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Prevalence and influential factors of erectile dysfunction in male renal transplant recipients： a multiple center survey

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Chinese Medical Journal 2008年第9期121卷 795-799页

作者： TIAN Ye JI Zheng-guo TANG Ya-wang ZHANG lei LU Wen-cheng lin Jun GUO hong-bo XIE Ze-lin sun Wen DU lin-dong AO jian-hua MA lin-lin CHEN Li-sheng xu Yuan-cheng Depatment of Urology Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Urology General Hospital of People's Liberation Army Beijing 100036 China Department of Urology Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China Nanjing Jinling Andrology Hospital Nanjing Jiangsu 200029 China

Background Renal transplants can improve the quality of life for recipients, but the quality of their sexual life might not be improved. This study was conducted to research the prevalence of erectile dysfunction （ED） and the influential factors in male renal transplant recipients （RTRs）. Methods A cross-sectional survey was conducted in three renal transplantation centers. Structured questionnaires were administrated by trained interviewers to 824.male renal transplant patients, who had active sexual lives in the last 6 months. Results Complaints of ED were reported by 75.5% of the 809 RTRs （age range 19-75 years, mean age （4.±10） years）, whose questionnaires were completed. Mild, moderate and severe ED were reported at 53.6%, 8.3% and 13.6%, respectively. The mean age and the graft duration were significantly higher in male RTRs with ED compared to potent graft recipients （P=-0.00 and 0.04. respectively）. The prevalence of ED increased with the increase in age. It was 60.7%, 65.8%, 75.2%, 87.5% and 92.2% in patients with age below 30 years, 31-4. years, 4.-50 years, 51-60 years and over 60 years, respectively （P=-0.000）. Moreover, the severity of ED increased with aging. The percentage of moderate and severe cases of ED increased from 6.7% in patients below 4. years to 28.9% in those over 4. years （P=-0.000）. The prevalence of ED in the RTR who had no occupation was higher than in those who were holding a position （P=-0.001）. The prevalence of ED decreased with the increase in the education level. The prevalence of ED was 94.3%, 86.4., 74.0% and 67.8% in men with elementary school or lower, middle school, high school, and college or higher degrees, respectively （P=0.000）. Patients, whose distal end of arteria iliaca interna was interrupted and underwent iterative transplantation, worried transplanted kidney function was impacted by sexual life, and received cyclosporine （CsA）-based immunosuppressive regimens, were more likely to have ED （P=-0.000, 0.001, 0.000, 0.

关键词： erectile dysfunction prevalence renal transplant

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P300/CBP-associated factor(PCAF)-mediated acetylation of Fascin at lysine 4.1 inhibits its actin-bundling activity and tumor metastasis in esophageal cancer

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Cancer Communications 2021年第12期41卷 1398-1416页

作者： Yin-Wei cheng Fa-Min Zeng Da-Jia Li Shao-hong Wang jian-Zhong He Zhen-Chang Guo Ping-Juan Nie Zhi-Yong Wu Wen-Qi Shi Bing Wen Xiu-E {4. Lian-di Liao Zhi-Mao Li jian-Yi Wu Jun Zhan hong-Quan Zhang Zhi-Jie Chang Kai Zhang Li-Yan {4. En-Min Li The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area Department of Biochemistry and Molecular BiologyShantou University Medical CollegeShantouGuangdong 515041P.R.China Institute of Basic Medical Science Cancer Research CenterShantou University Medical CollegeShantouGuangdong 515041P.R.China Shantou Central Hospital Affiliated Shantou Hospital of Sun Yat-sen UniversityShantouGuangdong 515041P.R.China Guangdong Provincial Key Laboratory of Infectious diseases and Molecular Immunopathology Institute of Oncologic PathologyShantou University Medical CollegeShantouGuangdong 515041P.R.China Tianjin Key Laboratory of Medical Epigenetics Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesTianjin Medical UniversityTianjin 300070P.R.China State Key Laboratory of Natural and Biomimetic Drugs Peking University Health Science CenterBeijing 100191P.R.China school of Medicine Tsinghua UniversityBeijing 100084P.R.China

