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Synthetic and Systems Biotechnology 2023年第4期8卷 640-646页

作者： Haowen Zhao Yuhao Ren Feng Xie Huanqin Dai Hongwei Liu chengzhang fu Rolf Müller Helmholtz Institute for Pharmaceutical Research Saarland(HIPS) Helmholtz Centre for Infection Research(HZI)and Department of PharmacySaarland University66123SaarbrückenGermany Helmholtz International Lab for Anti-Infectives Helmholtz Center for Infection Research38124BraunschweigGermany Institute of Marine Biology and Pharmacology Ocean CollegeZhejiang University316021ZhoushanChina State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences555 Zuchongzhi Road201203ShanghaiChina State Key Lab of Mycology Institute of MicrobiologyChinese Academy of Sciences100101BeijingChina

The biosynthetic potential of actinobacteria to produce novel natural products is still regarded as *** this paper,we correlated a cryptic biosynthetic gene cluster to chemical molecules by genome mining and chemical analyses,leading to the discovery of a new group of catecholate-hydroxamate siderophores,nobachelins,from Nocardiopsis baichengensis DSM *** biosynthesis genes are conserved in several bacteria from the family ***,nobachelins feature fatty-acylated hydroxy-ornithine and a rare chlorinated catecholate ***,nobachelins rescued Caenorhabditis elegans from Pseudomonas aeruginosa-mediated killing.

关键词： Nocardiopsis Genome mining Siderophore Pseudomonas aeruginosa Infection

Interrogation of Streptomyces avermitilis for efficient production of avermectins

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Synthetic and Systems Biotechnology 2016年第1期1卷 7-16页

作者： Jinsong Chen Mei Liu Xueting Liu Jin Miao chengzhang fu Heyong Gao Rolf Muller Qing Zhang Lixin Zhang Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijingChina Graduate University of Chinese Academy of Sciences BeijingChina Helmholtz Institute for Pharmaceutical Research Saarland Helmholtz Centre for Infection Research66123SaarbruckenGermany Department of Pharmaceutical Biotechnology Saarland UniversityBuilding C 2.366123SaarbruckenGermany Inner Mongolia New Veyong Biochemical Co. LtdInner Mongolia Dalad BannerChina

The 2015 Nobel Prize in Physiology or Medicine has been awarded to avermectins and artemisinin,*** produced by Streptomyces avermitilis are excellent anthelmintic and potential antibiotic *** wild-type strains only produce low levels of avermectins,much research effort has focused on improvements in avermectin production to meet the ever increasing demand for such *** review describes the strategies that have been widely employed and the future prospects of synthetic biology applications in avermectin yield *** the help of genome sequencing of *** and an understanding of the avermectin biosynthetic/regulatory pathways,synthetic and systems biotechnology approaches have been applied for precision *** focus on the design and synthesis of biological chassis,parts,devices,and modules from diverse microbes to reconstruct and optimize their dynamic processes,as well as predict favorable effective overproduction of avermectins by a 4Ms strategy(Mine,Model,Manipulation,and Measurement).

关键词： Avermectins Metabolic engineering Streptomyces avermitilis Synthetic biology

Mechanisms of tigecycline resistance in Gram-negative bacteria:A narrative review

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Engineering Microbiology 2024年第3期4卷 54-61页

作者： Wenya Su Wenjia Wang Ling Li Mengge Zhang Hai Xu chengzhang fu Xiuhua Pang Mingyu Wang State Key Laboratory of Microbial Technology Microbial Technology InstituteShandong UniversityQingdao 266237PR China Helmholtz Institute for Pharmaceutical Research Saarland(HIPS) Helmholtz Centre for Infection Research(HZI)and Department of PharmacySaarland UniversitySaarbrücken 66123Germany

Tigecycline serves as a critical“final-resort”antibiotic for treating bacterial infections caused by multidrug-resistant bacteria for which treatment options are severely *** increasing prevalence of tigecycline resistance,particularly among Gram-negative bacteria,is a major *** mechanisms have been iden-tified as contributors to tigecycline resistance,including upregulation of nonspecific Resistance Nodulation Divi-sion(RND)efflux pumps due to mutations in transcriptional regulators,enzymatic modification of tigecycline by monooxygenase enzymes,and mutations affecting tigecycline binding *** review aims to consolidate our understanding of tigecycline resistance mechanisms in Gram-negative bacteria and offer insights and perspectives for further drug development.

