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Supramolecular systems for bioapplications:recent research progress in China

Science China Chemistry 2024年第5期67卷 1397-1441页

作者： Yue-Yang Liu Xiao-Yong Yu Yu-chen Pan Hang Yin Shuang Chao Yujie Li He Ma Minzan Zuo Kun-Xu Teng Jun-Li Hou Yong chen Dong-Sheng Guo Ruibing Wang Yuxin pei Zhichao pei Jiang-Fei Xu Xiao-Yu Hu Chunju Li Qing-Zheng Yang Leyong Wang Yu Liu Zhan-Ting Li State Key Laboratory of Organometallic Chemistry Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional MoleculesShanghai Institute of Organic ChemistryChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200032China Department of Chemistry Fudan UniversityShanghai 200438China College of Chemistry State Key Laboratory of Elemento-Organic ChemistryCollaborative Innovation Center of Chemical Science and EngineeringNankai UniversityTianjin 300071China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China College of Chemistry&Pharmacy Northwest A&F UniversityYangling 712100China Key Lab of Organic Optoelectronics&Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China Tianjin Key Laboratory of Structure and Performance for Functional Molecules College of ChemistryTianjin Normal UniversityTianjin 300387China State Key Laboratory of Analytical Chemistry for Life Science Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Supramolecular systems feature dynamic,reversible and stimuli-responsive characteristics,which are not easily achieved by molecular *** last decade has witnessed tremendous advances in the investigations of supramolecular systems for various bioapplications,which include drug delivery,anticancer therapy,antibacterial therapy,photodynamic therapy,photothermal therapy,combination therapy,antidotes for residual drugs or toxins,and bioimaging and ***-guest chemistry has played a key role in the development of such bioactive supramolecular systems,and natural macrocycles(such as cyclodextrins),synthetic macrocycles(such as calixarenes,cucurbit[n]urils,and pillararenes),and porous framework polymers(such as supramolecular organic frameworks and flexible organic frameworks)have been most successfully used as hosts to build different kinds of host-guest systems for attaining designed *** self-assembly of rationally designed amphiphilic molecules,macromolecules and polymers represent another important approach for the construction of supramolecular architectures with advanced *** this review,we summarize the important contributions made by Chinese researchers in this field,with emphasis on those reported in the past five years.

关键词： host-guest chemistry drug delivery anticancer and antibacterial photodynamic therapy photothermal therapy antidote transmembrane channel bioimaging and biosensing

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LivePod LP2检测人体运动中能量消耗水平的信、效度检验

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体育科学 2012年第1期32卷 48-53页

作者：赵壮壮陈培友邱悦雯南京师范大学体育科学学院江苏南京210046 烟台工程职业技术学院汽车系山东烟台264006

加速度传感器以其轻便、客观、精确等特点,在人体体力活动测量与评价中被广泛使用。LivePod LP2是一款国产新型加速度传感器,它基于3轴加速度MEMS传感器技术,采用人体动作智能模糊识别模型和个性化能耗模型测量人体运动中的能量消耗。对... 详细信息

加速度传感器以其轻便、客观、精确等特点,在人体体力活动测量与评价中被广泛使用。LivePod LP2是一款国产新型加速度传感器,它基于3轴加速度MEMS传感器技术,采用人体动作智能模糊识别模型和个性化能耗模型测量人体运动中的能量消耗。对LivePodLP2在测量人体运动能量消耗的信度和效度水平进行了验证。26名受试者在4个不同部位佩戴LivePod LP2,在3种速度下(4km/h、6km/h、8km/h)运动。通过计算ICC,发现其值处于0.978～0.997;采用相关分析、配对样本t检验以及Bland-Altman分析法等方法对仪器和MAXII测量数据分析表明:LivePod LP2佩戴于右侧臀部上方,在慢跑速度水平下效度水平最高。LivePod LP2可以用于记录体力活动能量消耗,在日常应用中,用户可以选择将LivePod LP2固定于腰部来监测运动能量消耗情况。

关键词： LivePod LP2 人体运动能量消耗信度效度

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学校体育现代化评价指标体系的研究

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南京体育学院学报（社会科学版） 2009年第2期23卷 17-25页

