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Identification of risk factors and construction of a nomogram predictive model for post-stroke infection in patients with acute ischemic stroke

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World Journal of Clinical Cases 2024年第20期12卷 4048-4056页

作者： xiao-chen liu xiao-Jie Chang Si-Ren Zhao Shan-Shan Zhu Yan-Yan Tian Jing Zhang Xin-Yue Li Department of Neurosurgery Shandong Provincial Third HospitalJinan 250031Shandong ProvinceChina Department of Neurology Shandong Provincial Third HospitalJinan 250031Shandong ProvinceChina

BACKGROUND Post-stroke infection is the most common complication of stroke and poses a huge threat to *** addition to prolonging the hospitalization time and increasing the medical burden,post-stroke infection also significantly increases the risk of disease and *** the risk factors for post-stroke infection in patients with acute ischemic stroke(AIS)is of great *** can guide clinical practice to perform corresponding prevention and control work early,minimizing the risk of stroke-related infections and ensuring favorable disease *** To explore the risk factors for post-stroke infection in patients with AIS and to construct a nomogram predictive *** The clinical data of 206 patients with AIS admitted to our hospital between April 2020 and April 2023 were retrospectively *** data and post-stroke infection status of all study subjects were assessed,and the risk factors for poststroke infection in patients with AIS were *** Totally,48 patients with AIS developed stroke,with an infection rate of 23.3%.Age,diabetes,disturbance of consciousness,high National Institutes of Health Stroke Scale(NIHSS)score at admission,invasive operation,and chronic obstructive pulmonary disease(COPD)were risk factors for post-stroke infection in patients with AIS(P<0.05).A nomogram prediction model was constructed with a C-index of 0.891,reflecting the good potential clinical efficacy of the nomogram prediction *** calibration curve also showed good consistency between the actual observations and nomogram *** area under the receiver operating characteristic curve was 0.891(95%confidence interval:0.839–0.942),showing predictive value for post-stroke *** the optimal cutoff value was selected,the sensitivity and specificity were 87.5%and 79.7%,*** Age,diabetes,disturbance of consciousness,NIHSS score at admission,invasive surgery,and COPD are risk factors for post-st

关键词： Acute ischemic stroke Infection Risk factors Nomogram prediction model Chronic obstructive pulmonary disease

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Analysis of effect of nicotine on microbial community structure in sediment using PCR-DGGE fingerprinting

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Water Science and Engineering 2015年第4期8卷 309-314页

作者： Ai-dong Ruan chen-xiao liu State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University

Solid or liquid waste containing a high concentration of nicotine can pollute sediment in rivers and lakes, and may destroy the ecological balance if it is directly discharged into the environment without any treatment. In this study, the polymerase chain reaction （PCR） and denaturing gradient gel electrophoresis （DGGE） method was used to analyze the variation of the microbial community structure in the control and nicotinecontaminated sediment samples with nicotine concentration and time of exposure. The results demonstrated that the growth of some bacterial species in the nicotine-contaminated sediment samples was inhibited during the exposure. Some bacteria decreased in species diversity and in quantity with the increase of nicotine concentration or time of exposure, while other bacteria were enriched under the effect of nicotine, and their DGGE bands changed from undertones to deep colors. The microbial community structure, however, showed a wide variation in the nicotine- contaminated sediment samples, especially in the sediment samples treated with high-concentration nicotine. The Jaccard index was only 35.1% between the initial sediment sample and the sediment sample with a nicotine concentration of 0.030 μg/g after 28 d of exposure. Diversity indices showed that the contaminated groups had a similar trend over time. The diversity indices of contaminated groups all decreased in the first 7 d after exposure, then increased until day 42. It has been found that nicotine decreased the diversity of the microbial community in the sediment.

关键词： Nicotine Sediment PCR-DGGE Microbial community structure Diversity index

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Transcript and Sequence Analysis of S-RNases in Self-Compatible Tetraploid Chinese Cherry (Prunus pseudocerasus L.)

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Agricultural Sciences in China 2010年第6期9卷 792-798页

作者： ZHANG xiao-yan chen Xue-sen MENG Qing-wei JIANG Yuan-mao ZHENG Yang chen xiao-liu Institute of Horticulture Science and Engineering/State Key Laboratory of Crop Biology Shandong Agricultural University Tai＇an 271018 P.R.China Life Science Shandong Agricultural University Tai＇an 271018 PR.China

Chinese cherry （Prunus pseudocerasus L.） is an allotetraploid species and exhibits natural ***,the full-length cDNA sequences,functional analysis and the transcripts of S-RNase alleles in Chinese cherry cultivars are not *** the two cultivars Taixiaohongying and Laiyang Short Cherry with S1S2S3S4 genotypes,two S-RNases were transcribed in Northern blotting,and the two full-length cDNAs of S-RNase were cloned and *** the result,the transcribed S-RNases were S1-RNase and *** two complete cDNA sequences of S1-RNase and S2-RNase were registered as EU073938 and EU073939,respectively,and had characteristic structure of rosaceous S-RNases based on their sequences indicating that they had normal function for S-RNase in the *** S3-RNase and S4-RNase were not transcribed in the style and were nonfunctional for S-RNase,so S3m and S4m could be used to represent the nonfunctional S3-RNase and *** phylogenetic analysis implied that the S-RNases of Prunus,including Chinese cherry,had lower intra-specific similarity and diverged earlier than the divergence of species in Prunus.

