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GLI1 and PTTG1 expression in colorectal carcinoma patients undergoing radical surgery and their correlation with lymph node metastasis

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1328-1335页

作者： feng Cao yang-Yan Chen Hong-cheng Wang Department of Care Section Beijing Geriatric HospitalBeijing 100095China Research Department Shanghai Zhangjiang Institute of Medical InnovationShanghai 200000China Care Department Beijing Geriatric HospitalBeijing 100095China

BACKGROUND Few studies have investigated the expression of GLI1 and PTTG1 in patients undergoing radical surgery for colorectal carcinoma(CRC)and their association with lymph node metastasis(LNM).Therefore,more relevant studies and analyses need to be conducted.AIM To explore GLI1 and PTTG1 expression in patients undergoing radical surgery for CRC and their correlation with LNM.METHODS This study selected 103 patients with CRC admitted to our hospital between April 2020 and April 2023.Sample specimens of CRC and adjacent tissues were collected to determine the positive rates and expression levels of GLI1 and PTTG1.The correlation of the two genes with patients’clinicopathological data(e.g.,LNM)was explored,and differences in GLI1 and PTTG1 expression between patients with LNM and those without were analyzed.Receiver operating characteristic(ROC)curves were plotted to evaluate the predictive potential of the two genes for LNM in patients with CRC.RESULTS Significantly higher positive rates and expression levels of GLI1 and PTTG1 wereobserved in CRC tissue samples compared with adjacent tissues.GLI1 and PTTG1 were strongly linked to LNM in patients undergoing radical surgery for CRC,with higher GLI1 and PTTG1 levels found in patients with LNM than in those without.The areas under the ROC curve of GLI1 and PTTG1 in assessing LNM in patients with CRC were 0.824 and 0.811,respectively.CONCLUSION GLI1 and PTTG1 expression was upregulated in patients undergoing radical surgery for CRC and are significantly related to LNM in these patients.Moreover,high GLI1 and PTTG1 expression can indicate LNM in patients with CRC undergoing radical surgery.The expression of both genes has certain diagnostic and therapeutic significance.

关键词： Colorectal carcinoma GLI1 PTTG1 Radical resection Lymph node metastasis

Perforated gastric ulcer causing mediastinal emphysema: A case report

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World Journal of Clinical Cases 2024年第4期12卷 859-864页

作者： Zhi-cheng Dai Xun-Wu Gui feng-He yang Hao-Yuan Zhang Wen-feng Zhang Department of General Surgery Mengcheng County First People's HospitalMengcheng 233500Anhui ProvinceChina Department of Medical Imaging Mengcheng County First People's HospitalMengcheng 233500Anhui ProvinceChina

BACKGROUND Mediastinal emphysema is a condition in which air enters the mediastinum between the connective tissue spaces within the pleura for a variety of reasons.It can be spontaneous or secondary to chest trauma,esophageal perforation,medi-cally induced factors,etc.Its common symptoms are chest pain,tightness in the chest,and respiratory distress.Most mediastinal emphysema patients have mild symptoms,but severe mediastinal emphysema can cause respiratory and circulatory failure,resulting in serious consequences.CASE SUMMARY A 75-year-old man,living alone,presented with sudden onset of severe epigastric pain with chest tightness after drinking alcohol.Due to the remoteness of his residence and lack of neighbors,the patient was found by his nephew and brought to the hospital the next morning after the disease onset.Computed tomography(CT)showed free gas in the abdominal cavity,mediastinal emph-ysema,and subcutaneous pneumothorax.Upper gastrointestinal angiography showed that the esophageal mucosa was intact and the gastric antrum was perforated.Therefore,we chose to perform open gastric perforation repair on the patient under thoracic epidural anesthesia combined with intravenous anesthesia.An operative incision of the muscle layer of the patient's abdominal wall was made,and a large amount of subperitoneal gas was revealed.And a continued incision of the peritoneum revealed the presence of a perforation of approx-imately 0.5 cm in the gastric antrum,which we repaired after pathological examination.Postoperatively,the patient received high-flow oxygen and cough exercises.Chest CT was performed on the first and sixth postoperative days,and the mediastinal and subcutaneous gas was gradually reduced.CONCLUSION After gastric perforation,a large amount of free gas in the abdominal cavity can reach the mediastinum through the loose connective tissue at the esophageal hiatus of the diaphragm,and upper gastrointestinal angiography can clarify the site of perforation.In patients with mediastinal emphysema,open surgery av

