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Phenomics 2024年第1期4卷 51-55页

作者： Jialin Li Qingxia Huang Yingzhe Wang Mei Cui Kelin Xu chen suo Zhenqiu Liu Yanpeng An Li Jin Huiru Tang Xingdong chen Yanfeng Jiang State Key Laboratory of Genetic Engineering Human Phenome InstituteZhangjiang Fudan International Innovation Centerand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan University2005 Songhu RdShanghai 200438China Fudan University Taizhou Institute of Health Sciences Taizhou 225326China State Key Laboratory of Genetic Engineering School of Life SciencesMetabonomics and Systems Biology Laboratory at Shanghai International Centre for Molecular PhenomicsHuman Phenome InstituteZhongshan HospitalFudan University2005 Songhu RdShanghai 200438China Department of Neurology Huashan HospitalFudan UniversityShanghai 200040China Ministry of Education Key Laboratory of Public Health Safety Department of BiostatisticsSchool of Public HealthFudan UniversityShanghai 200032China Ministry of Education Key Laboratory of Public Health Safety Department of EpidemiologySchool of Public HealthFudan UniversityShanghai 200032China Shanghai Institute of Infectious Disease and Biosecurity Shanghai 200032China Yiwu Research Institute of Fudan University Yiwu 322000ZhejiangChina International Human Phenome Institute(Shanghai) Shanghai 201203China Greater Bay Area Institute of Precision Medicine(Guangzhou) Fudan UniversityGuangzhou 511462China

Cardiovascular health metrics are now widely recognized as modifable risk factors for cognitive decline and dementia.Metabolic perturbations might play roles in the linkage of cardiovascular diseases and dementia.Circulating metabolites profling by metabolomics may improve understanding of the potential mechanism by which cardiovascular risk factors contribute to cognitive decline.In a prospective community-based cohort in China(n=725),312 serum metabolic phenotypes were quantifed,and cardiovascular health score was calculated including smoking,exercise,sleep,diet,body mass index,blood pressure,and blood glucose.Cognitive function assessments were conducted in baseline and follow-up visits to identify longitudinal cognitive decline.A better cardiovascular health was signifcantly associated with lower risk of concentration decline and orientation decline(hazard ratio(HR):0.84–0.90;p<0.05).Apolipoprotein-A1,high-density lipoprotein(HDL)cholesterol,cholesterol ester,and phospholipid concentrations were signifcantly associated with a lower risk of longitudinal memory and orientation decline(p<0.05 and adjusted-p<0.20).Mediation analysis suggested that the negative association between health status and the risk of orientation decline was partly mediated by cholesterol ester and total lipids in HDL-2 and-3(proportion of mediation:7.68–8.21%,both p<0.05).Cardiovascular risk factors were associated with greater risks of cognitive decline,which were found to be mediated by circulating lipoproteins,particularly the medium-size HDL components.These fndings underscore the potential of utilizing lipoproteins as targets for early stage dementia screening and intervention.

关键词： Cardiovascular risk factors Lipoproteins Lipids Cognition Cognitive decline

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Monophase-homointerface electrodes intrinsically stabilize high-voltage all-solid-state batteries

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Science China Chemistry 2024年第5期67卷 1729-1739页

作者： Xiaolin Xiong Xianguo Ma Tianshi Lv Liquan chen Liumin suo Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of ScienceBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

