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Hyperbaric oxygen therapy for cerebral blood flow and electroencephalogram in patients with acute cerebral infarction Choice for therapeutic occasion

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Neural Regeneration Research 2007年第3期2卷 171-174页

作者： lei chen Fei li Dexiang Gu Department of Neurology Shidong Hospital Yangpu District Shanghai 200438 China

BACKGROUND： Hyperbaric oxygen （HBO） therapy increases blood oxygen content, changes cerebral blood flow （CBF） and cerebral metabolism. Its therapeutic effects on cerebrovascular disease have been fully confirmed, but the occasion for HBO therapy is still unclear. OBJECTIVE： To observe the therapeutic effects of HBO therapy at different time on CBF and electroencephalogram （EEG） in patients with acute cerebral infarction （CI）. DESIGN： Randomized controlled trial. SETTING： Department of Neurology, Shidong Hospital, Yangpu District of Shanghai. PARTICIPANTS： Ninety-six inpatients with acute CI, admitted to Department of Neurology, Shidong Hospital, Yangpu District of Shanghai from January 2001 to December 2006, were involved in this experiment. The involved participants met the diagnosis criteria of acute CI and confirmed by skull CT or MRI. They all were patients with moderate CI （16- 30 points） according to neurologic deficit score formulated by Chinese Medical Association. Informed consents of detected items and therapeutic regimen were obtained from all the involved participants. They were randomized into two groups with 48 in each： early-stage treatment group and advanced-stage treatment group. Among the 48 patients in the early-stage treatment group, 21 male and 27 female, aged 53 -68 years, 22 patients were found with basal ganglia infarction, 10 with brain lobe infarction, 16 with multiple infarction, 27 accompanied with hypertension and 2 accompanied with diabetes meUitus. Among the 48 patients in the advanced-stage treatment group, 23 male and 25 female, aged 52 - 71 years, 25 patients were found with basal ganglia infarction, 10 with brain lobe infarction, 12 with multiple infarction, 1 with brain stem infarction, 28 accompanied with hypertension and 1 accompanied with diabetes mellitus. METHODS： After admission, patients of two groups received routine drug treatment. ① Patients in the early-stage treatment group and advanced-stage treatment group began to r

关键词： rehabilitation cerebra/infarction cerebral blood flow electroencephalography

Ten-channel mode-division-multiplexed silicon photonic integrated circuit with sharp bends

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Frontiers of Information Technology & Electronic Engineering 2019年第4期20卷 498-506页

作者： chen-lei li Xiao-hui JIANG Yung HSU Guan-hong chen Chi-wai CHOW Dao-xin DAI Centre for Optical and Electromagnetic Research State Key Laboratory for Modern Optical InstrumentationCollege of Optical Science and Engineering Zhejiang University Ningbo Research Institute Zhejiang University Department of Photonics and Institute of Electro-Optical Engineering Chiao Tung University

A multimode silicon photonic integrated circuit(PIC) comprising a pair of on-chip mode(de)multiplexers with 10-mode channels and a multimode bus waveguide with sharp bends is demonstrated to enable multi-channel on-chip transmissions. The core width of the multimode bus waveguide is chosen such that it can support 10 guided modes, of which there are four transverse-magnetic polarization modes and six transverse-electric polarization modes. This multimode bus waveguide comprises sharp bends based on modified Euler curves. Experimental results demonstrate that the present silicon PIC enables the 10-channel on-chip transmission with a low inter-mode crosstalk of approximately-20 dB over a broad bandwidth of 1520–1610 nm even when the bending radius of the S-bend is as small as 40 μm. Compared with a silicon PIC using a conventional arc-bend with the same bending radius, our proposed PIC demonstrates a significant improvement.

关键词： Silicon Multimode Waveguide Euler-bends

Multi-Level Web Cache Model Used in Data Grid Application

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Wuhan University Journal of Natural Sciences 2006年第5期11卷 1216-1221页

作者： chen lei li Sanli Department of Computer Science and Technology Tsinghua University Beijing 100084China

This paper proposed a novel multilevel data cache model by Web cache （MDWC） based on network cost in data grid. By constructing a communicating tree of grid sites based on network cost and using a single leader for each data segment within each region, the MDWC makes the most use of the Web cache of other sites whose bandwidth is as broad as covering the job executing site. The experiment result indicates that the MDWC reduces data response time and data update cost by avoiding network congestions while designing on the parameters concluded by the environment of application.

