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Routine blood tests to predict liver fibrosis in chronic hepatitis C

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World Journal of Gastroenterology 2012年第8期18卷 746-753页

作者： Yung-Yu Hsieh Shui-Yi Tung cheng-shyong wu Kuo- Liang Wei Chien-Heng Shen Te-Sheng Chang Kamfai Lee Yi-Hsiung Lin Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital Chiayi 613 Taiwan Chang Gung University College of Medicine Taoyuan 333 Taiwan Chiayi School ChangOung Institute of Technology Chiayi 613 Taiwan Department of Pathology Chang Gung MemorialHospital Chiayi 613 Taiwan Department of Health Care Administration Taiwan Shoufu University Tainan 721 Taiwan

AIM: To verify the usefulness of FibroQ for predicting fi brosis in patients with chronic hepatitis C, compared with other noninvasive tests. METHODS: This retrospective cohort study included 237 consecutive patients with chronic hepatitis C who had undergone percutaneous liver biopsy before treatment. FibroQ, aspartate aminotransferase (AST)/alanine aminotransferase ratio (AAR), AST to platelet ratioindex, cirrhosis discriminant score, age-platelet index (API), Pohl score, FIB-4 index, and Lok's model were calculated and compared. RESULTS: FibroQ, FIB-4, AAR, API and Lok's model results increased significantly as fibrosis advanced (analysis of variance test: P < 0.001). FibroQ trended to be superior in predicting signifi cant fi brosis score in chronic hepatitis C compared with other noninvasive tests. CONCLUSION: FibroQ is a simple and useful test for predicting signifi cant fi brosis in patients with chronic hepatitis C.

关键词： Liver fibrosis Noninvasive test FibroQ Aspartate aminotransferase, Alanine aminotransferase FIB-4 index Aspartate aminotransferase to plateletratio index Lok's model Cirrhosis discriminant score Pohl score

Fusobacterium nucleatum colonization is associated with decreased survival of helicobacter pylori-positive gastric cancer patients

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World Journal of Gastroenterology 2021年第42期27卷 7311-7323页

作者： Yung-Yu Hsieh Shui-Yi Tung Hung-Yu Pan Te-Sheng Chang Kuo-Liang Wei Wei-Ming Chen Yi-Fang Deng Chung-Kuang Lu Yu-Hsuan Lai cheng-shyong wu Chin Li Department of Gastroenterology and Hepatology Chiayi Chang Gung Memorial HospitalChiayi 61301Taiwan College of Medicine Chang Gung UniversityTaoyuan 33302Taiwan Department of Applied Mathematics National Chiayi UniversityChiayi 60035Taiwan Department of Biomedical Sciences National Chung Cheng UniversityChiayi 62130Taiwan

BACKGROUND An increased amount of Fusobacterium nucleatum(***)is frequently detected in the gastric cancer-associated microbiota of the Taiwan Residents *** is known to exert cytotoxic effects and play a role in the progression of colorectal cancer,though the impact of *** colonization on gastric cancer cells and patient prognosis has not yet been *** To identify ***-dependent molecular pathways in gastric cancer cells and to determine the impact of *** on survival in gastric *** Coculture of *** with a gastric cancer cell line was performed,and changes in gene expression were *** with significant changes in expression were identified by RNA *** analysis was carried out to determine deregulated cellular functions.A cohort of gastric cancer patients undergoing gastrectomy was recruited,and nested polymerase chain reaction was performed to detect the presence of *** in resected cancer *** analysis was performed to determine whether *** colonization affects patient *** RNA sequencing and subsequent pathway analysis revealed a drastic interferon response induced by a high colonization *** response peaked within 24 h and subsided after 72 h of *** contrast,deregulation of actin and its regulators was observed during prolonged incubation under a low colonization load,likely altering the mobility of gastric cancer *** to the clinical specimen analysis,approximately one-third of the gastric cancer patients were positive for ***,and statistical analysis indicated that the risk for colonization increases in late-stage cancer *** analysis demonstrated that *** colonization was associated with poorer outcomes among patients also positive for Helicobacter pylori(***).CONCLUSION *** colonization leads to deregulation of actin dynamics and likely changes cance

关键词： Fusobacterium nucleatum Helicobacter pylori Gastric cancer Survival Interferon Mobility

Selection Method for New Energy Output Guaranteed Rates Considering Optimal Energy Storage Configuration

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 539-547页

作者： Xin cheng Tong wu Wei Yao Yan Yang Guangdong Power Grid Corporation Guangzhou 510620China State Key Laboratory of Advanced Electromagnetic Engineering and Technology and School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The output of new energy represented by wind power and photovoltaic power features volatility and randomness. It is a practical approach to use the guaranteed rate with statistical characteristics to analyze the output coefficient of new energy. However, there is a lack of analysis and demonstration on the value of the new energy output guaranteed rate. To solve this problem, a selection method for the new energy output guaranteed rate considering optimal energy storage configuration is proposed. First, the influence of the new energy output guaranteed rate on the new energy output coefficient is analyzed. Secondly, with the goal of minimizing the comprehensive costs, an optimal configuration model of energy storage based on the output guaranteed rate of new energy is constructed, and particle swarm optimization is used for the optimization solution. Then, according to the optimal energy storage configuration results under different guaranteed rates, a reasonable new energy output guaranteed rate is determined by maximizing the comprehensive benefits obtained from energy storage. Finally, an example applied to the power grid in an area of Guangdong in Southern China is provided to illustrate the effectiveness of the proposed method.

