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Polyphenol based hybrid nano-aggregates modified collagen fibers of biological valve leaflets to achieve enhanced mechanical,anticoagulation and anti-calcification properties

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Journal of Leather Science and Engineering 2022年第4期4卷 394-408页

作者： Shufen Li Shiying Lang Zhiqian chen jingruo chen Weihua Zhuang Yangrui Du Yawen Yao Gongyan Liu Mao chen Laboratory of Heart Valve Disease West China HospitalSichuan University37 Guoxue AlleyChengdu 610041China The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education College of Biomass Science and EngineeringSichuan UniversityChengdu 610065China University of California Davis 1 Shields AveDavisCA 95616USA Faculty of Science and Engineering Aachen-Maastricht Institute for Biobased Materials(AMIBM)Maastricht UniversityBrightlands Chemelot Campus6167 RD GeleenThe Netherlands Department of Cardiology West China HospitalSichuan University37 Guoxue AlleyChengdu 610041China Regenerative Medicine Research Center West China HospitalSichuan University37 Guoxue AlleyChengdu 610041China

Glutaraldehyde(Glut)-crosslinked porcine pericardium and bovine pericardium are mainly consisted of collagen and widely used for the preparation of heterogenous bioprosthetic heart valves(BHV),which play an important role in the replacement therapy of severe valvular heart disease,while their durability is limited by degeneration due to calcification,thrombus,endothelialization difficulty and prosthetic valve ***,we develop a novel BHV,namely,TPly-BP,based on natural tannic acid and polylysine to improve the durability of Glut crosslinked bovine pericardium(Glut-BP).Impressively,tannic acid and polylysine could form nanoaggregates via multiple hydrogen bonds and covalent bonds,and the introduction of nanoaggregates not only improved the mechanical properties and collagen stability but also endowed TPly-BP with good biocompatibility and *** to Glut-BP,TPly-BP showed significantly reduced cytotoxicity,improved endothelial cell adhesion,a low hemolysis ratio and obviously reduced platelet ***,TPly-BP exhibited great antibacterial and in vivo anti-calcification ability,which was expected to improve the in vivo durability of *** results suggested that TPly-BP would be a potential candidate for BHV.

关键词： Tannic acid Bioprosthetic heart valve Antibacterial and anti-calcification

Expression of insulin-like growth factor-1 in breast cancer tissues

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The Chinese-German Journal of Clinical Oncology 2009年第6期8卷 326-328页

作者： Mingxun chen Mengquan Li jingruo Li Department of Breast Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 China

Objective: We investigated the expression of insulin-like growth factor-1 (IGF-1) so as to explore its relationship with carcinogenesis and development of breast cancer. Methods: IGF-1 mRNA levels in tissues of breast cancer, adjacent breast cancer in 70 cases breast cancer patients were analyzed by RT-PCR with the normal breast tissues of paired breast as the control. Results: The level of IGF-1 mRNA expression in breast cancer tissues was significantly higher than that in the paired adjacent to breast cancer tissues, normal mammary gland tissues. The ration of IGF-1/β-actin were 0.679 ± 0.075, 0.463 ± 0.085, 0.305 ± 0.031, respectively. There was significant difference between different groups (P 0.005). Conclusion: The high-level expression of IGF-1 in breast cancer tissues is correlated with carcinogenesis, development and metastasis of breast cancer.

关键词： insulin-like growth factor-1 (IGF-1) breast cancer

Polyphenol based hybrid nano-aggregates modified collagen fibers of biological valve leaflets to achieve enhanced mechanical,anticoagulation and anti-calcification properties

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Collagen and Leather

Collagen and Leather 2023年第04期 116-130页

作者： Shufen Li Shiying Lang Zhiqian chen jingruo chen Weihua Zhuang Yangrui Du Yawen Yao Gongyan Liu Mao chen Laboratory of Heart Valve Disease West China HospitalSichuan University The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education College of Biomass Science and EngineeringSichuan University University of California Davis Faculty of Science and Engineering Aachen-Maastricht Institute for Biobased Materials (AMIBM)Maastricht UniversityBrightlands Chemelot Campus Department of Cardiology West China HospitalSichuan University Regenerative Medicine Research Center West China HospitalSichuan University

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The Effects of Herceptin and its Combination with 2-Deoxyglucose on Proliferation,Migration and Invasion of ErbB2-overexpressing Breast Cancer Cells

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The Effects of Herceptin and its Combination with 2-Deoxyglu...

