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Differentiation and immunosuppressive function of CD19^(+)CD24^(hi)CD27^(+) regulatory B cells are regulated through the miR-29a-3p/NFAT5 pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 472-480页

作者： Jin-Yang li Tian-Shuo Feng Ji Gao Xin-xiang Yang xiang-cheng li Zhen-Hua Deng Yong-xiang Xia Zheng-Shan Wu Hepatobiliary Center the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Key Laboratory of liver Transplantation Chinese Academy of Medical SciencesNanjing 210029China NHC Key Laboratory of living Donor liver Transplantation Nanjing Medical UniversityNanjing 210029China

Background: Regulatory B cells(Bregs) is an indispensable element in inducing immune tolerance after liver transplantation. As one of the microRNAs(miRNAs), mi R-29a-3p also inhibits translation by degrading the target mRNA, and yet the relationship between Bregs and mi R-29a-3p has not yet been fully explored. This study aimed to investigate the impact of miR-29a-3p on the regulation of differentiation and immunosuppressive functions of memory Bregs(m Bregs) and ultimately provide potentially effective therapies in inducing immune tolerance after liver transplantation. Methods: Flow cytometry was employed to determine the levels of Bregs in peripheral blood mononuclear cells. TaqMan low-density array miRNA assays were used to identify the expression of different miRNAs, electroporation transfection was used to induce mi R-29a-3p overexpression and knockdown, and dual luciferase reporter assay was used to verify the target gene of miR-29a-3p. Results: In patients experiencing acute rejection after liver transplantation, the proportions and immunosuppressive function of m Bregs in the circulating blood were significantly impaired. mi R-29a-3p was found to be a regulator of m Bregs differentiation. Inhibition of miR-29a-3p, which targeted nuclear factor of activated T cells 5(NFAT5), resulted in a conspicuous boost in the differentiation and immunosuppressive function of m Bregs. The inhibition of mi R-29a-3p in CD19~+ B cells was capable of raising the expression levels of NFAT5, thereby promoting B cells to differentiate into m Bregs. In addition, the observed enhancement of differentiation and immunosuppressive function of m Bregs upon mi R-29a-3p inhibition was abolished by the knockdown of NFAT5 in B cells. Conclusions: mi R-29a-3p was found to be a crucial regulator for m Bregs differentiation and immunosuppressive function. Silencing mi R-29a-3p could be a potentially effective therapeutic strategy for inducing immune tolerance after liver transplantation.

关键词： Regulatory B cells miR-29a-3p NFAT5 liver transplantation

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王树楠新疆文化交游及其学术意义初考

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石河子大学学报（哲学社会科学版） 2024年第3期38卷 108-116页

作者：成湘丽何虞雯新疆大学中国语言文学学院新疆乌鲁木齐830000 香港理工大学人文学院中国香港999077

1906年王树楠由河北入新疆,1911年再从新疆返京畿,他曾以新疆布政使的身份,聚集起一批调任流放的官员共同推进新疆文化教育事业发展大业,为20世纪初的新疆文坛带来了振兴国粹的文化气象,并通过主持编纂《新疆图志》等促进了中华文脉在... 详细信息

1906年王树楠由河北入新疆,1911年再从新疆返京畿,他曾以新疆布政使的身份,聚集起一批调任流放的官员共同推进新疆文化教育事业发展大业,为20世纪初的新疆文坛带来了振兴国粹的文化气象,并通过主持编纂《新疆图志》等促进了中华文脉在新疆地区的传承与发展。寓居迪化时期,王树楠与不同身份赴新疆人员有过交往唱和、书信题跋与文物交流活动。在返回京城之后,他与新疆旧友保持了稳定长久的文化联系,其对近代新疆文化事业的重要功绩已为时人所重视。不仅如此,王树楠还与不同国家各类身份赴新疆人员多有诗文交往与文物交流活动,这也为西域学的海外传播提供了条件。

关键词：王树楠新疆交游《新疆图志》文物收藏西域学

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Effect of Slab Subsurface Microstructure Evolution on Transverse Cracking of Microalloyed Steel during Continuous Casting

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Journal of Iron and Steel Research International 2014年第8期21卷 737-744页

作者： Yun-feng li Guang-hua WEN Ping TANG Jian-quan li cheng-li xiang College of Materials Science and Engineering Chongqing University Pangang Group Panzhihua Steel and Vanagium Co. Ltd.