Background:Fascin is crucial for cancer cell filopodium formation and tumor metastasis,and is functionally regulated by post-translational ***,whether and how Fascin is regulated by acetylation remains *** study explored the regulation of Fascin acetylation and its corresponding roles in filopodium formation and tumor ***:Immunoprecipitation and glutathione-S-transferase pull-down assays were performed to examine the interaction between Fascin and acetyltransferase P300/CBP-associated factor(PCAF),and immunofluorescence was used to investigate their *** in vitro acetylation assay was performed to identify Fascin acetylation sites by using mass spectrometry.A specific antibody against acetylated Fascin was generated and used to detect the PCAF-mediated Fascin acetylation in esophageal squamous cell carcinoma(ESCC)cells using Western blotting by overexpressing and knocking down PCAF *** in vitro cell migration assay was performed,and a xenograft model was established to study in vivo tumor ***-cell imaging and fluorescence recovery after photobleaching were used to evaluate the function and dynamics of acetylated Fascin in filopodium *** clinical significance of acetylated Fascin and PCAF in ESCC was evaluated using ***:Fascin directly interacted and colocalized with PCAF in the cytoplasm and was acetylated at lysine 4.1(K4.1)by *** the specific antiAcK4.1-Fascin antibody,Fascin was found to be acetylated in ESCC cells,and the acetylation level was consequently increased after PCAF overexpression and decreased after PCAF ***,Fascin-K4.1 acetylation markedly suppressed in vitro ESCC cell migration and in vivo tumor metastasis,whereas Fascin-K4.1 deacetylation exhibited a potent oncogenic ***,Fascin-K4.1 acetylation reduced filopodial length and density,and lifespan of ESCC cells,while its deacetylation produced the opp

关键词： acetylation actin-bundling esophageal cancer fascin filopodium formation P300/CBPassociated factor(PCAF) tumor metastasis

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Silicon detector array for radioactive beam experiments at HIRFL-RIBLL

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Nuclear Science and Techniques 2018年第11期29卷 271-278页

作者： Fang-Fang Duan Yan-Yun Yang Bi-Tao Hu jian-Song Wang Zhi-Hao Gao Xing-Quan Liu dipikap Patel Peng Ma Jun-Bing Ma Shu-Ya Jin Zhen Bai Qiang Hu Guo Yang Xin-Xin sun Nan-Ru Ma Li-Jie sun Hui-Ming Jia Xin-Xing {4. cheng-jian lin school of Nuclear Science and Technology Lanzhou University Institute of Modern Physics Chinese Academy of Sciences Department of Nuclear Physics China Institute of Atomic Energy school of Physics and Astronomy Shanghai Jiao Tong University Department of Physics The University of Hong Kong

A new and innovative detector system based on a silicon strip detector dedicated to the study of the reaction induced by lighter radioactive beams is described *** detector system consists of five sets of three types of telescopes,which are successfully used to measure the angular distributions of both elastic scattering and breakup simultaneously, on the Radioactive Ion Beam line in Lanzhou at Heavy Ion Research Facility in Lanzhou. This silicon detector array is used to measure the elastic scattering angular distributions of ^(11) Be on a ^(208) Pb target at E_(lab) = 14. and 209 MeV. A comparison of the Monte Carlo simulations with the experimental results shows a reasonable consistency.

关键词： direct nuclear reactions Silicon detector array Radioactive ion beams Monte Carlo simulation

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A detector setup for the measurement of angular distribution of heavy-ion elastic scattering with low energy on RIBLL

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Nuclear Science and Techniques 2017年第7期28卷 85-89页

作者： Gao-Long Zhang Yong-Jin Yao Guang-Xin Zhang Zhen-Wei Jiao cheng-jian lin Ya-Zhou Niu Wei-Wei Qu lei Yang Nan-Rou Ma lei Zheng Hui-Ming Jia Li-Jie sun Xing-Xing Liu Xiao-Tong Chu Jie-cheng Yang jian-Song Wang Shi-Wei xu Peng Ma Jun-Bing Ma Shi-Lun Jin Zhen Bai Mei-Rong Huang {4.-Liang Zang Biao Yang Yang Liu school of Physics and Nuclear Energy Engineering Beihang University Beijing 100191 China China Institute of Atomic Energy Beijing 102413 China school of Radiation Medicine and Protection Medical College of Soochow University Soochow 215123 China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 China school of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100871 China

A detector setup for the measurement of angular distribution of heavy-ion elastic scattering at energies around Coulomb barrier on the radioactive ion beam line in Lanzhou at the heavy-ion research facility in Lanzhou is *** beam profile and the scattering angles on the target are deduced by two parallel plate avalanche counters,and four sets of detector telescopes(including doublesided silicon strip detectors) are placed systematically with the beam line,incorporating with Monte Carlo *** data of ^(16)O on ^(89)Y target were analyzed to compare with the simulation *** is found that the simulated distribution is agreeable with the experimental *** assuming the pure Rutherford scattering at small scattering angles,the angular distribution of elastic scattering of^(16)O+^(89)Y at low energies can be reasonably *** indicates that this set of detector setup can be used for the measurement of angular distributions of heavy-ion elastic scattering at energies around Coulomb barrier.

