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Prolonged impacts of COVID-19-associated cystitis:A study on longterm consequences

World Journal of Clinical Cases 2023年第33期11卷 7987-7993页

作者： Sophie Wittenberg Jack Vercnocke Michael Chancellor Sorabh Dhar Aron liaw Steven Lucas Nivedita Dhar Department of Urology Wayne State University School of MedicineDetroitMI 48201United States Department of Urology Beaumont HospitalRoyal OakMI 48067United States Infectious Disease Wayne State University School of MedicineDetroitMI 48201United States Infectious Disease John D.Dingell VA Medical CenterDetroitMI 48201United States Infectious Disease Detroit Medical CenterDetroitMI 48201United States Department of Urology John D.Dingell VA Medical CenterDetroitMI 48201United States Department of Urology Detroit Medical CenterDetroitMI 48201United States

BACKGROUND The Coronavirus Disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2 virus is an international health concern with substantial morbidity and ***-associated cystitis(CAC),presents as new onset or exacerbated urinary symptoms,resembling overactive bladder(OAB)*** To examines the long-term outcomes of patients with CAC in the context of Long *** A cohort of 350 patients admitted to Detroit Hospitals with COVID-19 between May and December 2020,displaying CAC symptoms following discharge,was prospectively *** urologic evaluations occurred at 10-14 wk and were repeated at 21-28 mo *** were managed conservatively,employing behavioral modifications and standard OAB *** completed surveys assessing urinary symptoms and quality of life(QoL)at both time *** primary outcome was the Urology Care Foundation Overactive Bladder Assessment *** 87%of the final cohort(n=310)reported symptom improvement at 21-28 mo *** with new onset CAC symptoms showed a median decrease of 9-10 points in OAB and QoL scores,while those with existing symptoms experienced a decrease of 6 ***,95.4%of patients with new onset symptoms reported symptom improvement at follow-up,contrasting with 60.7%among those with existing *** This study presents the first long-term follow-up of adult patients with CAC,revealing a promising prognosis with conservative management measures in the context of Long *** findings provide reassurance to patients regarding symptom resolution and underscore the need for further research into this evolving aspect of COVID-19's impact on urological health.

关键词： COVID associated cystitis COVID-19 Long COVID Overactive bladder

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沉淀强化高熵合金屈服强度及本构模型研究

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Acta Mechanica Sinica 2023年第6期39卷 1-11页

作者：任思危李甲冯慧 Peter K.liaw 方棋洪 College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA

沉淀强化高熵合金表现出优异的强度和延展性.然而,由于现有的模型忽略了高熵合金中复杂化学元素、析出相尺寸分布和空间分布在内的关键作用,使之无法准确预测高熵合金中固溶强化和沉淀强化对屈服强度的贡献.此外,还缺乏统一的强度模型... 详细信息

沉淀强化高熵合金表现出优异的强度和延展性.然而,由于现有的模型忽略了高熵合金中复杂化学元素、析出相尺寸分布和空间分布在内的关键作用,使之无法准确预测高熵合金中固溶强化和沉淀强化对屈服强度的贡献.此外,还缺乏统一的强度模型来分析高熵合金中的屈服强度.本文建立了考虑尺寸分布和空间分布的沉淀强化模型,与现有模型相比,该模型具有更高的精度.结果表明,沉淀强化在屈服强度中起主要贡献作用.此外,空间分布对沉淀强化的影响比析出相尺寸分布的影响更显著.该模型为确定高熵合金的沉淀强化和屈服强度提供了理论框架,并为设计高强度高熵合金提供指导.

关键词：沉淀强化固溶强化高熵合金屈服强度尺寸分布析出相强度模型现有模型

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Hepatocyte growth factor gene therapy prevents radiation-induced liver damage

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World Journal of Gastroenterology 2005年第10期11卷 1496-1502页

作者： Chau-Hua Chi I-Li Liu Wei-Yu Lo Bor-Song liaw Yu-Shan Wang Kwan-Hwa Chi Institute of Veterinary Science Anawrahta Biotech. Co. Department of Radiation Therapy and Oncology