作者：孙庆祝陈家起陈培友南京师范大学体育科学学院南京210096

对学校体育现代化评价的基本理论问题进行了剖析,为评价指标体系的建构奠定理论基础,通过专家访谈、观察、实证调研等手段,结合我国学校体育现代化的现状及未来发展趋势,借鉴国内外教育现代化评价指标体系建构的相关经验,对我国学校体... 详细信息

对学校体育现代化评价的基本理论问题进行了剖析,为评价指标体系的建构奠定理论基础,通过专家访谈、观察、实证调研等手段,结合我国学校体育现代化的现状及未来发展趋势,借鉴国内外教育现代化评价指标体系建构的相关经验,对我国学校体育现代化评价指标体系建构问题进行了大胆尝试,以易于操作为出发点,经过多轮筛选,最后确定了包括4个1级指标、7个2级指标和14个三级指标在内的学校体育现代化评价指标体系。研究结果表明:学校体育现代化评价存在主观和客观两个向度,本课题在设计评价综合指标体系时,以客观指标为主要框架,同时兼顾到某些对评价具有较大影响的主观意愿方面的指标。进行学校体育现代化评价研究,对于促进学校体育活动开展,完善学校体育管理及进行科研开发具有重要的意义。学校体育现代化评价的基本特点可概括为:与区域发展相结合;评价与建设目标紧密相联;评价内容的广泛性;评价方法的综合性。学校体育现代化评价体系的构建需要一定的理论指导,本课题选择了以主客体价值理论、科学人文主义理论和可持续发展理论作为建构评价指标体系的理论依据。前瞻性的理念将会成为下一步实践活动的思想先导,在学校体育现代化评价指标体系构建过程中,我们秉持了如下理念:以学生的健康为本的理念;以促进学校和谐发展的理念;面向多元的理念;突出地方特色的理念。在学校体育现代化评价指标的设计过程中,我们坚持了如下原则:实事求是;以人为本;动态发展;简明科学;可操作性;总量指标和人均指标相结合。

关键词：学校体育现代化评价指标体系

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Ten-year observation of corneal densitometry and associated factors following small incision lenticule extraction

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 485-490页

作者： Xiao-Song Han Fei Xia Zhuo-Yi chen pei-Jun Yao Dong-Mei Yang Jing Zhao Xing-Tao Zhou Eye Institute and Department of Ophthalmology Eye&ENT HospitalFudan UniversityShanghai 200031China NHC Key Laboratory of Myopia(Fudan University) Key Laboratory of MyopiaChinese Academy of Medical SciencesShanghai 200031China Shanghai Research Center of Ophthalmology and Optometry Shanghai 200031China Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care(20DZ2255000) Shanghai 200031China

●AIM:To investigate the long-term changes of corneal densitometry(CD)and its contributing elements after small incision lenticule extraction(SMILE).●METHODS:Totally 31 eyes of 31 patients with mean spherical equivalent of-6.46±1.50 D and mean age 28.23±7.38y were ***-scale examinations were conducted on all patients preoperatively and during *** acuity,manifest refraction,axial length,corneal thickness,corneal higher-order aberrations,and CD were evaluated.●RESULTS:All surgeries were completed successfully without complications or adverse ***-year safety index was 1.17±0.20 and efficacy 1.04±*** value of 0–6 mm zones in central layer was statistically significantly lower 10y postoperatively,compared with preoperative values(0–2 mmΔ=-1.62,2–6 mmΔ=-1.24,P<0.01).There were no correlations between CD values and factors evaluated.●CONCLUSION:SMILE is a safe and efficient procedure for myopia on a long-term *** values get lower 10y postoperatively,whose mechanism is to be further discussed.