关键词： Energystorage optimization guaranteed output guaranteed rate new energy consumption

Capillary Property of Entangled Porous Metallic Wire materials and Its Application in Fluid Buffers:Theoretical Analysis and Experimental Study

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Defence Technology（防务技术） 2024年第1期31卷 400-416页

作者： Yu Tang Yiwan wu Hu cheng Rong Liu Engineering Research Center for Metal Rubber School of Mechanical Engineering and AutomationFuzhou UniversityFuzhou 350156China AECC Guizhou Liyang Aviation Power Co. LTDGuiyang 550014China College of Computer and Information Sciences Fujian Agriculture and Forestry UniversityFuzhou 350156China

Strong impact does serious harm to the military industries so it is necessary to choose reasonable cushioning material and design effective buffers to prevent the impact of *** on the capillary property entangled porous metallic wire materials(EPMWM),this paper designed a composite buffer which uses EPMWM and viscous fluid as cushioning materials under the low-speed impact of the recoil force device of weapon equipment(such as artillery,mortar,etc.).Combined with the capillary model,porosity,hydraulic diameter,maximum pore diameter and pore distribution were used to characterize the pore structure characteristics of *** calculation model of the damping force of the composite buffer was *** low-speed impact test of the composite buffer was *** parameters of the buffer under low-speed impact were identified according to the model,and the nonlinear model of damping force was *** test results show that the composite buffer with EPMWM and viscous fluid can absorb the impact energy from the recoil movement effectively,and provide a new method for the buffer design of weapon equipment(such as artillery,mortar,etc.).

关键词： Entangled porous metallic wire materials Capillary property Viscousfluid Low-speed impact Damping force

Recent advances in post-chiroptical manipulation of supramolecular aggregates assembled with molecular modules

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Science China Chemistry 2024年第9期67卷 2842-2863页

作者： Yanling Shen Wanhua wu Zhipeng Yu cheng Yang Key Laboratory of Green Chemistry&Technology of Ministry of Education College of Chemistry InstitutionSichuan UniversityChengdu 610064China

Recently,various supramolecular assembly systems have been identified where the pre-existing chiral supramolecular structure can be manipulated through environmental adjustments,such as temperature,solvent,and *** changes result in diverse microscopic morphologies during the assembly process and induce chiroptical variations,particularly in circular dichroism(CD)and circularly polarized luminescence(CPL)*** chiroptical properties serve as direct indicators of the chiral supramolecular structure and hold promise for applications in sensing,molecular recognition,asymmetric synthesis,and material *** review focuses on research published in the last five years,highlighting instances where assembled structures aggregated by small organic molecular modules demonstrate in-situ chiroptical changes through external condition *** categorizes and discusses different modes of regulation,aiming to offer insights and guidelines for exploring dynamic changes in assembly processes and designing in-situ adjustable structures of assembly modules.

关键词： supramolecular assemblies post-chiroptical manipulation in-situ structural changes

Fault-tolerant identity-based encryption from SM9

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Science China(Information Sciences) 2024年第2期67卷 104-117页

作者： Xiaohong LIU Xinyi HUANG Zhaohui cheng Wei wu Fujian Provincial Key Laboratory of Network Security and Cryptology College of Computer and Cyber SecurityFujian Normal University Artificial Intelligence Thrust Information HubThe Hong Kong University of Science and Technology (Guangzhou) Olym Information Security Technology Ltd. Center for Applied Mathematics of Fujian Province School of Mathematics and StatisticsFujian Normal University

This paper initiates the formal study of attribute-based encryption within the framework of SM9,the Chinese National Cryptography Standard for Identity-Based Cryptography, by presenting two new faulttolerant identity-based encryption(FIBE) schemes. Our first scheme uses the same private-key/ciphertext structure as the original SM9 algorithm and operates in a small attribute universe. As a result, it can be effectively and smoothly integrated into the information systems using SM9. In the random oracle model,we prove that our scheme is ciphertext-indistinguishable against fuzzy selective-identity and chosen-plaintext attacks under the(k + 3)-DBDHI assumption. Our second design is a large universe FIBE scheme based on SM9 that is ciphertext-indistinguishable against chosen-plaintext attacks in the random oracle model under the(f, g)-GDDHE assumption. Finally, we compare the communication and computing costs of our schemes to those of other classical ones. The comparison shows that our schemes have comparable performance as others. We believe that our findings will accelerate the applications of SM9 in modern information systems such as cloud computing and blockchain.