中国生物化学与分子生物学会2020全国学术在线会议

作者： Sinan Lv Yue Shen Li He jingruo chen Xuejiao Ma Hua Li Yuhua Zhao Department of Biochemistry and Molecular Biology West China School of Basic Medical Sciences and Forensic MedicineSichuan University Department of Anatomy West China School of Basic Medical Sciences and Forensic MedicineSichuan University Department of Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education West China School of PharmacySichuan University

Purpose:To investigate the effects of Herceptin alone and in combination with 2-deoxyglucose(2-DG) on proliferation,migration,and invasion of ErbB2-overexpressing breast cancer cell lines MCF7/ErbB2 and SK-BR-3,as well as their underlying molecular ***:MCF7/ErbB2 and SK-BR-3 cells were treated with PBS,2-DG,Herceptin alone or in combination with *** proliferation was detected by MTS *** migration and invasion were measured by transwell *** uptake and lactate production in the media were measured by using Glucose Oxidase Assay kit and Lactate Assay kit,***2,lactate dehydrogenase A(LDHA) and hexokinase II(HKII) protein levels were detected by Western *** addition,the combination index(CI) was calculated to evaluate if there was a synergism of combination ***:In MCF7/ErbB2 and SK-BR-3 cells,Herceptin alone effectively inhibited proliferation,migration,invasion,glucose uptake and lactate production,and downregulated ErbB2 and LDHA protein *** of Herceptin with 2-DG synergistically inhibits proliferation,migration,and invasion of both *** to 2-DG or Herceptin alone group,combination group significantly inhibited glucose uptake and lactate production in both *** both cell lines,compared to PBS group,Herceptin alone decreased HKII protein level;the combination significantly inhibited ErbB2,LDHA,HKII protein *** SK-BR-3 cells,the inhibitory effect on the expression of LDHA and HKII protein by combination was more prominent than 2-DG or Herceptin individually ***,these differences were not observed in MCF7/ErbB2 ***:We concluded that combining Herceptin with 2-DG synergistically inhibited proliferation,migration,and invasion of MCF7/ErbB2 and SK-BR-3 cells by downregulating LDHA and HKII protein levels which affected cell glycolysis.

关键词： Breast neoplasms ErbB2 Glycolysis Herceptin 2-Deoxyglucose

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Profile of *** chen

Science China(Life Sciences) 2024年第10期67卷 2062-2063页

作者： chen, Songlin Yellow Sea Fisheries Res Inst Qingdao Peoples R China

For decades,*** has been engaged in fish germplasm preservation,sex control and research focusing on molecular breeding for disease *** discovered the first sex-specific molecular marker of fish(chen et al.,2007),deciphered the first fish genome(Chinese tongue sole)in China,revealed the sex determination mechanism in fish(chen et al.,2014),and created molecular sex control *** also discovered the molecular mechanism of metamorphosis in flatfish(Shao et al.,2017)and developed China's first fish disease-resistant breeding gene chip,“YUXIN No.1”.

关键词： technology breeding

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论魏晋士人的自然主义生命意识

理论界 2022年第12期 35-42页

作者：陈静若胡静中国人民大学哲学院中央团校(中国青年政治学院)马克思主义学院

“自然”是道家哲学的重要概念。自先秦时期,老、庄即主张回归本真、顺应自然,以自然态度面对人生。至魏晋之际,玄学大畅,士人个体生命意识觉醒,其思想以先秦道家为主流,体现鲜明的自然主义色彩,由此发展出王弼的“喜、惧、哀、乐,民之... 详细信息

“自然”是道家哲学的重要概念。自先秦时期,老、庄即主张回归本真、顺应自然,以自然态度面对人生。至魏晋之际,玄学大畅,士人个体生命意识觉醒,其思想以先秦道家为主流,体现鲜明的自然主义色彩,由此发展出王弼的“喜、惧、哀、乐,民之自然”、嵇康的“越名教而任自然”,以及郭象的“物皆自然,无物使然”等观点。魏晋士人通过对“自然”的体悟,追求生命本真的存在状态,向往诗意自由的人生,彰显自然主义的生命意识,对魏晋士人群体本身、魏晋社会、美学发展乃至后世哲学都产生了深远影响。