关键词： myopia small incision lenticule extraction corneal densitometry

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Investigating the causal associations between five anthropometric indicators and nonalcoholic fatty liver disease:Mendelian randomization study

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World Journal of Clinical Cases 2024年第7期12卷 1215-1226页

作者： Xian-pei Xiao Yong-Jun Dai Yu Zhang Meng Yang Jian Xie Guo chen Zheng-Jun Yang Department of Oncology Luojiang District People's Hospital of Deyang CityDeyang 618000Sichuan ProvinceChina Department of Orthopaedics Luojiang District People's Hospital of Deyang CityDeyang 618000Sichuan ProvinceChina Department of Infectious Diseases Hospital of Chengdu University of Traditional Chinese MedicalChengdu 610500Sichuan ProvinceChina

BACKGROUND Although the etiology of nonalcoholic fatty liver disease(NAFLD)has not been thoroughly understood,the emerging roles of anthropometric indicators in assessing and predicting the risk of NAFLD have been highlighted by accumulating *** To evaluate the causal relationships between five anthropometric indicators and NAFLD employing Mendelian randomization(MR)*** The Anthropometric Consortium provided genetic exposure data for five anthropometric indicators,including hip circumference(HC),waist circumference(WC),waist-to-hip ratio(WHR),body mass index(BMI),and body fat percentage(BF).Genetic outcome data for NAFLD were obtained from the United Kingdom Biobank and FinnGen ***-wide significant single nucleotide polymorphisms were chosen as instrumental *** MR(UVMR)and multivariable MR(MVMR)designs with analytical approaches,including inverse variance weighted(IVW),MR-Egger,weighted median(WM),and weighted mode methods,were used to assess the causal relationships between anthropometric indicators and *** Causal relationships were revealed by UVMR,indicating that a higher risk of NAFLD was associated with a perunit increase in WC[IVW:odds ratio(OR)=2.67,95%CI:1.42-5.02,P=2.25×10^(−3)],and BF was causally associated with an increased risk of NAFLD(WM:OR=2.23,95%CI:1.07-4.66,P=0.033).The presence of causal effects of WC on the decreased risk of NAFLD was supported by MVMR after adjusting for BMI and ***,no causal association between BF and NAFLD was *** addition,other causal relationships of HC,WHR(BMI adjusted),and BMI with the risk of NAFLD were not retained after FDR *** This study establishes a causal relationship,indicating that an increase in WC is associated with a higher risk of *** demonstrates that a suitable decrease in WC is advantageous for preventing NAFLD.

关键词： Anthropometric indicator Waist circumference Nonalcoholic fatty liver disease Mendelian randomization Genetic variant

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Evolutionary mechanism and frequency response of graphite electrode at extreme temperatures

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Nano Research 2024年第8期17卷 7283-7289页

作者： Shanpeng pei Zhiyong Zhang Xiuli Zhang Yan Liu Xiang Han Linshan Luo Pengfei Su Chaofei Lan Wei Huang Ziqi Zhang Ming-Sheng Wang Songyan chen Department of Physics Xiamen UniversityXiamen 361005China Shandong Electric Power Engineering Consulting Institute Corporation Jinan 250031China State Key Lab of Physical Chemistry of Solid Surfaces College of MaterialsXiamen UniversityXiamen 361005China School of Semiconductor Science and Technology South China Normal UniversityFoshan 528225China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037China National Key Laboratory of Integrated Circuits and Microsystems Chongqing 400000China

The battery management system is employed to monitor the external temperature of the lithium-ion battery in order to detect any potential ***,this outside–in detection method often suffers from a lag and is therefore unable to accurately predict the battery’s real-time ***,an inside–out frequency response approach is used to accurately monitor the battery’s state at various temperatures in real-time and correlate it with the solid electrolyte interphase(SEI)evolution of the graphite *** SEI evolution at temperatures of−15,25,60,and 90℃exhibits certain regular characteristics with temperature *** a temperature of−15℃,the Li^(+)-solvent interaction of lithium-ion slowed down,resulting in a significant reduction in *** 25℃,a LiF-rich inorganic SEI was identified as forming,which facilitated lithium-ion ***,high temperatures would induce decomposition of lithium hexafluorophosphate(LiPF_(6))and lithium-ion *** the extreme temperature of 90℃,the SEI would be organic-rich,and Li_(x)P_(y)F_(z),a decomposition product of lithium salts,was further oxidized to Li_(x)PO_(y)F_(z),which led to a surge in the charge-transfer resistance at SEI(R_(sei))and a reduction in Coulombic efficiency(CE).This changing relationship can be recorded in real time from the inside out by electrochemical impedance spectroscopy(EIS)*** provides a new theoretical basis for the structural evolution of lithium-ion batteries and the regular characterization of EIS.

