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Paclitaxel-lipid prodrug liposomes for improved drug delivery and breast carcinoma therapy

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Chinese Chemical Letters 2024年第2期35卷 335-340页

作者： Xin Wu Xinmei chen Xinyu Wang Haisheng He jianming chen Wei Wu Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Department of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Shanghai Wei Er Lab Shanghai 201707China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Paclitaxel(PTX)is widely applied for the treatment of unresectable and metastasis breast carcinoma as well as other cancers,whereas its efficacy is always impeded by poor *** are one kind of the most successful drug carriers which are capable of solubilizing PTX and improving patients’tolerance owing to excellent biocompatibility and ***,poor compatibility between PTX and liposomes compromises the stability,drug loading and anti-tumor capacity of liposomal *** address this issue,three lipids with various chain lengths,namely,myristic acid(MA,14C),palmitic acid(PA,16C)and stearic acid(SA,18C),were conjugated to PTX via ester bonds and the synthesized prodrugs with high lipophilicity were further formulated into liposomes,*** liposomes show high stability and drug loadings,as well as sustained drug *** chain lengths of lipids are negatively correlated with drug release and enzymatic conversion rates,which further impact the pharmacokinetics,tumor accumulation,and anti-tumor efficacy of liposomal *** rapid nor slow drug release facilitates high tumor accumulation as well as anti-tumor efficacy of *** all liposomes,PTX-PA-loaded liposomes show the longest circulation and highest tumor accumulation of PTX and exert the most potent anti-tumor capacities in vivo,owing to its moderate drug release and enzymatic conversion *** its superior safety,PTX-PA liposomes hold potential for further clinical translation.

关键词： Paclitaxel Lipids Prodrugs Liposomes Drug release Chemotherapy

Numerical simulation of gas–liquid flow in the bubble column using Wray–Agarwal turbulence model coupled with population balance model

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Chinese Journal of Chemical Engineering 2023年第6期58卷 205-223页

作者： Hongwei Liang Wenling Li Zisheng Feng jianming chen Guangwen Chu Yang Xiang State Key Laboratory of Organic–Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China

In this paper,an improved computational fluid dynamic(CFD)model for gas-liquid flow in bubble column was developed using the one-equation Wary-Agarwal(WA)turbulence model coupled with the population balance model(PBM).Through 18 orthogonal test cases,the optimal combination of interfacial force models,including drag force,lift force,turbulent dispersion *** modified wall lubrication force model was proposed to improve the predictive ability for hydrodynamic behavior near the wall of the bubble *** values simulated by optimized CFD model were in agreement with experimental data,and the errors were within±20%.In addition,the axial velocity,turbulent kinetic energy,bubble size distribution,and the dynamic characteristic of bubble plume were analyzed at different superficial gas *** research work could provide a theoretical basis for the extension of the CFD-PBM coupled model to other multiphase reactors..

关键词： CFD–PBM Wray–Agarwal turbulence model Gas–liquid flow Bubble column Interfacial force Wall lubrication force

Label-free quantitative proteomics analysis models in vivo and in vitro reveal key proteins and potential roles in sciatic nerve injury

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BIOCELL 2023年第9期47卷 2069-2080页

作者： YANG GU MINGGUANG BI DEHUI chen NING NI jianming chen Department of Trauma Orthopedics Surgery Ningbo No.6 HospitalNingbo University School of MedicineNingbo315000China Department of Orthopedics Ningbo Medical CenterLihuili HospitalNingbo University School of MedicineNingbo315000China Department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhou350001China School of Medicine Ningbo UniversityNingbo315000China

Background:The underlying mechanism of sciatic nerve injury(SNI)is a common motor functional disorder,necessitates further ***:A rat model of SNI was established,with the injury group subjected to compressive injury of the right sciatic nerve exposed at the midpoint of the thigh and the sham surgery group undergoing the same surgical *** oxygen-glucose deprivation model was employed to simulate in vitro SNI in PC12 *** data acquisition and quality control,differentially expressed proteins(DEPs)in each model were identified through differential analysis,and enrichment analysis was used to explore the potential functions and pathways of the *** diagrams were drawn,and DEPs from both in vivo and in vitro SNI models were imported into the STRING database to construct a protein-protein interaction network and screen for hub ***:After the peptide segments obtained from rat nerve blockade and PC12 cells met quality requirements,258 DEPs were identified in rat nerve samples,and 119 DEPs were screened in PC12 *** analysis revealed that DEPs in the rat model were predominantly concentrated in biological functions such as myogenic cell proliferation and signaling related to lipid and energy *** in the in vitro model were mainly enriched in biological processes such as phagocytosis and were associated with lipid transport and *** hub proteins,amyloid precursor protein(APP)and fibronectin 1(FN1),were identified through MCC,MCODE,and Degree *** PC12 cells and external validation sets showed relatively higher expression of APP and FN1 in injured *** of gene set enrichment analysis indicated that these two proteins were associated with metabolic pathways,such as biosynthesis of glycosaminoglycan chondroitin sulfate and biosynthesis of unsaturated fatty ***:APP and FN1 are potential key molecules involved in SNI and are associated with various metabolic pathways