The electrochemical stability and contact reliability of heterointerfaces between the solid electrolyte(SE) and electrode are critical for all-solid-state batteries(ASSBs), particularly much more challenging for high-voltage ASSBs, owing to the limited thermodynamically electrochemical window and mechanical inflexibility of SE, aggravating interfacial side reactions and contact failure. Considering all those issues originating from intrinsic heterogeneity in physicochemical features between the cathode material and SE, we are thinking about simplifying the heterointerfaces into a homointerface as a permanent cure to solve all electrochemical-mechanical interfacial failure. Herein, we propose monophase cathodes to construct thermodynamically stable all-in-one homointerfaces in ASS electrodes, removing unstable heterointerfaces by excluding SEs and intrinsically eliminating the Li chemical potential gap to avoid the formation of lithium-depleted space-charge layer and highly resistive mixed ion–electron conductor interphase. Our conception is successfully validated in the layered transition-metal oxide cathodes, which display outstanding stability no matter the MH-LiCoO_(2) cathode charging to 4.7 V or MH-Li_(1.2)Mn_(0.54)Ni_(0.13)-Co_(0.13)O_(2) cathode charging to 5.3 V. It is undeniable that our current version of above-illustrated MH-cathodes would bring out some new challenges for the practical application due to abandoning the SE. However, we believe our work also offers a brandnew direction to ultimately address the electrochemical–mechanical interfacial issues that would be promising for high-energy ASSBs with more discoveries of advanced monophase cathodes in the future.

关键词： monophase-homointerface electrode high-voltage all-solid-state batteries electrochemical-mechanical interfacial issue

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Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1768-1776页

作者： Hang Chi suo-Qun Zhao Ru-Yi chen Xing-Xing suo Rong-Rong Zhang Wen-Hui Yang Dong-Sheng Zhou Min Fang Bo Ying Yong-Qiang Deng cheng-Feng Qin State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAMMS100071BeijingChina College of Life Sciences Inner Mongolia Agricultural UniversityHohhot010018Inner MongoliaChina School of Life Sciences Henan UniversityKaifeng475004HenanChina Suzhou Abogen Biosciences Co. LtdSuzhou215123JiangsuChina Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical Sciences100071BeijingChina

The Orthopoxvirus genus,especially variola virus(VARV),monkeypox virus(MPXV),remains a significant public health threat worldwide.The development of therapeutic antibodies against orthopoxviruses is largely hampered by the high cost of antibody engineering and manufacturing processes.mRNA-encoded antibodies have emerged as a powerful and universal platform for rapid antibody production.Herein,by using the established lipid nanoparticle(LNP)-encapsulated mRNA platform,we constructed four mRNA combinations that encode monoclonal antibodies with broad neutralization activities against orthopoxviruses.In vivo characterization demonstrated that a single intravenous injection of each LNP-encapsulated mRNA antibody in mice resulted in the rapid production of neutralizing antibodies.More importantly,mRNA antibody treatments showed significant protection from weight loss and mortality in the vaccinia virus(VACV)lethal challenge mouse model,and a unique mRNA antibody cocktail,Mix2a,exhibited superior in vivo protection by targeting both intracellular mature virus(IMV)-form and extracellular enveloped virus(EEV)-form viruses.In summary,our results demonstrate the proof-of-concept production of orthopoxvirus antibodies via the LNP-mRNA platform,highlighting the great potential of tailored mRNA antibody combinations as a universal strategy to combat orthopoxvirus as well as otheremerging viruses.

关键词： proof universal neutral

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Hepatitis B cure:Current situation and prospects

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World Journal of Hepatology 2024年第6期16卷 900-911页

作者： Ya-Ping Li chen-Rui Liu Ling He Shuang-suo Dang Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina

Achievement of a‘clinical cure’in chronic hepatitis B(CHB)implies sustained virological suppression and immunological control over the infection,which is the ideal treatment goal according to domestic and international CHB management guidelines.Clinical practice has shown encouraging results for specific patient cohorts using tailored treatment regimens.These regimens incorporate either nucleos(t)ide analogs,immunomodulatory agents such as pegylated interferonα,or a strategic combination of both,sequentially or concurrently administered.Despite these advancements in the clinical handling of hepatitis B,achieving a clinical cure remains elusive for a considerable subset of patients due to the number of challenges that preclude the realization of optimal treatment outcomes.These include,but are not limited to,the emergence of antiviral resistance,incomplete immune recovery,and the persistence of covalently closed circular DNA.Moreover,the variance in response to interferon therapy and the lack of definitive biomarkers for treatment cessation also contribute to the complexity of achieving a clinical cure.This article briefly overviews the current research progress and existing issues in pursuing a clinical cure for hepatitis B.