AIM: To transfer human HGF gene into the liver of rats by direct electroporation as a means to prevent radiationinduced liver ***: Rat whole liver irradiation model was accomplished by intra-operative approach. HGF plasmid was injected into liver and transferred by electroporation using a pulse generator. Control rats (n = 8) received electrogene therapy (EGT) vehicle plasmid and another 8rats received HGF-EGT 100 μg 48 h before *** of HGF in liver was examined by RT-PCR and ELISA methods. Apoptosis was determined by TUNEL assay. Histopathology was evaluated 10 wk after whole liver ***: Marked decrease of apoptotic cells and downregulation of transforming growth factor-beta 1 (TGF-β1)mRNA were observed in the HGF-EGT group 2 d after liver irradiation compared to control animals. Less evidence of radiation-induced liver damage was observed morphologically in liver specimen 10 wk after liver irradiation and longer median survival time was observed from HGF-EGT group (14 wk) compared to control rats (5 wk). (P = 0.031).CONCLUSION: For the first time it has been demonstrated that HGF-EGT would prevent liver from radiation-induced liver damage by preventing apoptosis and down-regulation of TGF-β1.

关键词： Hepatocyte growth factor HGF Radiation Liver Electroporation Electrogene therapy

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Enhanced antibacterial behavior of a novel Cu-bearing high-entropy alloy

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Journal of Materials Science & Technology 2022年第22期117卷 158-166页

作者： Guangyu Ren Lili Huang kunling Hu Tianxin Li Yiping Lu Dongxu Qiao Haitao Zhang Dake Xu Tongmin Wang Tingju Li Peter K.liaw Engineering Research Center of High Entropy Alloy Materials(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China College of Food Science and Engineering Ocean University of ChinaQingdao 266100China Shenyang National Laboratory for Materials Science Northeastern UniversityShenyang 110819China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996United States

Contact infection of bacteria and viruses has been a critical threat to human health. The worldwideoutbreak of COVID-19 put forward urgent requirements for the research and development of the selfantibacterial materials, especially the antibacterial alloys. Based on the concept of high-entropy alloys, thepresent work designed and prepared a novel Co_(0.4)FeCr_(0.9)Cu_(0.3) antibacterial high-entropy alloy with superior antibacterial properties without intricate or rigorous annealing processes, which outperform the antibacterial stainless steels. The antibacterial tests presented a 99.97% antibacterial rate against Escherichiacoli and a 99.96% antibacterial rate against Staphylococcus aureus after 24 h. In contrast, the classic antibacterial copper-bearing stainless steel only performed the 71.50% and 80.84% antibacterial rate, respectively. The results of the reactive oxygen species analysis indicated that the copper ion release and theimmediate contact with copper-rich phase had a synergistic effect in enhancing antibacterial ***, this alloy exhibited excellent corrosion resistance when compared with the classic antibacterialstainless steels, and the compression test indicated the yield strength of the alloy was 1015 MPa. Thesefindings generate fresh insights into guiding the designs of structure-function-integrated antibacterial alloys.

关键词： High-entropy alloy Antibacterial property Corrosion resistance Mechanical property

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Achieving strength-ductility synergy in novel paramagnetic Fe-based medium-entropy alloys through deep cryogenic deformation

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Rare Metals 2024年第9期43卷 4493-4507页

作者： Hu-Wen Ma Yan-Chun Zhao Li Feng Tian-Zeng Liu Zhi-Qi Yu Bo Jin Wang-Chun Duan Peter K.liaw Dong Ma State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of TechnologyLanzhou 730050China Wenzhou Pump and Valve Engineering Research Institute Lanzhou University of TechnologyWenzhou 325105China Iron and Steel Research Institute Jiuquan Iron and Steel CorporationJiayuguan 735100China Lanzhou Resources and Environment Voc-Tech University Lanzhou 730123China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996-2200USA Neutron Science Center Songshan Lake Materials LaboratoryDongguan 523808China

Cryogenic pre-deformation treatment has been widely used to effectively improve the comprehensive mechanical properties of steels and novel ***,the dislocation evolution and phase transformation induced by different degrees of deep cryogenic deformation are not yet fully *** this study,the effects of multiple cryogenic pre-treatments on the mechanical properties and deformation mechanisms of a paramagnetic Fe_(63.3)Mn_(14-)Si_(9.1)Cr_(9.8)C_(3.8)medium-entropy alloy(MEA)were investigated,leading to the discovery of a pretreated MEA that exhibits exceptional mechanical properties,including a fracture strength of 3.0 GPa,plastic strain of 26.1%and work-hardening index of *** addition,X-ray diffraction(XRD)and transmission electron microscopy(TEM)analyses revealed that multiple cryogenic pre-deformation treatments significantly increased the dislocation density of the MEA(from 9×10^(15)to 4×10^(16)m^(-2)after three pretreatments),along with a transition in the dislocation type from predominantly edge dislocations to mixed dislocations(including screw-and edge-type dislocations).Notably,this pretreated MEA retained its paramagnetic properties(μ_(r)<1.0200)even after *** calculations showed that cryogenic pretreatment can significantly reduce the stacking fault energy of the MEA by a factor of approximately four(i.e.,from 9.7 to2.6 m J·m^(-2)),thereby activating the synergistic effects of transformation-induced plasticity,twinning-induced plasticity and dislocation strengthening *** synergistic effects lead to simultaneous strength and ductility enhancement of the MEA.