关键词：魏晋士人自然生命意识道家

Effect of Reclamation on the Groundwater-Lake Water Interaction in chen Lake

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Journal of Earth Science 2024年第3期35卷 1083-1086页

作者： Kun Lei Teng Ma Liuzhu chen Zhenxing Li Yu chen School of Environmental Studies State Key Laboratory of Biogeology and Environmental GeologyChina University of GeosciencesWuhan 430078China

0 INTRODUCTION To relieve the short supply of suitable land for residing,cultivating,and commerce,it is accepted to reclaim land from lakes,river estuaries,and coastal regions in many countries(Mancini et al.,2020).The large-scale reclamation activities have an irreversible effect on the mico-geomorphology and hydrodynamic system of seasonally flooded areas(Zhang et al.,2019;Yu et al.,2018).For example,coastal regions reclaimed extended the groundwater flow paths,as well as created groundwater level rise,resulting in water-logging in the reclaimed area(Hu et al.,2008).Similar changes in groundwater flow systems may alter groundwater-lake water interactions,and it can ultimately affect the water cycle in the lake ***,such detailed studies are presently *** addition,natural exchanges between the lake and groundwater systems can be strongly affected by physical hydrological processes(Javadzadeh et al.,2020),chemical properties(Kamtchueng et al.,2015),and bioto behavior(Hancock et al.,2005).

关键词： groundwater coastal logging

Meridional deflection of global eddy propagation derived from tandem altimetry: Mechanism and implication

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Science China Earth Sciences 2024年第3期67卷 811-825页

作者： Ge chen Xiaoyan chen Frontiers Science Center for Deep Ocean Multispheres and Earth System School of Marine TechnologyOcean University of ChinaQindao 266100China Laboratory for Regional Oceanography and Numerical Modeling Laoshan LaboratoryQindao 266237China

A common view on meridional deflection of eddy propagation is poleward for cyclones and equatorward for anticyclones. This widely accepted polarity-sensitive pattern has been increasingly undermined given that it is systematically violated on both zonal and regional scales as recently reported. Here, we approach the problem by exploring these violations in terms of eddy effects of spatiotemporal geostrophy, thermal fading, and flow dragging, yielding the following main conclusions.(1) The polarity-dependent deflection discrepancy is a pseudo feature resulting from a biased fit to the normalized eddy tracks which are spatially asymmetric(though azimuthally symmetric) between the two signs;Instead, the primary pattern of eddy deflection appears to be geographically correlated and polarity independent.(2) Geostrophic adjustment plays a critical role in defining the meridional movement of an eddy. Specifically, a consistent poleward(equatorward) trajectory bending of spatially(temporally) ageostrophic eddies is observed irrespective of their polarity.(3) The mechanism of eddy deflection is also determined by its zonal propagation direction. Westward propagating eddies are substantially affected by thermal fading, while opposite ones by flow dragging. A realistic and comprehensive understanding of eddy deflection mechanisms serves as a significant contribution to the prediction of eddy trajectory, and the protection of ocean environment.

关键词： Mesoscale eddies Eddy propagation Eddy meridional deflection Satellite observation Geostrophic adjustment

A refined representation method of the particle size distribution curve based on grading entropy

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Particuology 2024年第5期88卷 302-311页

作者： Xing Li Qun chen Zhaozhao Liu cheng Zhou chen Wang chen chen State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China

The particle size distribution(PSD)curve is an important expression of the basic properties of the *** characteristic parameters such as median particle size D_(50),effective particle size D_(10),and some combinations of characteristic parameters can only represent some points of the PSD curve,failing to represent all information of the PSD *** this paper,a fraction characteristic parameter F that could reflect the fraction size variation of the PSD curve was introduced based on grading *** a new presentation method of the A-B-F three parameters was proposed for a refined representation of the PSD *** was found that the newly constructed model not only better represents the differences in the width of PSD curves but also has a higher sensitivity than the A-B two-parameter model proposed by Lő*** PSD curves with similar distributions,the new presentation method has a higher degree of discrimination than that of the D_(50)-C_(u)-C_(c) three-parameter or the four-parameter combination G_(c) proposed by ***,the application of this new method in describing the spatial nonuniformity distribution of depositions and predicting the soil hydraulic conductivity was *** research results can provide a reference for the refined representation of PSD curves.

关键词： Grading entropy Particle size distribution curve Refined representation