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Caenorhabditis elegans deep lipidome profiling by using integrative mass spectrometry acquisitions reveals significantly altered lipid networks

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Journal of Pharmaceutical Analysis 2022年第5期12卷 743-754页

作者： Nguyen Hoang Anh Young cheol Yoon Young Jin Min Nguyen Phuoc Long cheol woon jung Sun Jo Kim Suk Won Kim Eun Goo Lee Daijie Wang Xiao Wang Sung Won Kwon College of Pharmacy Seoul National UniversitySeoul08826Republic of Korea School of Pharmaceutical Sciences Shandong Analysis and Test CenterQilu University of Technology(Shandong Academy of Sciences)Jinan250014China Biological Engineering Technology Innovation Center of Shandong Province Heze Branch of Qilu University of Technology(Shandong Academy of Sciences)HezeShandong274000China

Lipidomics coverage improvement is essential for functional lipid and pathway construction.A powerful approach to discovering organism lipidome is to combine various data acquisitions,such as full scan mass spectrometry(full MS),data-dependent acquisition(DDA),and data-independent acquisition(DIA).Caenorhabditis elegans(***)is a useful model for discovering toxic-induced metabolism,highthroughput drug screening,and a variety of human disease *** determine the lipidome of *** and investigate lipid disruption from the molecular level to the system biology level,we used integrative data *** methyl-tert-butyl ether method was used to extract L4 stage *** after exposure to triclosan(TCS),perfluorooctanoic acid,and nanopolystyrene(nPS).Full MS,DDA,and DIA integrations were performed to comprehensively profile the *** lipidome by Q-Exactive Plus *** annotated lipids were then analyzed using lipid ontology and pathway *** annotated up to 940 lipids from 20 lipid classes involved in various functions and *** biological investigations revealed that when *** were exposed to nPS,lipid droplets were disrupted,whereas plasma membrane-functionalized lipids were likely to be changed in the TCS treatment *** nPS treatment caused a significant disruption in lipid ***,glycerophospholipid,and ether class lipids were those primarily hindered by ***,toxicant exposure frequently involved numerous lipid-related pathways,including the phosphoinositide 3-kinase/protein kinase B *** conclusion,an integrative data acquisition strategy was used to characterize the *** lipidome,providing valuable biological insights into hypothesis generation and validation.

关键词： Caenorhabditis elegans Lipidomics Data-dependent acquisition Data-independent acquisition

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Anaphylactic shock induced by polyethylene glycol after bowel preparation for the colorectal cancer surgery:A case report

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World Journal of Clinical Cases 2023年第23期11卷 5589-5594页

作者： Go woon Park Nahyeon Park jung cheol Kuk Eung Jin Shin Dae Ro Lim Department of General Surgery Soonchunhyang Bucheon HospitalBucheon 14584South Korea

BACKGROUND Polyethylene glycol(PEG)is widely used as an additive because of its hydrophilic and chemically inert ***,there are been increasing reports of PEG allergies,including anaphylaxis,although they are still *** case report aims to raise awareness,that the commonly used bowel cleansing agent containing PEG can cause serious allergic *** SUMMARY Prior to surgery for sigmoid colon cancer,a 63-year-old man was prescribed a bowel cleansing agent containing *** 30 min of ingestion,he developed symptoms of anaphylactic shock and did not respond to initial intramuscular epinephrine *** diagnosis of anaphylaxis to PEG,he was stabilized with fluid hydration and continuous norepinephrine *** While allergic reactions to PEG are rare,they can be ***,it is crucial for clinicians to be aware of this possibility and to diagnose and resuscitate patients immediately.

关键词： Polyethylene glycol Anaphylaxis Sigmoid colon cancer Bowel preparation Case report

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A p53 genetic polymorphism of gastric cancer: Difference between early gastric cancer and advanced gastric cancer

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World Journal of Gastroenterology 2006年第40期12卷 6536-6539页

作者： Sun Young Yi woon jung Lee Department of Internal Medicine and Medical Research Center College of Medicine Ewha Womans University Seoul Korea

AIM: To investigate the role of the polymorphism of p53 codon 72 in early gastric cancer (EGC) and advanced gastric cancer (AGC) in Korean patients. METHODS: DNA was extracted from blood samples of gastric cancer patients (n = 291) and controls (n = 216). In the p53 codon 72 genotypes were determined by ***: Patients with gastric cancer had a significantly higher frequency of the homozygous proline (Pro) allele than the control (P = 0.032). Patients with AGC had a significantly higher frequency of the Arg/Arg (arginine) allele (P = 0.038) than EGC and a similar Pro/Pro allele. The signet ring cell type had a higher frequency of the Pro/Pro allele than other types (P = 0.031). The Pro/Pro genotype carries a 3.9-fold increased risk of developing gastric cancer (95% CI, 1.3-15.4, P = 0.039) when compared to Arg/Arg and Arg/Pro genotypes and to develop EGC is a 5.25 fold increased risk (95% CI, 1.8-19.6, P = 0.021). CONCLUSION: The Pro/Pro genotype of the p53 codon 72 polymorphism carries a higher risk for gastric cancer in general and is also associated with a much higher risk for EGC than AGC.

