Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease
作者机构：Department of NephrologyChinese People's Liberation Army(PLA)General HospitalChinese PLA Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center of Kidney DiseasesBeijing Key Laboratory of Kidney DiseaseBeijing 100853China Department of NephrologyHenan Provincial Key Laboratory of Kidney Disease and ImmunologyHenan Provincial People's Hospital(Zhengzhou University People's Hospital)Zhengzhou 450003China
出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)
年 卷 期：2020年第14卷第3期
页 面：293-304页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This study was supported by the National Key R&D Program of China(No.2016YFC1305500) the National Natural Science Foundation of China(Nos.81770725,61671479,and 61971441)
主 题：netrin-1 VEGF-165 UNC5B angiogenesis diabetic kidney disease
摘 要：Netrin-1,an axon guidance factor,and its receptor UNC5B play important roles in axonal development and *** study examined netrin-1 and UNC5B expression in kidneys with diabetic kidney disease (DKD) and investigated their roles in ***-1 and UNC5B were upregulated in streptozotocininduced DKD Wistar rats,and their expression was compared with that in healthy ***,exogenous netrin-1 in UNC5B-depleted human renal glomerular endothelial cells (HRGECs) inhibited cell migration and *** effect was likely associated with SRC pathway ***-1 treatment also eliminated the pro-angiogenic effects of exogenous VEGF-165 on UNC5B-silenced *** results indicate that UNC5B antagonizes netrin-1 and that UNC5B upregulation contributes partly to enhancing angiogenesis in ***,introducing exogenous netrin-1 and depleting endogenous UNC5B are potential strategies for reducing the incidence of early angiogenesis and mitigating kidney injury in DKD.
维普期刊数据库