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Chinese Journal of Chemistry 2024年第8期42卷 846-852页

作者： Ting chen Wei Feng Ruitong Yang Shanping chen Guo-jun Deng Key Laboratory for Green Organic Synthesis and Application of Hunan Province Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationCollege of ChemistryXiangtan UniversityXiangtanHunan411105 China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiangHunan453007 China

Comprehensive Summary,A convenient approach for the construction of 2-aminobenzothiazoles via I2-catalyzed tandem cyclization reaction of amines and carbon disulfide has been developed.The present approach starts from simple and readily available starting materials,affording a series of 2-aminobenzothiazoles in up to 89%yields under metal-free conditions.In this work,C—H/N—H functionalization was achieved and multiple C-hetero bonds were successfully constructed in one pot.

关键词： Sulfur heterocycles C-H functionalization Cyclization Tandem reaction Transition-metal-free Amines lodine N-Heterocycles

Preface:special topic on rechargeable battery technology

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Science China Chemistry 2024年第1期67卷 1-3页

作者： Yu-Guo Guo Qiang Zhang jun chen Li-jun Wan CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Frontiers Science Center for New Organic Matter Renewable Energy Conversion and Storage Center(RECAST)Haihe Laboratory of Sustainable Chemical TransformationsKey Laboratory of Advanced Energy Materials Chemistry(Ministry of Education)College of ChemistryNankai UniversityTianjin 300071China

Rechargeable batteries play a major role in the transition from fossil energy to renewable energy and are considered the key-enabling decarbonization technology for several industries,including electronics,transportat... 详细信息

关键词： battery artificial technology

Causal roles of gut microbiota in cholangiocarcinoma etiology suggested by genetic study

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1319-1333页

作者： Zhi-Tao chen chen-chen Ding Kai-Lei chen Yang-jun Gu Chi-cheng Lu Qi-Yong Li Division of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310000Zhejiang ProvinceChina Pediatric Psychology The Affiliated Mental Health Centre&Hangzhou Seventh People’s HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina School of Medicine Zhejiang Shuren UniversityHangzhou 310000Zhejiang ProvinceChina School of Medicine Zhejiang Chinese Medical University Zhejiang Shuren CollegeHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Cholangiocarcinoma(CCA)is a highly malignant biliary tract cancer with poor prognosis.Previous studies have implicated the gut microbiota in CCA,but evidence for causal mechanisms is lacking.AIM To investigate the causal relationship between gut microbiota and CCA risk.METHODS We performed a two-sample mendelian randomization study to evaluate potential causal associations between gut microbiota and CCA risk using genome-wide association study summary statistics for 196 gut microbial taxa and CCA.Genetic variants were used as instrumental variables.Multiple sensitivity analyses assessed result robustness.RESULTS Fifteen gut microbial taxa showed significant causal associations with CCA risk.Higher genetically predicted abundance of genus Eubacteriumnodatum group,genus Ruminococcustorques group,genus Coprococcus,genus Dorea,and phylum Actinobacteria were associated with reduced risk of gallbladder cancer and extrahepatic CCA.Increased intrahepatic CCA risk was associated with higher abundance of family Veillonellaceae,genus Alistipes,order Enterobacteriales,and phylum Firmicutes.Protective effects against CCA were suggested for genus Collinsella,genus Eisenbergiella,genus Anaerostipes,genus Paraprevotella,genus Parasutterella,and phylum Verrucomicrobia.Sensitivity analyses indicated these findings were reliable without pleiotropy.CONCLUSION This pioneering study provides novel evidence that specific gut microbiota may play causal roles in CCA risk.Further experimental validation of these candidate microbes is warranted to consolidate causality and mechanisms.

关键词： Cholangiocarcinoma Mendelian randomization Gut microbiota Instrumental variables Sensitivity analyses

Potassium isotopic signatures of modern offshore detrital sediments from different climatic regimes and the implications

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Science China Earth Sciences 2024年第2期67卷 405-419页

作者： jun MU Tianyu chen Qian YU Shichao AN Jianfang chen Xuefa SHI Weiqiang LI State Key Laboratory for Mineral Deposits Research School of Earth Sciences and EngineeringNanjing UniversityNanjing210023China Ministry of Education Key Laboratory for Coast and Island Development School of Geography and Ocean ScienceNanjing UniversityNanjing210023China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou310012China Key Laboratory of Marine Geology and Metallogeny First Institute of OceanographyMinistry of Natural ResourcesQingdao266061China

