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Individualized Traditional Chinese Medicine treatment vs antibiotics for recurrent urinary tract infections: a multicenter, randomized controlled study

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Journal of Traditional Chinese Medicine 2024年第3期44卷 524-529页

作者： GU xiangchen QIU Meisi XIE Lin chen Min DENG Yueyi ZHANG Changming JIAN Guihua WANG chen WANG Yi Department of Nephrology Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200437China Department of Nephrology Rizhao Hospital of Traditional Chinese MedicineShanghai 200437China Department of Nephrology Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai200032China Department of Nephrology Shanghai Municipal Traditional Chinese Medicine Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200071China Department of Nephrology the Sixth People's Hospital Affiliated Shanghai Jiaotong UniversityShanghai 200233China Department of Nephrology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

OBJECTIVE: To systematically assess the effects of individualized Chinese medicines on recurrent urinary tract infections(rUTIs).METHODS: This study recruited 230 adult female patients in the remission phase of rUTIs from five hospitals in China. The patients were randomly allocated to two groups: an individualized Chinese medicine group(n = 114) and a control group(n = 116). Patients in the Chinese medicine group received individualized Chinese herbs, which were evaluated for syndrome *** in the control group received antibiotic treatment combined with a Chinese medicine placebo. The duration of treatment was three courses of four weeks each, with a three-month subsequent follow-up. UTI recurrence rate,Traditional Chinese Medicine(TCM) syndrome scores,36-item Short Form Survey(SF-36) score, and urine secretory immunoglobulin A(SIgA) were measured and analyzed before and after treatment in each group. RESULTS: Patients from the Chinese medicine group exhibited significant decreases in both short-and longterm UTI recurrence rates compared with the control group(P < 0.05). The changes in TCM syndrome scores between the Chinese medicine and control groups were significant(P < 0.05). The changes in the average SF-36 quality-of-life scores in the Chinese medicine group were also significantly higher than those in the control group after treatment(P < 0.05). The Chinese medicine group also demonstrated a significant increase in urine SIg A expression. CONCLUSION: Taken together, compared to the oftenused long-term antimicrobial prophylaxis during the remission stage of r UTIs, treating patients with an individualized Chinese medicine decoction by syndrome differentiation could effectively reduce the recurrence rate, improve the patients' TCM syndrome scores and quality of life, and enhance immunity, which in turn helps to prevent antibiotic resistance.

关键词： urinary tract infections medicine Chinese traditional syndrome differentiation quality of life immunoglobulin A secretory randomized controlled trial

Multiomics and single‐cell sequencings reveal the specific biological characteristics of low Ki‐67 triple‐negative breast cancer

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Cancer Innovation 2024年第5期3卷 112-127页

作者： Boyue Han xiangchen Han Hong Luo Javaria Nasir Chao chen Zhiming Shao Hong Ling Xin Hu Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina Precision Cancer Medical Center Fudan University Shanghai Cancer CenterShanghaiChina

Background:Triple‐negative breast cancer(TNBC)displays high *** majority of TNBC cases are characterized by high Ki‐67 *** with low Ki‐67 expression accounts for only a small fraction of cases and has been relatively less ***:This study analyzed a large single‐center multiomics TNBC data set,combined with a single‐cell data *** clinical,genomic,and metabolic characteristics of patients with low Ki‐67 TNBC were ***:The clinical and pathological characteristics were analyzed in 2217 TNBC *** Ki‐67 TNBC was associated with a higher patient age at diagnosis,a lower proportion of invasive ductal carcinoma,increased alterations in the PI3K‐AKT‐mTOR pathway,upregulated lipid metabolism pathways,and enhanced infiltration of M2 *** Ki‐67 TNBC exhibited a higher prevalence of TP53 gene mutations,elevated nucleotide metabolism,and increased infiltration of M1 ***:We identified specific genomic and metabolic characteristics unique to low Ki‐67 TNBC,which have implications for the development of precision therapies and patient stratification strategies.

关键词： genomics Ki‐67 index metabolic pathways triple‐negative breast cancer

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基于CT扫描的煤岩孔裂隙表征

煤田地质与勘探 2016年第5期44卷 58-62,70页

作者：李相臣陈德飞康毅力孟祥娟西南石油大学油气藏地质及开发工程国家重点实验室四川成都610500 中国石油塔里木油田分公司油气工程研究院新疆库尔勒841000

煤岩中孔隙与裂隙的结构、形态等特征直接影响煤层气在煤层中的聚集和运移。为对煤岩中孔裂隙类型及孔裂隙的空间分布进行表征,选取宁武盆地中煤阶煤岩,利用微CT扫描技术对煤岩进行扫描获得CT图像,运用FDK算法重建煤岩的灰度图像并基于... 详细信息

