检索结果-南通市图书馆

PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第5期11卷 390-406页

作者： Fengsheng Dai Yixiao yuan Jiaqi Hao Xing cheng Xiangyi Zhou li Zhou Rui Tian Yi Zhao Tingxiu Xiang Department of Oncology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China Department of Neurosurgery Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Neuro-Oncology Chongqing University Cancer HospitalChongqing 400030China

Programmed cell death 2(PDCD2)is related to cancer progression and chemotherapy *** role of PDCD2 in solid cancers(excluding hematopoietic malignancies)and their diagnosis and prognosis remains *** TCGA,CGGA,GEPIA,cBioPortal,and GTEx databases were analyzed for expression,prognostic value,and genetic modifications of PDCD2 in cancer *** enrichment analysis,CCK8,colony formation assay,transwell assay,and xenograft tumor model were undertaken to study the PDCD2’s biological function in glioma(GBMLGG).The PDCD2 gene was associated with solid cancer *** the functional enrichment analysis results,PDCD2 was shown to participate in several important GBMLGG biological *** cells may be inhibited in their proliferation,migration,invasion,and xenograft tumor growth by knocking down *** research can provide new insights into solid cancer prognostic biomarkers of PDCD2.

关键词： Biomarker Glioma Programmed cell death 2 Progression Solid cancer

Room-temperature ferrimagnetism and size-modulated electronic structures in two-dimensional cluster-based metal-organic frameworks

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第4期67卷 1334-1340页

作者： Jing cheng Xingxing li Jinlong Yang Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of ChinaHefei 230026China Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China

Cluster-assembled materials have attracted particular attention for their complex hierarchical structures and unique ***,the majority of cluster-based assemblies developed so far are either non-magnetic or only exhibit magnetic ordering with a relatively low Curie temperature,limiting their applications in ***,two-dimensional(2D)cluster-assembled materials with room-temperature magnetism remain highly *** this purpose,based on first principles calculations,we design a series of thermodynamically stable 2D cluster-based metal-organic frameworks(MOFs)Fe_(n)-(pyz)(n=1-6)by utilizing Fenmetal clusters as nodes and nitrogen-containing pyrazine ligands as organic *** 2D cluster-based MOFs exhibit robust ferrimagnetic ordering due to the strong d-p direct exchange interaction between d-electron spin of Fe_(n)(n=1-6)clusters and charge transfer-induced p-electron spin of pyrazine *** particular,the ferrimagnetic Curie temperatures are well above room temperature(up to 836 K).Additionally,altering the size of Fe_(n)clusters in Fe_(n)-(pyz)(n=1-6)MOFs results in diverse functional spintronic properties,including bipolar magnetic semiconductors,half semiconductors and Dirac half ***,these 2D assembled MOFs possess sizable magnetic anisotropy energies,up to 9.16 me V per formula.

关键词： metal-organic framework two-dimensional material half metal bipolar magnetic semiconductor magnet

Unsupervised construction of health indicator for rotating machinery via multi-criterion feature selection and attentive variational autoencoder

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2024年第5期67卷 1524-1537页

作者： li XinYu cheng ChangMing PENG ZhiKe State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai200240China School of Mechanical Engineering Ningxia UniversityYinchuan750021China

Health indicator(HI)construction is a crucial task in degradation evaluation and facilitates the prognostic and health management(PHM)of rotating *** interference from artificial labeling,the HI construction approaches in an unsupervised manner have attracted substantial ***,current unsupervised methods generally struggle with two problems:(1)ignorance of both redundancy between features and global variability of features during the feature selection process;(2)inadequate utilization of information from different sampling *** tackle these problems,this work develops a novel unsupervised approach for HI construction that integrates multi-criterion feature selection and the Attentive Variational Autoencoder(Attentive VAE).Explicitly,a multi-criterion feature selection(Mc FS)algorithm together with an elaborately designed metric is proposed to determine a superior feature subset,considering the relevance,the redundancy,and the global variability of features ***,for the adequate utilization of the information from distinct sampling moments,a deep learning model named Attentive VAE is *** Attentive VAE is solely fed with the selected features in the health state for model training and the HI is derived through the reconstruction error to reveal the degradation degree of *** case studies based on genuine experimental datasets are involved to quantitatively evaluate the superiority of the developed approach,demonstrating its superiority over other unsupervised methods for characterizing degradation *** effectiveness of both the Mc FS algorithm and the Attentive VAE is verified by ablation experiments,respectively.

