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genome-wide association study identifies quantitative trait loci affecting cattle temperament

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Zoological Research 2022年第1期43卷 14-25页

作者： jia-Fei Shen Qiu-Ming chen Feng-Wei Zhang Quratulain Hanif Bi-Zhi Huang Ning-Bo chen Kai-Xing Qu Jing-Xi Zhan Hong chen Yu jiang Chu-Zhao Lei Key Laboratory of Animal genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China College of Animal Science Xinjiang Agricultural UniversityUrumqiXinjiang 830052China National Institute for Biotechnology and genetic Engineering Pakistan Institute of Engineering and Applied SciencesFaisalabad 577Pakistan Yunnan Academy of grassland and Animal Science KunmingYunnan 650212China Academy of Science and Technology Chuxiong Normal UniversityChuxiongYunnan 675000China

Cattle temperament is an interesting trait due to its correlation with production efficiency,labor safety,and animal *** date,however,its genetic basis is not clearly ***,we performed a genome-wide association study for a series of temperament traits in cattle,assessed with via open field and novel object tests,using autosomal single nucleotide polymorphisms(SNPs)derived from the whole-genome *** identified 37 and 29 genome-wide significant loci in the open field and novel object tests,*** set analysis revealed the most significant pathway was the neuroactive ligand-receptor interaction pathway,which may be essential for emotional control in *** of the expression levels of 18 tissue-specific genes based on transcriptomic data showed enrichment in the brain,with some candidate genes involved in psychiatric and neurodegenerative diseases in *** on principal component analysis,the first principal component explained the largest variance in the open field and novel object test data,and the most significant loci were assigned to SORCS3 and SESTD1,*** findings should help facilitate cattle breeding for sound temperament by pyramiding favorable alleles to further improve cattle production.

关键词： Cattle temperament Open field test Novel object test SORCS3 SESTD1

Unsteady flow structures in centrifugal pump under two types of stall conditions

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Journal of Hydrodynamics 2018年第6期30卷 1038-1044页

作者： Pei-jian Zhou jia-cheng Dai Ya-fei Li Ting chen Jie-gang Mou College of Mechanical Engineering Zhejiang University of Technology Engineering Research Center of Process Equipment and Remanufacturing Ministry of Education School of Science Wuhan Institute of Technology

The stall is an unsteady flow phenomenon that always causes instabilities and low efficiency for pumps. This paper focuses on the unsteady flow structures and evolutions under two types of stall conditions in centrifugal pump impellers. Two centrifugal pump impellers, one with 6 and another with 5 blades, are considered and a developed large-eddy simulation method is adopted. The results show that the alternative stall occurs in the impeller with 6 blades, while, the rotating stall is observed in that with 5 blades. The flow structure and the pressure fluctuation characteristics are further analyzed. For the alternative stall, the stall cells are fixed relative to the impeller, but a large vortex in the stalled passage is always swaying. The outlet vortex is generated from it, and then develops and sheds periodically. For the rotating stall, the stall cells first occur in the suction side of the blade. With the growth of the stall cells, the block area gradually increases until the inlet region is almost blocked, then moves to the pressure side with a continuous decay. When the rotating stall occurs, the amplitude of the pressure fluctuation is much larger than that under the alternative stall condition. The propagation of the stall cells has a significant effect on the pressure fluctuations in the impeller.

关键词： Centrifugal pump flow structures rotating stall alternative stall large-eddy simulation

Allele mining of wheat ABA receptor at Ta PYL4 suggests neo-functionalization among the wheat homoeologs

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Journal of Integrative Agriculture 2022年第8期21卷 2183-2196页

作者： WU Bang-bang SHI Meng-meng Mohammad POURKHEIRANDISH ZHAO Qi WANg Ying YANg chen-kang QIAO Ling ZHAO jia-jia YAN Su-xian ZHENg Xing-wei ZHENg Jun Institute of Wheat Research Shanxi Agricultural UniversityLinfen 041000P.R.China Plant Molecular Biology and Biotechnology Laboratory Faculty of Veterinary and Agricultural SciencesThe University of MelbourneParkvilleVictoria 3010Australia

ABA receptors(PYR/PYL/RCAR)play a central role in the water loss control of plants.A previous report indicated that TaPYL4 is a critical gene in wheat that improves grain production under drought conditions and increases water use *** this study,we analyzed the sequence polymorphisms and genetic effects of *** on isolated TaPYL4 genes from chromosomes 2A,2B and 2D,three haplotypes were detected in the promoter region of TaPYL4-2A,and two haplotypes were present in TaPYL4-2B and TaPYL4-2D,***/trait association analysis indicated that TaPYL4-2A was significantly associated with plant height in 262 Chinese wheat core collection accessions,as well as the drought tolerance coefficient(DTC)for plant height in 239 wheat varieties from Shanxi Province in multiple ***,the frequencies of favored drought-tolerant haplotype TaPYL4-2A-Hap2 were considerably low,accounting for only 10%,and lines with this certain Hap could be reserved in the breeding ***4-2B was significantly associated with grain number,and the favored haplotype TaPYL4-2B-Hap1 was the dominant allele of above 90% in the *** TaPYL4-2D,there were no significant differences in these traits between the two haplotypes in either of the two *** results indicate that variation might lead to functional differentiation among the homoeologs and the haplotypes had undergone artificial selection during *** molecular markers developed to distinguish these haplotypes could be used for breeding in water-limited regions.

