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APPROXIMATE COMMON DIVISORS OF POLYNOMIALS AND DEGREE REDUCTION FOR RATIONAL CURVES

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Applied Mathematics(A Journal of Chinese Universities) 1998年第4期13卷 437-444页

作者： SUN JIANZHONG,chen FALAI AND QU yongming Department of Mathematics University of Science and Technology of China

Abstract This paper deals with how to perturb a given set of polynomials so as to include a common linear factor. An algorithm is derived for determining such a set of perturbation polynomials which are subject to certain constrains at the endpoints of a prescribed parametric interval and minimized in a certain sense. This result can be combined with subdivision technique to obtain a continuous piecewise approximation to a rational curve.

关键词： Rational curve degree reduction subdivision approximate common divisor

Emulsion confined block copolymer self-assembly:Recent progress and prospect

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Nano Research 2023年第1期16卷 564-582页

作者： Yilin Liu Fangfang Ke Yuanchao Li Yi Shi Zhen Zhang yongming chen School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510006China

In the past few decades,significant progress in block copolymer self-assembly has been achieved in many fields,and with the development of nanoscience and nanotechnology,more and more complex situations need block copolymer self-assembly based nanoplatforms having more complex structures for specific multimodal or multiplexed *** the combination of emulsification and self-assembly of the block copolymer,different materials with exotic architectures and functions could be combined within an entity,such as controlled vesicles,Janus particles,and composite particles which are more like ideal *** designs can show their different desired properties depending upon the application situation,including molecular delivery,surfactants,and multicolor *** review will provide a complete summary of the optimization and the synthesis method for the recently designed emulsion confined block copolymer assemblies,and also the challenges and limitations this method faces,and the potential solutions in this field.

关键词： emulsion block copolymer confined volume self-assembly exotic architectures

A method for online detection and lifespan evaluation of light sources

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Optoelectronics Letters 2023年第11期19卷 693-697页

作者： YU Kanghua chen Huacai ZHU Zhouhong HU Jinzhao chen yongming College of Optical and Electronic Technology China Jiliang UniversityHangzhou310018China

Light emitting diode(LED) light source degradation detection and lifetime evaluation usually use the data of light flux change as a basis,but the process of light flux measurement is complicated and tedious,requiring the use of an integrating sphere,and cannot be performed *** is unfriendly to the detection of machine vision light sources used in production *** address this problem,this paper proposes and designs a method for online detection and lifetime evaluation of light sources by using a mini spectrometer to detect the intensity of light sources online,and evaluates the light degradation and lifetime of light sources based on the changes in light intensity during *** determines whether the light source needs to be adjusted or replaced,avoiding misjudgment or missed judgment in production detection due to light source *** experiment was conducted on LED under high-temperature accelerated *** light intensity data after aging was fitted by an acceleration and life evaluation model,and the fitting result showed that the error of life evaluation by this method was 8.37%.As a comparison,this paper also detects the changes in light flux of light sources during the experiment,and the average error between the decay of light intensity and the decay of light flux was only 0.102%.It has been validated that the error in evaluating the lifetime of light sources using this method is 10.71%,and the accuracy of the evaluation is about 90%.The results show that the method is accurate,reliable,and can be used as a basis for online detection and evaluation of LED light source degradation.

关键词： lifetime fitted integrating

Di-PEGylated insulin:A long-acting insulin conjugate with superior safety in reducing hypoglycemic events

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2761-2772页

作者： Zhipeng Zeng Runcheng Tan Shi chen Haolin chen Zhijia Liu Lixin Liu Mingqiang Li yongming chen Laboratory of Biomaterials and Translational Medicine Center for NanomedicineThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China School of Materials Science and Engineering Center of Functional BiomaterialsKey Laboratory of Polymeric Composite Materials and Functional Materials of Ministry of EducationSun Yat-sen UniversityGuangzhou 510275China

Although the discovery of insulin 100 years ago revolutionized the treatment of diabetes,its therapeutic potential is compromised by its short half-life and narrow therapeutic *** long-acting insulin analogs,such as insulin-polymer conjugates,are mainly used to improve pharmacokinetics by reducing renal ***,these conjugates are synthesized without sacrificing the bioactivity of insulin,thus retaining the narrow therapeutic index of native insulin,and exceeding the efficacious dose still leads to ***,we report a kind of di-PEGylated insulin that can simultaneously reduce renal clearance and receptor-mediated *** impairing the binding affinity to the receptor and the activation of the receptor,di-PEGylated insulin not only further prolongs the half-life of insulin compared to classical mono-PEGylated insulin but most importantly,increases its maximum tolerated dose *** target of long-term glycemic management in vivo has been achieved through improved pharmacokinetics and a high *** work represents an essential step towards long-acting insulin medication with superior safety in reducing hypoglycemic events.