As to the continuous casting process of low carbon microalloyed steel, subsurface microstructure evolution plays an important role in the slab surface cracking. In order to study the effect of the slab subsurface microstructure evolution on the transverse cracking, three different secondary cooling patterns （i. e. , mild cooling, strong cooling and controlled cooling） were performed in the corresponding slab curved continuous caster. Based on the metallo- graphic results, three transformation regions were found to be formed with the evolution of microstructures at different depths in the slab subsurface. The three regions are strong cooling transformation （SCT） region, double phase transformation （DPT） region and mild cooling transformation （MCT） region, respectively. Meanwhile, it was also found that the crack index used for evaluating slab surface cracking susceptibility was decreased when the range of the DPT region was increased. This can be explained by the fact that the double phase transformation （austenite-ferrite-austenite） occurred resulting from thermal cycling in DPT region, which resulted in promoting the refinement of prior austenite grains and inhibiting the precipitation of film-like ferrite and chain-like precipitates. Under the con- trolled cooling pattern, the widely-distributed DPT region was formed in the range of 3.5--8.0 mm to the slab surface. And compared with other cooling patterns, the cracking susceptibility is lowest with a crack index of 0.4.

关键词： continuous casting microalloyed steel surface transversal cracking microstructure evolution cooling pattern

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Generation of Polycyclic Aromatic Hydrocarbons During Coking

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Journal of Iron and Steel Research International 2010年第12期17卷 6-10页

作者： cheng xiang-li li En-ke CANG Da-qiang SHI Yan li Mao-jing State Key Laboratory of Advanced Steel Processing and Products Central Iron and Steel Research Institute Beijing 100081 China Tangshan Environmental Protection Bureau Tangshan 063000 Hebei China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China College of Metallurgy and Energy Hebei Polytechnic University Tangshan 063009 Hebei China

The generation of polycyclic aromatic hydrocarbons （PAHs） during coking was studied and the contents of sixteen PAHs were measured by the devices of ultrasonic abstraction and high performance liquid chromatography for single coal coking and blended coal coking. The results indicated that the amount of generated PAHs during the first 1--4 h of coking is the most. Among these PAHs, the tetranuclear PAHs have a major portion and the Benzo[a]pyrene which can cause cancer, and teratogenesis and mutation is generated for a larger concentration more than emission standard value. Two PAHs are the main pollutants of PAHs pollution.

关键词： polycyclic aromatic hydrocarbon coking single coal blended coal

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Direct Reduction Experiment on Iron-Bearing Waste Slag

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Journal of Iron and Steel Research International 2013年第3期20卷 24-29,35页

作者： cheng xiang-li ZHAO Kai QI Yuan-hong SHI Xue-feng ZHEN Chang-liang State Key Laboratory of Advanced Steel Process and Products Central Iron and Steel Research Institute

A lot of iron-bearing slags were produced,and whose grade is much more than that of industrial iron ore *** analysis and phase identification shows that the iron-bearing slag is amorphous,has fayalite main phase,iron grade is 36.10%,and is difficult to recover iron from the *** calculation indicates that CO cannot reduce fayalite at high temperature and carbon direct reduction can be ***,the reaction begins at 770 ℃ and the temperature can be reduced down to 500℃ when CaO is *** this basis,a method is put forward to making direct enrichment of iron by taking carbon contained pellets to realize the rapid reduction of fayalite,and the direct reduction process were studied in this *** show that xC/xO should be less than 1.5 for the need of reduction and carburization,and CaO and Al2O3 can spur the reduction of *** conditions that xC/xO is 1.2,metallization rate can be 77% when temperature is 1 250 ℃ and only carbon is added,and metallization rate can be 74% when temperature is 1 200 ℃ and only CaO is *** the addition of Al2O3 can get a higher metallization rate（10% or so） than usual as R is between 0.4 and *** the optimized condition of R equals to 0.6,temperature of 1 250 ℃,slag melting point of 1 320 ℃,and time of 30 min,the metallization rate can reach 88.43%.