关键词： Gram-negative bacteria Tigecycline Tigecycline resistance Resistance mechanisms RND efflux pump

Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea

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Synthetic and Systems Biotechnology 2016年第1期1卷 39-46页

作者： Hang Wu Yansheng Wang Li Yuan Yongrong Mao Weiwei Wang Lin Zhu Panpan Wu chengzhang fu Rolf Muller David T.Weaver Lixin Zhang Buchang Zhang Institute of Health Sciences School of Life SciencesAnhui UniversityHefei 230601China CAS Key Laboratory of Pathogenic Microbiology&Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Helmholtz Institute for Pharmaceutical Research Helmholtz Centre for Infection Research and Department of Pharmaceutical BiotechnologySaarland UniversityP.O.Box 1511566041 SaarbruckenGermany

Erythromycin A is a widely used antibiotic produced by Saccharopolyspora erythraea;however,its biosynthetic cluster lacks a regulatory gene,limiting the yield enhancement via regulation engineering of ***,six TetR family transcriptional regulators(TFRs)belonging to three genomic context types were individually inactivated in *** A226,and one of them,SACE_3446,was proved to play a negative role in regulating erythromycin *** and qRT-PCR analysis revealed that SACE_3446 covering intact N-terminal DNA binding domain specifically bound to the promoter regions of erythromycin biosynthetic gene eryAI,the resistant gene ermE and the adjacent gene SACE_3447(encoding a longchain fatty-acid CoA ligase),and repressed their ***,we explored the interaction relationships of SACE_3446 and previously identified TFRs(SACE_3986 and SACE_7301)associated with erythromycin *** demonstrated relatively independent regulation mode of SACE_3446 and SACE_3986 in erythromycin biosynthesis,we individually and concomitantly inactivated them in an industrial *** *** with WB,the WBΔ3446 and WBΔ3446Δ3986 mutants respectively displayed 36%and 65%yield enhancement of erythromycin A,following significantly elevated transcription of eryAI and *** cultured in a 5 L fermentor,erythromycin A ofWBΔ3446 and WBΔ3446Δ3986 successively reached 4095 mg/L and 4670 mg/L with 23%and 41%production improvement relative to *** strategy reported here will be useful to improve antibiotics production in other industrial actinomycete.

关键词： Saccharopolyspora erythraea Erythromycin TetR family SACE_3446 Regulatory network

青海都兰热水墓群2018血渭一号墓出土鋬指金杯考——兼谈吐谷浑与粟特的商贸关系

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故宫博物院院刊 2024年第1期 43-52,166页

作者：付承章中山大学历史学系(珠海)

在青海都兰热水墓群2018血渭一号墓中出土了一件鋬指金杯。本文通过将其与唐、粟特艺术中的同类器物进行比较,认为它可能是一件7世纪的粟特输入品,反映了吐谷浑同粟特之间密切的商贸往来。这样的发现在当时并非孤例,共同验证了吐谷浑在... 详细信息

在青海都兰热水墓群2018血渭一号墓中出土了一件鋬指金杯。本文通过将其与唐、粟特艺术中的同类器物进行比较,认为它可能是一件7世纪的粟特输入品,反映了吐谷浑同粟特之间密切的商贸往来。这样的发现在当时并非孤例,共同验证了吐谷浑在中西文化交流史上的重要地位和作用,由此也进一步证明,多元文化的碰撞交融是吐蕃时期青藏高原东部十分普遍的文化现象。

关键词： 2018血渭一号墓鋬指金杯粟特吐谷浑

再论大同南郊北魏遗址所出人物纹银碗——兼谈东信家居广场所出银戒指

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中国国家博物馆馆刊 2019年第9期 68-77页

作者：付承章中国人民大学北方民族考古研究所

大同南郊北魏遗址所出的人物纹银碗,上面的徽章式半身人物像在萨珊银器中十分盛行。经对比研究,大同银碗上人物所戴圆帽不同于萨珊银器中的人物头饰,缺乏飘带、球状物等萨珊式特征,多在中亚一带的印章、银器上有所体现,但不一定带有嚈... 详细信息

大同南郊北魏遗址所出的人物纹银碗,上面的徽章式半身人物像在萨珊银器中十分盛行。经对比研究,大同银碗上人物所戴圆帽不同于萨珊银器中的人物头饰,缺乏飘带、球状物等萨珊式特征,多在中亚一带的印章、银器上有所体现,但不一定带有嚈哒风格。银碗可能产自中亚,而头部侧面、胸部正面的姿势也并不局限于萨珊文化,带有这种姿势的徽章式半身人物像早在公元3-4世纪的罗马玻璃碗上就有出现。其年代跨度较大,文化属性复杂多样。另外,人物面向不一的特点表明这一时期多元文化交融的现象十分盛行。而大同东信家居广场所出银戒指上的半身女性人物像,具有眼部呈三角形、高鼻、圆下巴、双长辫分开的特点,这些特征多体现在带有嚈哒风格的中亚戒面和印章之中。