关键词： Chinese cherry self-compatibility S-RNase Prunus tetraploid

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Rapid construction of the tricyclic cores of the abietane- and icetexane-type diterpenoids

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Chinese Chemical Letters 2011年第7期22卷 774-776页

作者： De Lin chen xiao Yu liu Hang cheng Feng Peng Wang Department of Chemistry of Medicinal Natural Products West China College of Pharmacy Sichuan University Chengdu 610041 China

A short synthesis of the tricyclic 6-6-6 and 6-7-6 ring systems of the abietane- and icetexane-type diterpenoids from a common intermediate is presented, using alkylation and acid-catalyzed cyclization as key steps.

关键词： Abietanes Icetexanes Alkylation Cyclization

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The Role of HIV Replicative Fitness in Perinatal Transmission of HIV

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Virologica Sinica 2011年第3期26卷 147-155页

作者： Xue-qing chen Chang liu xiao-hong Kong （Laboratory of Medical Molecular Virology School of Medicine Nankai University Tianjin 300071 China）

Perinatal transmission of Human immunodeficiency virus(HIV),also called mother-to-child transmission(MTCT),accounts for 90% of infections in infants worldwide and occurs in 30%-45% of children born to untreated HIV-1 infected *** HIV-1 infected mothers,some viruses are transmitted from mothers to their infants while others are *** relationship between virologic properties and the pathogenesis caused by HIV-1 remains *** studies have demonstrated that one obvious source of selective pressure in the perinatal transmission of HIV-1 is maternal neutralizing *** studies have shown that viruses which are successfully transmitted to the child have growth advantages over those not transmitted,when those two viruses are grown ***,the higher fitness is determined by the gp120 protein of the virus *** suggests that the selective transmission of viruses with higher fitness occurred exclusively,regardless of transmission *** are many factors contributing to the selective transmission and HIV replicative fitness is an important one that should not be *** review summarizes current knowledge of the role of HIV replicative fitness in HIV MTCT transmission and the determinants of viral fitness upon MTCT.

关键词： Human immunodeficiency virus(HIV) Acquired immune deficiency syndrome(AIDS) Mother-to-child transmission(MTCT) Replicative fitness Gp120

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Revolution in thermoelectric cooling using PbSe thermoelectrics by grid plainification

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Science China Materials 2024年第5期67卷 1672-1673页

作者： xiao-Lei Shi Qingfeng liu Zhi-Gang chen School of Chemistry and Physics ARC Research Hub in Zero-emission Power Generation for Carbon Neutralityand Centre for Materials ScienceQueensland University of TechnologyBrisbaneQueensland4000Australia State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing211816China

Thermoelectric materials and devices enable direct conversion between heat and electricity,holding potential applications in thermoelectric power generation,localized cooling,and electronic thermal management[1].Howev... 详细信息

关键词： enable thermoelectric constrained

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Rbm8a regulates neurogenesis and reduces Alzheimer's disease-associated pathology in the dentate gyrus of 5×FAD mice

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Neural Regeneration Research 2024年第4期19卷 863-871页

作者： chenlu Zhu xiao Ren chen liu Yawei liu Yonggang Wang Department of Neurology Lanzhou University Second Hospital Department of Neurology The First Affiliated Hospital of Nanchang University Department of Neurology Xiaogan City Central Hospital Health Service Department of the Guard Bureau of the General Office of the Central Committee of the Communist Party of China Headache Center Department of NeurologyBeijing Tiantan HospitalCapital Medical University

Alzheimer’s disease is a prevalent and debilitating neurodegenerative condition that profoundly affects a patient’s daily functioning with progressive cognitive decline,which can be partly attributed to impaired hippocampal *** in the hippocampal dentate gyrus is likely to persist throughout life but declines with aging,especially in Alzheimer’s *** evidence indicated that RNA-binding protein 8A(Rbm8a)promotes the proliferation of neural progenitor cells,with lower expression levels observed in Alzheimer’s disease patients compared with healthy *** study investigated the hypothesis that Rbm8a overexpression may enhance neurogenesis by promoting the proliferation of neural progenitor cells to improve memory impairment in Alzheimer’s ***,Rbm8a overexpression was induced in the dentate gyrus of 5×FAD mice to validate this *** Rbm8a levels in the dentate gyrus triggered neurogenesis and abated pathological phenotypes(such as plaque formation,gliosis reaction,and dystrophic neurites),leading to ameliorated memory performance in 5×FAD *** sequencing data further substantiated these findings,showing the enrichment of differentially expressed genes involved in biological processes including neurogenesis,cell proliferation,and amyloid protein *** conclusion,overexpressing Rbm8a in the dentate gyrus of 5×FAD mouse brains improved cognitive function by ameliorating amyloid-beta-associated pathological phenotypes and enhancing neurogenesis.

