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Chinese Chemical Letters 2024年第3期35卷 87-95页

作者： Peiwen Liu Hui Jin yan Chen Derong Wang Haohui yan Mingzhao Wu Fang Zhao Weiping zhu State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China Engineering Research Center of Pharmaceutical Process Chemistry Ministry of EducationSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

The pharmaceutical industry is now paying increased attention to continuous *** the revolution to continuous and automated manufacturing is deepening in most of the top pharma companies in the world,the advancement of automated pharmaceutical continuous manufacturing in China is relatively slow due to some key challenges including the lack of knowledge on the related technologies and shortage of qualified *** this review,emphasis is given to two of the crucial technologies in automated pharmaceutical continuous manufacturing,i.e.,process analytical technology(PAT)and self-optimizing *** work published in recent 5 years employing advanced PAT tools and self-optimization algorithms is introduced,which represents the great progress that has been made in automated pharmaceutical continuous manufacturing.

关键词： Pharmaceutical continuous manufacturing Automation Process analytical technology Self-optimization algorithm

Optimizing piezoelectric performance of complex perovskite through increasing diversity of B-site cations

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Journal of Materials Science & Technology 2024年第3期170卷 78-86页

作者： Mengdi cheng Dongyan Zhang yangxi yan Zhimin Li Pangpang Wang Ri-ichi Murakami School of Advanced Materials and Nanotechnology Xidian UniversityXi’an 710126China Nanomaterials Group Institute of SystemInformation Technologies and Nanotechnologies(ISIT)Fukuoka Industry-Academia Symphonicity(FiaS)4-1 KyudaishinmachiNishi-kuFukuoka 819-0388Japan School of Mechanical Engineering Chengdu UniversityChengdu 610106China

Piezoelectric materials with unique properties are hugely appealing for high sensitivity sensors and ultrasonic ***,Pb(Ni_(1/3)Nb_(2/3))O_(3)-Pb(Yb_(1/2)Nb_(1/2))O_(3)-PbTiO_(3)piezoelectric system was designed and investigated in *** optimized piezoelectric response(d_(33)=826 pC/N,d_(33)∗=1017 pm/V)together with good temperature stability and negligible performance degradation up to 10^(6) cycles was achieved in 0.58PNN-0.10PYN-0.32PT *** analysis revealed the amplification of intrinsic and extrinsic contributions in MPB region due to more spontaneous polarization orientations and an increase in chemical disorder of system after the introduction of *** origin of high piezoelectric response was investigated through the combination of scanning electron microscopy and piezoresponse force *** diversity of B-site cations was shown to enhance local structural heterogeneity,weaken long-range ferroelectric ordered domains,and lower free energy barrier via the formation of nanodomain configuration that promoted polarization rotation,thereby improving piezoelectric properties of the ***,it is suggested that increasing the diversity of B-site cations is an effective strategy for achieving outstanding piezoelectric performance.

关键词： PNN-PYN-PT ceramics Piezoelectricity enhancement Relaxation behavior Domain structure

Microstructure,wear and friction behavior of CoCrAITaY-xCNTs composite coatings deposited by laser-induction hybrid cladding

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Rare Metals 2024年第4期43卷 1815-1827页

作者： Sheng-Feng Zhou Yu Long yan-Liang Yi cheng Deng Lian-Xi Hu Institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou510632China Wuhan National Laboratory for Optoelectronics(WNLO) Huazhong University of Science and TechnologyWuhan430074China MOE Key Laboratory of New Processing Technology for Non-Ferrous Metals and Materials Guangxi Key Laboratory of Processing for Non-Ferrous Metals and Featured MaterialsGuangxi UniversityNanning530004China School of Mechatronics Engineering Guangdong Polytechnic Normal UniversityGuangzhou510635China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin150001China

To improve the wear performance of CoCrAlYTa coating,part of the carbon nanotubes(CNTs)chemically reacted with Ta to form reinforcement phase(TaC),while the other CNTs were retained as lubrication ***,the CoCrAlYTa-xCNTs(x=0,1,2,and 4;wt%)composite coatings were prepared by laserinduction hybrid cladding(LIHC),and the microstructure and wear resistance of coatings were systematically *** show that the coatings are mainly composed of TaC,y-(Co,Cr)andβ-(Co,Cr)*** the CNTs content increases from 0 wt%to 4 wt%,the volume fraction of TaC increases from 13.11 vol%to 16.12 vol%.Meanwhile,the nano-hardness ofγ-(Co,Cr)andβ-(Co,Cr)Al are improved from 7.49 and 9.72 to 9.36 and 11.19 GPa,*** a result,the microhardness of coating increases from HV536.25 to HV 738.16,the wear rate decreases from32.4×10^(-3)to 6.1×10^(-3)mg·m^(-1),and the average friction coefficient decreases from 0.55 to *** good wear performance of the coating is attributed to the formation of TaC and the existence of remained CNTs lubricant film.