关键词： Deep cryogenic transformation Iron-based medium-entropy alloys Dislocation evolution Phase transformation Stacking fault energy

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Cluster-formula-embedded machine learning for design of multicomponent β-Ti alloys with low Young’s modulus

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npj Computational Materials 2020年第1期6卷 824-834页

作者： Fei Yang Zhen Li Qing Wang Beibei Jiang Biaojie Yan Pengcheng Zhang Wei Xu Chuang Dong Peter K.liaw Key Laboratory of Materials Modification by Laser Ion and Electron Beams(Ministry of Education)School of Materials Science and EngineeringDalian University of TechnologyDalian116024 LiaoningChina School of Mechanical Engineering Dalian University of TechnologyDalian116024 LiaoningChina Analysis and Test Center Guangdong University of TechnologyGuangzhou510006 GuangdongChina Institute of Materials China Academy of Engineering PhysicsJiangyou621908 SichuanChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819 LiaoningChina Department of Materials Science and Engineering The University of TennesseeKnoxville37996 TNUSA

The present work formulated a materials design approach,a cluster-formula-embedded machine learning(ML)model,to search for body-centered-cubic(BCC)β-Ti alloys with low Young’s modulus(E)in the Ti–Mo–Nb–Zr–Sn–Ta *** characteristic parameters,including the Mo equivalence and the cluster-formula approach,are implemented into the ML to ensure the accuracy of prediction,in which the former parameter represents the BCC-βstructural stability,and the latter reflects the interactions among elements expressed with a composition *** auxiliary gradient-boosting regression tree and genetic algorithm methods were adopted to deal with the optimization problem in the ML model.

关键词： alloys modulus formula

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A novel Cu-bearing high-entropy alloy with significant antibacterial behavior against corrosive marine biofilms

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Journal of Materials Science & Technology 2020年第11期42卷 201-210页

作者： Enze Zhou Dongxu Qiao Yi Yang Dake Xu Yiping Lu Jianjun Wang Jessica A.Smith Huabing Li Hongliang Zhao Peter K.liaw Fuhui Wang Shenyang National Laboratory for Materials Science Northeastern UniversityShenyang 110819China Key Laboratory for Anisotrotropy and Texture of Materials(Ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China Department of Biomolecular Sciences Central Connecticut State University1615 Stanley StreetNew BritainCT 06050USA School of Materials Science and Engineering Zhengzhou University100 Kexue AvenueZhengzhou 450001China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN37996USA

The design of novel high-entropy alloys(HEAs)provides a unique opportunity for the development of structure-function integrated materials with high mechanical and antimicrobial *** this study,by employing the antibacterial effect of copper,a novel Al0.4CoCrCuFeNi HEA with broad-spectrum antibacterial and strong mechanical properties was *** concentrations of copper ions released from the HEA prevented growth and biofilm formation by biocorrosive marine bacterial *** findings serve as a proof-of-concept for further development of unique HEA materials with high antimicrobial efficiency and mechanical properties,compared to conventional antibacterial alloys.

关键词： High entropy alloys Biofilms Antibacterial property Mechanical properties

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高浑浊河流悬沙质量浓度的地面遥感监测方法

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生态环境 2005年第5期14卷 706-709页

作者：周跃吕喜玺陈平 S.liaw 朱云梅昆明理工大学环境科学与工程学院云南昆明650093 新加坡国立大学

以金沙江中下游一级支流龙川江为例,通过探讨河流地面反射光谱与河流悬沙质量浓度的关系,初步开发了河流悬沙质量浓度的地面遥感预测技术。研究发现,基于R800/R550的经验模型,仅能够预测浓度范围在400 g.m-3以下的悬沙质量浓度值,对于... 详细信息