关键词： TaPYL4 haplotypes neo-functionalization molecular markers

Biogeographic divergence in leaf traits of Sapindus mukorossi and Sapindus delavayi and its relation to climate

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Journal of Forestry Research 2021年第4期32卷 1445-1456页

作者： Xin Wang Jiming Liu Xue Rui Yuanyuan Xu guochun Zhao Lixian Wang Xuehuang Weng Zhong chen Liming jia Key Laboratory of Silviculture and Conservation of the Ministry of Education College of ForestryBeijing Forestry UniversityBeijing 100083People’s Republic of China Yuanhua Forestry Biological Technology Co. Ltd.Sanming 650216FujianPeople’s Republic of China

To explore differences in leaf morphology between Sapindus mukorossi and Sapindus delavayi,and how the environment might drive these differences,80 germplasm samples from the Sapindus germplasm nursery in Fujian Province were *** study revealed a wide variation and diversity in 16 germplasm traits,both within and between species grown under the same *** average,the relative contribution of intraspecific variability to total variability was more important(83%) than the relative contribution of interspecific variability(17%).PERMANOVA analysis showed differences in leaflet thickness,length,perimeter,length to width ratio,and leaf hairs or trichome *** analyses between leaf morphological traits and environmental variables indicated that leaves tended to be larger,longer,and thicker in wetter,warmer,and low-altitude *** analysis of the relationship between climate and leaf morphology revealed that *** had a greater sensitivity to climate variation,particularly in response to mean temperatures of the coldest and warmest seasons,which led to differences in leaf traits and the distribution of the two *** findings contribute to the understanding of leaf morphology variations in *** and ***,and provide a basis for the collection of Sapindus germplasm resources,their cultivation and use to help address climate change.

关键词： Climate Leaf morphology Sapindus delavayi Sapindus mukorossi

DataCon:面向安全研究的多领域大规模竞赛开放数据

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信息安全学报 2024年第1期9卷 123-136页

作者：郑晓峰段海新陈震宇应凌云何直泽汤舒俊郑恩南刘保君陆超逸沈凯文张甲陈卓林子翔清华大学网络科学与网络空间研究院北京100084 奇安信科技集团北京100088

网络安全数据是开展网络安全研究、教学的重要基础资源,尤其基于实战场景下的安全数据更是科研教学成果更符合安全实践的保障。然而,由于网络安全的技术变化快、细分领域多、数据敏感等原因,寻找合适的网络安全数据一直是研究者们进行... 详细信息

网络安全数据是开展网络安全研究、教学的重要基础资源,尤其基于实战场景下的安全数据更是科研教学成果更符合安全实践的保障。然而,由于网络安全的技术变化快、细分领域多、数据敏感等原因,寻找合适的网络安全数据一直是研究者们进行科研和老师开展实践教学时关注的重要问题。本文总结并分析了多个领域的经典公开安全数据集,发现其在研究应用时存在数据旧、规模小、危害大等不足;克服安全数据领域选择、大规模实战数据获取、安全隐私开放等困难,构造了更符合当前科研需求DataCon安全数据集。数据集大规模覆盖DNS、恶意软件、加密恶意流量、僵尸网络、网络黑产等多个领域,且均来自实战化场景,并基于DataCon竞赛平台将其开放给参赛者和科研人员。目前,DataCon数据集涵盖了已成功举办四届的“DataCon大数据安全分析大赛”的全部数据,大赛被国家教育部评为优秀案例,并进入多所高校研究生加分名单,数据内容也一直随着真实网络环境中攻防场景的变化而持续更新。目前,DataCon数据集涵盖了已成功举办四届的“DataCon大数据安全分析大赛”的全部数据,大赛被国家教育部评为优秀案例,并进入多所高校研究生加分名单,数据内容也一直随着真实网络环境中攻防场景的变化而持续更新。数据集持续收到科研人员、学术的数据使用申请,支撑了多篇学术论文的发表,充分说明了其有效性和可用性。我们希望DataCon数据及竞赛能够对网络安全领域产、学、研结合有所帮助和促进。