关键词： Web cache data grid coherence replica

Relationship between hyperuricemia and metabolic syndrome

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第8期8卷 593-598页

作者： chen li-ying ZHU Wen-hua chen Zhou-wen DAI Hong-lei REN Jing-jing chen Jian-hua chen lei-qian FANG li-zheng Department of Family Medicine Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Objective: To investigate the relationship between metabolic syndrome and hyperuricemia. Methods: A total of 2 374 subjects who received health examination in our hospital from Jan. 2004 to Dec. 2006 were enrolled in our study. Hyperuricemia is defined as ≥7 mg/dl (in men) or ≥6.0 mg/dl (in women). Metabolic syndrome was defined using AHA/NHLBI (American Heart Association/National Heart, Lung, and Blood Institute) criteria. Results: (1) The overall prevalence of hyperuricemia was 13.10%. The condition was more common in men than in women (19.07% vs 3.42%). (2) Among men, uric acid concentration is statistically significantly positively correlated with waist circumference, blood pressure, and triglyceride. Uric acid is negatively correlated with serum high-density lipoprotein-cholesterol (HDL-C). Uric acid concentration is most strongly correlated with serum triglyceride (r=0.379) and waist circumference (r=0.297). Among women, statistically significant positive correlations were noted for the serum uric acid concentrations with waist circumference, triglyceride and fasting plasma glucose. Serum triglyceride (r=0.329) and waist circumference (r=0.234) are most strongly correlated with uric acid concentrations. (3) Men with hyperuricemia had a 1.634-fold increased risk of metabolic syndrome as compared with those without hyperuricemia odds ratio (OR)=1.634, P=0.000. Women with hyperuricemia had a 1.626-fold increased risk of metabolic syndrome (OR=1.626, P=0.000) as compared with those without hyperuricemia. Conclusion: Hyperuricemia is prevalent among Chinese population. Additionally, serum uric acid is positively associated with metabolic syndrome.

关键词： Hyperuricemia Metabolic syndrome Triglyceride

Adaptive-basis decomposition-based low-rank network for efficient non-uniform motion deblurring

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Optoelectronics Letters 2025年第1期21卷 43-50页

作者： chen lei XIONG Qingbo ZHANG Wei li Runde School of Software Henan University School of Applied Technology China University of Labor Relations

In this study, we present a unified sparsity-driven framework that significantly enhances motion deblurring performance by integrating two key components: a custom-designed dataset and a low-rank module(LRM). This framework leverages the inherent sparsity of per-pixel blur kernels to bolster both deblurring accuracy and model interpretability. Firstly, we propose an adaptive-basis decomposition-based deblurring(ADD) approach, which constructs a tailored training dataset to enhance the generalization capacity of the deblurring network. The ADD framework adaptively decomposes motion blur into sparse basis elements, effectively addressing the intricacies associated with non-uniform blurs. Secondly, an LRM is proposed to improve the interpretability of deblurring models as a plug-and-play module, primarily designed to identify and harness the intrinsic sparse features in sharp images. A series of ablation studies have been conducted to substantiate the synergistic advantages of combining the proposed ADD with the LRM for overall improvement in deblurring efficacy. Subsequently, we empirically demonstrate through rigorous experimentation that incorporating the LRM into an existing Uformer network leads to substantial enhancement in reconstruction performance. This integration yields a sparsity-guided low-rank network(SGLRN). Operating under the overarching principle of sparsity, SGLRN consistently outperforms state-of-the-art methods across multiple standard deblurring benchmarks. Comprehensive experimental results, assessed through quantitative metrics and qualitative visual evaluations, provide compelling evidence of its effectiveness. The overall deblurring results are available at Google Drive.

关键词： Image enhancement

Hepatocyte-like cells from directed differentiation of mouse bone marrow cells in vitro

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Acta Pharmacologica Sinica 2005年第4期26卷 469-476页

作者： Xiao-lei SHI~2 Yu-dong QIU~2 Qiang li Ting XIE~2 Zhang-hua ZHU~2 lei-lei chen~3 lei li~3 Yi-tao DING~(2,4) 2 Department of Hepatobiliary Surgery 3 Scientific Research Department,Affiliated Drum Tower Hospital,Medical College of Nanjing University,Nanjing 210008,China Department of Hepatobiliary Surgery Affiliated Drum Tower Hospital Medical College of Nanjing University Nanjing China Scientific Research Department Affiliated Drum Tower Hospital Medical College of Nanjing University Nanjing China