关键词： Chronic hepatitis B Clinical cure Polyethylene glycol interferon Treatment strategies Research progress

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An in-situ study of static recrystallization in Mg using high temperature EBSD

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Journal of Magnesium and Alloys 2024年第4期12卷 1419-1430页

作者： Xu Ye Zhe suo Zhonghao Heng Biao chen Qiuming Wei Junko Umeda Katsuyoshi Kondoh Jianghua Shen School of Aeronautics Northwestern Polytechnical UniversityXi’anShaanxiChina Shaanxi Key Laboratory of Impact Dynamic and Its Engineering Application Xi’anShaanxiChina School of Mechanical Engineering Qinghai UniversityXiningQinghaiChina School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’anShaanxiChina Department of Mechanical Engineering University of North Carolina at CharlotteCharlotteNCUSA Joining and Welding Research Institute Osaka University11-1 MihogaokaOsakaJapan

It has been a common method to improve the mechanical properties of metals by manipulating their microstructures via static recrystallization,i.e.,through heat treatment.Therefore,the knowledge of recrystallization and grain growth is critical to the success of the technique.In the present work,by using in-situ high temperature EBSD,the mechanisms that control recrystallization and grain growth of an extruded pure Mg were studied.The experimental results revealed that the grains of priority for dynamic recrystallization exhibit fading competitiveness under static recrystallization.It is also found that grain boundary movement or grain growth is likely to show an inverse energy gradient effect,i.e.,low energy grains tend to swallow or grow into high energy grains,and grain boundaries of close to 30°exhibit superior growth advantage to others.Another finding is that{10-12}tensile twin boundaries are sites of hardly observed for recrystallization,and are finally swallowed by adjacent recrystallized grains.The above findings may give comprehensive insights of static recrystallization and grain growth of Mg,and may guide the design of advanced materials processing in microstructural engineering.

关键词： Pure Mg In-situ HT-EBSD Recrystallization Grain growth

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Investigating the Effect of Metabolic Phenotypes on Health Events in Alcoholic and Nonalcoholic Fatty Liver Disease

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 525-533页

作者： Hong Fan Pengyan Zhang Zhenqiu Liu Renjia Zhao chen suo Xingdong chen Tiejun Zhang Department of Epidemiology School of Public HealthFudan UniversityKey Laboratory of Public Health Safety(Fudan Uni-versity)Ministry of EducationShanghaiChina Shanghai Institute of Infectious Disease and Biosecurity School of Public HealthFudan UniversityShanghaiChina State Key Laboratory of Genetic Engineering Human Phenome Instituteand School of Life SciencesFudan UniversityShanghaiChina Fudan University Taizhou Institute of Health Sciences TaizhouZhejiangChina

