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Medication Rule Analysis of the Diagnosis and Treatment Programs of Chinese Medicine for the Prevention and Treatment of COVID-19 in China

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Chinese Journal of Integrative Medicine 2022年第9期28卷 779-784页

作者： JI Xin-yu MA Yan SHI Shuai LIU Si-hong TONG Lin lyu cheng ZHANG Hua-min WANG Yan-ping Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China Guang’anmen Hospital China Academy of Chinese Medical SciencesBeijing100053China Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing100700China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing100700China

Objectives:To summarize the measures and rules of Chinese medicine(CM)and provide reference for clinical application in the prevention and treatment of coronavirus disease(COVID-19).Methods:The data source was from CM COVID-19 prevention and treatment programs on government websites and official media websites of the different provinces and *** search lasted from December 8,2019 to March 10,*** variables were medication frequency and combinations of *** analysis and complex network analysis were used by prevention and treatment stage and by ***:Among 27 CM diagnosis and treatment plans,203 therapeutic prescriptions were enrolled,of which the top 4 herbs were:Radix glycyrrhizae,Semen armeniacae amarum,Herba ephedrae,and Herba agastachis,*** core combinations were Herba ephedrae and Semen armeniacae ***-eight preventive formulae were *** herbs,including Radix Astragali seu hedysari,Radix glycyrrhizae,Radix saposhnikoviae,Flos lonicerae,*** most frequently *** core prescription of CM compatibility was Radix astragali seu hedysari,Radix glycyrrhizae,and Radix saposhnikoviae,which is the main component of Yu Ping Feng *** were 45 prevention and treatment prescriptions in East China;the most used CM was Radix glycyrrhizae,Herba agastachis,Pericarpium citri reticulatae,and Gypsum *** prescriptions were identified in North *** to CM analyses,Herba agastachis,Semen armeniacae amarum,Herba ephedrae,and Poria were most frequently ***:CM for COVID-19 prevention mainly focuses on improving human immunity;for treatment,prescription focuses on clearing the lungs and removing *** vary with regions,perhaps due to climatic and environmental differences,which help clinicians to quickly make CM plans and treat patients according to clinical status,further minimizing resource wastage.

关键词： COVID-19 Chinese medicine regularity of medication

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Carbohydrate antigen 19-9 as a novel prognostic biomarker in distal cholangiocarcinoma

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World Journal of Gastrointestinal Surgery 2021年第9期13卷 1025-1038页

作者： Tao Jiang Shao-cheng lyu Lin Zhou Jing Wang Han Li Qiang He Ren Lang Department of Hepatobiliary Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China

BACKGROUND Distal cholangiocarcinoma(DCC)presents as one of the relatively rare malignant tumors in the digestive system and has a poor long-term *** resection is currently the most appropriate therapy for patients with DCC because of the lack of effective adjuvant ***,it is important to accurately predict the prognosis for formulating a reasonable treatment plan and avoiding unnecessary surgical *** To minimize the interference of obstructive jaundice on carbohydrate antigen 19-9(CA19-9)level by adapting CA19-9 toγ-glutamyltransferase(GGT)as an indicator,to determine the strong associations between CA19-9/GGT and postoperative neoplasm recurrence and long-term outcome of *** We enrolled 186 patients who were diagnosed with DCC between January 2010 and December 2019 and performed radical excision with strict criteria as follows in our *** operating characteristic curves were drawn according to preoperative CA19-9/GGT and 1-year *** on this,patients were divided into two groups(group 1,low-ratio,n=81;group 2,high-ratio,n=105).Afterwards,by the way of univariate and multivariate analysis,the risk factors influencing postoperative tumor recrudesce and long-term prognosis of patients with DCC were screened *** Optimum cut-off value of CA19-9/GGT was *** in group 2 represented higher CA19-9 and lymphatic metastasis rate accompanied by lower GGT,when compared with group 1(P<0.05).The 1-,3-and 5-year overall survival rates of patients in groups 1 and 2 were 88.3%,59.2%and 48.1%,and 61.0%,13.6%and 13.6%,respectively(P=0.000).Multivariate analysis indicated that CA19-9/GGT,lymphatic metastasis and tumor differentiation were independent risk factors for tumor recurrence and long-term prognosis of *** Elevation of CA19-9/GGT performed better as a biomarker of aggressive carcinoma and predictor of poor clinical outcomes by reducing the effect of obstruction of biliary tract on CA

关键词： Distal cholangiocarcinoma Pancreaticoduodenectomy Carbohydrate antigen 19-9 γ-Glutamyltransferase Relapse Prognosis

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Potential therapeutic mechanism of traditional Chinese medicine monomers on neurological recovery after spinal cord injury

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Chinese Medical Journal 2021年第14期134卷 1681-1683页

作者： Tao Zhang Kai Gao Ting-Zhen Yan cheng-Wei lyu Chao-Liang lyu Medical College Jining Medical UniversityJiningShandong 272000China Department of Orthopedics Jining No.1 People’s HospitalJiningShandong 272000China.

