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H2 strain attenuated live hepatitis A vaccines:protective efficacy in a hepatitis A outbreak

World Journal of Gastroenterology 2000年第6期6卷 829-832页

作者： Yu Liang Zhao Zong Da Meng Zhi Yi Xu Jun Jie Guo Shao Ai Chai cheng gang duo Xuan Yi Wang Jin Feng Yao Hong Bin Liu Shun Xiang Qi Hui Bin Zhu Department of Virology Hebei Provincial Sanitary and Antiepidemic StationBaoding 071000Hebei ProvinceChina Department of Epidemiology Shanghai Medical University.Shanghai 200032China Fucheng County Sanitary and Anti-epidemic Station Zhejiang Academy of Medical Sciences Hangzhou

AIM:To investigate the protective efficacy of H2 strain attenuated live hepatitis A vaccines (H2-strain vaccines) in hepatitis A (HA) ***:With the permission of their parents, 5551 pre-school and grade 1-3 primary school children were inoculated with 1 dose (10(6.5) TCID(50)) of H2 strain vaccines in a nonrandomized, controlled trial conducted in Fucheng County, Hebei Province in May *** 6485 children in the same grades and compatible in gender and age were enrolled as controls. Epidemiological and serological survey was conducted to evaluate the protective efficacy of the vaccines. ELISA was used to detect serum IgM ***:HA outbreak started in early May 1998, peaked in the middle of the same month, and lasted about 80 days. Overall 302 HA cases were found, 192(63.58%) were 5-9 years old. One vaccinee and 25 control cases were found to have hepatitis A, which account for 0.28% (1/356) and 5.92% (25/422) of all vaccinees and controls in the 14 villages, respectively. The protective efficacy of vaccines was 95.27% (95% CI: 85.83%-104.72%). In subjects tested for anti-HAV IgM from 13 villages, 1(0.40%) overt and 11(4.06%) asymptomatic HAV cases were found in 271 vaccinees but 21(6.69%) of overt and asymptomatic ones were found in 314 ***:H2 strain vaccines were excellent in preventing overt hepatitis A,but not so effective in preventing asymptomatic hepatitis A virus infection.A booster dose might be needed to get permanent reliable immunity.

关键词： hepatitis A/prevention and control vaccines, attenuated vaccines, inactivated viral hepatitis vaccines disease outbreaks protective efficacy

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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang gang Li Xing cheng Peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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Controllable synthesis of high loading LiFePO_4/C nanocomposites using bimodal mesoporous carbon as support for high power Li-ion battery cathodes

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Journal of Energy Chemistry 2013年第6期22卷 907-913页

作者： Fei cheng duo Li Anhui Lu Wencui Li State Key Laboratory of Fine Chemicals School of Chemical Engineering Faculty of Chemical Environmental and Biological Science and Technology Dalian University of Technology

Mesoporous LiFePO4/C composites containing 80 wt% of highly dispersed LiFePO4 nanoparticles(4-6 nm) were fabricated using bimodal mesoporous carbon(BMC) as continuous conductive networks. The unique pore structure of BMC not only promises good particle connectivity for LiFePO4, but also acts as a rigid nano-confinement support that controls the particle size. Furthermore, the capacities were investigated respectively based on the weight of LiFePO4 and the whole composite. When calculated based on the weight of the whole composite, it is 120 mAh·g-1at 0.1 C of the high loading electrode and 42 mAh·g-1at 10 C of the low loading electrode. The electrochemical performance shows that high LiFePO4 loading benefits large tap density and contributes to the energy storage at low rates, while the electrode with low content of LiFePO4 displays superior high rate performance, which can mainly be due to the small particle size, good dispersion and high utilization of the active material, thus leading to a fast ion and electron diffusion.

关键词： LiFePO4 high loading fast ion diffusion high rate performance lithium-ion batteries

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UAVs cooperative task assignment and trajectory optimization with safety and time constraints

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Defence Technology（防务技术） 2023年第2期20卷 149-161页

作者： duo Zheng Yun-fei Zhang Fan Li Peng cheng UAV Autonomous Control Institute Beijing Institute of TechnologyBeijing100081China Shanghai Institute of Mechanical and Electrical Engineering Shanghai201100China CASIC Research Institute of Intelligent Decision Engineering Wuhan100074China

This paper proposes new methods and strategies for Multi-UAVs cooperative attacks with safety and time constraints in a complex *** triangle is designed to construct a map of the complex flight environment for aerial ***-Map,Safe Flight Corridor(SFC),and Relative Safe Flight Corridor(RSFC)are applied to ensure each UAV flight trajectory's *** using such techniques,it is possible to avoid the collision with obstacles and collision between ***-curve is further developed to ensure that multi-UAVs can simultaneously reach the target at the specified time,and the trajectory is within the flight *** trajectory tracking controller is also designed based on model predictive control to track the planned trajectory *** simulation and experiment results are presented to verifying developed strategies of Multi-UAV cooperative attacks.

