical potential of Koning and Delaroche,the KD02 ***,we found that the micro-scopic WLH potential described the(p,d)reaction angular distributions similarly to the phenomenological KD02 potential;however,the former was slightly better than the latter for radioactive *** average,the obtained spectroscopic factors(SFs)using both microscopic and phenomenological potentials were similar when the incident energies were below approxi-mately 120 ***,their difference tended to increase at higher incident energies,which was particularly apparent for the doubly magic target nucleus 40Ca.

关键词： Microscopic optical model potential (p,d)transfer Spectroscopic factors

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钒钛铁尾矿制备绿色建筑材料的研究进展

材料导报 2024年第19期38卷 115-124页

作者：田小平王长龙 Hidayati Asrah lim Chung Han 平浩岩齐洋马锦涛荆牮霖刘治兵郑永超翟玉新刘枫河北工程大学土木工程学院河北邯郸056038 马来西亚沙巴大学工程学院沙巴哥打京那巴鲁88400 北京建筑材料科学研究总院有限公司固废资源化利用与节能建材国家重点实验室北京100041 中铁建设集团有限公司北京100040 中铁建设集团建筑发展有限公司北京100070

钒钛磁铁矿是以铁、钒、钛为主的多金属元素共生的复合矿,在世界分布不均衡。中国是该矿石的主要产出国之一,该矿石分布在五个主要矿带。钒钛铁尾矿是钒钛磁铁矿选矿过程中产生的固体工业废弃物,是一种多金属伴生的铁尾矿。该尾矿在中... 详细信息

钒钛磁铁矿是以铁、钒、钛为主的多金属元素共生的复合矿,在世界分布不均衡。中国是该矿石的主要产出国之一,该矿石分布在五个主要矿带。钒钛铁尾矿是钒钛磁铁矿选矿过程中产生的固体工业废弃物,是一种多金属伴生的铁尾矿。该尾矿在中国的堆存量巨大,富含很多有用化学组分,也被称为人工矿床。该尾矿以硅酸盐为主,主要化学成分是二氧化硅、三氧化二铝、氧化钙和氧化铁等,主要矿物是脉石矿物。国内外学者对其在绿色建筑材料综合利用方面做了很多有益探索,但总体来看,这些研究更多停留在实验室里。主要原因是(1)不同尾矿库甚至同一尾矿库的钒钛铁尾矿理化性能可能有较大差异,尾矿原料的稳定性不足;(2)受尾矿原料不稳定的理化性能影响,中试结果经常出现较大差异,难以实现规模化利用;(3)钒钛铁尾矿库大多地处偏僻,运输成本高,且缺乏高附加值的尾矿产品,规模以上企业因投入大产出小望而生畏。本文综述了钒钛铁尾矿在中国的地域分布和堆存量,重点研究了其化学组成、矿物组成、粒度分布和重金属浸出,分析了其作为主要原料在绿色建筑材料方面的研究进展,指出了存在问题并展望了发展前景。

关键词：钒钛磁铁矿钒钛铁尾矿绿色建筑材料混凝土矿物掺合料

Effect of formulation of alginate beads on their mechanical behavior and stiffness

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Particuology 2011年第3期9卷 228-234页

作者： Eng-Seng Chan Tek-Kaun lim Wan-ping Voo Ravindra Pogaku Beng Ti Tey Zhibing Zhang School of Engineering Monash University Jalan Lagoon Selatan 4~150 Bandar Sunway 5elangor Malaysia Centre of Materials and Minera/s School of Engineering and Information Technology Universiti Malaysia Sabah 88999 Kota Kinabalu Sabah Malaysia Department of Chemical and Environmental Engineering Faculty of Engineering Universiti Putra Malaysia 43400 Serdang Selangor Malaysia School of Chemical Engineering University of Birmingham Edgbaston Birmingham BI5 27Z United Kingdom

The aim of this work was to determine the effect of formulation of alginate beads on their mechanical behavior and stiffness when compressed at high speed. The alginate beads were formulated using different types and concentrations of alginate and gelling cations and were produced using an extrusiondripping method, Single wet beads were compressed at a speed of 40 mm/min, and their elastic limits were investigated, and the corresponding force versus displacement data were obtained. The Young＇s moduli of the beads were determined from the force versus displacement data using the Hertz＇s contact mechanics theory. The alginate beads were found to exhibit plastic behavior when they were compressed beyond 50% with the exception of copper-alginate beads for which yield occured at lower deformation, Alginate beads made of higher guluronic acid contents and gelling cations of higher chemical affinity were found to have greater stiffness. Increasing the concentration of alginate and gelling ions also generated a similar effect. At such a compression speed, the values of Young＇s modulus of the beads were found to be in the range between 250 and 900 kPa depending on the bead formulation.