Spinal cord injury(SCI)is a common traumatic disease of the central nervous system;it causes serious physical and psychological harm to patients and a huge economic burden on the entire society.[1]The tough situation of SCI treatment requires further exploration of the mechanism and obtaining a new therapeutic *** Chinese medicine(TCM)is based on syndrome differentiation and treatment and overall concepts,and TCM compounds are used as the main method to treat ***,its specific molecular mechanism has not been elucidated.

关键词： therapeutic mechanism injury

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集体土地使用权转让的宪法依据及其规范解释

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中国土地科学 2021年第12期35卷 36-43页

作者：吕成安徽省社会科学院安徽合肥230051

研究目的:探求集体土地使用权转让宪法依据的规范内涵。研究方法:规范分析法。研究结果:通过文义解释、体系解释和目的解释发现,作为集体土地使用权转让的宪法依据,“土地的使用权可以依照法律的规定转让”既没有专门为集体土地使用权... 详细信息

研究目的:探求集体土地使用权转让宪法依据的规范内涵。研究方法:规范分析法。研究结果:通过文义解释、体系解释和目的解释发现,作为集体土地使用权转让的宪法依据,“土地的使用权可以依照法律的规定转让”既没有专门为集体土地使用权转让提供宪法依据的立法意图,也没有限制集体土地使用权转让的立法意图。该规定的立法目的是同时为国有土地使用权转让和集体土地使用权转让提供一个制度框架,以此框架建构的法秩序均具备形式合宪性。研究结论:应在具备形式合宪性基础上建构具备实质合宪性的集体土地使用权转让法秩序。

关键词：集体土地使用权转让宪法依据规范解释

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Clinical value of extended lymphadenectomy in radical surgery for pancreatic head carcinoma at different T stages

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World Journal of Gastrointestinal Surgery 2022年第11期14卷 1204-1218页

作者： Shao-cheng lyu Han-Xuan Wang Ze-Ping Liu Jing Wang Jin-Can Huang Qiang He Ren Lang Department of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China School of Biomedicine Bejing City UniversityBeijing 100084China

BACKGROUND As the lymph-node metastasis rate and sites vary among pancreatic head carcinomas(PHCs)of different T stages,selective extended lymphadenectomy(ELD)performance may improve the prognosis of patients with *** To investigate the effect of ELD on the long-term prognosis of patients with PHC of different T *** We analyzed data from 216 patients with PHC who underwent surgery at our hospital between January 2011 and December *** patients were divided into extended and standard lymphadenectomy(SLD)groups according to extent of lymphadenectomy and into T1,T2,and T3 groups according to the 8 th edition of the American Joint Committee on Cancer’s staging *** data and prognoses were compared among *** factors associated with prognoses were identified through univariate and multivariate *** The 1-,2-and 3-year overall survival(OS)rates in the extended and SLD groups were 69.0%,39.5%,and 26.8%and 55.1%,32.6%,and 22.1%,respectively(P=0.073).The 1-,2-and 3-year disease-free survival rates in the extended and SLD groups of patients with stage-T3 PHC were 50.3%,25.1%,and 15.1%and 22.1%,1.7%,and 0%,respectively(P=0.025);the corresponding OS rates were 65.3%,38.1%,and 21.8%and 36.1%,7.5%,and 0%,respectively(P=0.073).Multivariate analysis indicated that portal vein invasion and lymphadenectomy extent were risk factors for prognosis in patients with stage-T3 *** ELD may improve the prognosis of patients with stage-T3 PHC and may be of benefit if performed selectively.

关键词： Pancreatic head carcinoma Extended lymphadenectomy T stage Surgical treatment Risk factor Long-term prognosis

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穿心莲内酯磺化物抗耐甲氧西林金黄色葡萄球菌及其生物膜的药效及机制

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环球中医药 2024年第9期17卷 1731-1741页

作者：温博冯小玉张璐璐李丽 Tariq Mahmood 吕诚杨伟峰谭勇中国中医科学院中医临床基础医学研究所北京100700 巴基斯坦真纳大学植物科学系中国中医科学院医学实验中心