关键词： Carbon nanotube MCrAlY coating Friction and wear performance Laser-induction hybrid cladding

Scene text recognition via dual character counting-aware visual and semantic modeling network

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Science China(Information Sciences) 2024年第3期67卷 313-314页

作者： Ke XIAO Anna zhu Brian Kenji IWANA cheng-Lin LIU School of Computer Science and Artificial Intelligence Wuhan University of Technology Human Interface Laboratory Kyushu University State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of Sciences School of Artificial Intelligence University of Chinese Academy of Sciences

Scene text recognition(STR) is drawing increasing attention nowadays due to its wide application in real life. Character counting information, as auxiliary information, has been shown to be effective in boosting text ... 详细信息

关键词： Decoding

Airblast evolution initiated by Wangjiayan landslides in the M_(s)8.0 Wenchuan earthquake and its destructive capacity analysis

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China Geology 2024年第2期7卷 237-247页

作者： Yu-feng Wang Qian-gong cheng Qi zhu Department of Geological Engineering Southwest Jiaotong UniversityChengdu 610031China Sichuan Highway Planning SurveyDesign and Research Institute LtdChengdu 610041China

Airblasts,as one common phenomenon accompanied by rapid movements of landslides or rock/snow avalanches,commonly result in catastrophic damages and are attracting more and more scientific *** quantitatively analyze the intensity of airblast initiated by landslides,the Wangjiayan landslide,occurred in the Wenchuan earthquake,is selected here with the landslide propagation and airblast evolution being studied using FLUENT by introducing the Voellmy rheological *** results reveal that:(1)For the Wangjiayan landslide,its whole travelling duration is only 12 s with its maximum velocity reaching 36 m/s at t=10 s;(2)corresponding to the landslide propagation,the maximum velocity,28 m/s,of the airblast initiated by the landslide also appears at t=10 s with its maximum pressure reaching594.8 Pa,which is equivalent to violent storm;(3)under the attack of airblast,the load suffered by buildings in the airblast zone increases to 1300 Pa at t=9.4 s and sharply decreased to-7000 Pa as the rapid decrease of the velocity of the sliding mass at t=10 s,which is seriously unfavorable for buildings and might be the key reason for the destructive collapse of buildings in the airblast zone of the Wangjiayan landslide.

关键词： Landslide Voellmy rheological law 3D FLUENT simulation Airblast Intensity Building destructive collapse Wenchuan earthquake Geological hazards survey engineering

Pyrotinib and chrysin synergistically potentiate autophagy in HER2-positive breast cancer

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Signal Transduction and Targeted Therapy 2024年第1期9卷 295-307页

作者： Xiaoxiao Liu Xing Zhang Zhiying Shao Xiaorong Zhong Xin Ding Liang Wu Jie Chen Ping He yan cheng Kunrui zhu Dan Zheng Jing Jing Ting Luo Institute for Breast Health Medicine Cancer CenterBreast CenterWest China HospitalSichuan University610041 ChengduSichuanChina Department of Radiation Oncology Cancer CenterAffiliated Hospital of Xuzhou Medical UniversityJiangsu Center for the Collaboration and Innovation of Cancer BiotherapyCancer InstituteXuzhou Medical University221000 XuzhouChina Department of Orthopedics Trauma and Reconstructive SurgeryUniversity Hospital RWTH AachenAachen 52074Germany Cancer Institute Xuzhou Medical University221000 XuzhouJiangsuChina Division of Nephrology and Transplantation Department of Internal MedicineUniversity Medical Center Rotterdam Erasmus MCRotterdam 3015 GDThe Netherlands Institute for Breast Health Medicine Department of General SurgeryBreast CenterWest China HospitalSichuan University610041 ChengduSichuanChina Institute for Breast Health Medicine West China HospitalSichuan University610041 ChengduSichuanChina

Human epidermal growth factor receptor 2(HER2)-positive breast cancer(BC)has been the most challenging subtype of BC,consisting of 20%of BC with an apparent correlation with poor *** that pyrotinib,a new HER2 inhibitor,has led to dramatic improvements in prognosis,the efficacy of pyrotinib monotherapy remains largely restricted due to its acquired ***,identifying a new potential antitumor drug in combination with pyrotinib to amplify therapeutic efficacy is a pressing ***,we reported a novel combination of pyrotinib with chrysin and explored its antitumor efficacy and the underlying mechanism in HER2-positive *** determined that pyrotinib combined with chrysin yielded a potent synergistic effect to induce more evident cell cycle arrest,inhibit the proliferation of BT-474 and SK-BR-3 BC cells,and repress in vivo tumor growth in xenograft mice *** may be attributed to enhanced autophagy induced by endoplasmic reticulum ***,the combined treatment of pyrotinib and chrysin induced ubiquitination and glucose-6-phosphate dehydrogenase(G6PD)degradation by upregulating zinc finger and BTB/POZ domain-containing family protein 16(ZBTB16)in tumorigenesis of ***,we identified that miR-16-5p was a potential upstream regulator of ZBTB16,and it showed a significant inverse correlation with *** of miR-16-5p overexpression by restoring ZBTB16 significantly potentiated the overall antitumor efficacy of pyrotinib combined with chrysin against HER2-positive ***,these findings demonstrate that the combined treatment of pyrotinib and chrysin enhances autophagy in HER2-positive BC through an unrecognized miR-16-5p/ZBTB16/G6PD axis.

