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Ginsenoside Rk3 modulates gut microbiota and regulates immune response of group 3 innate lymphoid cells to against colorectal tumorigenesis

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Journal of Pharmaceutical Analysis 2024年第2期14卷 259-275页

作者： Xue Bai Rongzhan Fu Yannan Liu Jianjun Deng Qiang Fei Zhiguang Duan chenhui zhu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi'an710069China Biotech&Biomed Research Institute Northwest UniversityXi'an710069China School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'an710069China

The gut microbiota plays a pivotal role in the immunomodulatory and protumorigenic microenvironment of colorectal cancer(CRC).However,the effect of ginsenoside Rk3(Rk3)on CRC and gut microbiota remains unclear.Therefore,the purpose of this study is to explore the potential effect of Rk3 on CRC from the perspective of gut microbiota and immune regulation.Our results reveal that treatment with Rk3 significantly suppresses the formation of colon tumors,repairs intestinal barrier damage,and regulates the gut microbiota imbalance caused by CRC,including enrichment of probiotics such as Akkermansia muciniphila and Barnesiella intestinihominis,and clearance of pathogenic Desulfovibrio.Subsequent metabolomics data demonstrate that Rk3 can modulate the metabolism of amino acids and bile acids,particularly by upregulating glutamine,which has the potential to regulate the immune response.Furthermore,we elucidate the regulatory effects of Rk3 on chemokines and inflammatory factors associated with group 3 innate lymphoid cells(ILC3s)and T helper 17(Th17)signaling pathways,which inhibits the hyperactivation of the Janus kinase-signal transducer and activator of transcription 3(JAK-STAT3)signaling pathway.These results indicate that Rk3 modulates gut microbiota,regulates ILC3s immune response,and inhibits the JAK-STAT3 signaling pathway to suppress the development of colon tumors.More importantly,the results of fecal microbiota transplantation suggest that the inhibitory effect of Rk3 on colon tumors and its regulation of ILC3 immune responses are mediated by the gut microbiota.In summary,these findings emphasize that Rk3 can be utilized as a regulator of the gut microbiota for the prevention and treatment of CRC.

关键词： Colorectal cancer Ginsenoside Immune cells Gut microbiota

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Delineation of urban growth boundary based on FLUS model under the perspective of land use evaluation in hilly mountainous areas

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Journal of Mountain Science 2024年第5期21卷 1647-1662页

作者： ZHANG Yunping LIN Jianping HUANG Yimin CHEN Zebin zhu chenhui YUAN Hao School of Geography and Environmental Engineering Gannan Normal UniversityGanzhou 341000China Key Laboratory of Low Carbon Recycling Technology for Municipal Solid Waste in Jiangxi Province Ganzhou 341000China

With rapid economic development,the size of urban land in China is expanding dramatically.The Urban Growth Boundary(UGB)is an expandable spatial boundary for urban construction in a certain period in order to control the urban sprawl.Reasonable delineation of UGB can inhibit the disorderly spread of urban space and guide the normal development of the city.It is of practical significance for the construction of green urban space.The study utilizes GIS technology to establish a land construction suitability evaluation system for Nankang city,which is experiencing rapid urban expansion,and outlines the preliminary UGB under the future land use simulation(FLUS)model.At the same time,considering the coupled coordination of"Production-Living-Ecological Space",and based on the suitability evaluation,we revised the preliminary UGB by combining the advantages of the patch-generating land use simulation(PLUS)model and the convex hull model to delineate the final UGB.The results show that:1)the comprehensive score of the evaluation of the suitability of the construction of land from high to low shows the distribution of the center of the city to the surrounding circle type spread,the center of the city has the highest suitability score.The results of convex hull model show that the urban expansion type of Nankang is epitaxial.In the future,the urban expansion will mainly occur in the northern part of the city.The PLUS model predicts an increase of 3359.97 hm^(2)of construction land in Nankang by 2035,of which 2022.97 hm^(2)is urban construction land.2)The FLUS model has a prediction accuracy of 86.3%and delineates a preliminary UGB area of 9215.07 hm^(2).3)We used the results of the construction suitability evaluation,PLUS model simulation results,and convex hull model predictions to revise the originally delineated UGB.The final delineated UGB area is 8895.67 hm^(2)and it is capable of meeting the future development of the study area.The results of the delineation can promote sustainable urban development,and the delineati

