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Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

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Frontiers of Medicine 2020年第3期14卷 293-304页

作者： Xiaojing Jiao Dong Zhang Quan Hong Lei Yan Qiuxia Han Fengmin Shao Guangyan Cai xiangmei chen Hanyu Zhu Department of Nephrology Chinese People's Liberation Army(PLA)General HospitalChinese PLA Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center of Kidney DiseasesBeijing Key Laboratory of Kidney DiseaseBeijing 100853China Department of Nephrology Henan Provincial Key Laboratory of Kidney Disease and ImmunologyHenan Provincial People's Hospital(Zhengzhou University People's Hospital)Zhengzhou 450003China

Netrin-1,an axon guidance factor,and its receptor UNC5B play important roles in axonal development and *** study examined netrin-1 and UNC5B expression in kidneys with diabetic kidney disease (DKD) and investigated their roles in ***-1 and UNC5B were upregulated in streptozotocininduced DKD Wistar rats,and their expression was compared with that in healthy ***,exogenous netrin-1 in UNC5B-depleted human renal glomerular endothelial cells (HRGECs) inhibited cell migration and *** effect was likely associated with SRC pathway ***-1 treatment also eliminated the pro-angiogenic effects of exogenous VEGF-165 on UNC5B-silenced *** results indicate that UNC5B antagonizes netrin-1 and that UNC5B upregulation contributes partly to enhancing angiogenesis in ***,introducing exogenous netrin-1 and depleting endogenous UNC5B are potential strategies for reducing the incidence of early angiogenesis and mitigating kidney injury in DKD.

关键词： netrin-1 VEGF-165 UNC5B angiogenesis diabetic kidney disease

Precore mutation enhances viral replication to facilitate persistent infection especially in HBeAg-negative patients

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Virologica Sinica 2024年第2期39卷 319-330页

作者： Guixin Li Danli Yang Xin Liu Ting Zhang Hui Liu Jun Zou Zimeng Xu xiangmei chen Lizhong Dai Hongsong chen Fengmin Lu Peking University People's Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisBeijing100044China Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking UniversityBeijing100191China Baruch S.Blumberg Institute DoylestownPA18901USA Shenzhen Sanyuansheng Biotechnology Co. LtdShenzhen518000China Precision Medicine Center of Zhengzhou University Academy of Medical SciencesZhengzhou UniversityZhengzhou450001China Peking University-Sansure Biotech Joint Laboratory of Molecular Medicine Sansure Biotech Co.LtdChangsha410205China

Naturally occurred precore(PC,G1896A)and/or basal core promoter(BCP,A1762T/G1764A)mutations are prevalent in chronic HBV-infected patients,especially those under HBeAg-negative ***,the replicative capacity of HBV with PC/BCP mutations remains ***,meta-analysis showed that,only under HBeAg-negative status,the serum HBV DNA load in patients with PC mutation was 7.41-fold higher than those without the *** PC mutation alone and BCPþPC mutations promoted HBV replication in cell and hydrodynamic injection mouse *** human hepatocyte chimeric mouse model,BCPþPC mutations led to elevated replicative capacity and intrahepatic core protein ***,preC RNA harboring PC mutation could serve as mRNA to express core and P proteins,and such pgRNA-like function favored the maintenance of cccDNA pool under HBeAg-negative ***,BCPþPC mutations induced more extensive and severe human hepatocyte damage as well as activated endoplasmic reticulum stress and TNF signaling pathway in livers of chimeric *** study indicates that HBeAg-negative patients should be monitored on HBV mutations regularly and are expected to receive early antiviral treatment to prevent disease progression.