关键词： Multi-UAV Cooperative attacks Task assignment Trajectory optimization Safety constraints

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Isolated interrupted aortic arch in an adult:A case report

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World Journal of Clinical Cases 2021年第4期9卷 992-998页

作者： Shu-Wen Dong duo-duo Di Guan-Xun cheng Medical Imaging Department Peking University Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina Medical Imaging Department Anhui Medical UniversityHefei 230000Anhui ProvinceChina

BACKGROUND Interrupted aortic arch(IAA)is a rare congenital heart disease defined by an interruption of the lumen and anatomical continuity between the ascending and descending major *** is usually found within a few hours or days of *** surgery,the chances of survival are *** IAA patients have an effective collateral circulation established,they can survive into ***,IAA in adults is extremely rare,with few reported *** SUMMARY A 27-year-old woman presented with a 6-year history of progressively worsening shortness of breath and chest tightness on *** had cyanotic lips and clubbing of the fingers.A transthoracic echocardiogram revealed an enlarged heart and dilation of the main pulmonary *** was an abnormal 9 mm passage between the descending aorta and pulmonary *** ventricular septal outflow tract had a 14 mm *** ultrasound suggested a patent ductus arteriosus and computed tomographic angiography showed the absence of the aortic *** diagnoses were ventricular septal defect,patent ductus arteriosus,and definite interruption of the aortic *** surgical correction was recommended,the patient declined due to the surgical risks and was treated with medications to reduce pulmonary artery pressure and treat heart *** condition has been stable for 12 mo of *** Although rare,IAA should be considered in adults with refractory hypertension or unexplained congestive heart failure.

关键词： Interrupted aortic arch Diagnostic imaging Multimodal imaging Patent ductus arteriosus Ventricular septal defect Case report

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Permeability measurement of the fracture-matrix system with 3D embedded discrete fracture model

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Petroleum Science 2022年第4期19卷 1757-1765页

作者： Bao Jia cheng-gang Xian State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Bejing)Beijing 102249China Unconventional Petroleum Research Institute China University of Petroleum(Bejing)Bejing 102249China

In this work, we performed the pulse-decay experiment on a fractured shale core and applied the 3 D embedded discrete fracture model(EDFM) to simulate the experiment process. The irregularly rough fracture surface was depicted in detail using a 3 D scanner. Then the fracture surface profile was imported in the discrete fracture network model to simulate the flow process in the fracture-matrix system realistically. History matching was efficiently performed to simultaneously obtain porosity and permeability for the matrix and fracture. Gas properties after applying nanopore confinement were obtained by modifying Sutton's viscosity correlation with sensitivity analysis on the pore diameter ranging from 2 to50 nm. Nanopore confinement results in low matched permeability due to viscosity reduction in the matrix-only porous media. The fracture-matrix system complicates the interpretation of nanopore confinement impact on flow behavior in shale reservoirs. Different scenarios of the highly fractured and matrix-dominated systems were discussed in detail by constructing the digital twin model.

关键词： Permeability Fracture Pulse-decay Shale Viscosity

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Provenance of the Southeastern South China Block in the Late Triassic and Initiation of Paleo-Pacific Subduction:Evidence from Detrital Zircon U-Pb Geochronology

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Journal of Earth Science 2024年第5期35卷 1426-1446页

作者： Jintao Kong Zhongjie Xu Rihui cheng duo Wan College of Earth Sciences Jilin UniversityChangchun 130061China Key Laboratory of Mineral Resources Evaluation in Northeast Asia Ministry of Natural and ResourcesChangchun 130061China

During the Late Paleozoic-Early Mesozoic Era,the sediment transport system and tectonic regime in the southeastern margin of the South China Block(SESCB)all changed,significantly affected by the Paleo-Pacific ***,controversy exists about the Paleo-Pacific subduction's initiation *** study uses detrital zircon U-Pb ages to discuss the Late Triassic source-tosink system in the *** provides some references for the Paleo-Pacific subduction process based on crucial age information and zircons'trace *** paleogeography and similarity of detrital zircon age distribution indicate that three sinks were found in the SESCB during the Late Triassic:*** Yangchun-Kaiping-Gaoming area,comprising major age ranges of 260-220,460-400,and 1200-800 Ma,which might be sourced from the Yunkai terrane;*** Jiexi-Kanshi-Nanjing area,characterized by the significant age component of 2000-1800 Ma,which corresponded to the Wuyi terrane;*** Xinan area,consisting of significant age groups of 290-250 and 380-320 Ma,which might be sourced from the magmatic rocks formed by the Huinan Movement and Paleo-Pacific *** that 290-250 Ma zircons were widely distributed in the Upper Triassic strata,and their trace elements suggested the existence of a magmatic arc near the SESCB during the 290-250 ***,we propose that the Paleo-Pacific subduction might have begun in the Early Permian.