关键词： Urban sprawl FLUS model Spatial correction Urban growth boundary Sustainable development

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Construction of multifunctional hydrogel based on the tannic acid-metal coating decorated MoS2 dual nanozyme for bacteria-infected wound healing

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Bioactive Materials 2022年第3期7卷 461-474页

作者： Yang Li Rongzhan Fu Zhiguang Duan chenhui zhu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi’an710069ShaanxiChina Shaanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityXi’an710069ShaanxiChina Biotech.&Biomed.Research Institute Northwest UniversityXi’an710069ShaanxiChina

Bacterial infection,tissue hypoxia and inflammatory response can hinder the infected wound repair process.To mitigate the above issues,tannic acid-chelated Fe-decorated molybdenum disulfide nanosheets(MoS2@TA/Fe NSs)with dual enzyme activities were developed and anchored to a multifunctional hydrogel.The hydrogel exhibited excellent antibacterial ability owing to the combined effects of photothermal therapy(PTT),glutathione(GSH)loss,and the peroxidase(POD)-like activity(catalyse H2O_(2)into⋅OH under acid condition)of MoS2@TA/Fe NSs.Benefitting from the catalase(CAT)-like activity,the hydrogel could decompose H2O_(2)into O_(2)at neutral pH to relieve hypoxia and supply adequate O_(2).POD-like activity was mainly attributed to MoS2 NSs,while CAT-like activity was primarily due to TA/Fe complex.Moreover,MoS2@TA/Fe NSs endowed the hydrogel with outstanding anti-oxidant ability to scavenge redundant reactive oxygen species(ROS)and reactive nitrogen species(RNS)under neutral environment to maintain the balance of antioxidant systems and prevent inflammation.In addition,the hydrogel could inhibit the release of inflammatory factors for the anti-inflammatory property of TA.TA retained partial phenolic hydroxyl groups,which cross-linked the nanosheets to the network structure of the hydrogel and promoted the adhesion of hydrogels.Due to the dynamic boron ester bonds between polyvinyl alcohol(PVA),dextran(Dex),MoS2@TA/Fe,and borax,the hydrogel demonstrated fast self-healing and rapid shape adaptability.This shape-adaptable adhesive hydrogel could fill the whole wound and closely contact the wound,ensuring that it achieved its functions with maximum efficiency.The MoS2@TA/Fe nanozyme-anchored multifunctional hydrogel showed high potential for bacteria-infected wound healing.

关键词： MoS2@TA/Fe nanozyme Multifunctional hydrogel POD-Like CAT-Like Anti-inflammation

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Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing

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Bioactive Materials 2022年第11期7卷 1-17页

作者： Wanyi Zhou Zhiguang Duan Jing Zhao Rongzhan Fu chenhui zhu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi’an710069ShaanxiChina Shaanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityXi’an710069ShaanxiChina Biotech.&Biomed.Research Institute Northwest UniversityXi’an710069ShaanxiChina

