Blood lead level in Chinese adults with and without coronary artery disease

作     者：Shi-Hong LI Hong-Ju ZHANG Xiao-Dong LI Jian CUI Yu-Tong CHENG Qian WANG Su WANG Chayakrit Krittanawong Edward A El-Am Rody G.Bou Chaaya Xiang-Yu WU Wei GU Hong-Hong LIU Xian-Liang YAN Zhi-Zhong LI Shi-Wei YANG Tao SUN Shi-Hong LI;Hong-Ju ZHANG;Xiao-Dong LI;Jian CUI;Yu-Tong CHENG;Qian WANG;Su WANG;Chayakrit Krittanawong;Edward A El-Am;Rody G.Bou Chaaya;Xiang-Yu WU;Wei GU;Hong-Hong LIU;Xian-Liang YAN;Zhi-Zhong LI;Shi-Wei YANG;Tao SUN

作者机构：Department of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of EchocardiographyBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of CardiologyShougang Changzhi Steel HospitalChangzhiChina Department of CardiologyBaylor College of MedicineHoustonUSA Department of MedicineIndiana University School of MedicineIndianapolisUSA 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2021年第18卷第11期

页      面：857-866页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Beijing Nature Science Foundation of China(Grant No.7192062,7202046) Shanxi Provincial Key Research and Development Project(Grant No.201903D321177) 

主　　题：coronary Blood admitted 

摘      要：BACKGROUND The Trial to Assess Chelation Therapy study found that edetate disodium(disodium ethylenediaminetet-raacetic acid)chelation therapy significantly reduced the incidence of cardiac events in stable post-myocardial infarction patients,and a body of epidemiological data has shown that accumulation of biologically active metals,such as lead and cadmium,is an important risk factor for cardiovascular ***,limited studies have focused on the relationship between angiograph-ically diagnosed coronary artery disease(CAD)and lead *** study compared blood lead level(BLL)in Chinese pa-tients with and without *** In this prospective,observational study,450 consecutive patients admitted to Beijing Anzhen Hospital with sus-pected CAD from November 1,2018,to January 30,2019,were *** patients underwent coronary angiography,and an experienced heart team calculated the SYNTAX scores(SXscore)for all available coronary *** were determined with atomic absorption spectrophotometry and compared between patients with angiographically diagnosed CAD and those without *** In total,343(76%)patients had CAD,of whom 42%had low(0−22),22%had intermediate(23−32),and 36%had high(≥33)*** were 36.8±16.95μg/L in patients with CAD and 31.2±15.75μg/L in those without CAD(P=0.003).When BLLs were categorized into three groups(low,middle,high),CAD prevalence increased with increasing BLLs(P0.05).In the multivariate regression model,BLLs were associated with CAD(odds ratio(OR):1.023,95%confidence interval(CI):1.008−1.039;P=0.0017).OR in the high versus low BLL group was 2.36(95%CI:1.29−4.42,P=0.003).Furthermore,BLLs were independently associated with intermediate and high SXscore(adjusted OR:1.050,95%CI:1.036-1.066;P0.0001).CONCLUSION BLLs were significantly associated with angiographically diagnosed ***,BLLs showed excel-lent predictive value for SXscore,especially for complex coronary artery lesions.