关键词： Oxygen glucose deprivation Proteomics Sciatic nerve injury Peripheral nerve injury

A new Cu^(2+)-induced color reaction of a rhodamine derivative N-(3-carboxy)acryloyl rhodamine B hydrazide

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Science China Chemistry 2011年第7期54卷 1101-1108页

作者： SUN chengDong chen jianming MA HuiMin LIU Yang ZHANG JingHua LIU QingJun Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living Biosvstems Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China Beijing Center for Physical and Chemical Analysis Beijing 100089 China

A new rhodamine derivative,N-(3-carboxy)acryloyl rhodamine B hydrazide(CARB),has been synthesized,and its unusual spectroscopic reaction with Cu2+ has been *** derivative exhibits a rapid and reversible non-fluorescent absorption upon coordination to Cu2+,which is a rather unusual phenomenon for rhodamine B *** measurements using the Job's method and the molar ratio method reveal that one CARB molecule combines two Cu2+ ions,and the two Cu2+ ions play different roles:one opens the spirocyclic structure and the other quenches the fluorescence of the xanthene *** reaction mechanism is supported by a comparative study on the model compound N-acryloyl rhodamine B hydrazide as well as by the density functional theory ***,the absorption response of CARB is highly selective for Cu2+ over other common ions,which implies that CARB may be used as a colorimetric probe for the rapid visual detection of Cu2+.

关键词： N-(3-carboxy)acryloyl rhodamine B hydrazide reaction mechanism colorimetric probe visual detection copper N-acryloyl rhodamine B hydrazide

VOICE ACTIVITY DETECTION UNDER RAYLEIGH DISTRIBUTION

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Journal of Electronics(China) 2009年第4期26卷 552-556页

作者： Li Yu chen jianming Tan Hongzhou School of Information Science and Technology Sun Yat-Sen University Guangzhou 510275 China

This paper presents an improved Voice Activity Detection （VAD） algorithm which uses the Signal-to-Noise Ratio （SNR） measure. We assume that noise Power Spectral Density （PSD） in each spectral bin follows a Rayleigh distribution. Rayleigh distributions with its asymmetric tail characteristics give a better description of the noise PSD distribution than Gaussian distribution. Under this asstlmption, a new threshold updating expression is derived. Since the analytical integral of the false alarm probability, the threshold updating expression can be represented without the inverse complementary error function and low computational complexity is achieved in our system. Experimental results show that the proposed VAD outperforms or at least is comparable with the VAD scheme presented by Davis under several noise environments and has a lower computational complexity.

关键词： Statistical Voice Activity Detection (VAD) Threshold update Rayleigh distribution Computational complexity

Design and simulation of self-powered radio frequency identification (RFID) tags for mobile temperature monitoring

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Science China(Technological Sciences) 2013年第1期56卷 1-7页

作者： CHU HeQun WU GuangMin chen jianming FEI Fei MAI John D LI Wen J MEMS Laboratory Department of Physics Faculty of Science Kunming University of Science and Technology Department of Mechanical and Biomedical Engineering City University of Hong Kong

This paper presents a design for a self-powered radio frequency identification (RFID) tag with a thin film bulk acoustic reso- nating piezoelectric power supply (PPS), which can be used for portable remote temperature monitoring. We call this system a PPS-RFID for short. The RFID systems have been found to have many applications in the internet of things (IOT) in the past decade. But semi-active RFID tags require an onboard battery which limits their applications in many fields. For these reasons, our research focuses on power sources for the RFID tags. This paper emphasizes the circuit design and simulation of PPS. In our tests, 0.283 mW was generated by PPS at 1 Hz vibration by a 650 N impact force. The results showed that the integrated PPS could supply sufficient power for the designed PPS-RFID tag. The PPS-RFID tag can be widely used for temperature monitoring during mobile transport of perishable items such as medicines or food.