Background and Aims:Metabolic dysfunction and obe-sity commonly coexist with both alcoholic and nonalcoholic fatty liver disease(AFLD and NAFLD).The association of AFLD and NAFLD with incident diseases in individuals with different metabolic phenotypes are unclear.Methods:UK Biobank study participants were screened for the presence of fatty liver at baseline.Body mass index and metabolic dysfunction were used to define metabolic phenotypes.Cox regression model was performed to examine the associations of AFLD and NAFLD with incident significant liver diseases(SLDs),cardiovascular diseases(CVDs),chronic kidney dis-eases(CKDs),and cancers,respectively.Results:A total of 43,974 AFLD and 103,248 NAFLD cases were identified.Both AFLD and NAFLD were associated with an increased risk of diseases of interest.The effects were amplified by obesity and metabolic abnormalities and modified by metabolic phe-notypes.Compared to individuals free of fatty liver and with phenotype of metabolically healthy-normal weight,AFLD[hazard ratio(HR 3.27;95%CI:1.95-5.47)]and NAFLD(HR 2.25;95%CI:1.28-3.94)cases with phenotype of met-abolically obese-normal weight had the greatest risk of SLDs.For CVDs,CKDs,and cancer,the greatest risks were detected in AFLD and NAFLD cases with phenotype of metabolically obese-overweight/obesity.In this subpopulation,AFLD and NAFLD conferred a 2.75-fold(95%CI:2.32-3.25)and 4.02-fold 95%CI:(3.64-4.43)increased risk of CVDs,4.37-fold 95%CI:(3.38-5.64)and 6.55-fold 95%CI:(5.73-7.48)increased risk of CKDs,and 1.19-fold 95%CI:(1.08-1.27)and 1.21-fold 95%CI:(1.14-1.28)increased risk of cancers,respectively.Conclusions:Metabolic phenotypes modified the association of AFLD and NAFLD with intrahepatic and ex-trahepatic diseases.

关键词： AFLD NAFLD Obesity Metabolic dysfunction Metabolic phenotype

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Phenome-Wide Association Analysis Reveals Novel Links Between Genetically Determined Levels of Liver Enzymes and Disease Phenotypes

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Phenomics 2022年第5期2卷 295-311页

作者： Zhenqiu Liu chen suo Yanfeng Jiang Renjia Zhao Tiejun Zhang Li Jin Xingdong chen State Key Laboratory of Genetic Engineering Human Phenome InstituteSchool of Life SciencesFudan UniversityShanghai 200438China Fudan University Taizhou Institute of Health Sciences Taizhou 225316China Key Laboratory of Public Health Safety Fudan UniversityMinistry of EducationShanghai 200032China Department of Epidemiology School of Public HealthFudan UniversityShanghai 200032China

Serum liver enzymes(alanine aminotransferase[ALT],aspartate aminotransferase[AST],λ-glutamyl transferase[GGT]and alkaline phosphatase[ALP])are the leading biomarkers to measure liver injury,and they have been reported to be associated with several intrahepatic and extrahepatic diseases in observational studies.We conducted a phenome-wide association study(PheWAS)to identify disease phenotypes associated with genetically predicted liver enzymes based on the UK Biobank cohort.Univariable and multivariable Mendelian randomization(MR)analyses were performed to obtain the causal esti-mates of associations that detected in PheWAS.Our PheWAS identified 40 out of 1,376 pairs(16,17,three and four pairs for ALT,AST,GGT and ALP,respectively)of genotype-phenotype associations reaching statistical significance at the 5%false discovery rate threshold.A total of 34 links were further validated in Mendelian randomization analyses.Most of the disease phenotypes that associated with genetically determined ALT level were liver-related,including primary liver cancer and alcoholic liver damage.The disease outcomes associated with genetically determined AST involved a wide range of phenotypic categories including endocrine/metabolic diseases,digestive diseases,and neurological disorder.Genetically predicted GGT level was associated with the risk of other chronic non-alcoholic liver disease,abnormal results of function study of liver,and cholelithiasis.Genetically determined ALP level was associated with pulmonary heart disease,phlebitis and thrombophlebitis of lower extremities,and hypercholesterolemia.Our findings reveal novel links between liver enzymes and disease phenotypes providing insights into the full understanding of the biological roles of liver enzymes.