关键词：兰州放射性束流线重离子研究装置探测器望远镜角分布测量弹性散射低能量设置平行板雪崩计数器

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Degradable Hybrid CuS Nanoparticles for Imaging-Guided Synergistic Cancer Therapy via Low-Power NIR-II Light Excitation

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CCS Chemistry 2021年第5期3卷 1336-1349页

作者： Yidan sun Hua Shi Xiaoyang cheng Luyan Wu Yuqi Wang Zhengyang Zhou jian He hong-Yuan Chen Deju Ye State Key Laboratory of Analytical Chemistry for Life Science Chemistry and Biomedicine Innovation Center(ChemBIC)School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023 Department of Radiology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008

Near-infrared(NIR)-II light-excitable photonic agents capable of generating tumor hyperthermia and cytotoxic free radicals are promising for synergistic phototherapy of ***,the lack of NIR-II excitable agents makes it challenging to achieve combinational tumor ***,the authors have reported on a tumor-targeting and degradable hybrid copper sulfide(CuS)nanoparticle(AIBA@CuS-FA)via loading a hydrophilic Azo initiator(AIBA)into an amphiphilic lipid-encapsulating CuS ***@CuS-FA shows high photothermal conversion efficiency(PCE≈4..5%)at 1064.nm,enabling heat production to trigger tumor hyperthermia and thermal decomposition of AIBA into cytotoxic free alkyl radicals upon irradiation with a 1064.nm laser under low-power density(0.5 W/cm2).Moreover,alkyl radicals can drive degradation of AIBA@CuS-FA and embedded CuS nanodisks,releasing Cu^(2+)ions that can catalyze a Fenton-like reaction for hydroxyl radical(•OH)production to promote tumor *** demonstrate promise for combinational photothermal therapy(PTT),oxygen-independent alkyl radical therapy,and chemodynamic therapy(CDT)of tumors.

关键词： NIR-II copper sulfide alkyl radical synergistic therapy imaging

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Identification of antigens by monoclonal antibody PD4.and its expression in Escherichia coli

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World Journal of Gastroenterology 2003年第10期9卷 2164-2168页

作者： Jin-Ying Ning Guo-xun sun Su Huang hong Ma Ping An lin Meng Shu-Mei Song {4. Wu cheng-Chao Shou, Department of Biochemistry and Molecular Biology, school of Oncology and Beijing Institute for Cancer Research, Peking {4., Beijing 100034. China Department of Biochemistry and Molecular Biology School of Oncology and Beijing Institute for Cancer Research Peking University Beijing 100034 China.

AIM: To clone and express the antigen of monoclonal antibody (Mab) PD4.for further investigation of its ***: MGC803 cDNA expression library was constructed and screened with PD4.as probes to clone the antigen. After failed in the library screening, immunoprecipitation and SDSpolyacrylamide gel electrophoresis were applied to purify the antigen for sequence analysis. The antigen coming from Nycoplasma hyorhinis (M. Hyorhinis) was further confirmed with Western blot analysis by infecting M. Hyorhinis-free HeLa cells and eliminating the M. Hyorhinis from MGC803cells. The full p37 gene was cloned by PCR and expressed successfully in Escherichia coli after site-directed *** assay was used to demonstrate if p37protein could directly bind to gastric tumor cell ***: The cDNA library constructed with MGC803 cells was screened by Mab PD4.as probes. Unfortunately, the positive clones identified with Mab PD4.were also reacted with unrelated antibodies. Then, immunoprecipitation was performed and the purified antigen was identified to be a membrane protein of Mycoplasrna hyorhinis (M. Hyorhinis)by sequencing of N-terminal amino acid residues. The membrane protein was intensively verified with Western blot by eliminating M. Hyorhinis from MGC803 cells and by infecting M. Hyorhinis-free HeLa cells. The full p37 gene was cloned and expressed successfully in Escherichia coli after site-directed mutations. Immunofluorescence demonstrated that p37protein could directly bind to gastric tumor cell ***: The antigen recognized by Mab PD4.is from M. Hyorhinis, which suggests the actions involved in Mab PD4.is possibly mediated by p37 protein or M. Hyorhinis. As p37 protein can bind directly to tumor cells, the pathogenic role of p37 involved in tumorigenesis justifies further investigation.