Potassium isotopes are a novel tracer for continental weathering.Previous K isotope studies on chemical weathering generally targeted weathering profiles under a particular climate region,yet the effects of chemical weathering on K isotopes under different climatic backgrounds remain unclear.Moreover,little is known about the K isotope signatures of modern unconsolidated detrital sediments.Here,we report K isotopic data of surficial seafloor sediments from continental shelves along the east coast of China(ECC),as well as those around the tropical Hainan island in the northern South China Sea.The ECC sediments have a relatively narrow distribution ofδ^(41)K(with reference to NIST3141a)values,which range from(-0.40±0.01)‰to(-0.57±0.04)‰,with an average of(-0.51±0.09)‰.By contrast,δ^(41)K values of Hainan offshore sediments display a larger variation,ranging from(-0.28±0.07)‰to(-0.67±0.02)‰.Theδ^(41)K values of Hainan offshore sediments exhibit negative correlations with the chemical index of alteration(CIA),Al/K,Ti/K,and total iron(FeT),which underlines the control of chemical weathering on K isotopic signatures of detritus inputs into oceans.We also measured Mg isotope compositions for the same samples;interestingly,the variability inδ^(26)Mg of the samples is small(~0.24‰)for all ECC and Hainan offshore sediments,andδ^(26)Mg values do not show clear correlations with indexes of chemical weathering.Our study demonstrates the link between K isotopic variability of detrital sediments and climatic conditions including rainfall intensity,which indicates that K isotopes of the detrital component of marine sediments could be applied to study Earth’s climate in deep time.Theδ^(41)K values of the offshore detrital sediments are significantly less variable than those of pelagic marine sediments,highlighting the importance of distinguishing the effects of diagenesis and neoformation of clay minerals from continental weathering in attempts to study deep-time climate-weathering link by K isotopes in detrital sedimentary recor

关键词： Potassium isotopes Magnesium isotopes Chemical weathering Detrital sediments Climatic regimes Mean annual precipitation

Recent Advances in Deciphering the Mechanisms and Biological Functions of DNA Demethylation

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Chinese Journal of Chemistry 2024年第6期42卷 645-651页

作者： Yang Feng Sheng-jun chen Bi-Feng Yuan Key Laboratory of Aquatic Product Processing Ministry of Agriculture and Rural AffairsNational R&D Center for Aquatic Product ProcessingSouth China Sea Fisheries Research InstituteChinese Academy of Fishery SciencesGuangzhouGuangdong510300 China School of Public Health Research Center of Public HealthRenmin Hospital of Wuhan UniversityWuhan UniversityWuhanHubei430071 China

5-Methylcytosine (5mC) is a dynamic and reversible epigenetic modification in genomic DNA of higher eukaryotes.It has been well-established that the demethylation of 5mC occurs through the ten-eleven translocation (TET)-mediated oxidation of 5mC followed by thymine DNA glycosylase (TDG)-initiated base excision repair (BER).Recent findings also have identified an alternative pathway of DNA demethylation.In this pathway,TET enzymes directly oxidize 5mC to form 5-formylcytosine (5fC) or 5-carboxylcytosine (5caC).These modified bases can undergo direct deformylation or decarboxylation,respectively.Additionally,DNA demethylation can also occur through the deamination of 5mC and 5hmC,resulting in the production of thymine and 5-hydroxymethyluracil (5hmU),respectively.Various DNA demethylation pathways possess critical functional implications and roles in biological processes.This Recent Advances article will focus on the studies of mechanisms and biological functions of DNA demethylation,shedding light on the reversible nature of the epigenetic modification of 5mC.

关键词： Epigenetics DNA DNA methylation 5-Methylcytosine Demethylation Mechanisms Biological functions C—C bond cleavage Mass spectrometry

BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response

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Genes & Diseases 2024年第1期11卷 19-22页

作者： Zhenhai Li Wenchao Xu Feng chen jun Zhang Wei-Guo Zhu Guangdong Key Laboratory of Genome Instability and Human Disease Prevention Department of Biochemistry and Molecular BiologyShenzhen University School of MedicineShenzhenGuangdong 518055China School of Pharmaceutical Sciences Shenzhen University Health Science CenterShenzhenGuangdong 518055China Base for International Science and Technology Cooperation:Carson Cancer Stem Cell Vaccines R&D Center International Cancer CenterShenzhen University Health Science CenterShenzhenGuangdong 518055China Shenzhen Bay Laboratory Shenzhen University School of MedicineShenzhenGuangdong 518055China Marshall Laboratory of Biomedical Engineering Shenzhen University School of MedicineShenzhenGuangdong 518055China

Etoposide is widely used for cancer chemotherapy in the clinic.However,long-term etoposide treatment can lead to adverse effects or drug resistance.To improve the situation,we evaluated the therapeutic efficiency of etoposide combined with inhibitors of bromodomain and extraterminal(BET)family proteins,which have recently emerged as novel anti-cancer targets due to their critical roles in cancer development.Firstly,we showed BRD4,one of the main targets of BET inhibitors,was involved in DNA damage response(DDR)via the homologous recombination(HR)repair pathway.

