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Genes & Diseases 2024年第5期11卷 94-97页

作者： chengbin guo Yuqin Tang Zhihai Liu a Chuanliang Chen Xun Hu Yongqiang Zhang Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhouGuangdong 510623China Clinical Bioinformatics Experimental Center Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan 450003China School of Pharmacy Macao University of Science and TechnologyTaipaMacao 999078China Clinical Research Center The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310003China Biorepository State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China West China School of Medicine West China HospitalSichuan UniversityChengduSichuan 610041China

The high recurrence and low responsiveness to immunotherapy make ovarian cancer(OC)the most lethal gynecological *** microenvironment is critical in risk stratification and the discovery of molecular *** developed a prognostic classification for OC,which could also predict the prognosis of other gynecological cancers including breast cancer,endometrial cancer,and cervical *** mutation,hallmark pathways,and immune landscapes were *** analysis of immune checkpoints and multiple immune signatures revealed the low-risk group responds better to immune checkpoint inhibitors,which was validated by an external immunotherapeutic cohort(IMvigor210).Singlecell RNA sequencing(scRNA-seq)confirmed the high expression of SERPINB1 and SERPINB9 in dendritic cells,and AlphaFold2 was used to infer their 3D protein *** molecular compounds binding to SERPINB1/SERPINB9 were predicted by virtual screening.

关键词： prognosis cancer treatment

Hallmark guided identification and characterization of a novel immune-relevant signature for prognostication of recurrence in stageⅠ-Ⅲlung adenocarcinoma

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Genes & Diseases 2023年第4期10卷 1657-1674页

作者： Yongqiang Zhang Zhao Yang Yuqin Tang chengbin guo Danni Lin d Linling Cheng Xun Hu Kang Zhang Gen Li West China School of Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhouGuangdong 510620China State Key Laboratory of Southwestern Chinese Medicine Resources School of Basic Medical SciencesChengdu University of Traditional Chinese MedicineChengduSichuan 611137China Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and TechnologyMacao 999078China Clinical Research Center The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310003China Biorepository State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China

The high risk of postoperative mortality in lung adenocarcinoma(LUAD)patients is principally driven by cancer recurrence and low response rates to adjuvant ***,A combined cohort containing 1,026 stageⅠ-Ⅲpatients was divided into the learning(n Z 678)and validation datasets(n Z 348).The former was used to establish a 16-mRNA risk signature for recurrence prediction with multiple statistical algorithms,which was verified in the valida-tion *** and multivariate analyses confirmed it as an independent indicator for both recurrence-free survival(RFS)and overall survival(OS).Distinct molecular characteristics between the two groups including genomic alterations,and hallmark pathways were compre-hensively ***,the classifier was tightly linked to immune infiltrations,high-lighting the critical role of immune surveillance in prolonging survival for ***,the classifier was a valuable predictor for therapeutic responses in patients,and the low-risk group was more likely to yield clinical benefits from immunotherapy.A transcription factor regulato-ry proteineprotein interaction network(TF-PPI-network)was constructed via weighted gene co-expression network analysis(WGCNA)concerning the hub genes of the *** con-structed multidimensional nomogram dramatically increased the predictive ***-fore,our signature provides a forceful basis for individualized LUAD management with promising potential implications.

关键词： Immune infiltration Lung adenocarcinoma Nomogram Recurrence Risk signature

Inhibition of MALT1 paracaspase activity improves lesion recovery following spinal cord injury

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Science Bulletin 2019年第16期64卷 1179-1194页

作者： Hua Zhang guodong Sun Xiaowei Li Zhen Fu chengbin guo Guangchao Cao Baocheng Wang Qian Wang Shuxian Yang Dehai Li Xichun Xia Peng Li Jing Zhu Wei Zhou Liangyan Zheng Jingxia Li Lei Zhang Jianlei Hao Libing Zhou Frederic Bornancin Zhizhong Li Zhinan Yin Yunfei Gao The First Affiliated Hospital Biomedical Translational Research Institute and School of PharmacyJinan UniversityGuangzhou 510632China Department of Orthopedics First Affiliated HospitalJinan UniversityGuangzhou 510632China Shandong Provincial Qianfoshan Hospital Shandong First Medical UniversityJinan 250014China Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhou 510632China Novartis Institutes for BioMedical Research CH-4002 BaselSwitzerland Department of Orthopedics Heyuan People’s Hospital(Heyuan Affiliated Hospital of Jinan University)Heyuan 517199China State Key Laboratory of Biotherapy Collaborative Innovation Center for BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Spinal cord injury(SCI) is a devastating traumatic injury that causes persistent, severe motor and sensory dysfunction. Immune responses are involved in functional recovery after SCI. Mucosa-associated lymphoid tissue lymphoma translocation 1(MALT1) has been shown to regulate the survival and differentiation of immune cells and to play a critical role in many diseases, but its function in lesion recovery after SCI remains unclear. In this paper, we generated KI(knock in) mice with a point mutation(C472 G) in the active center of MALT1 and found that the KI mice exhibited improved functional recovery after *** macrophages were recruited to the injury site in KI mice and these macrophages differentiated into anti-inflammatory macrophages. Moreover, macrophages from KI mice exhibited reduced phosphorylation of p65, which in turn resulted in decreased SOCS3 expression and increased pSTAT6 *** results were obtained upon inhibition of MALT1 paracaspase with the small molecule inhibitor‘‘MI-2' or the more specific inhibitor ‘‘MLT-827'. In patients with SCI, peripheral blood mononuclear cells(PBMC) displayed increased MALT1 paracaspase. Human macrophages showed reduced proinflammatory and increased anti-inflammatory characteristics following the inhibition of MALT1 paracaspase. These findings suggest that inhibition of MALT1 paracaspase activity in the clinic may improve lesion recovery in subjects with SCI.