关键词： Diabetes Insulin Therapeutic index Hypoglycemia PEGylation Receptor-mediated clearance Half-life Diabetic nephropathy

Optical resolution ability of optically active poly(N-diphenylmethyl maleimide)

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Chinese Science Bulletin 1998年第3期43卷 220-223页

作者： Weihong Liu Lianhe Shao yongming chen Chuanfu chen Guoquan Liu Fu Xi Chinese Acad Sci Inst Chem Beijing 100080 Peoples R China

A new optically active polymer, (+)poly(N_diphenylmethyl maleimide), was coated on macroporous silica gel and used as a chiral stationary phase for high performance liquid chromatographic resolution of enantiomers. The chiral polymer showed efficient resolution ability to some polar racemates, and eleven pairs of racemates are resolved effectively.

关键词： optical resolution chiral stationary phase high performance liquid chromatography N_diphenylmethyl maleimide optically active polymer.

Combinatorial synthesis of redox-responsive cationic polypeptoids for intracellular protein delivery application

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Science China Chemistry 2020年第11期63卷 1619-1625页

作者： Zhicheng Le Tong Xiao Zhijia Liu Xingliang Liu Hong Liu Lixin Liu yongming chen School of Materials Science and Engineering Key Laboratory of Polymeric Composite and Functional Materials of Ministry of EducationGD Research Center for Functional Biomaterials Engineering and TechnologySun Yat-sen UniversityGuangzhou 510275China

Biologics play an essential role in treating various indications from cancers to the metabolic diseases,while the current development of new classes of intracellular-acting protein drugs is still hindered because of high molecular mass and overall hydrophilicity of proteins creating extremely poor permeability across cell ***,there remains an unmet need to develop safe,potent approaches to augment intracellular protein delivery ***,we described a facile multicomponent reaction system for generating a small library of redox-responsive cationic polypeptoids with high *** co-assembly of optimized polymer with protein leads to the formation of compacted nanocomplexes with smaller size and high encapsulation efficiency,thus improving cellular internalization via the macropinocytosis and/or caveolae-mediated endocytosis *** endo-lysosomal escape,the nanocomplexes can be disassociated to efficiently release cargo proteins into the cytosol,owing to the intracellular glutathione(GSH)-triggered rapid cleavage of disulfide bonds in polymers *** a result,we screened a promising platform reagent for efficient cytosolic protein delivery application.

关键词： multicomponent reaction cationic polypeptoid redox-responsive intracellular delivery protein

Synthesis of novel hierarchical porous polymers with a nanowire-interconnected network structure from core-shell polymer nanoobjects

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Science China Chemistry 2017年第8期60卷 1084-1089页

作者： yeru liang yingbo ruan junlong huang bo peng chen-yang liu ruowen fu mingqiu zhang yongming chen dingcai wu Materials Science Institute Key Laboratory for Polymeric Composite ＆ Functional Material of Ministry of Education Guangdong Provincial Key Laboratory for High Performance Polymeric Composites School of Chemistry Sun Yat-sen University Guangzhou 510275 China aCAS Key Laboratory of Engineering Plasties Institute of Chemistry Chinese Academy of Sciences Be!jing 100190 China School of Materials Science and Engineering Sun Yat-sen University Guangzhou 510275 China

Design and fabrication of the micro/nanostructures of the network units is a critical issue for porous nanonetwork structured materials. Significant progress has been attained in construction of the network units with zero-dimensional spherical ***, owing to the limitations of synthetic methods, construction of porous building blocks in one dimension featuring high aspect ratios for porous nanonetwork structured polymer(PNSP) remains largely unexplored. Here we present the successful design and preparation of PNSP with a novel type of one-dimensional network unit, i.e., microporous heterogeneous nanowire. Well-defined core-shell polymer nanoobjects prepared from a gelable block copolymer, poly(3-(triethoxysilyl)propyl methacrylate)-block-polystyrene are employed as building blocks, and facilely transformed into PNSP via hypercrosslinking of polystyrene shell. The as-prepared PNSP exhibits unique three-dimensional hierarchical nanonetwork morphologies with large surface area. These findings could provide a new avenue for fabrication of unique well-defined PNSP, and thus generate valuable breakthroughs in many applications.