Aim:To design the effective directed differentiation medium to differentiate bonemarrow cells into hepatocyte-like ***:Bone marrow cells were cul-tured in the directed differentiation media including fibroblast growth factor-4(FGF-4)and oncostatin M(OSM).Hepatocyte-like cells from directed differentia-tion of bone marrow cells were identified through cell morphology,RNA expres-sions by reverse transcriptase-polymerase chain reaction(RT-PCR),protein ex-pressions by Western blot,and hepatocellular synthesis and metabolism func-tions by albumin EliSA,Periodic acid-Shift staining and urea ***:Some epithelial-like cells or polygonal cells appeared and increased in the courseof the cell directed *** nucleur factor-3[3(HNF-3β),albu-min(ALB),cytokeratin 18(CK18),transthyretin(TTR),glucose-6-phosphate(G-6-Pase),and tyrosine aminotransferase(TAT)mRNA were expressed in the courseof the directed *** directed differentiated cells on d 21 expressedHNF-3β,ALB,and CK18 *** directed differentiated cells producedalbumin and synthesized urea in a time-dependent *** could also syn-thesize ***:Our differentiation media,including FGF-4 andOSM,are effective to differentiate bone marrow cells into hepatocyte-like cells,which could be used for hepatocyte resources for bioartificial liver or hepatocytetransplantation.

关键词： bone marrow cells hepatocytes cell differen tiation stern cells

Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin chen Jinghong Xu Bin Jiang lei li Yawei li Yuliang Dai Bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

A Review on Thermal Management of li-ion Battery:from Small-Scale Battery Module to Large-Scale Electrochemical Energy Storage Power Station

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Journal of Thermal Science 2025年第1期34卷 1-23页

作者： chen Zhifeng JIA li YIN liaofei DANG Chao REN Honglei ZHANG Zhiqiang Beijing Key Laboratory of Flow and Heat Transfer of Phase Changing in Micro and Small Scale School of MechanicalElectronic and Control EngineeringBeijing Jiaotong University

li-ion battery is an essential component and energy storage unit for the evolution of electric vehicles and energy storage technology in the ***,in order to cope with the temperature sensitivity of li-ion battery and maintain li-ion battery safe operation,it is of great necessary to adopt an appropriate battery thermal management system(BTMS).In this paper,the current main BTM strategies and research hotspots were discussed from two aspects:small-scale battery module and large-scale electrochemical energy storage power station(EESPS).The practical application situation,advantages and disadvantages,and the future development trend of each heat dissipation method(air,liquid,PCM,heat pipe,hybrid cooling) were described in *** them,the air cooling and liquid cooling were reviewed in-depth based on the engineering *** PCM,heat pipe and hybrid cooling were reviewed extensively based on the latest *** research provides a comprehensive understanding for the BTMS in all scales.

关键词： battery thermal management cooling methods large-scale electrochemical energy storage power station small-scale battery module

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基于计算实验的公共交通需求预测方法

自动化学报 2017年第1期43卷 60-71页

作者：陈曦彭蕾李炜华中科技大学自动化学院武汉430074 华中科技大学非传统安全中心武汉430074 国家教育部图像处理与智能控制重点实验室武汉430074

一般来说,用于交通需求预测的数学模型往往缺少对出行个体微观水平上的异质性和可变交通情景的考虑.针对这些问题,本文提出了一种基于计算实验的公共交通需求预测方法.该方法主要由交通调查、基于Agent的人工交通系统(Artificial transp... 详细信息

一般来说,用于交通需求预测的数学模型往往缺少对出行个体微观水平上的异质性和可变交通情景的考虑.针对这些问题,本文提出了一种基于计算实验的公共交通需求预测方法.该方法主要由交通调查、基于Agent的人工交通系统(Artificial transportation system,ATS)和计算实验3部分组成.在出行个体Agent建模中引入BDI(Belief-desire-intention)模型,来推演各出行个体在出行过程中对各交通选择的决策制定过程.在人工交通系统的基础上,可以设计并执行大量的计算实验来进行交通需求预测.本文通过基于校车系统的一系列交通调查和计算实验验证了该方法的可行性和优越性,并针对各种不同交通情景进行了交通分布预测和交通方式划分预测.

关键词：计算实验交通需求预测基于Agent的建模与仿真 BDI(Belief-desire-intention)模型