关键词： HER2 synergistic Together

The Role of Grain Boundaries in Organic-Inorganic Hybrid Perovskite Solar Cells and its Current Enhancement Strategies:A Review

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Energy & Environmental Materials 2024年第4期7卷 175-204页

作者： Jindan Zhang Shicheng Tang Mengqi zhu Zhenghong Li Zhibin cheng Shengchang Xiang Zhangjing Zhang College of Chemistry and Materials Science Fujian Key Laboratory of Polymer Materials Fujian Normal University

Grain boundaries (GBs) in perovskite polycrystalline films are the most sensitive place for the formation of the defect states and the accumulation of ***,abundant works have been carried out to explore their properti... 详细信息

关键词： additives charge carrier dynamics grain boundaries perovskite solar cells

The Astrometric Performance of the China Space Station Telescope(CSST)Sky Survey in Extending the Gaia Celestial Reference Frame

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Research in Astronomy and Astrophysics 2024年第8期24卷 133-140页

作者： Jun Yao Jia-cheng Liu Niu Liu Zi zhu Zhen-Wei Wang School of Astronomy and Space Science Key Laboratory of Modern Astronomy and Astrophysics(Ministry of Education)Nanjing UniversityNanjing 210023China University of Chinese Academy of Sciences Nanjing 211135China

The multi-color imaging sky survey conducted by the China Space Station Telescope(CSST)holds significant promise for advancing the development of the celestial reference *** this study,we focus on assessing the astrometric performance of the CSST celestial reference frame(CSST-CRF)in extending the Gaia Celestial Reference Frame 3(Gaia-CRF3).First,the orientation precision of the CSST reference frame is evaluated using a simulated set of extragalactic sources with CSST g magnitudes ranging from 18 to 25 *** estimated orientation uncertainty caused by random error insignificantly affects the alignment between Gaia-CRF3 and the ***,the systematic effect of incomplete CSST sky coverage on the alignment between CSST-CRF and Gaia-CRF3 is discussed by analyzing the differences between the subset of Gaia-CRF3 in the CSST observation region(Gaia-CRF3′)and Gaia-CRF3 as a *** the third International Celestial Reference Frame(ICRF3)S/X band as an intermediate reference frame,the orientation offset between Gaia-CRF3′and GaiaCRF3 is estimated to be 20μ*** offset is marginally larger than the orientation offset between Gaia-CRF3 and the ICRF3,approximately 15μ*** residual spin and glide rate of Gaia-CRF3′are derived from the proper motions,consistent with that of Gaia-CRF3 within the formal ***,we explore the role of CSST in establishing a multi-band celestial reference frame by comparing its limiting magnitude and observation accuracy with existing catalogs in the infrared and ultraviolet *** to its broad wavelength coverage and highprecision measurements,CSST is well-positioned to make significant contributions to the development of a multiband celestial reference frame.

关键词： astrometry-reference systems-surveys

Single-atom alloys prepared by two-step thermal evaporation

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Nano Research 2024年第4期17卷 2808-2813页

作者： Honglin Wang Jing Li Meirong Huang Jizhe Cui Zhiying cheng Rong Yu Hongwei zhu State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China State Key Lab of Solid Waste Reuse for Building Materials Beijing Building Materials Academy of Science ResearchBeijing 100041China

Single-atom alloys(SAAs)have gained significant attention due to their remarkable atomic utilization efficiency,interactions between single atoms(SAs)and metal supports,and free-atom-like electronic structure of dopant *** this work,we observed the formation of SAs in pre-deposited metal particles by a two-step thermal evaporation technique,thereby establishing the first instance of discovering SAAs by thermal *** discovery of SAAs by thermal evaporation extends the range of SAAs preparation methods to include this traditional synthetic technique,which offers convenience,cost-efficiency,and *** formation mechanism of SAAs prepared using this technique was elucidated by density functional theory *** was demonstrated that thermal evaporation can be utilized to prepare SAAs with multiple SAs,further highlighting its universal applicability.

关键词： single-atom alloys thermal evaporation density functional theory

Binding SnO2 Nanoparticles with MoS2 Nanosheets Toward Highly Reversible and Cycle-Stable Lithium/Sodium Storage

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Energy & Environmental Materials 2024年第4期7卷 135-142页

作者： Deliang cheng Wenbiao Zhang Yi Tang Qingsheng Gao Renzong Hu Lichun yang Min zhu Institute of Advanced Materials Jiangxi Normal University School of Materials Science and Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials South China University of Technology College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications Jinan University Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Laboratory of Advanced Materials and Collaborative Innovation Center of Chemistry for Energy Materials Fudan University

SnO2,with its high theoretical capacity,abundant resources,and environmental friendliness,is widely regarded as a potential anode material for lithium-ion batteries （LIBs）.Nevertheless,the coarsening of the Sn nanop... 详细信息

关键词： 1 T-MoS2 heterostructure lithium-ion batteries Sn coarsening SnO2