Chronic diabetic wounds are an important healthcare challenge. High concentration glucose, high level of matrix metalloproteinase-9 (MMP-9), and long-term inflammation constitute the special wound environment of diabetic wounds. Tissue necrosis aggravates the formation of irregular wounds. All the above factors hinder the healing of chronic diabetic wounds. To solve these issues, a glucose and MMP-9 dual-response temperature-sensitive shape self-adaptive hydrogel (CBP/GMs@Cel&INS) was designed and constructed with polyvinyl alcohol (PVA) and chitosan grafted with phenylboric acid (CS-BA) by encapsulating insulin (INS) and gelatin microspheres con-taining celecoxib (GMs@Cel). Temperature-sensitive self-adaptive CBP/GMs@Cel&INS provides a new way to balance the fluid-like mobility (self-adapt to deep wounds quickly, approximately 37 ◦C) and solid-like elasticity (protect wounds against external forces, approximately 25 ◦C) of self-adaptive hydrogels, while simultaneously releasing insulin and celecoxib on-demand in the environment of high-level glucose and MMP-9. Moreover, CBP/ GMs@Cel&INS exhibits remodeling and self-healing properties, enhanced adhesion strength (39.65 ± 6.58 kPa), down-regulates MMP-9, and promotes cell proliferation, migration, and glucose consumption. In diabetic full-thickness skin defect models, CBP/GMs@Cel&INS significantly alleviates inflammation and regulates the local high-level glucose and MMP-9 in the wounds, and promotes wound healing effectively through the synergistic effect of temperature-sensitive shape-adaptive character and the dual-responsive system.

关键词： Dual-responsive Temperature-sensitive Shape self-adaptive hydrogels Diabetic wound healing

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乡村振兴的中国道路:特征、历程与展望

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农业经济问题 2024年第2期 4-17页

作者：杨骞祝辰辉山东财经大学经济学院济南250002

乡村振兴是新时代中国的国家战略,是实现农业农村现代化和建设农业强国的重要任务。党的二十大报告指出,全面推进乡村振兴,坚持农业农村优先发展,巩固拓展脱贫攻坚成果,加快建设农业强国,扎实推动乡村产业、人才、文化、生态、组织振兴... 详细信息

乡村振兴是新时代中国的国家战略,是实现农业农村现代化和建设农业强国的重要任务。党的二十大报告指出,全面推进乡村振兴,坚持农业农村优先发展,巩固拓展脱贫攻坚成果,加快建设农业强国,扎实推动乡村产业、人才、文化、生态、组织振兴。本文全景式展现了中国乡村振兴的基本特征,深刻阐释了中国乡村振兴的内在逻辑,系统梳理了中国乡村振兴的实践历程,真实立体地展示了新时代中国乡村振兴取得的阶段性重大成就。乡村振兴为中国化解社会主要矛盾提供了实践路径,为加快建设农业强国、推进中国式现代化提供了有力支撑,同时也为发展中国家解决“三农”问题提供了中国方案。面向全面建设社会主义现代化国家新征程,要继续发挥中国特色社会主义制度优势、建设数字乡村赋能乡村全面振兴、积极完善乡村振兴法治体系、深化城乡融合发展,谱写建设农业强国新篇章。

关键词：党的二十大乡村振兴中国道路道路自信

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Dietary phytochemicals: As a potential natural source for treatment of Alzheimer's Disease

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Food Innovation and Advances 2023年第1期2卷 36-43页

作者： zhuo Ren Haixia Yang chenhui zhu Daidi Fan Jianjun Deng Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringBiotech&Biomed Research InstituteSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China College of Food Science and Nutritional Engineering China Agricultural UniversityBeijing 100083China

Alzheimer's disease(AD)is a common neurodegenerative disease,which seriously impairs human health and life.At present,scientists have proposed more than a dozen hypotheses about the pathogenesis of AD,including the tau propagation hypothesis.However,the exact ultimate pathogenic factor of AD remains unknown.Based on the current hypotheses,some anti-AD drugs(e.g.,donepezil and Ketamine)have been developed and used in clinical treatment,which fall into two main categories,acetylcholinesterase inhibitors(AChEIs)and N-methyl-D-aspartate(NMDA)receptor antagonists,the former representative drug is donepezil,and the latter representative drug is memantine.Since these drugs have undesirable side effects,it is necessary to find safer alternatives for AD treatment.Interestingly,dietary phytochemicals have the advantages of wide source,safety,and high biological activity,which is the natural route for screening anti-AD drugs.In this study,several representatives’dietary phytochemicals with anti-AD effect,including resveratrol,lycopene,gallic acid,berberine,ginsenoside Rg1,pseudoginsenoside-F11,ginsenoside Rh2,artemisinin,and torularhodin were selected from the published data over the last 10 years and their potential molecular mechanisms and clinical applications reviewed in the treatment of AD.