以金沙江中下游一级支流龙川江为例,通过探讨河流地面反射光谱与河流悬沙质量浓度的关系,初步开发了河流悬沙质量浓度的地面遥感预测技术。研究发现,基于R800/R550的经验模型,仅能够预测浓度范围在400 g.m-3以下的悬沙质量浓度值,对于较低悬沙质量浓度的河流或其他水域有较大运用价值。光学拟合技术能够预测龙川江在其整个变化范围的河流悬沙质量浓度,最高预测浓度可以达到13 000 g.m-3。通过直接运用两种方法,或者进一步将它们提升成为卫星遥感运用技术后,对于中国西南众多的江河湖库有着重要的理论和现实意义。

关键词：悬沙质量浓度地面遥感光谱特征

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Manipulating internal flow units toward favorable plasticity in Zr-based bulk-metallic glasses by hydrogenation

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Journal of Materials Science & Technology 2022年第7期102卷 36-45页

作者： Fuyu Dong Yuexin Chu Mengyuan He Yue Zhang Weidong Li Peter K.liaw Binbin Wang Liangshun Luo Yanqing Su Robert O.Ritchie Xiaoguang Yuan School of Materials Science and Engineering Shenyang University of TechnologyShenyangChina School of Materials Science and Engineering Northeastern UniversityShenyangChina Department of Materials Science and Engineering The University of TennesseeKnoxvilleTNUSA School of Materials Science and Engineering Harbin Institute of TechnologyHarbinChina Department of Materials Science and Engineering University of CaliforniaBerkeleyCA94720USA

This work intends to manipulate the internal flow units in Zr_(55)Cu_(30)Ni_(5)Al_(10)bulk-metallic glasses(BMGs)through plasma-assisted hydrogenation to generate a positive microalloying effect on *** on the cooperative shear model theory,serration-flow statistics during nanoindentation loading and creep tests during the holding stage were used to analyze the influence of hydrogen on the behavior of flow units in *** observations showed that the hydrogen in the Zr_(55)Cu_(30)Ni_(5)Al_(10)BMGs caused mechanical softening,plasticity improvement,and structural *** also showed that the average volume,size,and activation energy of internal flow units in the BMGs all increased as a result of the increase in the hydrogen *** hydrogenation in the BMGs was found to lead to a prolifera-tion of shear bands,which promoted *** aggregation of these internal flow units reduced the stress required for plastic deformation through shear bands,ultimately causing softening and structural relaxation.

关键词： Bulk-metallic glass Plasma-assisted hydrogenation Nanoindentation Internal flow unit Serrations Nano-scale creep

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Cu含量对铁基中熵合金耐腐蚀及抗菌性能的影响

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稀有金属材料与工程 2024年第7期53卷 1817-1825页

作者：赵燕春宋海转马虎文胡若楠冯力段望春 liaw Peter K 兰州理工大学省部共建有色金属加工与再利用国家重点实验室甘肃兰州730050 兰州理工大学温州泵阀工程研究院浙江温州325105 兰州资源环境职业技术大学甘肃兰州730123 田纳西大学材料系美国诺克斯维尔TN 37996

采用水冷铜坩埚磁悬浮真空熔炼炉制备了(Fe_(63.3)Mn_(14)Si_(9.1)Cr_(9.8)C_(3.8))_(99.5-x)Cu_(x)Ag_(0.5)(x=1,2,3,4,5,at%)合金,并对合金试样进行抗菌时效处理,研究Cu含量对合金耐腐蚀性能以及抗菌性能的影响。结果表明,经过固溶时效处理后的中熵合金均为fcc结构,随着Cu含量的提高,fcc1富铁基体上逐渐析出了富Cu和富Ag的fcc2相。合金在3.5%(质量分数)NaCl溶液中的耐腐蚀性能优于AISI304。随Cu含量的增加,腐蚀电流密度先减小而后增加,容抗弧半径先增大后减小,表明合金的耐腐蚀性能先增强后减弱。合金在大肠杆菌悬浮液中的腐蚀速率呈现出先增大后减小的趋势,x=2合金的耐生物腐蚀能力最优,而抗菌性能和腐蚀性能存在倒置关系。富Cu和富Ag的fcc2相能有效提升合金的抗菌性能,x=5合金的抗菌性能最优,抗菌率达到99.94%.

关键词：中熵合金微观组织腐蚀性能抗菌性能

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