煤岩中孔隙与裂隙的结构、形态等特征直接影响煤层气在煤层中的聚集和运移。为对煤岩中孔裂隙类型及孔裂隙的空间分布进行表征,选取宁武盆地中煤阶煤岩,利用微CT扫描技术对煤岩进行扫描获得CT图像,运用FDK算法重建煤岩的灰度图像并基于宏观孔隙度值对灰度图像进行二值化分割,对CT图像中的微裂纹目标进行了识别;利用CT扫描获得的图像依据煤岩中基质、孔裂隙及矿物组分均表现出不同的CT值分布,实现了煤岩中孔裂隙的三维建模,对煤岩中孔裂隙的尺度以及空间分布进行综合表征。研究成果为后期研究煤岩中气体吸附–解吸–渗流的多尺度过程奠定了基础。

关键词：煤岩 CT扫描孔裂隙灰度值三维重构

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基于电阻层析成像的混凝土钢筋锈蚀无损检测

无损检测 2020年第1期42卷 37-40页

作者：孙世栋秦磊任宏伟陈祥晨济南大学土木建筑学院济南250022 济南大学自动化与电气工程学院济南250022 日照公路建设有限公司日照276599

钢筋锈蚀程度是评价混凝土耐久性和安全性的关键内容,针对实际工程中钢筋锈蚀检测方法中存在的问题,采用电阻层析成像(ERT)技术,搭建了16电极的ERT系统,采用埋入式电极注入电流采集电压的方式获取成像数据,运用基于共轭梯度法的电阻成... 详细信息

钢筋锈蚀程度是评价混凝土耐久性和安全性的关键内容,针对实际工程中钢筋锈蚀检测方法中存在的问题,采用电阻层析成像(ERT)技术,搭建了16电极的ERT系统,采用埋入式电极注入电流采集电压的方式获取成像数据,运用基于共轭梯度法的电阻成像技术进行图像重构,完成了混凝土钢筋锈蚀无损检测的试验设计与研究。结果表明:ERT方法可以对混凝土的钢筋锈蚀状况进行可视化处理,能定性分析钢筋锈蚀的区域范围。该研究可为混凝土钢筋锈蚀无损检测提供新的思路和参考。

关键词：钢筋锈蚀无损检测混凝土电阻层析成像图像重建埋入式电极

长双歧杆菌婴儿亚种利用母乳低聚糖的分子机制及益生作用研究进展

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食品科学 2024年第9期45卷 243-251页

作者：陈禹含李巧慧李岩苏倩郭欢新段勃帆孟祥晨东北农业大学食品学院乳品科学教育部重点实验室黑龙江哈尔滨150030

母乳是婴儿早期最主要的营养来源,它可以满足婴儿出生后6个月内的所有营养需求。母乳还含有许多生物活性物质,能够调节肠道菌群,促进免疫系统发育,增强肠道屏障。母乳低聚糖(human milk oligosaccharides,HMOs)是母乳中的活性物质之一,... 详细信息

母乳是婴儿早期最主要的营养来源,它可以满足婴儿出生后6个月内的所有营养需求。母乳还含有许多生物活性物质,能够调节肠道菌群,促进免疫系统发育,增强肠道屏障。母乳低聚糖(human milk oligosaccharides,HMOs)是母乳中的活性物质之一,它们无法被婴儿直接消化吸收,但可以作为一种益生元刺激肠道菌群的建立与进化。长双歧杆菌婴儿亚种(Bifidobacterium longum subsp. infantis)是母乳喂养婴儿肠道中的优势微生物,几乎拥有代谢主要HMOs所需的所有基因簇,其与HMOs的互作对早期婴儿肠道健康起着关键作用。本文综述了HMOs的组成和结构,描述了B. longum subsp. infantis对HMOs的利用方式,并总结了B. longum subsp. infantis代谢HMOs对婴儿产生的益生作用,以期为探究HMOs与肠道菌群的互作机制以及该机制对婴儿肠道发育和成熟的作用奠定基础。

关键词：母乳低聚糖长双歧杆菌婴儿亚种代谢产物利用机制益生作用

腘动脉逆行穿刺治疗股腘动脉闭塞性病变的临床研究进展

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血管与腔内血管外科杂志 2024年第7期10卷 822-825页

作者：陈岩朱杰昌戴向晨天津医科大学总医院普通外科天津300052

腘动脉逆行穿刺是治疗股腘动脉闭塞患者的一条重要入路选择。腘动脉逆行穿刺需在X线或超声的引导下完成,两种引导方式适用于腘动脉不同的穿刺位置。本文就腘动脉逆行穿刺治疗下肢股腘动脉闭塞性病变的临床研究进展做一综述。

关键词：腘动脉逆行穿刺股腘动脉闭塞性病变

Simultaneous recovery of carbon and sulfur resources from reduction of CO_2 with H_2S using catalysts