关键词： Gastric ulcer Perforated Mediastinal emphysema Case report

UVR8-TCP4-LOX2 module regulates UV-B tolerance in Arabidopsis

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Journal of Integrative Plant Biology 2024年第5期66卷 897-908页

作者： cheng Li Jiancan Du Huini Xu Zhenhua feng Caspar CCChater Yuanwen Duan Yongping yang Xudong Sun Yunnan Key Laboratory of Crop Wild Relatives Omics The Germplasm Bank of Wild SpeciesKunming Institute of BotanyChinese Academyof SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China CAs Key Laboratory of Tropical Plant Resources and Sustainable Use Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesKunming 650223China Faculty of Life Science and Technology Kunming University of Science and TechnologyKunming 650031China Royal Botanic Gardens KewRichmondSurrey TW93AEUK

The phytohormone jasmonate(JA)coordinates stress and growth responses to increase plant survival in unfavorable environments.Although JA can enhance plant UV-B stress tolerance,the mechanisms underlying the interaction of UV-B and JA in this response remain unknown.In this study,we demonstrate that the UV RESISTANCE LOCUS 8-TEOSINTE BRANCHED1,Cycloidea and PCF 4-LIPOXYGENASE2(UVR8-TCP4-LOX2)module regulates UV-B tolerance dependent on JA signaling pathway in Arabidopsis thaliana.We show that the nucleus-localized UVR8 physically interacts with TCP4 to increase the DNA-binding activity of TCP4 and upregulate the JA biosynthesis gene LOX2.Furthermore,UVR8 activates the expression of LOX2 in a TCP4-dependent manner.Our genetic analysis also provides evidence that TCP4 acts downstream of UVR8 and upstream of LOX2 to mediate plant responses to UV-B stress.Our results illustrate that the UV-B-dependent interaction of UVR8 and TCP4 serves as an important UVR8-TCP4-LOX2 module,which integrates UV-B radiation and JA signaling and represents a new UVR8 signaling mechanism in plants.

关键词： anthocyanin accumulation jasmonic acid TCP4 UV-B UVR8

Quantum phase transition of the Jaynes-Cummings model

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 1-9页

作者： cheng Liu Jin-feng Huang Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Key Laboratory for Matter Microstructure and Function of Hunan ProvinceDepartment of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsInstitute of Interdisciplinary StudiesHunan Normal UniversityChangsha 410081China

Herein,we propose an experimentally feasible scheme to show the quantum phase transition of the Jaynes-Cummings(JC)model by modulating the transition frequency of a two-level system in a quantum Rabi model with strong coupling.By tuning the modulation frequency and amplitude,the ratio of the effective coupling strength of the rotating terms to the effective cavity(atomic transition)frequency can enter the deep-strong coupling regime,while the counter-rotating terms can be neglected.Thus,a deep-strong JC model is obtained.The ratio of the coupling strength to resonance frequencies in the deep-strong JC model is two orders of magnitude larger than the corresponding ratio in the original quantum Rabi model.Our scheme can be employed in atom-cavity resonance and off-resonance cases,and it is valid over a broad range.The nonzero average cavity photons of the ground state indicate the emergence of a quantum phase transition.Further,we demonstrate the dependence of the phase diagram on the atom-cavity detuning and modulation parameters.All the parameters used in our scheme are within the reach of current experimental technology.Our scheme provides a new mechanism for investigating the critical phenomena of finite-sized systems without requiring classical field limits,thereby opening a door for studying fundamental quantum phenomena occurring in the ultrastrong and even deep-strong coupling regimes.

关键词： Jaynes-Cummings model quantum phase transition frequency modulation

Design,preparation,application of advanced array structured materials and their action mechanism analyses for high performance lithium-sulfur batteries

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Journal of Energy Chemistry 2024年第2期89卷 266-303,I0007页

作者： Nanping Deng Xiaofan feng Yongbing Jin Zhaozhao Peng yang feng Ying Tian Yong Liu Lu Gao Weimin Kang Bowen cheng State Key Laboratory of Separation Membranes and Membrane Processes/National Center for International Joint Research on Separation Membranes School of Textile Science and EngineeringTiangong UniversityTianjin 300387China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China