目的探讨穿心莲内酯磺化物(andrographolide sulfonate,AS)抗耐甲氧西林金黄色葡萄球菌(methicillin resistant staphylococcus aureus,MRSA)及其生物膜(biofilm,BF)的药效及机制。方法采用微量肉汤倍比稀释法测定AS对MRSA的最低抑菌浓度(minimum inhibition concentration,MIC);生长曲线法测定不同浓度AS作用MRSA 24小时内的细菌时间—生长曲线;微孔板法测定不同剂量AS给药对成熟MRSA生物膜(MRSA biofilm,MRSA-BF)活菌量的影响;扫描电镜(scanning electron microscope,SEM)观察不同剂量AS对成熟MRSA-BF的形态学变化;通过超高压液相色谱—飞行时间质谱仪法(UPLC-TOF-MS)分析不同剂量AS干预成熟MRSA-BF菌体的内源性代谢物谱特征。结果AS表现出显著的抗MRSA活性,MIC为50 mg/mL;12.5 mg/mL和6.25 mg/mL浓度的AS均可较好地抑制MRSA及其BF的生长,破坏已成熟的膜性结构,且抑制作用呈剂量依赖关系。代谢组学结果提示27个内源性终端代谢物是反映生物膜形成的代谢物,相关的生物通路有苯丙氨酸(phenylalanine,PA)、酪氨酸(tyrosine,Tyr)、色氨酸的生物合成以及牛磺酸和亚牛磺酸代谢;16个内源性终端代谢物是6.25 mg/mL AS干预MRSA-BF的代谢标志物,相关的生物通路为苯丙氨酸、酪氨酸和色氨酸的生物合成;18个内源性终端代谢物是12.5 mg/mL AS干预MRSA-BF的代谢标志物,通路分析未发现相关的生物通路;11个内源性终端代谢物是反映AS干预MRSA-BF的药效代谢标志物,其相关的生物通路包括苯丙氨酸、酪氨酸和色氨酸的生物合成、新生霉素的生物合成以及苯丙氨酸的代谢。结论AS对MRSA及其成熟生物膜均有抑制作用,抑制BF的机制与细菌苯丙氨酸、酪氨酸和色氨酸的生物合成、新生霉素的生物合成以及苯丙氨酸的代谢相关。AS可作为临床治疗MRSA-BF感染的潜在有效方案。

关键词：穿心莲内酯磺化物耐甲氧西林金黄色葡萄球菌生物膜代谢组学药效机制

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ZNF554 Inhibits Endometrial Cancer Progression via Regulating RBM5 and Inactivating WNT/β-Catenin Signaling Pathway

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Current Medical Science 2024年第2期44卷 406-418页

作者： cheng-cheng ZHU Heng-liang SUN Teng-fei LONG Yuan-yuan lyu Jiang-li LIU Guan-tai NI Anhui Medical University Hefei 230032China Department of Obstetrics and Gynecology The First Affiliated Hospital of Wannan Medical CollegeWuhu 241001China

Objective:Uterine corpus endometrial carcinoma(UCEC),a kind of gynecologic malignancy,poses a significant risk to women’s *** precise mechanism underlying the development of UCEC remains *** finger protein 554(ZNF554),a member of the Krüppel-associated box domain zinc finger protein superfamily,was reported to be dysregulated in various illnesses,including malignant *** study aimed to examine the involvement of ZNF554 in the development of ***:The expression of ZNF554 in UCEC tissues and cell lines were examined by qRT-PCR and Western blot *** with stably overexpressed or knocked-down ZNF554 were established through lentivirus ***-8,wound healing,and Transwell invasion assays were employed to assess cell proliferation,migration,and *** iodide(PI)staining combined with fluorescence-activated cell sorting(FACS)flow cytometer was utilized to detect cell cycle ***-PCR and Western blotting were conducted to examine relative mRNA and protein *** immunoprecipitation assay and luciferase reporter assay were used to explore the regulatory role of ZNF554 in RNA binding motif 5(RBM5).Results:The expression of ZNF554 was found to be reduced in both UCEC samples and cell *** expression of ZNF554 was associated with higher tumor stage,decreased overall survival,and reduced disease-free survival in ***554 overexpression suppressed cell proliferation,migration,and invasion,while also inducing cell cycle *** contrast,a decrease in ZNF554 expression resulted in the opposite ***,ZNF554 transcriptionally regulated RBM5,leading to the deactivation of the Wingless(WNT)/β-catenin signaling ***,the findings from rescue studies demonstrated that the inhibition of RBM5 negated the impact of ZNF554 overexpression onβ-catenin and p-glycogen synthase kinase-3β(p-GSK-3β).Similarly,the deliberate activation of RBM5 reduced the increase inβ-catenin and

关键词： zinc finger protein 554 endometrial carcinoma RNA binding motif 5 Wingless/β-catenin signaling pathway