关键词： Algioate Young's modulus Elastic limit Deformation Compression Hertz theory

Advances in fabricating spherical alginate hydrogels with controlled particle designs by ionotropic gelation as encapsulation systems

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Particuology 2016年第1期14卷 44-60页

作者： Jun-Yee Leong Weng-Hoong Lam Kiang-Wei Ho Wan-ping Voo Micky Fu-Xiang Lee Hui-Peng lim Swee-Lu lim Beng-Ti Tey Denis Poncelet alan Lagoon Selatan Bandar Sunway Selangor 46150 Malaysia Advanced Engineering Platform Monash University Malaysia Jalan Lagoon Selatan Bandar Sunway Selangor 46150 Malaysia Oniris UMR CNRS 6144 GEPEA rue de la Geraudiere BP82225 Nantes 44322 France

Alginate is a biopolymer that has exceptional gelling properties, which allow easy gel formation under safe and mild conditions. Consequently, it is often used to encapsulate a variety of cargos, such as cells, enzymes, and lipids, and is typically employed as a model to study hydrogel-based encapsulation sys- tems. Since the first use of alginate in the encapsulation field in the 1970s, many methods have been developed to produce alginate hydrogel particles of different sizes, structures, and morphologies. This review provides an overview of the current progress in the fabrication of alginate hydrogels with vari- ous particle designs, including a discussion of dispersion techniques to pre-template alginate particles, gelation mechanisms, considerations in selecting suitable fabrication methods, and future directions.

关键词： Alginate lonotropic gelation Immobilization Encapsulation Hydrogel

Stereotactic radiotherapy and the potential role of magnetic resonance-guided adaptive techniques for pancreatic cancer

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World Journal of Gastroenterology 2022年第7期28卷 745-754页

作者： Tai Ermongkonchai Richard Khor Vijayaragavan Muralidharan Niall Tebbutt Kelvin lim Numan Kutaiba Sweet ping Ng Department of Radiation Oncology Olivia Newton-John Cancer Centre at Austin HealthHeidelberg 3084VictoriaAustralia Department of Surgery Austin HealthHeidelberg 3084VictoriaAustralia Department of Medical Oncology Olivia Newton-John Cancer Centre at Austin HealthHeidelberg 3084VictoriaAustralia Department of Diagnostic Radiology Austin HealthHeidelberg 3084VictoriaAustralia

BACKGROUND Pancreatic cancer is a malignancy with one of the poorest prognoses amongst all *** with unresectable tumours either receive palliative care or undergo various chemoradiotherapy *** techniques are often associated with acute gastrointestinal toxicities,as adjacent critical structures such as the duodenum ultimately limits delivered *** body radiotherapy(SBRT)is an advanced radiation technique that delivers highly ablative radiation split into several fractions,with a steep dose fall-off outside target *** To discuss the latest data on SBRT and whether there is a role for magnetic resonance-guided techniques in multimodal management of locally advanced,unresectable pancreatic *** We conducted a search on multiple large databases to collate the latest records on radiotherapy techniques used to treat pancreatic *** of 1229 total records retrieved from our search,36 studies were included in this *** Studies indicate that SBRT is associated with improved clinical efficacy and toxicity profiles compared to conventional radiotherapy *** dose escalation to the tumour with SBRT is limited by the poor soft-tissue visualisation of computed tomography imaging during radiation planning and treatment *** resonance-guided techniques have been introduced to improve imaging quality,enabling treatment plan adaptation and re-optimisation before delivering each *** Therefore,SBRT may lead to improved survival outcomes and safer toxicity profiles compared to conventional techniques,and the addition of magnetic resonance-guided techniques potentially allows dose escalation and conversion of unresectable tumours to operable cases.

关键词： Magnetic resonance imaging Pancreatic cancer Radiotherapy Stereotactic Adaptive techniques

Advances on ultra-sensitive electrospun nanostructured electrochemical and colori metric sensors for diabetes mellitus detection

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Nano Materials Science 2021年第4期3卷 321-343页

作者： Mohamed Hasaan Hussain lim ping Fook Maria Kana Sanira Putri Huey Ling Tan Noor Fitrah Abu Bakar Norbert Radacsi School of Chemical Bngineering College of Engineering University Teknologi MARA 40450 Shah AlamSelangorMalaysia School of Engineering Institute for Materials and ProcessesThe University of EdinburghRobert Stevenson RoadEdinburghEH93FBUnited Kingdom

Recent developments in the biochemical and medicinal industries have been heavily focused on producing affordable glucose biosensors due to the condi nuous annual increase of diabetic patients *** devel-opment of a fast,accurate,and reliable glucose sensor will increase confidence in controlling di abetes mellitus and its assoclated health complications among the diabetic *** is a versatile method that can produce complex nanofbrous assemblies with attractiwe and functional characteristics from varlous *** nanofibers demonstrated high efficiency in the immobilization of biological molecules,which can improve the sensing performance *** ation of polymer electrospun nanofibers with metal nanoparticles,metal oxde or transition metal in producing nanobiocomposites is also a highly popul ar approach in the past few *** report presents the current progress and research trends of the technique,focusing on varous ma-terials and fabrication strategies used to produce biosensing *** helps readers decide the suitable approach in designing highly sensitive,selective,fast,and inexpensive glucose sensors.