关键词： p53 gene Polymorphism Gastric cancer

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Translocator protein 18 kDa(TSPO): old dogma, new mice, new structure, and new questions for neuroprotection

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Neural Regeneration Research 2015年第6期10卷 878-880页

作者： Eun-jung Kim Seong-woon Yu Department of Brain and Cognitive Science Daegu Gyeongbuk Institute of Science and Technology (DGIST)

The normal development and optimal functioning of the brain requires a vigilant immune surveillance system to detect and remove potential risk factors and prevent infection and tissue damage. Microglia are the resident immune cells and the frontline defenders responsible for the immune response of the brain. Resting microglia possess a ramified morphology with numerous thin processes that continuously sample the environment. In response to inflammatory signals, microglia become activated and transform their morphology into a thick, amoeboid-like shape. Activated microglia proliferate, tolerate to sites of iniurv,

关键词： TSPO old dogma Translocator protein 18 kDa new mice new structure

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Effects of compressive stress on the nonlinear electromechanical behavior of ferroelectric ceramics

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Science China(Technological Sciences) 2006年第1期49卷 29-37页

作者： LEE jung-Ju KIM Hyun cheol Department of Mechanical Engineering KAIST Taejon 305-701 Korea

The effects of compressive stress parallel and perpendicular to the polar axis of PZT ceramics on the nonlinear electromechanical behavior of the materials has been experimentally studied. A domain-switching model that divides each 180° switching to two successive 90° switching is proposed to explain these effects. In the case of stress parallel to the polar axis, domain switching in the ceramics is approximately axisymmetric and can be simulated by an analytical model. While in the case of stress perpendicular to the polar axis, domain switching is three-dimensional and cannot be simplified. The simulated re-sults that match the experiments well show the validity of the proposed domain-switching model.

关键词： ferroelectric ceramics, domain switching, electromechanical, PZT.

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CORE:Common Region Extension Based Multiple Protein Structure Alignment for Producing Multiple Solution

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Journal of Computer Science & Technology 2013年第4期28卷 647-656页

作者： Woo-cheol Kim Sanghyun Park jung-Im Won College of Information Sciences and Technology The Pennsylvania State University University Park Department of Computer Science Yonsei University Research Center of Information and Electronic Engineering Hallym University Chuncheon

Over the past several decades, biologists have conducted numerous studies examining both general and specific functions of proteins. Generally, if similarities in either the structure or sequence of amino acids exist for two proteins, then a common biological function is expected. Protein function is determined primarily based on the structure rather than the sequence of amino acids. The algorithm for protein structure alignment is an essential tool for the research. The quality of the algorithm depends on the quality of the similarity measure that is used, and the similarity measure is an objective function used to determine the best alignment because of their individual strength and weakness However, none of existing similarity measures became golden standard They require excessive filtering to find a single alignment. In this paper, we introduce a new strategy that finds not a single alignment, but multiple alignments with different lengths. This method has obvious benefits of high quality alignment. However, this novel method leads to a new problem that the running time for this method is considerably longer than that for methods that find only a single alignment. To address this problem~ we propose algorithms that can locate a common region （CORE） of multiple alignment candidates, and can then extend the CORE into multiple alignments. Because the CORE can be defined from a final alignment, we introduce CORE＊ that is similar to CORE and propose an algorithm to identify the CORE＊. By adopting CORE＊ and dynamic programming, our proposed method produces multiple alignments of various lengths with higher accuracy than previous methods. In the experiments, the alignments identified by our algorithm are longer than those obtained by TM-align by 17% and 15.48%, on average, when the comparison is conducted at the level of super-family and fold, respectively.

关键词： structure alignment similarity search protein structure

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High-Movement Human Segmentation in Video Using Adaptive N-Frames Ensemble

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Computers, Materials & Continua 2022年第12期73卷 4743-4762页

作者： Yong-woon Kim Yung-cheol Byun Dong Seog Han Dalia Dominic Sibu Cyriac Centre for Digital Innovation CHRIST(Deemed to be University)Bangalore560029India Department of Computer Engineering Jeju National UniversityJeju63243Korea School of Electronics Engineering Kyungpook National UniversityDaegu41566Korea

Awide range of camera apps and online video conferencing services support the feature of changing the background in real-time for aesthetic,privacy,and security *** studies show that theDeep-Learning(DL)is a suitable option for human segmentation,and the ensemble of multiple DL-based segmentation models can improve the segmentation ***,these approaches are not as effective when directly applied to the image segmentation in a *** paper proposes an Adaptive N-Frames Ensemble(AFE)approach for high-movement human segmentation in a video using an ensemble of multiple DL *** contrast to an ensemble,which executes multiple DL models simultaneously for every single video frame,the proposed AFE approach executes only a single DL model upon a current video *** combines the segmentation outputs of previous frames for the final segmentation output when the frame difference is less than a particular *** method employs the idea of the N-Frames Ensemble(NFE)method,which uses the ensemble of the image segmentation of a current video frame and previous video ***,NFE is not suitable for the segmentation of fast-moving objects in a video nor a video with low frame *** proposed AFE approach addresses the limitations of the NFE *** experiment uses three human segmentation models,namely Fully Convolutional Network(FCN),DeepLabv3,and *** evaluated our approach using 1711 videos of the TikTok50f dataset with a single-person *** TikTok50f dataset is a reconstructed version of the publicly available TikTok dataset by cropping,resizing and dividing it into videos having 50 frames *** paper compares the proposed AFE with single models and the Two-Models Ensemble,as well as the NFE *** experiment results show that the proposed AFE is suitable for low-movement as well as high-movement human segmentation in a video.

