检索结果-南通市图书馆

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

SARS病毒及相关冠状病毒的生物学特征

生物化学与生物物理学报 2003年第6期35卷 495-502页

作者：王承忠戚正武中国科学院上海生命科学院生物化学与细胞生物学研究所中国科学院上海生命科学院生物化学与细胞生物学研究所上海200031 复旦大学上海医学院生物化学与分子生物学系上海200032

重症急性呼吸综合征 (severeacuterespiratorysyndrome ,SARS) ,临床表现为非典型肺炎。2 0 0 2年底我国广东发现此种当时不明病因的疾病 ,此后在越南、中国香港、加拿大、美国等三十多个国家和地区也相继发现类似病例。由于SARS具有很... 详细信息

重症急性呼吸综合征 (severeacuterespiratorysyndrome ,SARS) ,临床表现为非典型肺炎。2 0 0 2年底我国广东发现此种当时不明病因的疾病 ,此后在越南、中国香港、加拿大、美国等三十多个国家和地区也相继发现类似病例。由于SARS具有很高的传染性 ,死亡率也高 ,各国和世界卫生组织 (WHO)对此病高度重视。WHO迅速建立起由全球 10个国家的 13个实验室组成的协作研究和监测网络。一种新型的冠状病毒 (coronavirus)被认为极可能是SARS的病原体 ,因为它满足了 6个科赫要点 (Koch’spostulates)。2 0 0 3年 4月 12日 ,加拿大科学家首次公布了SARS病毒Tor2的基因组序列。4月 16日 ,WHO正式确认SARS病毒是SARS的病原体。目前我国SARS的病情仍然十分严峻 ,现就SARS病毒及相关冠状病毒的生物学特征和可能的药物防治靶点作一综述。

关键词： SARS 非典型肺炎病毒冠状病毒生物学特征治疗

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

芋螺毒素研究进展

生物化学与生物物理进展 2003年第4期30卷 537-545页

作者：王承忠蒋辉戚正武中国科学院上海生命科学研究院生物化学与细胞生物学研究所

芋螺毒素是近年来国际上的一个研究热点 .它属于一类海洋生物活性多肽 ,多数由 12～ 4 6个氨基酸残基所组成 ,能特异性地作用于体内各种离子通道和细胞膜上神经递质和激肽的受体 .具有分子质量小、结构多样、作用靶点广泛、功能专一、... 详细信息

芋螺毒素是近年来国际上的一个研究热点 .它属于一类海洋生物活性多肽 ,多数由 12～ 4 6个氨基酸残基所组成 ,能特异性地作用于体内各种离子通道和细胞膜上神经递质和激肽的受体 .具有分子质量小、结构多样、作用靶点广泛、功能专一、组织特异性强等优点 ,因而较之其他生物来源的活性多肽有更多的优越性 .芋螺毒素是一待挖掘的“富矿区” ,可作为体内一些具有重要生理功能靶点的探针和“解密器” ,亦可作为新药的先导化合物或直接开发成新药。

关键词：芋螺毒素活性多肽离子通道神经递质拮抗剂激动剂

维普期刊数据库

Enhanced sensitivity of hepatocellular carcinoma cells to chemotherapy with a Smac-armed oncolytic adenovirus

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第12期28卷 1996-2004页

作者： Qiu-wei PAN~(2,5),Su-yang zhong~(2,5),Bi-sheng LIU~2,Jin LIU~2,Rong CAI~2,Yi-gang wang~2,Xin-yuan LIU~(2,3,4),cheng QIAN~(2,4)~2 Xin Yuan institute of Medicine and Biotechnology,Life Science College,Zhejiang Sci-Tech University Hangzhou 310018,china,~3 instituteof biochemistry and cell biology,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,china Xin Yuan institute of Medicine and Biotechnology Life Science CollegeZhejiang Sci-Tech UniversityHangzhou 310018China institute of biochemistry and cell biology Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 20003

Aim:The aim of the present study was to further improve the therapeutic effectsfor human hepatocellular carcinoma (HCC) and reduce the damage in normal cellsusing a novel chemo-gene-virotherapeutic ***:An oncolyticadenoviral vector (ZD55) similar to the typical oncolytic adenovirus ONYX-015,with a deletion of ElB-55K gene,was employed to express the second mitochon-dria-derived activator of caspases (Smac) protein by constructing a *** *** enhanced cytotoxicity of the combined treatment of ZD55-Smac with cisplatin or 5-fluorouracil (5-FU) was evaluated in several HCC ***,the negative effects on normal cells have been tested in humannormal liver cell lines L-02 and QSG-7701 cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and apoptotic cell ***:According to our observation,ZD55-Smac is superior to ONYX-015 in sensitizingchemotherapy,ZD55-Smac used in conjunction with chemotherapy was found toexhibit obviously enhanced cytotoxicity in HCC cells,yet significantly abolishedthe negative toxicity in normal cells by utilizing the tumor selective replicationvector and reducing the ***:This chemo-gene-virotherapeutic(cisplatin or 5-FU+ZD55-Smac) strategy is superior to the conventional chemo-gene or chemo-viro approach.

