Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles
作者机构：Institute of Neuroscience and State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain ScienceShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China State Key Laboratory of Cell BiologyInstitute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China School of Life Science and TechnologyShanghaiTech UniversityShanghai 201210China
出 版 物：《分子细胞生物学报:英文版》 (Journal of Molecular Cell Biology)
年 卷 期：2015年第7卷第5期
页 面：466-475页
核心收录：
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China(31130066) the Strategic Priority Research Program(B)of Chinese Academy of Sciences(XDB01020300)
主 题：fibroblast growth factor 7 dorsal root ganglion large dense-core vesicle nociceptive modulator inflammatory pain
摘 要：Fibroblast growth factor(FGF)7,a member of FGF family,is initially found to be secreted from mesenchymal cells to repair epithelial ***,its functions in the nervous system are largely *** present study showed that FGF7 was a neuromodulator localized in the large dense-core vesicles(LDCVs)in nociceptive ***7 was mainly expressed in small-diameter neurons of the dorsal root ganglion and could be transported to the dorsal spinal ***,FGF7 was mostly stored in LDCVs that did not contain neuropeptide substance *** recordings in the spinal cord slice showed that buffer-applied FGF7 increased the amplitude of excitatory post-synaptic current evoked by stimulating the sensory afferent *** tests showed that intrathecally applied FGF7 potentiated the formalin-induced acute nociceptive ***,both acute and inflammatory nociceptive responses were significantly reduced in Fgf7-deficient *** results suggest that FGF7 exerts an excitatory modulation of nociceptive afferent transmission.
维普期刊数据库