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Tumor initiation and early tumorigenesis:molecular mechanisms and interventional targets

Signal Transduction and Targeted Therapy 2024年第7期9卷 2900-2935页

作者： Shaosen Zhang Xinyi Xiao Yonglin Yi Xinyu Wang Lingxuan zhu Yanrong shen Dongxin Lin Chen Wu Department of Etiology and Carcinogenesis National Cancer Center/National Clinical Research Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College100021 BeijingChina Key Laboratory of Cancer Genomic Biology Chinese Academy of Medical Sciences and Peking Union Medical College100021 BeijingChina Changping Laboratory 100021 BeijingChina Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing 211166China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China CAMS Oxford Institute Chinese Academy of Medical Sciences100006 BeijingChina

Tumorigenesis is a multistep process,with oncogenic mutations in a normal cell conferring clonal advantage as the initial ***,despite pervasive somatic mutations and clonal expansion in normal tissues,their transformation into cancer remains a rare event,indicating the presence of additional driver events for progression to an irreversible,highly heterogeneous,and invasive ***,researchers are emphasizing the mechanisms of environmental tumor risk factors and epigenetic alterations that are profoundly influencing early clonal expansion and malignant evolution,independently of inducing ***,clonal evolution in tumorigenesis reflects a multifaceted interplay between cell-intrinsic identities and various cell-extrinsic factors that exert selective pressures to either restrain uncontrolled proliferation or allow specific clones to progress into ***,the mechanisms by which driver events induce both intrinsic cellular competency and remodel environmental stress to facilitate malignant transformation are not fully *** this review,we summarize the genetic,epigenetic,and external driver events,and their effects on the co-evolution of the transformed cells and their ecosystem during tumor initiation and early malignant evolution.A deeper understanding of the earliest molecular events holds promise for translational applications,predicting individuals at high-risk of tumor and developing strategies to intercept malignant transformation.

关键词： alterations mechanisms restrain

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Recent advancements in hydrometallurgical recycling technologies of spent lithium-ion battery cathode materials

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Rare Metals 2024年第3期43卷 879-899页

作者： Juan Wu Li Xiao Li shen Jian-Jun Ran Hui Zhong Yi-Rong zhu Han Chen College of Materials and Advanced Manufacturing Hunan University of TechnologyZhuzhou412007China School of Resources Processing and Bioengineering Central South UniversityChangsha410083China Guangdong JiaNa Energy Technology Company Qingyuan513000China

The rapidly increasing production of lithium-ion batteries(LIBs)and their limited service time increases the number of spent LIBs,eventually causing serious environmental issues and resource *** the perspectives of clean production and the development of the LIB industry,the effective recovery and recycling of spent LIBs require urgent *** study provides an overview of the current hydrometallurgical processes employed in the recycling of spent cathode materials,focusing on the leaching of valuable metals and their *** particular,this research reviews the various leaching systems(inorganic acid,organic acid,and ammonia)and the separation of valuable metals,and then,recommendations for subsequent study are offered in an attempt to contribute to the development of highly efficient methods for recycling spent cathode *** addition,a range of existing technologies,such as solvent extraction,chemical precipitation,electrochemical deposition,and regeneration,for the postprocessing of leaching solutions are ***,the promising technologies,existing challenges and suggestions with respect to the development of effective and environmentally friendly recycling methods for handling spent cathode materials are identified.

关键词： Spent lithium-ion batteries(LIBs) Cathode material Hydrometallurgy Leaching Recycling

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Shear resistance characteristics and influencing factors of root-soil composite on an alpine metal mine dump slope with different recovery periods

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Journal of Mountain Science 2024年第3期21卷 835-849页

作者： PANG Jinghao LIANG shen LIU Yabin LI shengwei WANG Shu zhu Haili LI Guorong HU Xiasong Department of Geological Engineering Qinghai UniversityXining 810016China Key Laboratory of Genozoic Resource&Environment in North Margin of the Tibetan Plateau Xining 810016China

Artificial vegetation restoration is the main measure for vegetation restoration and soil and water conservation in alpine mine dumps on the Qinghai-Tibet Plateau,***,there are few reports on the dynamic changes and the influencing factors of the soil reinforcement effect of plant species after artificial vegetation restoration under different recovery *** selected dump areas of the Delni Copper Mine in Qinghai Province,China to study the relationship between the shear strength and the peak displacement of the root-soil composite on the slope during the recovery period,and the influence of the root traits and soil physical properties on the shear resistance characteristics of the root-soil composite via in situ direct shear *** results indicate that the shear strength and peak displacement of the rooted soil initially decreased and then increased with the increase of the recovery *** shear strength of the rooted soil and the recovery period exhibited a quadratic function *** is no significant function relationship between the peak displacement and the recovery *** positive correlations(P0.05)between the shear strength of the root-soil composite and the root length density,and the root volume ratio of the coarse roots to the fine roots.A significant negative linear correlation(P0.05)with the root traits,other soil physical property indices(the moisture content and dry density of the soil),and slope *** coarse-grain content is the main factor controlling the peak displacement of the rooted soil.