Lithium-sulfur battery(LSB)has brought much attention and concern because of high theoretical specific capacity and energy density as one of main competitors for next-generation energy storage systems.The widely commercial application and development of LSB is mainly hindered by serious“shuttle effect”of lithium polysulfides(Li PSs),slow reaction kinetics,notorious lithium dendrites,etc.In various structures of LSB materials,array structured materials,possessing the composition of ordered micro units with the same or similar characteristics of each unit,present excellent application potential for various secondary cells due to some merits such as immobilization of active substances,high specific surface area,appropriate pore sizes,easy modification of functional material surface,accommodated huge volume change,enough facilitated transportation for electrons/lithium ions,and special functional groups strongly adsorbing Li PSs.Thus many novel array structured materials are applied to battery for tackling thorny problems mentioned above.In this review,recent progresses and developments on array structured materials applied in LSBs including preparation ways,collaborative structural designs based on array structures,and action mechanism analyses in improving electrochemical performance and safety are summarized.Meanwhile,we also have detailed discussion for array structured materials in LSBs and constructed the structure-function relationships between array structured materials and battery performances.Lastly,some directions and prospects about preparation ways,functional modifications,and practical applications of array structured materials in LSBs are generalized.We hope the review can attract more researchers'attention and bring more studying on array structured materials for other secondary batteries including LSB.

关键词： Array structured materials Preparation methods and structural designs Action mechanism analyses Advanced Li-S batteries Excellent electrochemical performances and safety

AP-1 and SP1 trans-activate the expression of hepatic CYP1A1 and CYP2A6 in the bioactivation of AFB1 in chicken

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Science China(Life Sciences) 2024年第7期67卷 1468-1478页

作者： Jiang Deng Jia-cheng yang Yue feng Ze-Jing Xu Kamil Kuča Meng Liu Lv-Hui Sun State Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryFrontiers Science Center for Animal Breeding and Sustainable ProductionCollege of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhan 430070China Department of Chemistry Faculty of ScienceUniversity of Hradec KraloveHradec Kralove 50003Czech Republic

Dietary exposure to aflatoxin B1(AFB1)is harmful to the health and performance of domestic animals.The hepatic cytochrome P450s(CYPs),CYP1A1 and CYP2A6,are the primary enzymes responsible for the bioactivation of AFB1to the highly toxic exo-AFB1-8,9-epoxide(AFBO)in chicks.However,the transcriptional regulation mechanism of these CYP genes in the liver of chicks in AFB1metabolism remains unknown.Dual-luciferase reporter assay,bioinformatics and site-directed mutation results indicated that specificity protein 1(SP1)and activator protein-1(AP-1)motifs were located in the core region-1,063/-948,-606/-541 of the CYP1A1 promoter as well as-636/-595,-503/-462,-147/-1 of the CYP2A6 promoter.Furthermore,overexpression and decoy oligodeoxynucleotide technologies demonstrated that SP1 and AP-1 were pivotal transcriptional activators regulating the promoter activity of CYP1A1 and CYP2A6.Moreover,bioactivation of AFB1to AFBO could be increased by upregulation of CYP1A1 and CYP2A6 expression,which was trans-activated owing to the upregulation of AP-1,rather than SP1,stimulated by AFB1-induced reactive oxygen species.Additionally,nano-selenium could reduce ROS,downregulate AP-1 expression and then decrease the expression of CYP1A1 and CYP2A6,thus alleviating the toxicity of AFB1.In conclusion,AP-1 and SP1 played important roles in the transactivation of CYP1A1 and CYP2A6 expression and further bioactivated AFB1to AFBO in chicken liver,which could provide novel targets for the remediation of aflatoxicosis in chicks.

关键词： aflatoxin B1 CYP1A1 CYP2A6 SP1 AP-1 transcriptional activation

Notoginsenoside Ft1 inhibits colorectal cancer growth by increasing CD8^(+)T cell proportion in tumor-bearing mice through the USP9X signaling pathway

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Chinese Journal of Natural Medicines 2024年第4期22卷 329-340页

作者： feng Yutao LI Yuan MA Fen WU Enjiang cheng Zewei ZHOU Shiling WANG Zhengtao yang Li SUN Xun ZHANG Jiwei Shanghai Key Laboratory of Compound Chinese Medicines The MOE Key Laboratory for Standardization of Chinese MedicinesInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China Gastrointestinal surgery Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

The management of colorectal cancer(CRC)poses a significant challenge,necessitating the development of innovative and effective therapeutics.Our research has shown that notoginsenoside Ft1(Ng-Ft1),a small molecule,markedly inhibits subcutaneous tumor formation in CRC and enhances the proportion of CD8^(+)T cells in tumor-bearing mice,thus restraining tumor growth.Investigation into the mechanism revealed that Ng-Ft1 selectively targets the deubiquitination enzyme USP9X,undermining its role in shieldingβ-catenin.This leads to a reduction in the expression of downstream effectors in the Wnt signaling pathway.These findings indicate that Ng-Ft1 could be a promising small-molecule treatment for CRC,working by blocking tumor progression via the Wnt signaling pathway and augmenting CD8^(+)T cell prevalence within the tumor environment.