关键词： etoposide damage cancer

Outlier-resistant distributed fusion filtering for nonlinear discrete-time singular systems under a dynamic event-triggered scheme

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Frontiers of Information Technology & Electronic Engineering 2024年第2期25卷 237-249页

作者： Zhibin HU jun HU Cai chen Hongjian LIU Xiaojian YI Department of Applied Mathematics Harbin University of Science and TechnologyHarbin150080China Heilongjiang Provincial Key Laboratory of Optimization Control and Intelligent Analysis for Complex Systems Harbin University of Science and TechnologyHarbin150080China School of Automation Harbin University of Science and TechnologyHarbin150080China School of Mathematics and Physics Anhui Polytechnic UniversityWuhu241000China School of Mechatronical Engineering Beijing Institute of TechnologyBeijing100081China Yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing314003China Tangshan Research Institute Beijing Institute of TechnologyTangshan063099China

This paper investigates the problem of outlier-resistant distributed fusion filtering(DFF)for a class of multi-sensor nonlinear singular systems(MSNSSs)under a dynamic event-triggered scheme(DETS).To relieve the effect of measurement outliers in data transmission,a self-adaptive saturation function is used.Moreover,to further reduce the energy consumption of each sensor node and improve the efficiency of resource utilization,a DETS is adopted to regulate the frequency of data transmission.For the addressed MSNSSs,our purpose is to construct the local outlier-resistant filter under the effects of the measurement outliers and the DETS;the local upper bound(UB)on the filtering error covariance(FEC)is derived by solving the difference equations and minimized by designing proper filter gains.Furthermore,according to the local filters and their UBs,a DFF algorithm is presented in terms of the inverse covariance intersection fusion rule.As such,the proposed DFF algorithm has the advantages of reducing the frequency of data transmission and the impact of measurement outliers,thereby improving the estimation performance.Moreover,the uniform boundedness of the filtering error is discussed and a corresponding sufficient condition is presented.Finally,the validity of the developed algorithm is checked using a simulation example.

关键词： Distributed fusion filtering Multi-sensor nonlinear singular systems Dynamic event-triggered scheme Outlier-resistant filter Uniform boundedness

Geographical patterns and determinants of insect biodiversity in China

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Science China(Life Sciences) 2024年第6期67卷 1255-1265页

作者： Huizhong Fan Tongyi Liu Youhua chen Ziyan Liao jun chen Yibo Hu Gexia Qiao Fuwen Wei CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&China-Croatia“Belt and Road”Joint Laboratory on Biodiversity and Ecosystem Services Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China Jiangxi Provincial Key Laboratory of Conservation Biology College of ForestryJiangxi Agricultural UniversityNanchang 330045China University of Chinese Academy of Sciences Beijing 100049China

Insects play important roles in the maintenance of ecosystem functioning and the provision of livelihoods for millions of people.However,compared with terrestrial vertebrates and angiosperms,such as the giant panda,crested ibis,and the metasequoia,insect conservation has not attracted enough attention,and a basic understanding of the geographical biodiversity patterns for major components of insects in China is lacking.Herein,we investigated the geographical distribution of insect biodiversity across multiple dimensions(taxonomic,genetic,and phylogenetic diversity)based on the spatial distribution and molecular DNA sequencing data of insects.Our analysis included 18 orders,360 families,5,275 genera,and 14,115 species of insects.The results revealed that Southwestern and Southeastern China harbored higher insect biodiversity and numerous older lineages,representing a museum,whereas regions located in Northwestern China harbored lower insect biodiversity and younger lineages,serving as an evolutionary cradle.We also observed that mean annual temperature and precipitation had significantly positive effects,whereas altitude had significantly negative effects on insect biodiversity in most cases.Moreover,cultivated vegetation harbored the highest insect taxonomic and phylogenetic diversity,and needleleaf and broadleaf mixed forests harbored the highest insect genetic diversity.These results indicated that human activities may positively contribute to insect spatial diversity on a regional scale.Our study fills a knowledge gap in insect spatial diversity in China.These findings could help guide national-level conservation plans and the post-2020 biodiversity conservation framework.