关键词： Alpine mine dump Artificial vegetation restoration period Rooted soil Shear resistance characteristics Root traits Soil physical properties

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Enhanced Crystallization of Poly(butylene adipate-co-terephthalate)by a Self-assembly Nucleating Agent

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Chinese Journal of Polymer Science 2024年第5期42卷 663-674,I0010页

作者： cheng Zhou Kun Chen Zi-Heng Zhang Meng-Fan Jing Chun-Tai Liu Chang-Yu shen Ya-Ming Wang State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentNational Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou450002China

Poly(butylene adipate-co-terephthalate)(PBAT)is a promising biodegradable flexible polymer but suffers from slow crystallization rate,making it less attractive for some applications like the injection-molded products in comparison with low-density polyethylene(LDPE).This work aimed to accelerate the crystallization of PBAT by adding a self-assembly nucleating agent octamethylenedicarboxylic dibenzoylhydrazide(OMBH).PBAT/OMBH composites with various OMBH contents(0 wt%,0.5 wt%,0.7 wt%,1 wt%,2 wt%,3 wt%and 5 wt%)were prepared through *** effect of OMBH on the crystallization behavior,morphologies and mechanical properties of PBAT was *** highest nucleation efficiency value of 59.6%was achieved for PBAT with 0.7 wt%OMBH,much higher than that of 22.7%for PBAT with 0.7 wt%*** force microscopy results showed that OMBH formed fine fibers and induced the formation of transcrystalline layers of *** transform infrared spectroscopy(FTIR)combined with two-dimensional correlation spectra suggested that the intermolecular dipole-dipole N—H…O=C interactions but not hydrogen bond between OMBH and PBAT promoted the crystallization of PBAT in the initial period of *** presence of OMBH did not change the crystal form of PBAT but had positive contribution in enhancing its crystallinity and mechanical *** work is essential for preparing PBAT with high crystallization rate,enhancing its potential applications in injection-molded products.

关键词： Poly(butylene adipate-co-terephthalate) Biodegradable Self-assembly nucleating agent Crystallization

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Eleven new species of the genus Ourapteryx Leach,1814(Lepidoptera:Geometridae)from China

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Zoological Systematics 2024年第2期49卷 158-174页

作者： Rui cheng Nan Jiang Chaodong zhu Yongqiang Xu Hongxiang Han Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute of Plateau Biology of Xizang Autonomous Region Lhasa 850000China

Eleven new species of Ourapteryx Leach,1814 were described:*** Jiang&Han,***.,*** cheng&Han,***.,*** cheng&Jiang,***.,*** Jiang&cheng,***.,*** Jiang&cheng,***.,*** Jiang&cheng,***.,*** cheng&zhu,***.,*** cheng&Jiang,***.,*** cheng&Han,***.,*** cheng&Han,***.,*** cheng&zhu,*** for these new species are provided,with illustrations of external features and genitalia.

关键词： Ennominae morphology taxonomy

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Putrescine Modulates Cadmium Fixation Ability of Cell Wall to Decrease Cadmium Accumulation in Rice,a Process Might Depend on Nitric Oxide

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Rice science 2024年第3期31卷 237-240,I0002-I0007页

作者： WANG Haoyu LI Su YANG Jibo HUANG Jing zhu Xiaofang shen Renfang ZENG Dali College of Advanced Agricultural Sciences Zhejiang A&F UniversityHangzhou 311300China State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of ScienceNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China

Although putrescine(PUT)has been linked to plants'responses to cadmium(Cd)stress,the exact mechanism is still *** the current investigation,the endogenous PUT concentration in rice roots was enhanced by Cd *** PUT increased root cell wall hemicellulose levels,which in turn increased its Cd binding capacity,concurrently decreasing the transcription level of genes such as OsNRAMP1 and OsCd1 that are responsible for root Cd *** a result。

关键词： absorption roots cadmium

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A justice and innovative way ahead of consumption-based emission accounting approach

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Science China Earth Sciences 2024年第10期67卷 2999-3010页

作者： Qun shen Hongbo DUAN Yun TANG Linbing TANG Li SHANG Xinyu DOU Wei WEI Weiqiang CHEN zhu LIU State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization CAS Key Laboratory of Low-Carbon Conversion Science&EngineeringShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China School of Economics&Management University of Chinese Academy of SciencesBeijing 100190China Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Department of Earth System Science Tsinghua UnivesityBeijing 100084China

Carbon emission accounting is an important basis for global climate *** on the consumption-based accounting(CBA)method,the characteristics of carbon flow between national,regional,and product processes could be more clearly ***,CBA is more conducive to clarifying the attribution of responsibilities between producers and consumers,with the principles of fairness and *** accounting for carbon emissions in typical countries from 1990 to 2019,we found that the CBA emissions are higher than the production-based accounting(PBA)emissions in major developed countries,while the results are reversed for developing *** the past 30 years,the CBA emissions in targeted developed countries generally have shown a downward trend,while in developing countries,they have shown an upward *** emissions in China have shown a continuous growth trend from 1990 to 2019,but the pace has slowed down significantly over the last ***,the embodied carbon intensity of China’s exports continues to decline,indicating that China is providing more green and low-carbon products to the *** the PV industry as an example,this study further reveals the contribution of specific product industries to the country’s carbon transfer through product carbon footprint *** order to provide a scientific basis for global mitigation and climate governance,it is urgent to innovate a scientific,practical,and standardized CBA technology system.