关键词： Anti-inflammatory macrophage Pro-inflammatory macrophage Spinal cord injury NF-j B MALT1 paracaspase activity

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插值滤波器在全数字超声探伤仪中的应用

无损检测 1996年第9期18卷 241-243,261页

作者：毛捷郭成彬中国科学院声学研究所北京100080

针对数字超声探伤仪模数变换速率不够高而带来的回波信号失真,介绍了一种频率抽样插值滤波器。在一定条件下经滤波插值,使回波信号最大幅值误差<5％。

关键词：滤波器超声探伤仪模数变换插值滤波器

SPATIAL AVERAGING OF STRUCTURE NOISE

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声学学报(英文版) 1988年第3期 224-231页

作者：郭成彬黄振俨陈庚应崇福

The relation between the signal-to-noise ratio enhancement and the correlation function of the structurenoise for varying acoustic parameters has been *** averaging in a simple case has been discussedand expressions for the correlation function and the signal-to-noise ratio enhancement have been *** calculated results are in good agreement with the experimental ones.

关键词： NOISE transducer deduced detecting averaging normalized crystalline diameters anisotropic averaged

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C扫描图象后处理的一些方法

无损检测 1993年第3期15卷 66-68页

作者：王秀芬郭成彬中国科学院声学研究所

介绍C扫描图象的后处理,包括图象的整体放大、局部放大和失真修正等。软件适用于IBM/PC 各类机及其兼容机的一般配置。软件用 QUICK BASIC 语言编制,有汉字显示的功能。

关键词： C扫描图象处理超声检验

足底电击诱导树鼠句条件恐惧记忆模型的建立及抹除

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安徽医科大学学报 2015年第10期50卷 1426-1430页

作者：郭呈斌张晨王烈成安徽医科大学基础医学院生理学教研室合肥230032 北京大学生命科学学院生物膜与膜生物工程国家重点实验室北京100871

目的探索足底电击诱导树鼩条件恐惧记忆模型的建立及抹除方法。方法测定在无刺激条件下,树鼩在明暗箱中的活动规律;然后用梯度刺激实验测定合适的足底电击电压;最后用合适的电压通过足底电击诱导并建立实验组树鼩条件恐惧记忆模型并抹... 详细信息

目的探索足底电击诱导树鼩条件恐惧记忆模型的建立及抹除方法。方法测定在无刺激条件下,树鼩在明暗箱中的活动规律;然后用梯度刺激实验测定合适的足底电击电压;最后用合适的电压通过足底电击诱导并建立实验组树鼩条件恐惧记忆模型并抹除其记忆。结果正常条件下,树鼩(n=4)在暗箱中的停留时间明显多于明箱中的停留时间(P<0.01);在两明箱中,足底电压梯度刺激实验显示,随着刺激电压的增加,树鼩(n=6)在有刺激的隔间中的停留时间逐渐减少。12 V以后树鼩在有刺激隔间与无刺激隔间的停留时间差异有统计学意义[12 V(P<0.05)、16 V(P<0.01)、20 V(P<0.01)];实验组(n=4)暗箱用16 V刺激电压足底电击能够形成明显的恐惧记忆(P<0.001)。在形成明显的恐惧记忆后,在明箱中给予相应的足底电击4 d,实验组(n=4)树鼩在明箱中停留的时间逐渐减少,与对照组比较差异无统计学意义。结论树鼩更趋于停留在暗箱中;16V为较为适合的足底电击电压;条件恐惧记忆能够被诱导并且被新的刺激完全抹除。