关键词： DataCon 安全研究开放数据竞赛

A pilot study on ^(99m)Tc-3PRgD2 scintigraphy in diagnosis of brain glioma

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Nuclear Science and Techniques 2013年第2期24卷 36-40页

作者： gAO Shi MA Qingjie CUI Qu LIU Lin ZHOU Xueyan jia Bing chen Zuowei ZHANg Haishan China-Japan Union Hospital Jilin University Medical Isotopes Research Center Peking University Department of Nuclear Medicine People's Hospital of Shenzhen

The 99mTc-3PRgD2 targeted SPECT/CT scanning was of significance in detecting differentiated *** this work,the diagnostic value of 99mTc-3PRgD2 scintigraphy in brain glioma was evaluated by the ten clinically verified brain glioma patients after obtaining informed *** patients first accepted X-ray imaging to localize the detecting regions before administrating with 99mTc-3PRgD2 at a mean radioactivity of 849±115 MBq via single intravenous bolus injection 2 h prior to SPECT/CT *** samples for detectingαvβ3 were collected by surgical operations two weeks after the *** results of CT and SPECT scanning were merged and *** correlation between tumor occupation（T/N ratio） andαvβ3 expression level were *** T/N ratios in brain glioma were proportionally correlated to av(33 positive cell percentage（R2=0.9253,pgD2 SPECT scintigraphy on brain *** more pathological types and detecting strategies covering a large amount of samples would aid to clarify the potentials.

关键词：脑胶质瘤诊断价值显像 SPECT 扫描检测 X射线成像临床验证静脉注射

Laparoscopic surgery for congenital biliary dilatation accompanied by accessory hepatic ducts:a report of seven cases

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World Journal of Pediatric Surgery 2022年第2期5卷 34-37页

作者： Yuebin Zhang jia Yu chen Qingjiang Duote Cai Zhigang gao general Pediatric Surgery Zhejiang University School of Medicine Children's HospitalHangzhouZhejiangChina PICU Zhejiang University School of Medicine Children's HospitalHangzhouZhejiangChina

Congenital biliary dilatation(CBD)is a congenital biliary tract anomaly characterized by expansion of the common bile duct and is thus known clinically as a choledochal *** form of CBD varies,and the commonly used clinical classification was described by Todani et al.1 Pancreaticobiliary maljunc-tion is reported to be present in 30%-96%of patients with CBD.23 The main aims of laparoscopic surgery include resection of the dilated biliary ducts,gallbladder,pancreatic-bile diversion,and biliary tract reconstruc-tion.

关键词： biliary surgery congenital

Dye-sensitized solid-state solar cells fabricated by screen-printed TiO_2 thin film with addition of polystyrene balls

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Chinese Chemical Letters 2008年第8期19卷 1004-1007页

作者： Jing Han Jin Mao chen Xiao Wen Zhou Yuan Lin Jing Bo Zhang jian guang jia Department of Chemistry School of Science Beijing University of Chemical Technology Beijing 100029 China Key Laboratory of Photochemistry Center for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

The screen-printed nanoporous TiO2 thin film was employed to fabricate dye-sensitized solid-state solar cells using CuI as hole-transport materials. The solar cell based on nanoporous TiO2 thin film with large pores formed by the addition of polystyrene balls with diameter of 200 nm to the TiO2 paste exhibits photovoltaic performance enhancement, which is attributed to the good contact of CuI with surface of dye-sensitized thin film due to easy penetration of CuI in the film with large pores.

关键词： Dye-sensitized solar ceils Screen-printed TiO2 film Cuprous iodide Polystyrene balls

Bistachybotrysins D and E,one stereoisomeric pair of cytotoxic phenylspirodrimane dimers from Stachybotrys chartarum

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Chinese Chemical Letters 2019年第2期30卷 435-438页

作者： Min Zhang jiamin Feng Xiaona jia Jinlian Zhao Jimei Liu Ridao chen Kebo Xie Dawei chen Yan Li Dan Zhang Jungui Dai State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College

Bistachybotrysins D and E (1 and 2), one stereoisomeric pair of phenylspirodrimane dimers, were isolated from Stachybotrys chartarum CgMCC 3.5365. They represent novel phenylspirodrimane dimers with a central [6,5,6]-tricyclic carbon scaffold containing a cyclopentanone core. The structures of 1 and 2 were elucidated through extensive spectroscopic data analysis, and their absolute configurations were characterized by calculated electronic circular dichroism (ECD). Compounds 1 and 2 displayed potent cytotoxic activity against the four human tumor cell lines HCT116, BgC823, Daoy and Hepg2 with IC_ (50)values ranging from 6.7 μmol/L to 11.6 μmol/L. Furthermore, a plausible biogenetic pathway for 1 and 2 is proposed.

关键词： Bistachybotrysin Stereoisomeric pair Phenylspirodrimane dimer Cytotoxic activity Stachybotrys chartarum