关键词： drugs Alzheimer treatment

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Unraveling the Effect of Stacking Configurations on Charge Transfer in WS_(2) and Organic Semiconductor Heterojunctions

Precision Chemistry

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Precision Chemistry 2023年第7期1卷 443-451页

作者： Shuchen Zhang Dewei Sun Jiaonan Sun Ke Ma Zitang Wei Jee Yung Park Aidan H.Coffey chenhui zhu Letian Dou Libai Huang Davidson School of Chemical Engineering Purdue UniversityWest LafayetteIndiana 47907United States Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCalifornia 94720United States Department of Chemistry Purdue UniversityWest LafayetteIndiana 47907United States

Photoinduced interfacial charge transfer plays a critical role in energy conversion involving van der Waals(vdW)heterostructures constructed of inorganic nanostructures and organic materials.However,the effect of molecular stacking configurations on charge transfer dynamics is less understood.In this study,we demonstrated the tunability of interfacial charge separation in a type-Ⅱ heterojunction between monolayer(ML)WS_(2) and an organic semiconducting molecule[2-(3″′,4′-dimethyl-[2,2′:5′,2′:5″,2″′-quaterthiophen]-5-yl)ethan-1-ammonium halide(4Tm)]by rational design of relative stacking configurations.The assembly between ML-WS_(2) and the 4Tm molecule forms a face-to-face stacking when 4Tm molecules are in a selfaggregation state.In contrast,a face-to-edge stacking is observed when 4Tm molecule is incorporated into a 2D organic-inorganic hybrid perovskite lattice.The face-to-face stacking was proved to be more favorable for hole transfer from WS_(2) to 4Tm and led to interlayer excitons(IEs)emission.Transient absorption measurements show that the hole transfer occurs on a time scale of 150 fs.On the other hand,the face-to-edge stacking resulted in much slower hole transfer without formation of IEs.This inefficient hole transfer occurs on a similar time scale as A exciton recombination in WS_(2),leading to the formation of negative trions.These investigations offer important fundamental insights into the charge transfer processes at organic−inorganic interfaces.

关键词： Charge transfer two-dimensional materials organic semiconductors heterojunction stacking configuration interlayer exciton

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中国三大粮食作物产能提升的源泉

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中国软科学 2024年第4期 46-55页

作者：杨骞祝辰辉寇相涛白鲁佳山东财经大学经济学院山东济南250014 山东财经大学高质量发展研究中心山东济南250014

保障粮食和重要农产品稳定安全供给始终是建设农业强国的头等大事。在新一轮千亿斤粮食产能提升背景下,聚焦稻谷、小麦、玉米三大主要粮食作物,利用增长核算分析框架揭示中国三大主要粮食作物产能提升的源泉。研究发现:对于稻谷和小麦而... 详细信息

保障粮食和重要农产品稳定安全供给始终是建设农业强国的头等大事。在新一轮千亿斤粮食产能提升背景下,聚焦稻谷、小麦、玉米三大主要粮食作物,利用增长核算分析框架揭示中国三大主要粮食作物产能提升的源泉。研究发现:对于稻谷和小麦而言,全要素生产率提升是这两类作物产能提升的主要源泉,其对稻谷、小麦产能提升的贡献率分别达到85.39%、100.93%,拉动稻谷、小麦产能分别提升0.91%、2.39%。就玉米而言,党的十八大之前,土地是玉米产能提升的主要源泉,其贡献率达到64.13%,拉动玉米产能提升4.11%;党的十八大以来,全要素生产率成为玉米产能提升的主要源泉,其贡献率达到64.38%,拉动玉米产能提升1.27%。研究结果为粮食品种结构优化及粮食产量可持续增长提供重要参考。