关键词： iron-bearing slag fayalite metallization rate basicity

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Drainage by urostomy bag after blockage of abdominal drain in patients with cirrhosis undergoing hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2013年第1期12卷 99-102页

作者： Guo-Qiang li Feng Zhang Hao Lu ling Lu xiang-cheng li Xue-Hao Wang Bei-cheng Sun liver Transplantation Center First Affiliated HospitalNanjing Medical University Key Laboratory of living Donor liver Transplantation of Ministry of Public Health

Abdominal drainage was previously recommended as a post-hepatectomy procedure for patients with *** report introduces a simple technique that prevents leakage of ascitic fluid after cirrhotic hepatectomy complicated by blockage of the abdominal *** 59 patients who had had cirrhotic hepatectomy complicated by leakage of ascites in the drain site after drainage removal between January 2001 and April 2011,31 underwent suture ligation(sutured group) and 28 were given urostomy bag at the abdominal drainage site(drainage group).The mean length of postoperative hospital stay in the drainage group was shorter than in the sutured group(16.11±2.61 vs 34.23±4.86 days,P=0.000).Meanwhile,the drainage group showed decreased postoperative complications,including leakage of ascites,wound infection,and collection of *** by urostomy bag can prevent prolonged leakage of ascitic fluid after the blockage of abdominal drains in patients undergoing cirrhotic hepatectomy.

关键词： abdominal drain ascitic fluid leak hepatectomy urostomy bag

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Mitigating set-stuck failure in 3D phase change memory: substituting square pulses with surge pulses

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Science China(Information Sciences) 2024年第5期67卷 295-301页

作者： Ninghua li Wang CAI Jun xiang Hao TONG Weiming cheng xiangshui MIAO School of Integrated Circuits Huazhong University of Science and Technology Hubei Yangtze Memory Laboratories Hubei Institute of Measurement and Testing Technology

In the devices that integrate phase change memory(PCM) and ovonic threshold switching(OTS),the OTS threshold voltage often surpasses the RESET operation voltage of PCM. The conventional application of square pulses hinders the successful completion of the SET operation in these integrated devices. To address this challenge, a novel pulse called the surge pulse is introduced, which comprises a high amplitude pulse for OTS activation and a low amplitude pulse for PCM operation. By employing COMSOL simulation,the operational effectiveness of both square pulses and surge pulses is validated. Test results reveal that using a square pulse to operate the integrated device accelerates the occurrence of SET-stuck failure(SSF).In contrast, the surge pulse enables the integrated device to operate for at least 1000 cycles while preserving the essential cyclic characteristics. Additionally, an investigation into the overshoot component of the surge pulse is conducted, revealing that an increase in overshoot amplitude and pulse width also accelerates the emergence of SSF. By applying the theory of ion migration induced by the electric field, the root cause of SSF in integrated devices is explained, and the accuracy of the theory is validated through the application of a reverse pulse. In summary, this study elucidates the rationality of replacing the square pulse with a surge pulse, presenting a superior approach for operating PCM and OTS integrated devices.

关键词： surge pulse phase change memory (PCM) integration SET-stuck failure (SSF) square pulse

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Calculation model of mass action concentrations for CaO-MgO-SiO_2-Al_2O_3-Cr_2O_3 penta-slag

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Chinese Chemical Letters 2010年第2期21卷 229-233页

作者： Guo, Hua Hu, Yu Ting Cang, Da Qiang Jin, Yi Wang, li Xin cheng, xiang li Bai, Hao Zong, Yan Bing Univ Sci & Technol Beijing Sch Met & Ecol Engn Beijing 100083 Peoples R China Taiyuan Iron & Steel Co Ltd Taiyuan 030003 Peoples R China

Two calculation models of mass action concentrations for CaO-MgO-SiO_2-Al_2O_3-Cr_2O_3 penta-slag was presented whether 3CaO·Cr_2O_3·3SiO_2 was existence or *** mass action concentration of each element structure was *** the models results were compared with experimental *** final results illustrated the model without 3CaO·Cr_2O_33SiO_2 was suit for *** model could response the element structure of slag as well.