关键词： Notoginsenoside Ft1 Colorectal cancer CD8^(+)T cell Ubiquitin-specific peptidase 9 X-linked β-Catenin Wnt

Hydrodynamic Characteristics of Undular Tidal Bores in the Qiantang River Based on Field Observations

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China Ocean Engineering 2024年第3期38卷 505-518页

作者： ZHANG Shu-yu PAN Cun-hong ZHANG Shen-yang LI Ruo-hua cheng Wenlong XIE Dong-feng Zhejiang Tongji Vocational College of Science and Technology Hangzhou 311231China Zhejiang Institute of Hydraulics and Estuary Hangzhou 310020China

Understanding the undular tidal bores in the Qiantang River is essential for effective river management and maintenance.While breaking tidal bores have been studied extensively, reports on undular tidal bores in the Qiantang Riverremain limited. Furthermore, observed data on undular tidal bores fulfilling the requirements of short measurementtime intervals, and spring, medium, and neap tide coverage, and providing detailed data for the global vertical stratificationof flow velocity are quite limited. Based on field observations at Qige in the Qiantang estuary, we analyzedthe characteristics of undular tidal bores. The results showed that the flooding amplitude (a) of the first wave isalways larger than its ebbing amplitude (b). Moreover, the vertical distribution of the maximum flood velocity exhibitesthree shapes, influenced by the tidal range, while that of the maximum ebb velocity exhibites a single shape. Duringthe initial phase of the flood tide in the spring and medium tides, the upper water body experiences multiple oscillatingchanges along the flow direction, corresponding to the alternating process of the crest and trough of the tide levelupon the arrival of the tidal bore. The tidal range is a crucial parameter in tidal bore hydrodynamics. By establishingthe relationship between hydrodynamic parameters and tidal range, other hydrodynamic parameters, such as the tidalbore height, maximum flood depth–averaged velocity, maximum flood stratified velocity at the measurement points,and duration of the flood tide current, can be effectively predicted, thereby providing an important reference for rivermanagement and maintenance.

关键词： tidal bores Qiantang Estuary tidal bore height tidal bore velocity propagation speed

Meta-analysis of factors influencing anterior knee pain after total knee arthroplasty

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World Journal of Orthopedics 2024年第2期15卷 180-191页

作者： Hui feng Ming-Li feng Jing-Bo cheng Xiang Zhang Hai-cheng Tao Department of Orthopaedic Surgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China

BACKGROUND Total knee arthroplasty(TKA)is a mature procedure recommended for correcting knee osteoarthritis deformity,relieving pain,and restoring normal biomechanics.Although TKA is a successful and cost-effective procedure,patient dissatisfaction is as high as 50%.Knee pain after TKA is a significant cause of patient dissatisfaction;the most common location for residual pain is the anterior region.Between 4%and 40%of patients have anterior knee pain(AKP).AIM To investigate the effect of various TKA procedures on postoperative AKP.METHODS We searched PubMed,EMBASE,and Cochrane from January 2000 to September 2022.Randomized controlled trials with one intervention in the experimental group and no corresponding intervention(or other interventions)in the control group were collected.Two researchers independently read the title and abstract of the studies,preliminarily screened the articles,and read the full text in detail according to the selection criteria.Conflicts were resolved by consultation with a third researcher.And relevant data from the included studies were extracted and analyzed using Review Manager 5.4 software.RESULTS There were 25 randomized controlled trials;13 were comparative studies with or without patellar resurfacing.The meta-analysis showed no significant difference between the experimental and control groups(P=0.61).Six studies were comparative studies of circumpatellar denervation vs non-denervation,divided into three subgroups for meta-analysis.The two-subgroup meta-analysis showed no significant difference between the experimental and the control groups(P=0.31,P=0.50).One subgroup meta-analysis showed a significant difference between the experimental and control groups(P=0.001).Two studies compared fixed-bearing TKA and mobile-bearing TKA;the results meta-analysis showed no significant difference between the experimental and control groups(P=0.630).Two studies compared lateral retinacular release vs non-release;the meta-analysis showed a significant difference between the experimental and c

关键词： Total knee arthroplasty Anterior knee pain Knee osteoarthritis Interventions Meta-analysis