关键词： health indicator(HI) unsupervised learning multi-criterion feature selection global variability attention mechanism

Recent progress in functional modification and crosslinking of bioprosthetic heart valves

在线全文

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2024年第1期3卷 1-16页

作者： cheng Zheng li Yang Yunbing Wang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China

Valvular heart disease(VHD),clinically manifested as stenosis and regurgitation of native heart valve,is one of the most prevalent cardiovascular diseases with high *** valve replacement surgery has been recognized as golden standard for the treatment of *** to the clinical application of transcatheter heart valve replacement technic and the excellent hemodynamic performance of bioprosthetic heart valves(BHVs),implantation of BHVs has been increasing over recent years and gradually became the preferred choice for the treatment of ***,BHVs might fail within 10-15 years due to structural valvular degeneration(SVD),which was greatly associated with drawbacks of glutaraldehyde crosslinked BHVs,including cytotoxicity,calcification,component degradation,mechanical failure,thrombosis and immune *** prolong the service life of BHVs,much effort has been devoted to overcoming the drawbacks of BHVs and reducing the risk of *** this review,we summarized and analyzed the research and progress on:(i)modification strategies based on glutaraldehyde crosslinked BHVs and(ii)nonglutaraldehyde crosslinking strategies for BHVs.

关键词： bioprosthetic heart valves modification crosslinking anticalcification antithrombosis

A novel micro-rolling&incremental sheet forming hybrid process:Deformation behavior and microstructure evolution

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第5期37卷 603-622页

作者： Yanle li Feifei liU Hao yuan Xiaoqiang li Jianfeng li Guoqun ZHAO Key Laboratory of High Efficiency and Clean Mechanical Manufacture Ministry of EducationShandong UniversityJi'nan 250061China School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Key Laboratory for liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJi'nan 250061China

Thin-walled metal parts with functional micro-featured surface have broad application prospects in the fields of resistance reduction,noise reduction,*** this study,a novel micro-rolling&incremental sheet forming hybrid process(μR-ISF)is proposed to fabricate thin-walled metal parts with microgroove *** analytical model which relates the rolling force and microgroove depth in the micro-rolling stage was first ***,the formation mechanism of microgroove morphology during both micro-rolling stage and macro-shape forming stage are *** the micro-grooved sheet being incrementally formed,a significant reduction(between 21%to nearly 60%)is occurred in the depth of both transverse and longitudinal grooves compared to the flat ***,the width of transverse grooves decreases slightly by about 10%on average,while the width of longitudinal microgrooves increases significantly by more than 30%on *** micro-rolling,85°{102}tensile twins appear on the micro-grooved sheet and the percentage of 65°{112}compressive twins *** incremental forming,the percentage of low-angle grain boundaries and the density of geometrically necessary dislocations in the formed part increase significantly,and the grain size distribution becomes more *** present work provides a new strategy for the fabrication of 3D metal thin-walled components with surface micro-features.

关键词： Incremental sheet forming Microgrooves rolling Surface micromachining Groove size Microstructural evolution

Health outcomes of electronic cigarettes

在线全文

学校读者我要写书评

暂无评论

中华医学杂志(英文版) 2024年第16期137卷 1903-1911页

作者： li Xinmeng yuan lingzhi Wang Fen Department of Gastroenterology The Third Xiangya Hospital Central South University Changsha Hunan China Hunan Key Laboratory of Non-resolving Inflammation and Cancer The Third Xiangya Hospital Central South University Changsha Hunan China

The usage of electronic cigarettes (e-cigarettes) sparked an outbreak of unidentified vaping-related lung disease in the US during late 2019. With e-cigarettes becoming more and more popular, smokers have more options other than conventional cigarettes. Under these circumstances, a comprehensive evaluation of the general safety of new tobacco and tobacco-related products, represented by e-cigarettes, to human health is necessary. In this review, we summarize the current research on potential negative impacts of e-cigarette exposure on human health. In particular, studies detailing the relationship between e-cigarettes and the digestive system are summarized, with mechanisms mainly including hepatic metabolic dysfunction, impaired gut barrier, and worsened outcomes of inflammatory bowel disease (IBD). Although believed to be safer than traditional cigarettes, e-cigarettes exert adverse effects on systemic health and induce the development of multiple diseases including asthma, cardiovascular disease, and IBD. Moreover, nicotine-containing e-cigarettes have a negative impact on the childhood development and increase the risk of arterial stiffness compared to the non-nicotine e-cigarettes. However, non-nicotine e-cigarette components have detrimental effects including promoting liver damage and metabolic disorders.