关键词： oncolytic adenovirus inhibitor of apoptosis proteins second mitochondria-derived activator of caspases chemotherapy hepatocellular carcinoma

ATP-dependent retrograde axonal transport of P2X3 receptor in primary sensory neurons

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

ATP-dependent retrograde axonal transport of P2X3 receptor i...

Emerging contaminants:A One Health perspective

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Bin wang~1,Xu-Qiao CHEN~1,cheng-Biao wu~2,Jin PAN~1,Bo YUAN~3,Yuan-Yuan SU~1,Xing-Yu JIANG~3, Xu ZHANG~4,Lan BAO~(1,*) 1 Laboratory of Molecular cell biology,institute of biochemistry and cell biology,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,china 2 Department of Neurosciences,School of Medicine,University of California,San Diego,La Jolla,California 92093- 0662,USA 3 National Center for Nanoscience and Technology,Beijing 100080,china 4 institute of Neuroscience and State Key Laboratory of Neuroscience,institutes for biological sciences,chinese academy of sciences,shanghai 200031,china

Objective P2X receptors are ATP-gated cation channels and play variable roles in pathophysiological *** P2X receptors,P2X

关键词： primary sensory neuron P2X3 receptor axonal retrograde transport

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

The Innovation 2024年第4期5卷 140-170,139页

作者： Fang wang Leilei Xiang Kelvin Sze-Yin Leung Martin Elsner Ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu Karl JJobst chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun wang Yuhao Fu zhong Wei Rainer Lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung Law chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao Li Tong Zhang Natàlia Corcoll Min Liu Daniel SAlessi Hui Li Kristian KBrandt Yolanda Pico cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun wu Willie Peijnenburg Edward Topp Xinde Cao Xin Jiang Minghui Zheng Taolin Zhang Yongming Luo Lizhong Zhu Xiangdong Li DamiàBarceló Jianmin Chen Baoshan Xing wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang wu Gang Yu James M.Tiedje State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of chinese academy of sciences Beijing 100049China Department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical University of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory of Environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of Environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA School of Environment Tsinghua UniversityBeijing 100084China School of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

分子细胞生物学报:英文版 2015年第5期7卷 466-475页

作者： Hui Liu Qing-Feng wu Jia-Yin Li Xing-Jun Liu Kai-cheng Li Yan-Qing zhong Dan wu Qiong wang Yin-Jing Lu Lan Bao Xu Zhang institute of Neuroscience and State Key Laboratory of Neuroscience CAS Center for Excellence in Brain ScienceShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China State Key Laboratory of cell biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

Fibroblast growth factor(FGF)7,a member of FGF family,is initially found to be secreted from mesenchymal cells to repair epithelial ***,its functions in the nervous system are largely *** present study showed that FGF7 was a neuromodulator localized in the large dense-core vesicles(LDCVs)in nociceptive ***7 was mainly expressed in small-diameter neurons of the dorsal root ganglion and could be transported to the dorsal spinal ***,FGF7 was mostly stored in LDCVs that did not contain neuropeptide substance *** recordings in the spinal cord slice showed that buffer-applied FGF7 increased the amplitude of excitatory post-synaptic current evoked by stimulating the sensory afferent *** tests showed that intrathecally applied FGF7 potentiated the formalin-induced acute nociceptive ***,both acute and inflammatory nociceptive responses were significantly reduced in Fgf7-deficient *** results suggest that FGF7 exerts an excitatory modulation of nociceptive afferent transmission.

关键词： fibroblast growth factor 7 dorsal root ganglion large dense-core vesicle nociceptive modulator inflammatory pain

Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

cellular & Molecular Immunology 2023年第7期20卷 794-807页

作者： Songling Zhu Shufen zhong Kebin cheng Li-Sha Zhang Jiu-wu Bai Zu Cao Su wang Wen Chen Shipeng cheng Liyan Ma Zhiyang Ling Yuying Huang wangpeng Gu Xiaoyu Sun Chunyan Yi Meng Zhao Shuo Liang Jin-Fu Xu Bing Sun Yaguang Zhang Division of Life sciences and Medicine University of Science and Technology of ChinaHefei 230022China State Key Laboratory of cell biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of Sciences320 Yueyang RoadShanghai 200031China Department of Respiratory and Critical Care Medicine Shanghai Pulmonary HospitalInstitute of Respiratory MedicineSchool of MedicineTongji University507 Zhengmin RoadShanghai 200433China