关键词： Hepatitis B virus Precore mutation Basal core promoter mutations Endoplasmic reticulum stress

The role of transcriptional factor D-site-binding protein in circadian CCL2 gene expression in anti-Thy1 nephritis

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Cellular & Molecular Immunology 2019年第9期16卷 735-745页

作者： Yang Lu Yan Mei Lei chen Lingling Wu Xu Wang Yingjie Zhang Bo Fu Xizhao chen Yuansheng Xie Guangyan Cai Xueyuan Bai Qinggang Li xiangmei chen Department of Nephrology Chinese PLA General HospitalChinese PLA Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijingChina

Mesangial proliferative glomerulonephritis(MsPGN)is an inflammatory disease,but both the nature of disease progression and its regulation remain *** the present study,we monitored the course of anti-Thy1 nephritis from days 1 to 5 and established gene expression profiles at each time point using microarrays to explore the development of *** to the gene expression profiles,macrophage infiltration(triggered by CCL2 activation)was evident on day 1 and enhanced inflammation over the next few *** screened for genes with expression levels similar to CCL2 and found that the upregulation of the circadian gene albumin D-site-binding protein(DBP)was involved in CCL2 activation in mesangial *** importantly,CCL2 expression showed oscillatory changes similar to DBP,and DBP induced peak CCL2 expression at 16:00 a clock on day 1 in the anti-Thy1 nephritis *** knocked down DBP through transfection with a small interfering RNA(siRNA)and used RNA sequencing to identify the DBP-regulated TNF-α-CCL2 *** performed chromatin immunoprecipitation sequencing(ChIP-Seq)and the dual luciferase assay to show that DBP bound to the TRIM55 promoter,regulating gene expression and in turn controlling the TNF-α-CCL2 *** conclusion,DBP-regulated circadian CCL2 expression by the TRIM55-TNF pathway in injured mesangial cells at an early stage,which promoted macrophage recruitment and in turn triggered infiltration and inflammation in a model of anti-Thy1 nephritis.

关键词： Mesangial proliferative glomerulonephritis DBP CCL2 Trim 55 Macrophage

Rapid antimicrobial susceptibility testing for mixed bacterial infection in urine by AI-stimulated Raman scattering metabolic imaging

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Medicine in Novel Technology and Devices 2022年第4期16卷 1-7页

作者： Weifeng Zhang Xun chen Jing Zhang xiangmei chen Liqun Zhou Pu Wang Weili Hong Instiute of Medical Photonics Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100191China School of Engineering Medicine Beihang UniversityBeijing100191China Department of Urology Peking University First HospitalBeijing100034China Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking University Health Science CenterBeijing100191China

Urinary tract infection with mixed microorganisms may lead to false-positive resistance *** antimicrobial susceptibility testing(AST)performed in clinical laboratories is based on bacterial culture and takes a long time for mixed bacterial ***,we propose a machine learning-based single-cell metabolism inactivation concentration(ML-MIC)model to achieve rapid AST for mixed bacterial *** *** and *** as a demonstration of mixed bacteria,we performed feature extraction and multi-feature analysis on stimulated Raman scattering(SRS)images of bacteria with the ML-MIC model to determine the subtypes and AST of the mixed ***,we assessed the AST of mixed bacteria in urine and obtained single-cell metabolism inactivation concentration in only 3 ***,we demonstrated that SRS imaging of bacterial metabolism can be extended to mixed bacterial infection cases for rapid AST.

关键词： Mixed bacterial infections Antimicrobial susceptibility testing Stimulated Raman scattering Machine learning

Enhancement of the scientific management of earthquake disaster rescue： improving the state level of disaster medical care

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Chinese Medical Journal 2014年第5期127卷 995-997页

作者： Zhang Li chen xiangmei Department of Nephrology State key Laboratory of Kidney DiseaseGeneral Hospital of Chinese People&#39 s Liberation Army Beijing 100853 China

A7.0-magnitude earthquake took place in Lushan county,Ya＇an in southwest China＇s Sichuan Province at 8：02 *** time,April 20,*** epicenter was located approximately 110 km away from chengdu,at 30.3 degrees north lat... 详细信息

关键词： earthquake disaster medical care infection control epidemiology rehabilitation medical education

Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model

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Frontiers of Medicine 2019年第5期13卷 618-625页

作者： Hanyu Zhu Bo Fu Yong Wang Jing Gao Qiuxia Han Wenjia Geng Xiaoli Yang Guangyan Cai xiangmei chen Dong Zhang Department of Nephrology Chinese PLA General HospitalChinese PLA Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center of Kidney DiseasesBeijing Key Laboratory of Kidney DiseaseBeijing 100853China Department of Clinical Biochemistry Chinese PLA General HospitalBeijing 100853China Department of Nephrology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

This study aimed to compare clinical features between membranous nephropathy (MN) and nonmembranous nephropathy (non-MN), to explore the clinically difTerential diagnosis of these two types, and to establish a diagnostic model of MN. After renal biopsy was obtained, 798 patients were divided into two groups based on their examination results: primary MN group (n = 248) and non-MN group (n = 550). Their data were statistically analyzed. Logistic regression analysis indicated that anti-PLA2R antibodies, IgG, and Cr were independently correlated with MN, and these three parameters were then used to establish the MN diagnostic model. A receiver operating characteristic (ROC) curve confirmed that our diagnostic model could distinguish between patients with and without MN, and their corresponding sensitivity, specificity, and AUC were 79.9%, 89.4%, and 0.917, respectively. The cutoff value for this combination in MN diagnosis was 0.34. The established diagnostic model that combined multiple factors shows a potential for broad clinical applications in differentiating primary MN from other kidney diseases and provides reliable evidence supporting the feasibility of noninvasive diagnosis of kidney diseases.

关键词： multiparameter analysis diagnosis model membranous nephropathy

Distribution of Traditional Chinese Medicine syndromes in diabetic kidney disease chronic kidney disease 1-5: a correlation study

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Journal of Traditional Chinese Medicine 2024年第3期44卷 572-580页

作者： LI Shuang DUAN Shuwei DONG Zheyi QU Yilun LUO Yayong KE Jianghua WANG Conghui PENG Yangzhi ZHOU Xuefeng chen xiangmei Department of Nephrology First Medical Center of Chinese PLA General HospitalNephrology Institute of the Chinese People's Liberation ArmyNational Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijing 100853China School of Clinical Medicine Guangdong Pharmaceutical Universityjuangzhou510006China Basic Medical College Chengdu University of Traditional Chinese MedicineChengdu610075China

OBJECTIVE: To analyze the distribution of Traditional Chinese medicine(TCM) syndromes in patients with diabetic kidney disease(DKD) and its related ***: We enrolled 435 patients with DKD, who were not undergoing dialysis, admitted to the Department of Nephrology, First Medical Center, Chinese PLA General Hospital from April 2020 to August *** of their TCM syndromes and related factors was carried ***: The 435 patients included 109, 117, 86, and 123 chronic kidney disease(CKD) 1-2, CKD3, CKD4, and CKD5 cases, respectively. With the progression of CKD1-5, the proportion of Yin deficiency and dry heat syndrome,and that of Qi and Yin deficiency syndrome showed a downward trend, whereas the proportion of spleen-kidney Yang deficiency, blood deficiency, blood stasis, water stagnation, and phlegm turbidity syndromes showed an upward trend;the differences were statistically significant(P < 0.05). Multivariate logistic regression analysis showed that Yin deficiency and dry heat syndrome was positively correlated with hemoglobin [odds ratio(OR) =1.022, P = 0.005], albumin(OR = 1.058, P = 0.006), and estimated glomerular filtration rate(eGFR)(OR = 1.020,P < 0.001) but negatively correlated with male sex(OR =0.277, P = 0.004). Qi and Yin deficiency syndrome was positively correlated with albumin(OR = 1.056, P < 0.001)and eGFR(OR = 1.008, P = 0.022) but negatively correlated with age(OR = 0.977, P = 0.023). Liver-kidney Yin deficiency syndrome was positively correlated with age(OR = 1.028, P = 0.021) and glycosylated hemoglobin(OR = 1.223, P = 0.007) but negatively correlated with total cholesterol(OR = 0.792, P = 0.006).Spleen-kidney Yang deficiency syndrome was negatively correlated with hemoglobin(OR = 0.977, P < 0.001),albumin(OR = 0.891, P < 0.001), and eGFR(OR = 0.978,P < 0.001) but positively correlated with high density lipoprotein(OR = 3.376, P = 0.001). CONCLUSION: With CKD1-5 progression, TCM syndromes changed from Yin deficiency and dry