关键词： Slag Cr_2O_3 Co-existence theory Thermodynamic calculation model

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Electron delocalization-enhanced sulfur reduction kinetics on an MXene-derived heterostructured electrocatalyst

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Nano Research 2024年第8期17卷 7153-7162页

作者： Yunmeng li Yinze Zuo xiang li Yongzheng Zhang cheng Ma Xiaomin cheng Jian Wang Jitong Wang Hongzhen lin licheng ling State Key Laboratory of Chemical Engineering Key Laboratory of Specially Functional Polymeric Materials and Related Technology(Ministry of Education)East China University of Science and TechnologyShanghai 200237China Institute of New Energy Materials and Engineering College of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China Key Laboratory of Specially Functional Polymeric Materials and Related Technology(Ministry of Education) School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China i-Lab&CAS Key Laboratory of Nanophotonic Materials and Device Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of SciencesSuzhou 215123China Helmholtz Institute Ulm(HIU) D89081 UlmGermany

lithium-sulfur(li-S)batteries mainly rely on the reversible electrochemical reaction of between lithium ions(li^(+))and sulfur species to achieve energy storage and conversion,therefore,increasing the number of free li^(+)and improving the li^(+)diffusion kinetics will effectively enhance the cell ***,Mo-based MXene heterostructure(MoS_(2)@Mo_(2)C)was developed by partial vulcanization of Mo_(2)C MXene,in which the introduction of similar valence S into Mo-based MXene(Mo_(2)C)can create an electron delocalization *** theoretical simulations and electrochemical characterisation,it is demonstrated that the MoS_(2)@Mo_(2)C heterojunction can effectively promote ion desolvation,increase the amount of free li^(+),and accelerate li^(+)transport for more efficient polysulfide *** addition,the MoS_(2)@Mo_(2)C material is also capable of accelerating the oxidation and reduction of polysulfides through its sufficient defects and vacancies to further enhance the catalytic ***,the li-S battery with the designed MoS_(2)@Mo_(2)C electrocatalyst performed for 500 cycles at 1 C and still maintained the ideal capacity(664.7 mAh·g^(−1)),and excellent rate performance(567.6 mAh·g^(−1)at 5 C).Under the extreme conditions of high loading,the cell maintained an excellent capacity of 775.6 mAh·g^(−1)after 100 *** also retained 838.4 mAh·g^(−1)for 70 cycles at a low temperature of 0℃,and demonstrated a low decay rate(0.063%).These results indicate that the delocalized electrons effectively accelerate the catalytic conversion of lithium polysulfide,which is more practical for enhancing the behaviour of li-S batteries.

关键词： delocalized electron lithium sulfur batteries MXene-based heterostructures catalytic desolvation multi-catalytic sites

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A double-layer radiative cooling coating that utilizes the refractive index difference between layers to achieve extremely high solar reflectivity

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Science China Technological Sciences 2024年第10期67卷 3182-3189页

作者： WANG FuQiang li ChunZhe YANG ZhenNing XIE WeiXin li xiang XU ZengHui YAN YuYing cheng ZiMing School of Energy Science and Engineering Harbin Institute of Technology School of New Energy Harbin Institute of Technology at Weihai China Construction Eco-Environmental Protection Technology Co. Ltd. Faculty of Engineering University of Nottingham

Passive daytime radiative cooling（PDRC） technology has great potential in reducing cooling energy consumption. In order to further improve the spectral performance of PDRC coatings, current researchers mostly focus on the selection and size design of functional particles, while ignoring the optical properties enhancement effect caused by the interlayer binder. In this study, based on the principle that the refractive index difference between layers enhanced the backscattering performance of the solar spectrum, we proposed and manufactured a double-layer PDRC coating with polyvinylidene difluoride（PVDF） as the filmforming material in the upper layer and polydimethylsiloxane（PDMS） as the film-forming material in the lower layer, both filled with Al2O3and SiO2particles. The double-layer PDRC coating exhibited excellent spectral performance that a high solar reflectivity of 98% and an emissivity of 0.95 at the “atmospheric window” band. In comparison, the solar spectrum reflectivity of the single-layer PDRC coatings based on PVDF and PDMS of the same thickness was 95% and 94.7%, respectively. Outdoor tests showed that the PDRC coating achieved a temperature decrease of up to 7.1℃ under direct sunlight at noon time. In addition, the PDRC coating had excellent weather resistance, water resistance, and other basic properties. This article opens up a new idea and provides methodological guidance for the design of double-layer PDRC coatings.

关键词： double-layer radiative cooling coating spectral modulation interlayer refractive index solar energy radiative transfer

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