关键词： Electronic cigarettes Electronic nicotine delivery system Smoking cessation Health promotion Tobacco harm reduction Smoker

An unprecedented synthesis of axially chiral biaryls by rearrangement and aromatization of carbocations with central-to-axial conversion of chirality

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第9期67卷 2998-3003页

作者： Qi liu Xue-Dong li liang cheng li liu Beijing National Laboratory for Molecular Sciences(BNLMS) CAS Key Laboratory of Molecular Recognition and FunctionCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The central-to-axial chirality conversion represents a fascinating class of chemical processes consisting of the destruction of stereogenic centers and the simultaneous installation of axial chiral elements,which provides efficient methods for the preparation of axially chiral ***,developing catalytic asymmetric approaches for constructing these central chirality precursors and the efficient central-to-axial chirality conversion remains a challenge due to the requirement of aromatization or elimination *** this work,we have developed an unprecedented enantioselective intramolecular FriedelCrafts alkylation with unactivated-ketone carbonyls from which a chiral tertiary alcohol was generated with high efficiency and excellent *** addition,the central-to-axial chirality conversion strategy has been successfully applied to the synthesis of enantioenriched biaryls via a less-explored carbocation-initiated rearrangement and aromatization under the promotion of Lewis *** methodology provided a straightforward and sustainable access to a broad range of biaryl-2-carboxylic acid and in excellent yields(up to 92%)and excellent central-to-axial chirality conversion(up to 99%conversion percentage).This work could be a great model for developing new methods for synthesizing axially chiral biaryls and a general protocol for the rearrangement and aromatization of carbocations for further functionalization.

关键词： br?nsted acid catalysis desymmetrization phosphoric acid axially chiral biaryls central-to-axial conversion

Structural Properties of Ions and Polyelectrolytes in Aqueous Solutions under External Electric Fields:The Sign Effect

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第9期42卷 1341-1352,I0007页

作者： cheng-Jiang lin Jun-Jun Wang yuan Jiang Shu-li Chen Hong-Fei li Wen-Han Zhao Qing-Rong Huang Chang-Ru Rong Xiao-Zheng Duan State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China National Key Laboratory of Advanced Vehicle Integration and Control China FAW Group Co.Ltd.Changchun130013China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200438China Department of Food Science Rutgers University65 Dudley RoadNew BrunswickNew Jersey08901USA

We utilize molecular dynamics simulations to investigate the microstructures of ions and polyelectrolytes in aqueous solutions under external electric *** focusing on the multi-body interactions between ionic components and H_(2)O molecules,as well as their responses to the external electric fields,we clarify several nontrivial molecular features of the ionic and polyelectrolyte solutions,such as the solvations of cations and anions,clustering of the ions,and dispersions/aggregations of polyelectrolyte chains,as well as the corresponding responses of H_(2)O molecules in these *** simulations illustrate the variations in structures of ionic solutions caused by reversing the charge sign of the ions,and elucidate the disparity in structures between anionic and cationic polyelectrolyte solutions in the presence of the external electric *** work clarifies the mechanism for the alternations in complex multi-body interactions in aqueous solutions caused by the application electric field,which can contribute to the fundamental understanding of the physical and chemical natures of ion-containing and charged polymeric systems.

关键词： Polyelectrolyte Ions Aqueous solutions External electric fields Asymmetric dipole

New insight into Ca^(2+)-permeable channel in plant immunity

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2024年第3期66卷 623-631页

作者： Wei Wang Hang-yuan cheng Jian-Min Zhou State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hainan Yazhou Bay Seed Laboratory Sanya 572025China

Calcium ions(Ca^(2+)) are crucial intracellular second messengers in eukaryotic cells. Upon pathogen perception, plants generate a transient and rapid increase in cytoplasmic Ca^(2+)levels, which is subsequently decoded by Ca^(2+)sensors and effectors to activate downstream immune responses. The elevation of cytosolic Ca^(2+)is commonly attributed to Ca^(2+)influx mediated by plasma membranelocalized Ca^(2+)–permeable channels. However, the contribution of Ca^(2+)release triggered by intracellular Ca^(2+)-permeable channels in shaping Ca^(2+)signaling associated with plant immunity remains poorly understood. This review discusses recent advances in understanding the mechanism underlying the shaping of Ca^(2+)signatures upon the activation of immune receptors, with particular emphasis on the identification of intracellular immune receptors as non-canonical Ca^(2+)-permeable channels. We also discuss the involvement of Ca^(2+)release from the endoplasmic reticulum in generating Ca^(2+)signaling during plant immunity.

关键词： Ca^(2+)-permeable channels endoplasmic reticulum phosphorylation plant immunity resistosome