关键词：大肠埃希氏杆菌单克隆抗体抗原 PCR 基因探针免疫沉淀反应 PD4

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Nanogeology in China:A review

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China Geology 2018年第2期1卷 286-303页

作者： Yi-wen Ju cheng Huang Yan sun Cai-neng Zou hong-ping He Quan Wan xue-qiu Wang Xian-cai Lu Shuang-fang Lu {4.-guang Wu hong-tai Chao Hai-ling Liu Jie-shan Qiu Fei Huang hong-{4. Zhu {4.-chao Cai Yue sun Key Laboratory of Computational Geodynamics Chinese Academy of SciencesCollege of Earth and Planetary SciencesUniversity of Chinese Academy of SciencesBeijing 100049 China Key Laboratory of Marginal Sea Geology of South China Sea Institute of Oceanology Chinese Academy of SciencesCruangzhou 510301China Carbon Research Laboratory School of Chemical EngineeringDalian University of TechnologyDalian 116012China Key Laboratory of Ministry of Education on Safe Mining of Deep MetalMines School of Resources and Civil EngineeringNorthwestern UniversityShenyang 110819China Institute of Geophysies and Geomatics China University ofGeosciences(Wuhan)Wuhan 430074China school of Earth Sciences and Engineering State Key Laboratory for Mineral Deposits ResearchNanjing UniversityNanjing 210093China PetroChina Research Institute of Petroleum Exploration and Development Beijing 100083China Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou 510640China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Institute of Geophysical and Geochemical Exploration CAGSKey Laboratory of Geochemical ExplorationMinistry of Land and ResourcesLangfang 065000China Research Institute of UnconventionalPetroleum and Renewable Energy Chinese University of Petroleum (East China)Qingdao 266580China China United CoalbedMethane Co. Ltd.Beijing 100011China Earthquake Administration of Shandong Province Jinan 250014China

Nanogeology is a subject that is a combination of geology and nanoscale science,and it has been a frontier field in recent *** is also a new subject with the features of intersectionality and multidisciplinary. digging deeper into geological problems and nanoscale phenomena helps better revealing the more essential mechanisms and processes in geological science,which is also an evitable path in the development of *** this paper,we elaborate the concept,feature and main subdisciplines,and summarize three stages ofnanogeology development from preliminary research in the 1990s to subject formation in *** summarizing the researchers'achievements in this field,we illustrate some primary research progresses of nanogeology in China as eight *** the basis of the above content,we propose the development prospect of nanogeology in *** are many geologic problems with scientific values and economic benefits,such as research of geologic fundamental problems,resource exploration and development,mechanism study and prediction of geological activities (disasters),mechanism research and management of environmental pollution and *** has a great potential in China to solve all of these *** a result,the theories and methods of nanogeology will become enriching and *** offers important theoretical basis and technological methods to deal with major issues concerning the national economy and the people's livelihoods,such as the prediction of geological activities,as well as resource dislribution and its exploration and utilization.

关键词： Nanogeology Nanoparticle Nanostructure Scientific frontier Research progress Research prospect

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Design and tests of the prototype a beam monitor of the CSR external target experiment

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Nuclear Science and Techniques 2022年第3期33卷 137-151页

作者： Hu-lin Wang Zhen Wang Chao-Song Gao jian-Wei Liao Xiang-Ming sun Hai-Bo Yang cheng-Xin Zhao Jun Liu Peng Ma Zi-Li Li Bi-Hui You Ping Yang {4. Guo le Xiao Dong-Liang Zhang Yue-Zhao Zhang Sheng Dong Wan-Han Feng Yu-Xin Qiao Zheng-Yu Hu Qing-Wen Ye Zeng-Tao Guo Guang-Ming Huang Feng Liu PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China Hubei Provincial Engineering Research Center of Silicon Pixel Chip&Detection Technology Wuhan 430079China school of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China

A prototype beam monitor was designed to provide tracking information for heavy-ion projectiles for the cool storage ring(CSR)external target experiment(CEE)at the Heavy Ion Research Facility in Lanzhou(HIRFL).High granularity and direct charge sensing are the main features of this *** measures the beam position in a two-dimensional(2D)plane transverse to the beam direction on an event-by-event *** current design consists of two field cages inside a single vessel that operates independently and has electrical drift fields in orthogonal *** tests of the prototype were performed using a^(24.)Am a *** results show that a spatial resolution of less than 4.μm and a time resolution of less than 600 ns can be achieved.