关键词： detrital zircon geochronology South China Block Paleo-Pacific Block provenance analysis geochronology geochemistry

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Exergy Analysis of Photo-Thermal Interaction Process between Solar Radiation Energy and Solar Receiver

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Journal of Thermal Science 2021年第5期30卷 1541-1547页

作者： WANG gang WANG cheng CHEN Zeshao School of Energy and Power Engineering Northeast Electric Power UniversityJilin132012China School of Engineering Science University of Science and Technology of ChinaHefei230027China

A unified theory of non-equilibrium radiation thermodynamics is always in search as it is meaningful for solar energy *** exergy analysis of photo-thermal interaction process between the solar radiation energy and solar receiver is conducted in this *** non-equilibrium radiation thermodynamic system is *** thermodynamic process of photo-thermal interaction between the solar radiation and solar receiver is ***,exergy and entropy equations for the photo-thermal process are *** for calculating the optimum receiving temperatures of the solar receiver under both non-concentration and solar concentration conditions are presented.A simple solar receiver is chosen as the calculation example to launch the exergy analysis under non-concentration ***,the effect analysis of solar concentration on the thermodynamic performance of the solar receiver for solar thermal utilization is carried *** analysis results demonstrate that both the output exergy flux and efficiency of the solar receiver can be improved by increasing the solar concentration ratio during the solar thermal utilization *** formulas and results provided in this paper may be used as a theoretical reference for the further studies of non-equilibrium radiation thermodynamic theory and solar thermal utilization.

关键词： non-equilibrium radiation thermodynamics solar energy exergy analysis optimum receiving temperature solar thermal utilization

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NIR-Ⅱ Fluorophores:From Synthesis to Biological Applications

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Journal of Analysis and Testing 2023年第3期7卷 245-259页

作者： You-Yang duo Liang Zhao Zhi-gang Wang Shu-Lin Liu State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Biosensing and Molecular RecognitionResearch Center for Analytical SciencesCollege of Chemistryand School of MedicineNankai UniversityTianjin 300071China

Fluorescence imaging is a useful tool in the field of biomedical ***,its imaging capacity is limited by the depth of tissue that can be penetrated when using visible light(400-700 nm)or the first near-infrared window(NIR-Ⅰ,700-900 nm).To overcome the problem,fluorescence imaging in the second near-infrared window(NIR-Ⅱ,1000-1700 nm)has been developed to reduce photon scattering,auto-absorption and tissue autofluorescence to achieve high spatiotemporal resolution and deep imaging *** key to NIR-Ⅱimaging is obtaining and analyzing highly selective information from functional fluorophores that emit in the 1000-1700 nm *** the rapid development of multidisciplinary research,various types of NIR-Ⅱfluorophores have been produced and used in non-invasive,real-time NIR-Ⅱbiomedical *** review summarizes some of the most prevalent NIR-Ⅱfluorophores and their synthesis,such as organic fluorophores(OFs),single-walled carbon nanotubes(SWCNTs),quantum dots(QDs),and rare-earth nanoparticles(RENPs).On this basis,we describe the applications of these fluorophores in biomedical fields,including bioimaging,biosensing,phototherapy and surgical ***,major challenges and prospects of NIR-Ⅱbiomedical application will be further explored.

关键词： In-vivo imaging Second near-infrared window Fluorophores Surgical navigation Phototherapy

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NUMERICAL SIMULATION OF FISH SWIMMING WITH RIGID PECTORAL FINS

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Journal of Hydrodynamics 2012年第2期24卷 263-272页

作者： XU Yi-gang WAN De-cheng State Key Laboratory of Ocean Engineering School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The numerical simulation of the self-propelled motion of a fish with a pair of rigid pectoral fins is presented.A Navier-Stokes equation solver incorporating with the multi-block and overset grid method is developed to deal with the multi-body and moving body *** lift-based swimming mode is selected for the fin *** the lift-based swimming mode,the fin can generate great thrust and at the same time have no generation of lift *** can be found when a pair of rigid pectoral fins generates the hydrodynamic moment,it may also generate a lateral force opposite to the centripetal direction,which has adverse effect on the turn motion of the ***,the periodic vortex structure generation and shedding,and their effects on the generation of hydrodynamic force are also demonstrated in this article.

关键词： pectoral fins lift-based swimming mode self-propelled motion overset grid method

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