关键词： attribute-based encryption identity-based encryption fault-tolerant SM9

Microstructure recognition of steels by machine learning based on visual attention mechanism

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Journal of Iron and Steel Research International 2024年第4期31卷 909-923页

作者： Xing-yu Chen Lin cheng cheng-yang Hu Yu-peng Zhang Kai-ming wu The State Key Laboratory of Refractories and Metallurgy Hubei Province Key Laboratory of Systems Science on Metallurgical ProcessingInternational Research Institute for Steel TechnologyCollaborative Center on Advanced SteelsWuhan University of Science and TechnologyWuhan 430081HubeiChina Metals Valley and Band(Foshan)Metallic Composite Materials Co. Ltd.Foshan 528000GuangdongChina

U-Net has achieved good performance with the small-scale datasets through skip connections to merge the features of the low-level layers and high-level layers and has been widely utilized in biomedical image segmentation as well as recent microstructure image segregation of the *** representative visual attention mechanism modules,named as squeeze-and-excitation networks,convolutional block attention module,and extended calibration algorithm,were intro-duced into the traditional U-Net architecture to further improve the prediction *** is found that compared with the original U-Net architecture,the evaluation index of the improved U-Net architecture has been significantly improved for the microstructure segmentation of the steels with the ferrite/martensite composite microstructure and pearlite/ferrite composite microstructure and the complex martensite/austenite island/bainite microstructure,which demonstrates the advantages of the utilization of the visual attention mechanism in the microstructure *** reasons for the accuracy improvement were discussed based on the feature maps analysis.

关键词： Microstructure recognition-Steel Machine learning Visual attention mechanism Visualization

Prediction of cell-cell communication patierns of dorsal root ganglion cells:single-cell RNA sequencing data analysis

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Neural Regeneration Research 2024年第6期19卷 1367-1374页

作者： Yanna Lian cheng wu Li Liu Xiangyao Li National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology Ministry of Education Frontier Science Center for Brain Research and Brain-Machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina International Institutes of Medicine the Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwuZhejiang ProvinceChina Zhejiang University-University of Edinburgh Institute Zhejiang University School of MedicineZhejiang UniversityHainingZhejiang ProvinceChina Biomedical Sciences College of Medicine and Veterinary MedicineThe University of EdinburghEdinburghUK Core Facilities of the School of Medicine Zhejiang UniversityHangzhouZhejiang ProvinceChina

Dorsal root ganglion neurons transmit peripheral somatic information to the central nervous system,and dorsal root ganglion neuron excitability affects pain *** root ganglion stimulation is a new approach for managing pain *** of the cell-cell communication among dorsal root ganglion cells may help in the development of new pain and itch management ***,we used the single-cell RNA-sequencing(scRNA-seq)database to investigate intercellular communication networks among dorsal root ganglion *** collected scRNA-seq data from six samples from three studies,yielding data on a total of 17,766 *** on genetic profiles,we identified satellite glial cells,Schwann cells,neurons,vascular endothelial cells,immune cells,fibroblasts,and vascular smooth muscle *** analysis revealed that eight types of dorsal root ganglion neurons mediated proprioceptive,itch,touch,mechanical,heat,and cold ***,we predicted several distinct forms of intercellular communication among dorsal root ganglion cells,including cell-cell contact,secreted signals,extracellular matrix,and neurotransmitter-mediated *** data mining predicted that Mrgpra3-positive neurons robustly express the genes encoding the adenosine Adora2b(A2B)receptor and glial cell line-derived neurotrophic factor family receptor alpha 1(GFRα-1).Our immunohistochemistry results confirmed the coexpression of the A2B receptor and GFRα-*** injection of the A2B receptor antagonist PSB-603 effectively prevented histamine-induced scratching behaviour in a dose-dependent *** results demonstrate the involvement of the A2B receptor in the modulation of itch ***,our findings provide insight into dorsal root ganglion cell-cell communication patterns and *** results should contribute to the development of new strategies for the regulation of dorsal root ganglion excitability.

关键词： cell-cell communications CellChat dorsal root ganglion scRNA-Seq database

Cosmological interpretation for the stochastic signal in pulsar timing arrays

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 43-50页

作者： Yu-Mei wu Zu-cheng Chen Qing-Guo Huang School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China Advanced Institute of Natural Sciences Beijing Normal UniversityZhuhai 519087China Department of Physics and Synergistic Innovation Center for Quantum Effects and Applications Hunan Normal UniversityChangsha 410081China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China

The pulsar timing array(PTA)collaborations have recently reported compelling evidence for a stochastic signal consistent with a gravitational-wave *** this paper,we combine the latest data sets from NANOGrav,PPTA,and EPTA to explore cosmological interpretations for the PTA signal from first-order phase transitions,domain walls,and cosmic strings,*** find that the domain wall model is strongly disfavored with the Bayes factors compared with the first-order phase transitions and cosmic strings being 1/90 and 1/189,respectively,breaking the degeneracy among these models in individual data *** also find that:(1)a strong phase transition at temperatures below the electroweak scale is favored,and the bubble collisions make the dominant contribution to the energy density spectrum;(2)a small reconnection probability p<1.55×10^(-1)allowed by strings in(super)string theory is favored at the 95%confidence level,and ground-based detectors can further constrain the parameter space.

关键词： puslar timing arrays gravitational-wave background first-order phase transitions domain walls cosmic strings