关键词： self-powered radio frequency identification (RFID) piezoelectric temperature monitoring energy harvesting internet of things

日汉比较性程度副词主观性对比研究——以“もっと”类和“更”类副词为例

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外语教学 2022年第4期43卷 22-29页

作者：陈建明西安外国语大学日本文化经济学院西安外国语大学外国语言学及应用语言学研究中心

本文从主观性规约度高低这一维度对日语的“もっと”类和汉语的“更”类比较性程度副词的主观性特征进行了探讨。结果表明,日语和汉语的比较性程度副词均具有较强主观性,前者强于后者。两者的主观性多与语用强化相关,相比之下,日语受语... 详细信息

本文从主观性规约度高低这一维度对日语的“もっと”类和汉语的“更”类比较性程度副词的主观性特征进行了探讨。结果表明,日语和汉语的比较性程度副词均具有较强主观性,前者强于后者。两者的主观性多与语用强化相关,相比之下,日语受语用强化机制影响更大。汉语比较性程度副词的主观性的产生与句式密切相关,这一现象源于其孤立语的特征.而日语比较性程度副词的主观性特征反映出其体验性语言特质。

关键词：比较性程度副词主观性语用强化

Optimizing protein and lipid levels in practical diet for juvenile northern snakehead fish(Channa argus)

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Animal Nutrition 2017年第2期3卷 156-163页

作者： Gladstone Sagada jianming chen Binqian Shen Aixia Huang Lihui Sun Jianhu Jiang Chunhua Jin School of Marine Sciences Ningbo University Agriculture Ministry Key Laboratory of Healthy Freshwater Aquaculture Zhejiang Institute of Freshwater Fisheries

A 3×3 factorial feeding trial was conducted to evaluate the production response of juvenile northern snakehead fish(Channa argus). Nine diets containing 3 protein levels(45%, 48% and 51%) and 3 lipid levels(9%,12% and 15%) were formulated and fed to triplicate groups of juvenile northern snakehead(15.78 ± 0.09 g/fish) for 8 weeks. The formulated diets were named as P45 L9, P45 L12, P45 L15, P48 L9,P48 L12, P48 L15, P51 L9, P51 L12 and P51 L15(P-Protein, L-Lipid), respectively. Fish fed diets with the lowest protein and lipid combination(P45 L9) had the lowest growth performance. Weight gains(WG) of fish fed the 4 diets P48 L12, P48 L15, P51 L9, and P51 L12 were not significantly different(P> 0.05), but significantly higher(P 0.05) by dietary treatments. Based on these results, the diet containing 48%protein with either 12% or 15% lipid is the optimal for supporting growth and feed utilization of juvenile northern snakehead under the current testing conditions.

关键词： Channa argus Growth Protein Lipid Diet

Two-Dimensional Borophene:Properties,Fabrication,and Promising Applications

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Research 2020年第1期2020卷 412-434页

作者： Zhongjian Xie Xiangying Meng Xiangnan Li Weiyuan Liang Weichun Huang Keqiang chen jianming chen chenyang Xing Meng Qiu Bin Zhang Guohui Nie Ni Xie Xiaobing Yan Han Zhang Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Institute of Microscale Optoelectronics and Otolaryngology Department and Biobank of the First Affiliated HospitalShenzhen Second People’s HospitalHealth Science CenterShenzhen UniversityShenzhen 518060China Shenzhen International Institute for Biomedical Research 518116 ShenzhenGuangdongChina National-Local Joint Engineering Laboratory of New Energy Photovoltaic Devices Key Laboratory of Digital Medical Engineering of Hebei ProvinceCollege of Electron and Information EngineeringHebei UniversityBaoding 071002China Nantong Key Lab of Intelligent and New Energy Materials College of Chemistry and Chemical EngineeringNantong UniversityNantong226019 JiangsuChina Center for Stretchable Electronics and Nanoscale Systems Key Laboratory of Optoelectronic Devices and Systems of Ministry of EducationCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Key Laboratory of Marine Chemistry Theory and Technology(Ocean University of China) Ministry of EducationQingdao 266100China

Monoelemental two-dimensional(2D)materials(Xenes)aroused a tremendous attention in 2D science owing to their unique properties and extensive ***,one emerging and typical Xene,has been regarded as a promising agent for energy,sensor,and biomedical ***,the production of borophene is still a challenge because bulk boron has rather intricate spatial structures and multiple chemical *** this review,we describe its excellent properties including the optical,electronic,metallic,semiconducting,photoacoustic,and photothermal *** fabrication methods of borophene are also presented including the bottom-up fabrication and the top-down *** the end,the challenges of borophene in the latest applications are presented and perspectives are discussed.

关键词： properties boron Bor