关键词： graphite electrode solid electrolyte interphase(SEI)film extreme temperatures frequency response evolutionary mechanism

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Clinical study of chemotherapy-related cognitive impairment in patients with non-Hodgkin lymphoma

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World Journal of Psychiatry 2024年第7期14卷 1062-1067页

作者： Qiang-Li Wang Hai-Yan Xu Yi Wang Yin-Ling Wang pei-Nan Lin Zhong-Lei chen Department of Oncology and Hematology Suzhou Kowloon HospitalShanghai Jiao Tong University School of MedicineSuzhou 215000Jiangsu ProvinceChina

BACKGROUND Chemotherapy for malignant tumors can cause brain changes and cognitive impairment,leading to chemotherapy-induced cognitive impairment(CICI).Current research on CICI has focused on breast cancer and Hodgkin’s *** patients with non-Hodgkin’s lymphoma(NHL)undergoing chemo-therapy have cognitive impairment has not been fully *** have cognitive impairment has not been fully *** To investigate whether NHL patients undergoing chemotherapy had cognitive *** The study included 100 NHL patients who were required to complete a compre-hensive psychological scale including the Brief Psychiatric Examination Scale(MMSE)at two time points:before chemotherapy and within 2 wk of two chemo-therapy courses.A language proficiency test(VFT),Symbol Number Pattern Test(SDMT),Clock Drawing Test(CDT),Abbreviated Daily Cognition Scale(ECog-12),Prospective and Retrospective Memory Questionnaire,and Karnofsky Perfor-mance Status were used to assess cognitive changes before and after *** The VFT scores for before treatment(BT)and after treatment(AT)groups were 45.20±15.62,and 42.30±17.53,respectively(t-2.16,P<0.05).The CDT scores were 8(3.5-9.25)for BT and 7(2.5-9)for AT groups(Z-2.1,P<0.05).Retrospective memory scores were 13.5(9-17)for BT and 15(13-18)for AT(Z-3.7,P<0.01).The prospective memory scores were 12.63±3.61 for BT and 14.43±4.32 for AT groups(t-4.97,P<0.01).The ECog-12 scores were 1.71(1.25-2.08)for BT and 1.79(1.42-2.08)for AT groups(Z-2.84,P<0.01).The SDMT and MMSE values did not show a significant difference between BT and AT *** Compared to the AT group,the BT group showed impaired language,memory,and subjective cognition,but objec-tive cognition and execution were not significantly affected.

关键词： Non-Hodgkin’s lymphoma Hodgkin lymphoma Lymphoma cognitive impairment Chemotherapy-related cogni-tive impairment Clinical study

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Comparative effectiveness of several adjuvant therapies after hepatectomy for hepatocellular carcinoma patients with microvascular invasion

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 554-570页

作者： Yin-Xuan pei chen-Guang Su Zheng Liao Wei-Wei Li Zi-Xiang Wang Jin-Long Liu Department of Hepatobiliary Surgery The Affiliated Hospital of Chengde Medical UniversityChengde 067000Hebei ProvinceChina

BACKGROUND For resectable hepatocellular carcinoma(HCC),radical hepatectomy is commonly used as a curative ***,postoperative recurrence significantly diminishes the overall survival(OS)of HCC patients,especially with microva-scular invasion(MVI)as an independent high-risk factor for *** some studies suggest that postoperative adjuvant therapy may decrease the risk of recurrence following liver resection in HCC patients,the specific role of adju-vant therapies in those with MVI remains *** To conduct a network meta-analysis(NMA)to evaluate the efficacy of various adjuvant therapies and determine the optimal adjuvant *** A systematic literature search was conducted on PubMed,EMBASE,and Web of Science until April 6,*** comparing different adjuvant therapies or comparing adjuvant therapy with hepatectomy alone were *** ratios(HRs)with 95%confidence intervals were used to combine data on recurrence free survival and OS in both pairwise meta-analyses and *** Fourteen eligible trials(2268 patients)reporting five different therapies were *** terms of reducing the risk of recurrence,radiotherapy(RT)[HR=0.34(0.23,0.5);surface under the cumulative ranking curve(SUCRA)=97.7%]was found to be the most effective adjuvant therapy,followed by hepatic artery infusion chemotherapy[HR=0.52(0.35,0.76);SUCRA=65.1%].Regarding OS improvement,RT[HR:0.35(0.2,0.61);SUCRA=93.1%]demonstrated the highest effectiveness,followed by sorafenib[HR=0.48(0.32,0.69);SUCRA=70.9%].INTRODUCTION Hepatocellular carcinoma(HCC)is the sixth most common malignant tumor in the world and ranks third in terms of worldwide malignant tumor mortality rates in 2020[1].Curative treatments for HCC include ablation,radical hepatectomy,and liver ***,ablation is suitable only for early-stage HCC patients,who represent a small percentage of the overall HCC *** liver transplantation serves as the optimal tre