关键词：粮食产能提升粮食安全索洛余值全要素生产率增长源泉

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High efficiency production of ginsenoside compound K by catalyzing ginsenoside Rb1 using snailase

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Chinese Journal of Chemical Engineering 2018年第7期26卷 1591-1597页

作者： Zhiguang Duan chenhui zhu Jingjing Shi Daidi Fan Jianjun Deng Rongzhan Fu Rong Huang Cuiying Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityTaibai North Road 229Xi'an 710069China Shanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical Engineering Northwest University Taibai North Road 229Xi'an 710069China

The rare ginsenoside Compound K(C-K) is attracting more attention because of its good physiological activity and urgent need. There are many pathways to obtain ginsenoside C-K, including chemical and biological methods. Among these, the conversion of PPD-type ginsenosides by enzymatic hydrolysis is a trend due to its high efficiency and mild conditions. For effectively extracting from the other panaxadiol saponins, the conversion process for ginsenoside C-K was investigated using snailases in this study. The univariate experimental design and response surface methodology were used to determine the optimal hydrolysis conditions for the conversion of ginsenoside Rb1 into ginsenoside C-K by snailases. The optimum conditions were as follows: p H 5.12, temperature 51 °C, ratio of snailase/substrate 0.21, and reaction time 48 h. On the basis of these parameters, the addition of 1.0 mmol·L^(-1) ferric ion was found to significantly improve the enzymolysis of snailases for the first time. With the above conditions, the maximum conversion rate reached 89.7%, suggesting that the process can obviously increase the yield of ginsenoside C-K. The bioassay tests indicated that the ginsenoside C-K showed anti-tumor activity in a series of tumor cell lines. Based on these results, we can conclude that the process of rare ginsenoside CK production by enzymolysis with snailase is feasible, efficient, and suitable for the industrial production and application.

关键词：人参皂甙工业生产混合物催化水解作用反应时间生物鉴定温和条件

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晚熟槜李新品种醉贵妃的选育

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果树学报 2024年第4期41卷 786-790页

作者：谢小波李斌江挺李昊朱晨辉浙江省农业科学院园艺研究所杭州310021 嘉兴市农渔技术推广站浙江嘉兴314050 嘉兴市南湖区农业管理服务中心浙江嘉兴314001 新昌县林业技术推广中心浙江新昌312500 嘉兴市秀洲区果树与蚕桑技术推广站浙江嘉兴314011

醉贵妃是从收集的槜李种质资源中选育出的晚熟槜李新品种。该品种在嘉兴地区一般7月上中旬成熟,有些年份在6月下旬成熟。醉贵妃结果性状好,产量稳定,成年树产量控制在9.0 t·hm^(-2)左右即可;成熟时口感极佳,汁水丰富,符合槜李易化浆、... 详细信息

醉贵妃是从收集的槜李种质资源中选育出的晚熟槜李新品种。该品种在嘉兴地区一般7月上中旬成熟,有些年份在6月下旬成熟。醉贵妃结果性状好,产量稳定,成年树产量控制在9.0 t·hm^(-2)左右即可;成熟时口感极佳,汁水丰富,符合槜李易化浆、可吸食特征;可溶性固形物含量(w,后同)16.0%左右,高达20%;果形大,平均单果质量69.5 g,呈扁圆形、较对称;成熟果实外皮深紫红色并密布灰白色果点,果肉黄色,黏核;少有细菌性穿孔病和流胶病;自交结果性较好,可单一品种种植;树姿稍显直立,需要拉枝并结合其他修剪措施塑造开心树形;进入结果期后以有机肥为主,需严格控制氮肥使用。该品种经多地试种,适宜在浙、赣、黔、川、渝、沪、苏等长江以南区域多省份种植。

关键词：中国李槜李新品种醉贵妃晚熟桐乡槜李

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