关键词： CEE Beam monitor Heavy ion Topmetal sensor Tracking Field cage

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Formation of unusual Cr^5+charge state in CaCr0.5Fe0.5O3 perovskite

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Chinese Physics B 2018年第3期27卷 433-438页

作者： jian-hong Dai Qing Zhao Qian sun Shuo Zhang Xiao Wang xu-Dong Shen Zhe-hong Liu Xi Shen Ri-cheng Yu Ting-Shan Chan Lun-Xiong Li Guang-Hui Zhou Yi-feng Yang Chang-Qing Jin You-Wen Long Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China school of Physics University of Chinese Academy of SciencesBeijing 100049China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201203China "National"Synchrotron Radiation Research Center 101 Hsin-Ann RoadHsinchu 30076TaiwanChina Institute for Brain Research and Rehabilitation South China Normal UniversityGuangzhou 510631China Department of Physics and Synergetic Innovation Center for Quantum Effects and Applications of Hunan Hunan Normal UniversityChangsha 410081China

A new oxide CaCr0.5Fe0.5O3 was prepared under high pressure and temperature conditions. It crystallizes in a B-site disordered Pbnm perovskite structure. The charge combination is determined to be Cr^5＋/Fe^3＋ with the presence of unusual Cr^5＋ state in octahedral coordination, although Cr^4. and Fe^4. occur in the related perovskites CaCrO3 and CaFeO3. The randomly distributed Cr^5＋ and Fe^3＋ spins {4.ad to short-range ferromagnetic coupling, whereas an antiferromagnetic phase transition takes place near 50 K due to the Fe^3＋-O-Fe^3＋ interaction. In spite of the B-site Cr^5＋/Fe^3＋ disorder, the compound exhibits e{4.ctrical insulating behavior. First-princip{4.s calculations further demonstrate the formation of CaCr0.5^5＋Fe0.5O3 charge combination, and the e{4.ctron correlation effect of Fe^3＋ plays an important ro{4. for the insulting ground state. CaCr0.5Fe0.5O3 provides the first Cr^5＋ perovskite system with octahedral coordination, opening a new avenue to explore novel transition-metal oxides with exotic charge states.

关键词： high pressure synthesis perovskite valence state

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Blood lead level in Chinese adults with and without coronary artery disease

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Journal of Geriatric Cardiology 2021年第11期18卷 857-866页

作者： Shi-hong LI hong-Ju ZHANG Xiao-Dong LI jian CUI Yu-Tong cheng Qian WANG Su WANG Chayakrit Krittanawong Edward A El-Am Rody G.Bou Chaaya Xiang-Yu WU Wei GU hong-hong LIU Xian-Liang YAN Zhi-Zhong LI Shi-Wei YANG Tao sun Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of Echocardiography Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of Cardiology Shougang Changzhi Steel HospitalChangzhiChina Department of Cardiology Baylor College of MedicineHoustonUSA Department of Medicine Indiana University School of MedicineIndianapolisUSA

BACKGROUND The Trial to Assess Chelation Therapy study found that edetate disodium(disodium ethy{4.nediaminetet-raacetic acid)chelation therapy significantly reduced the incidence of cardiac events in stab{4. post-myocardial infarction patients,and a body of epidemiological data has shown that accumulation of biologically active metals,such as {4.ad and cadmium,is an important risk factor for cardiovascular ***,limited studies have focused on the relationship between angiograph-ically diagnosed coronary artery disease(CAD)and {4.ad *** study compared blood {4.ad {4.vel(BLL)in Chinese pa-tients with and without *** In this prospective,observational study,4.0 consecutive patients admitted to Beijing Anzhen Hospital with sus-pected CAD from November 1,2018,to January 30,2019,were *** patients underwent coronary angiography,and an experienced heart team calculated the SYNTAX scores(SXscore)for all availab{4. coronary *** were determined with atomic absorption spectrophotometry and compared between patients with angiographically diagnosed CAD and those without *** In total,34.(76%)patients had CAD,of whom 4.%had low(0−22),22%had intermediate(23−32),and 36%had high(≥33)*** were 36.8±16.95μg/L in patients with CAD and 31.2±15.75μg/L in those without CAD(P=0.003).When BLLs were categorized into three groups(low,midd{4.,high),CAD preva{4.nce increased with increasing BLLs(P4.4.,P=0.003).Furthermore,BLLs were independently associated with intermediate and high SXscore(adjusted OR:1.050,95%CI:1.036-1.066;Pdiagnosed ***,BLLs showed excel-{4.nt predictive value for SXscore,especially for comp{4.x coronary artery {4.sions.

关键词： coronary Blood admitted

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