关键词： hierarchical porous polymer nanonetwork structure one-dimensional network unit hypercrosslinking microporous heterogeneous nanowire

Prognostic nutritional index is an independent prognostic factor for gastric cancer patients with peritoneal dissemination

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Chinese Journal of Cancer Research 2016年第6期28卷 570-578页

作者： Runcong Nie Shuqiang Yuan Shi chen Xiaojiang chen yongming chen Baoyan Zhu Haibo Qiu Zhiwei Zhou Junsheng Peng Yingbo chen Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Gastrointestinal Surgery the Sixth Affiliated Hospital Sun Yat-sen University

Objective： The predictive and prognostic role of prognostic nutritional index（PNI） in gastric cancer patients with peritoneal dissemination remains unclear. This study aims to explore the role of the PNI in predicting outcomes of gastric cancer patients with peritoneal ***： A total of 660 patients diagnosed with gastric adenocarcinoma with peritoneal metastasis between January 2000 and April 2014 at Sun Yat-sen University Cancer Center and the Sixth Affiliated Hospital of Sun Yatsen University were retrospectively analyzed. The clinicopathologic characteristics and clinical outcomes of patients with peritoneal dissemination were ***： Compared with PNI-high group, PNI-low group was correlated with advanced age（P=0.036）, worse performance status（P0.001）, higher frequency of ascites（P0.001） and higher frequency of multisite distant metastasis（P0.001）. Kaplan-Meier survival curves showed that PNI-high group had a significantly longer median overall survival than PNI-low group（13.13 vs. 9.03 months, P0.001）. Multivariate survival analysis revealed that Borrmann type IV（P=0.014）, presence of ascites（P=0.017） and lower PNI（P=0.041） were independent poor prognostic factors, and palliative surgery（P0.001） and first-line chemotherapy（P0.001） were good prognostic factors. For patients receiving palliative surgery, the postoperative morbidity rates in the PNI-low group and PNIhigh group were 9.1% and 9.9%, respectively（P=0.797）. The postoperative mortality rate was not significantly different between PNI-low and PNI-high groups（2.3% vs. 0.9%, P=0.362）.Conclusions： PNI is a useful and practical tool for evaluating the nutritional status of gastric cancer patients with peritoneal dissemination, and is an independent prognostic factor for these patients.

关键词： Prognostic nutritional index(PNI) gastric cancer peritoneal dissemination survival

Deciphering the evolution and complexity of wheat germplasm from a genomic perspective

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Journal of Genetics and Genomics 2023年第11期50卷 846-860页

作者： Zihao Wang Lingfeng Miao yongming chen Huiru Peng Zhongfu Ni Qixin Sun Weilong Guo Frontiers Science Center for Molecular Design Breeding Key Laboratory of Crop Heterosis and UtilizationBeijing Key Laboratory of Crop Genetic ImprovementChina Agricultural UniversityBeijing 100193China

Bread wheat provides an essential fraction of the daily calorific intake for *** to its huge and complex genome,progress in studying on the wheat genome is substantially trailed behind those of the other two major crops,rice and maize,for at least a *** rapid advances in genome assembling and reduced cost of high-throughput sequencing,emerging de novo genome assemblies of wheat and whole-genome sequencing data are leading to a paradigm shift in wheat ***,we review recent progress in dissecting the complex genome and germplasm evolution of wheat since the release of the first high-quality wheat *** insights have been gained in the evolution of wheat germplasm during domestication and modern breeding progress,genomic variations at multiple scales contributing to the diversity of wheat germplasm,and complex transcriptional and epigenetic regulations of functional genes in polyploid *** databases and bioinformatics tools meeting the urgent needs of wheat ge-nomics research are also *** ever-increasing omics data,along with advanced tools and well-structured databases,are expected to accelerate deciphering the germplasm and gene resources in wheat for future breeding advances.

关键词： Wheat genomics Evolution Wheat germplasm Multi-omics Databases and tools