关键词： Glucose sensor Electrospinning Nanofiber Electrochemical sensing Colorimetric sensing

Forensic examination of plastic drinking straws based on their physical characteristics and manufacturing marks

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Forensic Sciences Research 2020年第1期5卷 64-73页

作者： Alaric C.W.Koh Suat ping Oh Shing Min lim Sok Yee Yew Jean Chen Vicky Y.S.Chow Forensic Chemistry and Physics Laboratory Health Sciences AuthoritySingapore

This work highlights the evidential value of examining plastic drinking straws to establish linkages between multiple sources for forensic intelligence,investigative or prosecution *** drinking straws are commonly encountered in drug cases,either as inhalational paraphernalia or as packaging ***,to the best of our knowledge,systematic studies on the evidential value of straws have not previously been carried *** this study,over 80 packets of clear and colourless straws—most of which were visually similar—were purchased from various commercial outlets in *** physical characteristics(viz.,polarizing patterns,thickness,circumference and mass per unit length)and the manufactur-ing marks of these straws were examined to assess their potentials for discriminating straws from different *** of polarizing patterns yielded a discrimination of approximately 69%,while thickness,circumference,and mass per unit length measurements resulted in lower *** microscopy of manufacturing marks was found to be the most discriminating among all techniques employed herein,with a discrimination of about 95%,even among straws with similar polarizing patterns.

关键词： Forensic sciences drug packaging plastics manufacturing marks tool marks straw discrimination

Repeated exposure to moxa-burning smoke: its acute and chronic toxicities in rats

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Journal of Traditional Chinese Medicine 2018年第1期38卷 67-75页

作者： Han Li Liu Changxi Liu ping Hu Hai Yang Jia Cai Hong lim Minyee Zhu Maoxiang Pan Xiujie Huang Jian Cui Yingxue Lao Lixing Zhao Baixiao Shool of Chinese medicine Beijing University of Chinese Medicine Healthcare Management Center Beijing Electric Power Hospital Department of Acupunture Beijing Hospital of Acupuncture and Moxibustion Shool of Acupuncture-Moxibustion and Tuina Beijing University of Chinese Medicine Department of Traditional Chinese Medicine Chongqing Yubei District Hospital of Traditional Chinese Medicine Institute of Radiation Medicine China Academy of Military Medical Science Department of Acupunture Beijing Dong Fang Hospital Department of Acupunture Beijing Hospital of Traditional Chinese Medicine School of Chinese Medicine The University of Hong Kong

OBJECTIVE： To assess toxicities of the air in Chinese medicine clinics polluted by moxa-burning smoke due to moxibustion-derived burning products （MBP）. METHODS： Both acute and chronic toxicity studies were conducted. For the acute toxicity study, five groups of Wistar rats （n = 16/group, male： female = 1 ： 1） were exposed to five different concentrations （95%, 90%, 85%, 80% and 75%, respectively） of MBP for 2 h. For the chronic toxicity study, another three groups of male rats （n = 21/group） were ex- posed to MBP in three concentrations （10%, 40% and 70%, respectively） and one control group ex- posed to clean air 20 min/d for 144 d. Routine ex- aminations were performed and analyzed by analy- sis of variance and dose-response relationship. RESULTS： In the acute toxicity study, the number of dead rats in the 95%, 90%, 85%, 80% and 75% groups were 16, 13, 7, 6 LDS0 of 86.274% after or and 3, respectively, with during the 2 h exposure. In the chronic toxicity study, MBP exposure induced a decline in activity of the rats. Rats in the 10% group showed no signs of toxicity, while those in the 40% MBP group showed toxicity effects on the body weights （P 〈 0.05） and lung. Rats in the 70% MBP group also presented with reversible damage in the blood coagulation system （P 〈 0.05）. CONCLUSION： Exposure to 10% MBP, which is equivalent to 27.45 mg/m^3 was under the critical threshold for male rats＇safety. Exposure to MBP above that limit induced lung damage. MBP in clinics need to be reduced to a safe level with enhanced ventilation.

关键词： Smoke Moxibustion Environmental exposure Toxicity tests