Interleukin-33(IL-33)is a crucial nuclear cytokine that induces the type 2 immune response and maintains immune *** fine-tuned regulation of IL-33 in tissue cells is critical to control of the type 2 immune response in airway inflammation,but the mechanism is still ***,we found that healthy individuals had higher phosphate-pyridoxal(PLP,an active form of vitamin B6)concentrations in the serum than asthma *** serum PLP concentrations in asthma patients were strongly associated with worse lung function and *** a mouse model of lung inflammation,we revealed that PLP alleviated the type 2 immune response and that this inhibitory effect relied on the activity of IL-33.A mechanistic study showed that in vivo,pyridoxal(PL)needed to be converted into PLP,which inhibited the type 2 response by regulating IL-33 *** mice heterozygous for pyridoxal kinase(PDXK),the conversion of PL to PLP was limited,and IL-33 levels were increased in the lungs,aggravating type 2 ***,we found that the mouse double minute 2 homolog(MDM2)protein,an E3 ubiquitin-protein ligase,could ubiquitinate the N-terminus of IL-33 and sustain IL-33 stability in epithelial *** reduced MDM2-mediated IL-33 polyubiquitination and decreased the level of IL-33 through the proteasome *** addition,inhalation of PLP alleviated asthma-related effects in mouse *** summary,our data indicate that vitamin B6 regulates MDM2-mediated IL-33 stability to constrain the type 2 response,which might help develop a potential preventive and therapeutic agent for allergy-related diseases.

关键词： Type 2 inflammation IL-33 Vitamin B6

Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2020年第6期18卷 737-748页

作者： Yafei Chang Yisheng Jiang Cui Li Qin wang Feng Zhang cheng-Feng Qin Qing-Feng wu Jing Li Zhiheng Xu Department of Bioinformatics and Biostatistics School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Molecular Developmental biology CAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Department of Virology State Key Laboratory of Pathogen and BiosecurityBeijing Institute of Microbiology and EpidemiologyBeijing 100071China Parkinson’s Disease Center Beijing Institute for Brain DisordersBeijing 100101China University of chinese academy of sciences Beijing 100101China

The association of Zika virus(ZIKV)infection with microcephaly has raised alarm *** causal link has been confirmed in different animal models infected by ***,the molecular mechanisms underlying ZIKV pathogenesis are far from ***,we performed global gene expression analysis of ZIKV-infected mouse brains to unveil the biological and molecular networks underpinning *** found significant dysregulation of the sub-networks associated with brain development,immune response,cell death,microglial cell activation,and autophagy amongst *** provided detailed analysis of the related complicated gene networks and the links between ***,we analyzed the signaling pathways that were likely to be *** report provides systemic insights into not only the pathogenesis,but also a path to the development of prophylactic and therapeutic strategies against ZIKV infection.

关键词： Zika virus Brain development Microcephaly Gene network Signaling pathway

维普期刊数据库

A mitochondria-targeted AIE photosensitizer for enhancing specificity and efficacy of ferroptosis inducer

在线全文

学校读者我要写书评

暂无评论

Science china Chemistry 2022年第5期65卷 870-876页

作者： Shan wang Chao Chen Jianmin wu Jianyu Zhang Jacky W.Y.Lam Hongyang wang Lei Chen Ben zhong Tang Fudan University shanghai Cancer Center Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyState Key Laboratory of Molecular NanoscienceDivision of Life Scienceand Department of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyHong Kong 999077China institute of Metabolism and Integrative biology Fudan UniversityShanghai 200433China The International Cooperation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China National Center for Liver Cancer Shanghai 200441China Shenzhen institute of Aggregate Science and Technology School of Science and EngineeringThe Chinese University of Hong KongShenzhen 518172China AIE institute Guangzhou Development DistrictGuangzhou 510530China

Ferroptosis is a form of regulated cell death characterized by iron-dependent accumulation of lipid peroxidation and lethal reactive oxygen species(ROS).To date,misregulated ferroptosis has been implicated in several types of cancers,and ferroptosis inducers can be used to promote ferroptosis in tumor cells and play an anti-tumor ***,the specificity and efficacy of ferroptosis inducers remain ***,a new mitochondria-targeted photosensitizer(PS)with aggregation-induced emission(AIE)characteristic named TCSVP was designed,which efficiently generates ROS in mitochondria after light *** administration significantly sensitizes tumor cells to ferroptosis inducer(RSL3)-mediated cell death by specifically and light-dependently triggering a moderate ROS generation in vitro and in ***,the expression levels of ferroptosis related proteins Acyl-CoA synthetase long-chain family member 4(FACL4/ACSL4)and cyclooxygenase-2(COX2)were increased in TCSVP/RSL3-treated cells after light exposure,coupled with decreased Glutathione peroxidase 4(GPX4)activity and excessive malondialdehyde(MDA)*** study declared that light-induced moderate ROS generation within mitochondria in cancer cells by AIE-PS can be used to enhance the specificity and efficacy of ferroptosis inducers,bringing a new synergistic strategy for tumor intervention.

关键词： controlling ROS generation high-performance AIE-PS lipid peroxidation ferroptosis

维普期刊数据库