关键词：萨珊徽章圆帽嚈哒

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function,atrio-ventricular node function and hemodynamics

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Journal of Nanjing Medical University 2007年第6期21卷 386-389页

作者： Jingming Zhu Ningning Hui Xiuhong Jiang Huaxing Zhang chengzhang fu Department of Anesthesiology the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China

Objective：To investigate the influences of urapidil and nicardipine on rabbit sinus function, atrio-ventricular node function and hemodynamics. Methods：Thirty-two Angora＇ s rabbits were selected and randomly divided into four groups. U1 group：urapidil 0.25 mg/kg; U2 group：urapidil 0.5 mg/kg; N1 group：nicardipine 10 μg/kg; N2 group： nicardipine 20 μg/kg. All these medicine were administrated within 30 seconds. Measurements were taken before and after the administration of urapidil or nicardipine for the following data： mean blood pressure（MAP）, heart rate（HR）, sino-atrial conduction time（SACT）, maximal sinoatrial recovery time（SNRTmax） corrected sinus node recovery time（CSNRT）, index of sinus node recovery time（SNRTI）, Wenckebach A-V conduction frequency （WB）, and P-R interval. Results：Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine. No significant changes could be found in the rest of the parameters. Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group（P 〈 0.01）; the MAP decreased（P 〈 0.01） and the HR increased drastically（P〈 0.01）. Conclusions：Neither urapidil（0.25 mg/kg, 0,5 mg/kg） nor nicardipine（10 μg/kg, 20 μg/kg） has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function. Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.

关键词： urapidil nicardipine sinus function A-V node function hemodynamics

Anesthetic considerations for the patients with off-pump coronary artery bypass grafting

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Journal of Nanjing Medical University 2005年第5期19卷 270-276页

作者： Xinchun Chen chengzhang fu Chris Cokis Department of Anesthesia the Affiliated Hospital of Nanjing Medical University Nanjing 210029 Department of Anesthesia and pain medicine Royal Perth Hospital Western Australia Perth 6004 Australia

New surgical techniques for coronary artery bypass graft （CABG） have been explored in order to minimize disfiguring scars, avoid cardiopulmonary bypass and decrease hospital residence and costs etc. Improved surgical expense can perform the procedures in some high-risk patients such as poor left ventricular function, redo CABG, advanced age and renal dysfunction etc. Intraoperatively there is an obligatory period of myocardial ischemia, which may lead to significant hemodynamic consequences. It is a quite challenge to anesthetist in managing the intraoperative patient.

关键词： coronary artery bypass graft cardiopulmonary bypass myocardial ischemia bispectral index transesophageal echocardiography

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试论萨珊银器的相关概念及主要特征

丝绸之路研究集刊

丝绸之路研究集刊 2022年第2期 350-360,533页

作者：付承章中山大学历史学系珠海校区

作为古代伊朗文化的集大成者,萨珊艺术毫无疑问在世界艺术史上具有不可忽视的重要地位:它一方面继承和发扬了具有悠久历史的古代东方传统,另一方面又汲取了希腊罗马以及其他一些外来文化因素,最终融会贯通于本土艺术之中。在东西方艺术... 详细信息

作为古代伊朗文化的集大成者,萨珊艺术毫无疑问在世界艺术史上具有不可忽视的重要地位:它一方面继承和发扬了具有悠久历史的古代东方传统,另一方面又汲取了希腊罗马以及其他一些外来文化因素,最终融会贯通于本土艺术之中。在东西方艺术的碰撞交融过程中,独树一帜的萨珊艺术表现出了强劲的时空影响力。这其中又以传世最多且最具特色的金属细工最富代表性,尤其是银器。本文旨在通过对萨珊银器基本概念、主要特征的分析,尝试就其反映出的一些相关问题进行讨论,以求教于学界方家。

关键词：东西方艺术外来文化因素银器古代东方碰撞交融融会贯通希腊罗马萨珊

青海都兰热水墓群2018血渭一号墓出土指金杯考--兼谈吐谷浑与粟特的商贸关系

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中国土族 2024年第1期 36-43页

作者：付承章中山大学历史学系(珠海)

关键词：中西文化交流史吐谷浑吐蕃时期粟特青海都兰墓群多元文化商贸往来