关键词： insect spatial patterns multiple dimensions driving factors vegetation types

Metastatic stomach lymphoepithelioma-like carcinoma and immune checkpoint inhibitor therapy:A case report

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1436-1442页

作者： Guo-Feng chen jun Wang Yu Yan Song Xu Jian chen Department of Gastroenterology Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Cancer Center Zhejiang UniversityHangzhou 310000Zhejiang ProvinceChina Department of Pathology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Pulmonary lymphoepithelioma-like carcinoma(PLELC)is a rare type of nonsmall-cell lung cancer.Stomach lymphoepithelioma-like carcinoma(LELC)metastasis secondary to PLELC has not been reported recently.CASE SUMMARY A 64-year-old female was admitted to our hospital for a regular gastroscopy examination with a 6-year history of surgical resection for left PLELC.Positron emission tomography/computed tomography suggested high accumulation of 18F-fludeoxyglucose in the gastric cardia region.Upper gastrointestinal endoscopy confirmed a large mass at the stomach fundus.Immunohistochemistry(IHC)of the biopsy suggested metastatic stomach LELC.Proximal gastrectomy showed that this 6.5 cm×5.0 cm mass was located in the stomach fundus near the cardia.Histopathological examination showed a poorly differentiated carcinoma with prominent lymphoplasmacytic infiltration.IHC demonstrated that the tumor was positive for CK(AE1/AE3),p63,p40,p53,Ki-67(70%),and EGFR(3+)and negative for CK7,CK20,Her2,and CD10.In situ hybridization analysis showed positive staining Epstein-Barr virus-encoded RNA.Tumor programmed cell death ligand 1(PD-L1)expression score was 98%,and the combined positive score was 100,with no evidence of microsatellite instability.Thus,the patient was unequivocally diagnosed with metastatic stomach LELC secondary to pulmonary LELC.After discharge,this patient underwent PD-1 inhibitor treatment(toripalimab,240 mg)every 3 wk for ten cycles,and she has had no tumor recurrence.CONCLUSION For gastric LELC metastasis,PD-1 inhibitor therapy could become a new therapeutic approach,though there is still no evidence from large data sets to support this.

关键词： Stomach neoplasm Pulmonary lymphoepithelioma-like carcinoma Metastasis Immune checkpoint inhibitor Case report

Intake of tobacco nitrosamines of smokers in various provinces of China and their cancer risk:A meta-analysis

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Journal of Environmental Sciences 2024年第7期141卷 249-260页

作者： Xiao Li Zhiwei Ye jun Wang Pengfei Lin Xiaojin Zhang Shuguang Xie Chao chen Research Institute for Environmental Innovation(Suzhou) TsinghuaSuzhouJiangsu 215163China State Key Joint Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China Shenzhen Key Laboratory of Organic Pollution Prevention and Control State Key Laboratory of Urban Water Resource and EnvironmentHarbin Institute of TechnologyShenzhen 518055China State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Science and EngineeringPeking UniversityBeijing 100871China

Nitrosamines are a class of carcinogens which have been detected widely in food,water,some pharmaceuticals as well as tobacco.The objectives of this paper include reviewing the basic information on tobacco consumption and nitrosamine contents,and assessing the health risks of tobacco nitrosamines exposure to Chinese smokers.We searched the publications in English from“Web of Science”and those in Chinese from the“China National Knowledge Infrastructure”in 2022 and collected 151 literatures with valid information.The content of main nitrosamines in tobacco,including 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone(NNK),N-nitrosonornicotine(NNN),N-nitrosoanatabine(NAT),N-nitrosoanabasine(NAB),total tobacco-specific nitrosamines(TSNA),and N-nitrosodimethylamine(NDMA)were summarized.The information of daily tobacco consumption of smokers in 30 provinces of China was also collected.Then,the intakes of NNN,NNK,NAT,NAB,TSNAs,and NDMA via tobacco smoke were estimated as 1534ng/day,591 ng/day,685 ng/day,81 ng/day,2543 ng/day,and 484 ng/day by adult smokers in30 provinces,respectively.The cancer risk(CR)values for NNN and NNK inhalation intake were further calculated as 1.44×10^(-5)and 1.95×10^(-4).The CR value for NDMA intake via tobacco smoke(inhalation:1.66×10^(-4))indicates that NDMA is similarly dangerous in tobacco smoke when compared with the TSNAs.In China,the CR values caused by average nitrosamines intake via various exposures and their order can be estimated as the following:smoke(3.75×10^(-4))>food(1.74×10^(-4))>drinking water(1.38×10^(-5)).Smokers in China averagely suffer 200%of extra cancer risk caused by nitrosamines in tobacco when compared with non-smokers.

关键词： N-nitrosamine Tobacco Cancer risk Tobacco specific nitrosamines(TSNAs) N-nitrosodimethylamine(NDMA)