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Journal of Energy Chemistry 2016年第1期25卷 110-116页

作者： Hui Su Yuyang Li Ping Li Yongxiu chen Zhizhi Zhang xiangchen Fang State Key Laboratory of Chemical Engineering East China University of Science and Technology Fushun Research Institute of Petroleum & Petrochemicals Sinopec

An approach to the simultaneous reclamation of carbon and sulfur resources from CO2 and H2S has been proposed and effectively implemented with the aid of catalysts. A brief thermodynamic study reveals the potential of direct reduction of CO2 with H2S（15：15 mol% balanced with N2） for selective production of CO and elemental sulfur. The experiments carried out in a fixed-bed flow reactor over the temperature range of 400–800 °C give evidence of the importance of the employment of catalysts. Both the conversions of the reactants and the selectivities of the target products can be substantially promoted over most catalysts studied. Nevertheless, little difference appears among their catalytic performance. The results also prove that the presence of CO2 can remarkably enhance H2S conversion and the sulfur yield in comparison with H2S direct decomposition. A longtime reaction test on Mg O catalyst manifests its superior durability at high temperature（700 °C） and huge gas hourly space velocity（100,000 h-1）. Free radicals initiated by catalysts are supposed to dominate the reactions between CO2 and H2S.

关键词： Carbon dioxide Hydrogen sulfide Simultaneous recovery Reduction Catalyst

Signal acquisition of Luojia-1A low earth orbit navigation augmentation system with software defined receiver

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Geo-Spatial Information Science 2022年第1期25卷 47-62页

作者： Liang chen xiangchen Lu Nan Shen Lei Wang Yuan Zhuang Ye Su Deren Li Ruizhi chen State Key Laboratory Of Information Engineering In Surveying Mapping And Remote SensingWuhan UniversityWuhanChina

Low Earth Orbit(LEO)satellite navigation signal can be used as an opportunity signal in the case of a Global Navigation Satellite System(GNSS)outage,or as an enhancement by means of traditional GNSS positioning *** matter which service mode is used,signal acquisition is a prerequisite for providing enhanced LEO navigation *** with the medium orbit satellite,the transit time of the LEO satellite is ***,it is of great significance to expand the successful acquisition time range of the LEO *** studies on LEO signal acquisition are based on simulation ***,signal acquisition research based on real data is *** this work,the signal characteristics of LEO satellites:power space density in free space and the Doppler shift of LEO satellites are individually *** unified symbolic definitions of several integration algorithms based on the parallel search signal acquisition algorithm are *** verify these algorithms for LEO signal acquisition,a Software Defined Receiver(SDR)is *** performance of these integration algorithms on expanding the successful acquisition time range is verified by the real data collected from the Luojia-1A *** experimental results show that the integration strategy can expand the successful acquisition time range,and it will not expand indefinitely with the integration *** performance of the coherent integration and differential integration algorithms is better than the other two integration algorithms,so the two algorithms are recommended for LEO signal acquisition and a 20 ms integration duration is *** detection threshold of 2.5 is not suitable for all integration algorithms and various integration durations,especially for the Maximum-to-Mean Ratio indicator.

关键词： Coherent integration differential coherent integration Low Earth Orbit(LEO) non-coherent integration navigation augmentation signal acquisition

Analysis of Sulfate Corrosion Resistance and Reliability of Recycled Concrete

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Wuhan University Journal of Natural Sciences 2020年第3期25卷 208-216页

作者： QIAO Hongxia ZHU xiangchen chen Kefan PENG Kuan College of Civil Engineering Lanzhou University of TechnologyLanzhou 730000GansuChina

In order to study the effect of different recycled fine aggregate and recycled coarse aggregate substitution rate on the sulfate resistance of recycled concrete under dry-wet cycle conditions,the substitution rate of recycled fine aggregate and recycled coarse aggregate was designed to be 0%/0%,10%/0%,0%/25%,10%/25%,0%/50%and 10%/50%of the six groups of mixture *** mass loss rate and relative dynamic modulus of each group of test blocks were tested respectively and the optimal ratio was *** Wiener distribution probability method was used to establish the reliability function to optimize the remaining life of the *** results show that the dynamic elastic modulus and mass show a trend of increasing first and then decreasing during the dry-wet cycles of *** recycled concrete has the strongest resistance to sulfate attack under the substitution rate of recycled fine aggregate and recycled coarse aggregate is 10%and 0%,and the test blocks will be damaged after being subjected to 182 times of dry-wet cycles of *** effect of recycled coarse aggregate on the sulfate attack resistance of the test block is more obvious than that of the recycled fine aggregate,which leads to the durability of the concrete being greatly reduced.

关键词： recycled concrete dry-wet cycles of sulfate the Wiener distribution probability microscopic reaction mechanism