关键词： Adora2a Alzheimer’s disease astrocyte cAMP signaling pathway dentate gyrus dystrophic neurites microglia neurogenesis plaque Rbm8a

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Effects of electrothermal ageing on dielectric performance of metallised biaxial orientation polypropylene film capacitors in strong magnetic fields

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High Voltage 2024年第4期9卷 911-919页

作者： Haoliang liu Boxue Du Meng xiao Ke chen Yanwei Ma School of Electrical and Information Engineering Tianjin UniversityTianjinChina Institute of Electrical Engineering Chinese Academy of SciencesBeijingChina

The dielectric performance of the pristine and the electrothermal-aged metallised polypropylene capacitors are investigated under different magnetic *** energy storage capacity decreases under the magnetic *** 12 T,the capacitance value of the pristine capacitors decreases by 8.4%-17%and that of the aged capacitors declines by 15%-20%.The dielectric loss is reduced by 2.6%-6.3%,but the equivalent series resistance shows an 8.3%-23.1%*** leakage conductivity increases to 202%-354%,which leads to a weakened voltage holding *** addition to the effects of the magnetic fields,the impacts of ageing have also been *** effects of the magnetic field and ageing on the electrical parameters of the capacitors are discussed *** molecular chains of the dielectric are oxidised and decomposed during the ageing process,which reduces the insulating properties of the *** magnetic field inhibits polarisation by changing the polarisation behaviour through Lorentz force and excites the electrons to enhance charge transmission.

关键词： magnetic performance fields

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Recent Advances in the Synthesis of Zeolites from Solid Wastes

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Chemical Research in Chinese Universities 2024年第4期40卷 646-656页

作者： liu Pei WU Qinming chen Zhenghai xiao Feng-Shou Key Laboratory of Biomass Chemical Engineering of Ministry of Education and College of Chemical and Biological Engineering Zhejiang UniversityHangzhou310028P.R.China Zhejiang Provincial Innovation Center of Green Petrochemical Technology Ningbo315048P.R.China Kente Catalysts Inc. Xianju317300P.R.China

With the rapid development of industrialization,it is inevitable to produce solid wastes in the fields of energy petrochemical ***,the storage and utilization of these solid wastes have become a considerable *** to the main element composition of these solid wastes including silicon and aluminum,it has attracted extensive attention for synthesizing *** review summarized the properties of major solid wastes including coal fly ash,coal gangue,spent fluid catalytic cracking(FCC)catalyst,lithium slag,bauxite residue,and waste ***,the preparation of LTA,FAU,ZSM-5,SSZ-13,Beta,and MOR zeolites from these solid wastes were ***,the current challenges and perspectives were discussed.

关键词： Solid waste Zeolite Utilization Sustainable route Application

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GLP-1 receptor agonists and myocardial metabolism in atrial fibrillation

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Journal of Pharmaceutical Analysis 2024年第5期14卷 653-665页

作者： Jiani Zhong Hang chen Qiming liu Shenghua Zhou Zhenguo liu Yichao xiao Department of Cardiovascular Medicine Second Xiangya HospitalCentral South UniversityChangsha410011China Xiangya School of Medicine Central South UniversityChangsha410008China Center for Precision Medicine and Division of Cardiovascular Medicine Department of MedicineSchool of MedicineUniversity of MissouriColumbiaMO65211USA

Atrial fibrillation(AF)is the most common cardiac *** medical conditions,including hypertension,diabetes,obesity,sleep apnea,and heart failure(HF),increase the risk for *** have unique metabolic characteristics to maintain adenosine triphosphate *** changes occur in myocardial metabolism in ***-like peptide-1 receptor agonists(GLP-1RAs)have been used to control blood glucose fluctuations and weight in the treatment of type 2 diabetes mellitus(T2DM)and ***-1RAs have also been shown to reduce oxidative stress,inflammation,autonomic nervous system modulation,and mitochondrial *** article reviews the changes in metabolic characteristics in cardiomyocytes in *** the clinical trial outcomes are unsatisfactory,the findings demonstrate that GLP-1 RAs can improve myocardial metabolism in the presence of various risk factors,lowering the incidence of AF.

关键词： Atrial fibrillation Glucagon-like peptide-1 receptor agonists Metabolism

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