关键词： High movement human segmentation artificial intelligence deep learning ensemble video instance segmentation

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Surface effects of hybrid vibration-assisted femtosecond laser system for micro-hole drilling of copper substrate

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中国有色金属学会会刊：英文版 2012年第S3期22卷 801-807页

作者： jung-Kyu PARK Ji-woon YOON Myung-Chang KANG Sung-Hak CHO Nano Machining Laboratory Korea Institute of Machinery and Materials Department of Nano-Mechatronics University of Science and Technology National Core Research Center for Hybrid Materials Solution Pusan National University

The ultrafast laser based hybrid machining system was studied and a novel approach was demonstrated to improve laser machining quality on metals by vibrating the optical objective lens with a low frequency (500 Hz) and various displacements (0-16.5 μm) during a femtosecond laser machining *** laser used in this experiment is an amplified Ti:sapphire femtosecond (10-15 s) laser system that generates 100 femtosecond pulses having an energy of 3.5 mJ/pulse with a 5 kHz repetition rate at a central wavelength of 790 *** is found that both the wall surface finish of the machined structures and the aspect ratio obtained using the frequency vibration assisted laser machining are improved compared with those derived via laser machining without vibration assistance.

关键词： femtosecond laser hybrid machining vibration-assisted machining surface roughness aspect ratio

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Aged T cells and cardiovascular disease

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Cellular & Molecular Immunology 2017年第12期14卷 1009-1010页

作者： Min Kyung jung Eui-cheol Shin Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and EngineeringKAISTDaejeon 34141Republic of Korea

Memory T cells undergo replicative senescence via repetitive *** in other cells,replicative senescence of T cells is characterized by shortened telomeres.1 Immunophenotypes are also altered in replicative senescent T cells compared to young T *** humans,replicative senescent T cells typically lose expression of CD28,a costimulatory receptor,and acquire the expression of CD57 antigen,a terminally sulfated glycan carbohydrateepitope,1 though the mechanism underlying this regulation has not yet been clearly ***,CD28−or CD57+T cells are considered replicative senescent T cells in humans.

关键词： CD57 cardiovascular typically

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Influence of undissolved second-phase particles on dynamic recrystallization behavior of Mg–7Sn–1Al–1Zn alloy during low-and high-temperature extrusions

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Journal of Materials Science & Technology 2021年第12期71卷 87-97页

作者： Hyun Ji Kim Sang-cheol Jin Jae-Gil jung Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu41566Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChangwon51508Republic of Korea

This study investigates the effects of fine and coarse undissolved particles in a billet of the Mg–7 Sn–1 Al–1 Zn(TAZ711)alloy on the dynamic recrystallization(DRX)behavior during hot extrusion at low and high temperatures and the resultant microstructure and mechanical properties of the *** this end,partially homogenized(PH)and fully homogenized(FH)billets are extruded at temperatures of250 and 450°*** PH billet contains fine and coarse undissolved Mg_(2) Sn particles in the interdendritic region and along the grain boundaries,*** fine particles(<1μm in size)retard DRX during extrusion at 250°C via the Zener pinning effect,and this retardation causes a decrease in the area fraction of dynamically recrystallized(DRXed)grains of the extruded *** addition,the inhomogeneous distribution of fine particles in the PH billet leads to the formation of a bimodal DRXed grain structure with excessively grown grains in particle-scarce *** contrast,in the FH billet,numerous nanosized Mg_(2) Sn precipitates are formed throughout the material during extrusion at 250°C,which,in turn,leads to the formation of small,uniform DRXed grains by the grain-boundary pinning effect of the *** the PH billet is extruded at the high temperature of 450°C,the retardation effect of the fine particles on DRX is weakened by their dissolution in theα-Mg matrix and the increased extent of thermally activated grain-boundary *** contrast,the coarse Mg_(2) Sn particles in the billet promote DRX during extrusion through the particle-stimulated nucleation phenomenon,which results in an increase in the area fraction of DRXed *** both low and high extrusion temperatures,the extruded material fabricated using the PH billet,which contains both fine and coarse undissolved particles,has a lower tensile strength than that fabricated using the FH billet,which is virtually devoid of second-phase *** lower strength of the former is attributed mai

关键词： Mg–Sn alloy Second-phase particle Extrusion Homogenization Dynamic recrystallization

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