关键词： Liver enzyme Disease phenotype GWAS Mendelian randomization

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Effects of Perceived Teacher Support on Student Behavioral Engagement in the Blended Learning Environment:Learning Experience as a Mediator

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Journal of Contemporary Educational Research 2024年第5期8卷 297-316页

作者： Yanle Zhang Peipei chen suo Jiang Junjian Gao School of Foreign Language Studies Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina School of Psychiatry Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina College of Education Wenzhou-Kean UniversityWenzhou 325060Zhejiang ProvinceChina

Blended learning(BL)has been widely adopted to improve students’academic achievements in higher education.However,its success relies mainly on student engagement,which plays an essential role in active learning and provides a rich understanding of students’experiences.The study utilized three self-designed scales-the Teacher Support Scale,Student Engagement Scale,and Student Learning Experience Scale-to gauge and examine the impact and relationship between perceived teacher support,student behavioral engagement,and the intermediary role of learning experiences.A cohort of 899 college students undertaking the obligatory College English course through BL modes across five Chinese universities actively participated by completing a comprehensive questionnaire.The results showed significant correlations between perceived teacher support,learning experience,and behavioral engagement.Perceived teacher support significantly predicted students’behavioral engagement,with socio-affective support exerting the most substantial predictive effects.All predictive effects were partially mediated by learning experience(learning mode,online resources,overall LMS-based learning,interaction with their instructor and peers,and learning outcome).The influence of perceived teacher support on behavioral engagement differed between students who reported the most positive(vs.negative)learning experiences.Suggestions for further research are offered for consideration.

关键词： Student engagement Teacher support Learning experience Blended learning environment

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Research progress on the mechanism of exercise fatigue and the role of probiotics in counteracting it

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Food and Health 2024年第3期6卷 33-41页

作者： Zi-Xia chen Jing Yang Jia-Jia Song Hua-Yi suo College of Food Science Southwest UniversityChongqing400715China Chongqing Engineering Research Center for Processing&Storage of Distinct Agricultural Products Chongqing Technology and Business UniversityChongqing 400067China

Exercise fatigue is a physiological phenomenon where the body cannot maintain a specific level after being stimulated by excessive exercise.Its five main theories include“energy depletion”,“accumulation of metabolites”,“homeostasis disorder of the internal environment”,“free radicals”,and“central nervous system protection inhibition”.The imbalance of intestinal flora caused by vigorous exercise can further lead to fatigue.Therefore,maintaining healthy intestinal flora is crucial for athlete health and performance.Recent studies have demonstrated that probiotics can regulate intestinal flora and alleviate exercise fatigue;however,there are no systematic reviews on the anti-fatigue effects of probiotics.Based on the mechanisms of exercise-induced fatigue,this article summarizes the effects and mechanisms by which probiotics combat exercise fatigue,aiming to provide research ideas for the development of probiotics that prevent exercise fatigue.

关键词： probiotics gut microbiota exercise fatigue mechanism

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Fabrication of TiO_2 Nanotube Arrays by Rectified Alternating Current Anodization

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Journal of Materials Science & Technology 2015年第1期31卷 23-29页

作者： Han Song Jing Shang chen suo State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking University

Anodization is a popular method of preparing TiO2nanotube array films（TiNTs） by using direct current（DC）power as the driving voltage.In this study,three driving voltage modes,namely,the sine alternating current（sine） mode,the full-wave rectification of sine waves via four diodes（sine-4D,where D means diode） mode,and the DC mode,were used to prepare TiNTs by anodization.At 20 V,TiNTs were formed under sine-4D mode but only irregular porous TiO2films were formed under DC mode.At 50 V,TiNTs formed under both the sine-4D and DC modes.No TiNTs formed in the sine mode anodization at either 20 or 50 V.Compared with the DC mode,the sine-4D mode required a lower oxidation voltage for TiNT formation,which suggests that sine-4D is an economical,convenient,and efficient driving voltage for TiNT preparation by anodization.The morphologies and structures of TiNT samples anodized at 50 V in the sine-4D and DC modes at different oxidation time（1,5,10,30,60,and 120 min） were analyzed.TiNT growth processes were similar between the studied modes.However,the growth rate of the films was faster under the sine-4D mode than the DC mode during the first 30 min of anodization.

关键词： TiO2nanotube Anodization Alternating current Growt

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