关键词：树鼩足底电击条件恐惧记忆形成和抹除明暗箱

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结构噪声的空间平均处理

声学学报 1989年第3期14卷 210-215页

作者：郭成彬黄振俨陈庚应崇福中国科学院声学研究所

推导出了声参数变化时的信噪比增益与结构噪声相关函数的关系。探讨了一种简单情况下的空间平均处理,得到了相关函数和信噪比增益的表达式,与实验结果符合良好。

关键词：结构噪声空间平均处理

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智慧露天矿山底层平台构建

工矿自动化 2020年第12期46卷 116-119页

作者：王猛马晓燕国承斌辽宁工程技术大学矿业学院辽宁阜新123000 陕煤集团神南产业发展有限公司陕西神木719300 深圳市智物联网络有限公司广东深圳518000

指出了目前我国智慧露天矿山建设中存在的主要问题,即系统独立、人工管控为主、灾害监测被动执行和缺乏智能分析。归纳了智慧露天矿山内涵,认为智慧露天矿山是一个万物互联、平台融合、智慧驱动的大系统。提出了基于工业物联网云操作系... 详细信息

指出了目前我国智慧露天矿山建设中存在的主要问题,即系统独立、人工管控为主、灾害监测被动执行和缺乏智能分析。归纳了智慧露天矿山内涵,认为智慧露天矿山是一个万物互联、平台融合、智慧驱动的大系统。提出了基于工业物联网云操作系统的智慧露天矿山底层平台:①实时数据由高级可编程适配器通过Modbus/OPC/PPI/MPI等工业协议获得,离线数据按现场工作需要进行手工录入,数据接入露天矿山企业现有企业资源计划或制造执行系统,实现外部数据无缝连接。②以工业物联网云操作系统MixIOT为平台,按照数据不同来源,建立栅格数据库、离线数据库、统计数据库、报表数据库等,实现露天矿山各类数据路由、交换、存储,同时通过工业数据分析服务系统对露天矿山生产设备运行进行分析。分析了实现智慧露天矿山底层平台所依托的三大关键技术,即数据获取技术、数据分析服务技术和应用展示技术。

关键词：露天矿智慧矿山智慧露天矿山底层平台工业物联网云操作系统

The SARS-CoV-2 spike L452R-E484Q variant in the Indian B.1.617 strain showed significant reduction in the neutralization activity of immune sera

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Precision Clinical Medicine 2021年第3期4卷 149-154页

作者： Gen Li Zhongcheng Zhou Peng Du Meixing Yu Ning Li Xinxin Xiong Hong Huang Zhihai Liu Qinjin Dai Jie Zhu chengbin guo ShanyunWu Daniel T.Baptista-Hon Man Miao LamWai Ming Yong Wu Fanxin Zeng Charlotte L.Zhang Edward D.Zhang Haifeng Song Jianghai Liu Johnson Yiu-Nam Lau Andy P.Xiang Kang Zhang Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhou 510620China University Hospital and Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and TechnologyMacao 030027China Jinan University First Affiliated Hospital Jinan UniversityGuangzhou 510630China Department of Clinical Research Center Dazhou Central HospitalDazhou 635099China Department of Bioinformatics and AI Bioland LaboratoryGuangzhou 510000China ABLINK Biotech Co. Chengdu 610000China Department of Applied Biology and Chemical Technology Hong Kong Polytechnic UniversityHung HomHong Kong 610051China Center for Stem Cell Biology and Tissue Engineering Key Laboratory for Stem Cells and Tissue EngineeringMinistry of EducationSun Yat-sen UniversityGuangzhou 510000China

To assess the impact of the key non-synonymous amino acid substitutions in the RBD of the spike protein of SARS-CoV-2 variant B.1.617.1(dominant variant identified in the current India outbreak)on the infectivity and neutralization activities of the immune sera,L452R and E484Q(L452R-E484Q variant),pseudotyped virus was constructed(with the D614G background).The impact on binding with the neutralizing antibodies was also assessed with an ELISA *** virus carrying a L452R-E484Q variant showed a comparable infectivity compared with ***,there was a significant reduction in the neutralization activity of the immune sera from non-human primates vaccinated with a recombinant receptor binding domain(RBD)protein,convalescent patients,and healthy vaccinees vaccinated with anmRNA *** addition,there was a reduction in binding of L452R-E484Q-D614G protein to the antibodies of theimmune sera fromvaccinated nonhuman *** results highlight the interplay between infectivity and other biologic factors involved in the natural evolution of *** neutralization activities against the L452R-E484Q variant will have an impact on health authority planning and implications for the vaccination strategy/newvaccine development.

关键词： SARS-CoV-2 COVID-19 B.1.617.1 L452R E484Q infectivity immune neutralization