关键词： Consumption-based accounting Production-based accounting Carbon transfer Carbon footprint

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Cell Wall Fixation,Translocation,and Vacuolar Detoxification of Cadmium Contribute to Differential Grain Cadmium Accumulation in Two Rice Cultivars

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Rice science 2024年第3期31卷 241-244,I0008-I0010页

作者： zhu Xiaofang ZHAO Ling HUANG Jing HE Jiatong SONG Jiayin TENG Ying shen Renfang State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of ScienceNanjing 210008China State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityHangzhou 311300China

Cadmium(Cd)toxicity in rice is a major concern for human health and the environment,as it can accumulate in rice grains when grown in Cd-contaminated *** mitigate the risk of Cd toxicity,it is crucial to cultivate rice varieties with low grain Cd *** the summers of 2021 and 2022,we conducted Cd analysis on two rice cultivars,Tianyouhuazhan(TYHZ)and Xiushui 14,grown in fields with varying Cd pollution *** cultivars were also subjected to hydroponic treatment with or without 1μmol/L Cd for 7 d to assess Cd accumulation,nitric oxide(NO)production。

关键词： cultivar soils pollution

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ZNF554 Inhibits Endometrial Cancer Progression via Regulating RBM5 and Inactivating WNT/β-Catenin Signaling Pathway

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Current Medical Science 2024年第2期44卷 406-418页

作者： cheng-cheng zhu Heng-liang SUN Teng-fei LONG Yuan-yuan LYU Jiang-li LIU Guan-tai NI Anhui Medical University Hefei 230032China Department of Obstetrics and Gynecology The First Affiliated Hospital of Wannan Medical CollegeWuhu 241001China

Objective:Uterine corpus endometrial carcinoma(UCEC),a kind of gynecologic malignancy,poses a significant risk to women’s *** precise mechanism underlying the development of UCEC remains *** finger protein 554(ZNF554),a member of the Krüppel-associated box domain zinc finger protein superfamily,was reported to be dysregulated in various illnesses,including malignant *** study aimed to examine the involvement of ZNF554 in the development of ***:The expression of ZNF554 in UCEC tissues and cell lines were examined by qRT-PCR and Western blot *** with stably overexpressed or knocked-down ZNF554 were established through lentivirus ***-8,wound healing,and Transwell invasion assays were employed to assess cell proliferation,migration,and *** iodide(PI)staining combined with fluorescence-activated cell sorting(FACS)flow cytometer was utilized to detect cell cycle ***-PCR and Western blotting were conducted to examine relative mRNA and protein *** immunoprecipitation assay and luciferase reporter assay were used to explore the regulatory role of ZNF554 in RNA binding motif 5(RBM5).Results:The expression of ZNF554 was found to be reduced in both UCEC samples and cell *** expression of ZNF554 was associated with higher tumor stage,decreased overall survival,and reduced disease-free survival in ***554 overexpression suppressed cell proliferation,migration,and invasion,while also inducing cell cycle *** contrast,a decrease in ZNF554 expression resulted in the opposite ***,ZNF554 transcriptionally regulated RBM5,leading to the deactivation of the Wingless(WNT)/β-catenin signaling ***,the findings from rescue studies demonstrated that the inhibition of RBM5 negated the impact of ZNF554 overexpression onβ-catenin and p-glycogen synthase kinase-3β(p-GSK-3β).Similarly,the deliberate activation of RBM5 reduced the increase inβ-catenin and

关键词： zinc finger protein 554 endometrial carcinoma RNA binding motif 5 Wingless/β-catenin signaling pathway

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Thermoelectric transport properties of p-type Bi_(2)Se_(3)-Sb_(2)Se_(3)-In_(2)Se_(3) high entropy compounds

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Rare Metals 2024年第7期43卷 3415-3421页

作者： Feng Jiang cheng-Liang Xia Yong-Bin zhu Jun Li Yue Chen Wei-Shu Liu Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and TechnologyShenzhen 518055China

The introduction of entropy concept into thermoelectric materials recently has attracted broad ***,we showed the phase diagram of the ternary systems of Bi_(2)Se_(3)-Sb_(2)Se_(3)-In_(2)Se_(3).Among the high entropy compounds (HECs),we have identified an intrinsic p-type region near our previously reported Bi_(0.8)Sb_(0.8)In_(0.4)Se_(3) in the phase diagram.

关键词： entropy (3) compounds

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