关键词： diabetic nephropathies syndrome and complex hemoglobins albumins glomerular filtration rate correlation of data

Understanding autoimmune response after SARS-CoV-2 infection and the pathogenesis/mechanisms of long COVID

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Medical Review 2024年第5期4卷 367-383页

作者： Ming Guo Shunlai Shang Mengfei Li Guangyan Cai Ping Li xiangmei chen Qinggang Li Department of Nephrology First Medical Center of Chinese PLA General HospitalState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Diseases ResearchBeijing 100853China Department of Nephrology China-Japan Friendship HospitalBeijingChina Haihe Laboratory of Cell Ecosystem China

COVID-19 posed a major challenge to the healthcare *** and the adoption of numerous prevention and control measures enabled the gradual end of the COVID-19 ***,successive occurrence of autoimmune diseases in patients with COVID-19cannot *** COVID has been themajor focus of research due to the long duration of different symptoms and the variety of systems *** may play a crucial role in the pathogenesis of long ***,we reviewed several autoimmune disorders occurring after COVID-19 infection and the pathogenesis of long COVID.

关键词： COVID-19 SARS-CoV-2 long COVID autoimmunity

Targeted therapy of kidney disease with nanoparticle drug delivery materials

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Bioactive Materials 2024年第7期37卷 206-221页

作者： Shunlai Shang Xiangmeng Li Haoran Wang Yena Zhou Keying Pang Ping Li Xiaomin Liu Min Zhang Wenge Li Qinggang Li xiangmei chen Department of Nephrology China-Japan Friendship HospitalBeijingChina Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province China Peking Union Medical College BeijingChina Department of Nephrology First Medical Center of Chinese PLA General HospitalNephrology Institute of the Chinese People’s Liberation ArmyNational Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijingChina School of Medicine Nankai UniversityTianjinChina College of Pharmacy Hebei University of Chinese MedicineShijiazhuangHebei ProvinceChina Department of Nephrology Affiliated Beijing Chaoyang Hospital of Capital Medical UniversityBeijingChina

With the development of nanomedicine,nanomaterials have been widely used,offering specific drug delivery to target sites,minimal side effects,and significant therapeutic *** kidneys have filtration and reabsorption functions,with various potential target cell types and a complex structural environment,making the strategies for kidney function protection and recovery after injury *** also lays the foundation for the application of nanomedicine in kidney ***,evidence in preclinical and clinical settings supports the feasibility of targeted therapy for kidney diseases using drug delivery based on *** prerequisite for nanomedicine in treating kidney diseases is the use of carriers with good biocompatibility,including nanoparticles,hydrogels,liposomes,micelles,dendrimer polymers,adenoviruses,lysozymes,and elastin-like *** carriers have precise renal uptake,longer half-life,and targeted organ distribution,protecting and improving the efficacy of the drugs they ***,attention should also be paid to the toxicity and solubility of the *** the carriers mentioned above have been used in preclinical studies for targeted therapy of kidney diseases both in vivo and in vitro,extensive clinical trials are still needed to ensure the short-term and long-term effects of nano drugs in the human *** review will discuss the advantages and limitations of nanoscale drug carrier materials in treating kidney diseases,provide a more comprehensive catalog of nanocarrier materials,and offer prospects for their drug-loading efficacy and clinical applications.

关键词： Nanomedicine Materials Targeted drugs Kidney disease