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Defect engineering in transition-metal(Fe,Co,andNi)-based electrocatalysts for water splitting

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Carbon Energy 2024年第6期6卷 165-199页

作者： Kaili Wu Chaojie lyu Jiarun cheng Weifan Ding Jiwen Wu Qian Wang Woon-Ming Lau Jinlong Zheng Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijingChina School of Chemistry and Chemical Engineering Linyi UniversityLinyiChina Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijingChina Shunde Innovation School University of Science and Technology BeijingFoshanChina

Electrocatalytic water splitting seems to be an efficient strategy to deal with increasingly serious environmental problems and energy crises but still suffers from the lack of stable and efficient *** practical electrocatalysts by introducing defect engineering,such as hybrid structure,surface vacancies,functional modification,and structural distortions,is proven to be a dependable solution for fabricating electrocatalysts with high catalytic activities,robust stability,and good *** review is an overview of some relevant reports about the effects of defect engineering on the electrocatalytic water splitting performance of *** detail,the types of defects,the preparation and characterization methods,and catalytic performances of electrocatalysts are presented,emphasizing the effects of the introduced defects on the electronic structures of electrocatalysts and the optimization of the intermediates'adsorption energy throughout the ***,the existing challenges and personal perspectives of possible strategies for enhancing the catalytic performances of electrocatalysts are *** in-depth understanding of the effects of defect engineering on the catalytic performance of electrocatalysts will light the way to design high-efficiency electrocatalysts for water splitting and other possible applications.

关键词： defect engineering electrocatalytic water splitting element doping interfacial engineering vacancy

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中医药快速动态指南制定方法(一)——快速动态指南的定义及其在中医药领域的制定现状

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中医杂志 2024年第3期65卷 269-274页

作者：晏利姣梁宁胡紫腾张钰菁陈雅馨张福强李晓玲曹文杰赵晨吕诚史楠楠王燕平中国中医科学院中医临床基础医学研究所北京市100700 陕西省汉中市中医医院

快速动态指南是为应对突发公共卫生事件,在短时间内用科学、规范的方法制订的指南,并通过定期、频繁地更新临床证据和推荐意见,为决策者提供及时可靠的推荐意见。介绍快速动态指南的定义,分析截至2023年6月所发布的8部中医药领域快速动... 详细信息

快速动态指南是为应对突发公共卫生事件,在短时间内用科学、规范的方法制订的指南,并通过定期、频繁地更新临床证据和推荐意见,为决策者提供及时可靠的推荐意见。介绍快速动态指南的定义,分析截至2023年6月所发布的8部中医药领域快速动态指南的基本特征及针对实现快速制定、证据缺乏情况下形成推荐意见、确保指南的时效性三个核心问题的方法学要点。基于现有快速动态指南的分析结果,提出对未来研究的启示:中医药领域开展快速动态指南具有必要性,中医药领域多元证据快速整合方法有待进一步探讨,剖析指南更新的影响因素以促进指南及时更新,可为相关指南制订者和研究者提供参考。

关键词：临床实践指南快速动态指南中医药突发公共卫生事件

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Limit analysis of ultimate uplift capacity and failure mechanism ofshallow plate anchors in multi-layered soils

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Journal of Central South University 2022年第6期29卷 2049-2061页

作者： lyu cheng WANG Zhu-hong ZENG Zheng-qiang ZHANG Xiao State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu 610065China College of Water Resource and Hydropower Sichuan UniversityChengdu 610065China School of Civil Engineering Southwest Jiaotong UniversityChengdu 610000China College of Civil Engineering Tongji UniversityShanghai 200092China

Considering the fact that in some complex cases,plate anchors are buried in multi-layered geotechnical materials,the ultimate dynamic analysis was performed to investigate the uplift capacity and failure mechanism of shallow strips and circular plate anchors in multi-layered *** nonlinear strength criterion and non-associated flow rule of geotechnical materials were introduced to investigate the influence of nonuniformity on the pullout performance and failure mechanism of shallow plate *** expressions of the detaching curves or surfaces were obtained to reflect the failure mechanism,which can be used to figure out the ultimate uplift capacity and failure *** results are generally in agreement with the numerical simulations and previous *** effects of various parameters on the ultimate uplift capacity and failure mechanism of plate anchors in multi-layered soils were investigated,and it is found that the ultimate uplift capacity and failure range of shallow anchors increase with the increase of initial cohesion and dilatancy coefficient,but decrease with the unit weight,axial tensile stress and nonlinear coefficient.

关键词： limit analysis dilatancy coefficient ultimate uplift capacity plate anchors multi-layered soils

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