关键词： Hepatocellular carcinoma Adjuvant therapy Network meta-analysis Transarterial chemoembolization Hepatic artery infusion chemotherapy Radiotherapy Sorafenib

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Single pair of charge-2 Dirac and charge-2Weyl phonons in GeO_(2)

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Chinese Physics B 2024年第10期33卷 141-145页

作者： Dong-Chang He Jia-Xi Liu pei-Tao Liu Jiang-Xu Li Xing-Qiu chen Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

The presence of a pair of Weyl and Dirac points(WP-DP)in topological semimetal states is intriguing and sought after due to the effects associated with chiral topological ***,identifying these states in real materials poses a significant *** this study,by means of first-principles calculations we predict the coexistence of charge-2 Dirac and charge-2 Weyl phonons at high-symmetry points within a noncentrosymmetric P4_(1)2_(1)2 space ***,we propose GeO_(2)as an ideal candidate for realizing these ***,we observe two distinct surface arcs that connect the Dirac and Weyl points across the entire Brillouin zone,which could facilitate their detection in future experimental *** study not only presents a tangible material for experimentalists to explore the topological properties of WP-DP states but also opens up new avenues in the quest for ideal platforms to study chiral particles.

关键词： ological phonon Weyl points Dirac points

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FAM53B promotes pancreatic ductal adenocarcinoma metastasis by regulating macrophage M2 polarization

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1479-1499页

作者： Xuan-Zeng pei Min Cai Da-Wei Jiang Song-Hai chen Qing-Qing Wang Hui-Min Lu Yi-Fan Lu Department of Hepatological Surgery The First Hospital of JiaxingJiaxing 314000Zhejiang ProvinceChina Department of General Surgery West China Hospital of Sichuan UniversityChengdu 610044Sichuan ProvinceChina

BACKGROUND Our study investigated the role of FAM53B in regulating macrophage M2 polarization and its potential mechanisms in promoting pancreatic ductal adenocarcinoma(PDAC)*** To further investigate the role of FAM53B in regulating macrophage M2 polarization and its potential mechanism in promoting PDAC *** goal is to determine how FAM53B affects macrophage M2 polarization and to define its underlying mechanism in PDAC *** Cell culture and various experiments,including protein analysis,immunohisto-chemistry,and animal model experiments,were *** compared FAM53B expression between PDAC tissues and healthy tissues and assessed the correlation of FAM53B expression with clinical *** study analyzed the role of FAM53B in macrophage M2 polarization in vitro by examining the expression of relevant ***,we used a murine model to study the role of FAM53B in PDAC metastasis and analyzed the potential underlying *** Our research showed that there was a significant increase in FAM53B levels in PDAC tissues,which was linked to adverse tumor *** findings indicated that FAM53B can enhance macrophage M2 polarization,leading to increased anti-inflammatory factor *** results from the mouse model further supported the role of FAM53B in PDAC metastasis,as blocking FAM53B prevented tumor cell invasion and *** FAM53B promotes PDAC metastasis by regulating macrophage M2 *** discovery could lead to the development of new strategies for treating *** example,interfering with the FAM53B signaling pathway may prevent cancer *** research findings also provide important information for expanding our understanding of PDAC pathogenesis.

关键词： FAM53B Pancreatic ductal adenocarcinoma Tumor metastasis Macrophage polarization

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